The murine NF2 homologue encodes a highly conserved merlin protein with alternative forms.

No abstract is available for this paper.

• Publication year

  1994

• Venue

  Human Molecular Genetics

• Publication date

  1994-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1093/HMG/3.3.407PMID 8012352
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Exon scanning for mutation of the NF2 gene in schwannomas.

  1994cited by this paper
• DNA diagnosis of neurofibromatosis 2. Altered coding sequence of the merlin tumor suppressor in an extended pedigree.

  1993cited by this paper
• Alteration in a new gene encoding a putative membrane-organizing protein causes neuro-fibromatosis type 2

  1993cited by this paper
• Four tissue-specific mouse ltk mRNAs predict tyrosine kinases that differ upstream of their transmembrane segment.

  1993cited by this paper
• A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor.

  1993cited by this paper
• Analysis of chromosome 22 deletions in neurofibromatosis type 2-related tumors.

  1992cited by this paper
• A genetic study of type 2 neurofibromatosis in the United Kingdom. I. Prevalence, mutation rate, fitness, and confirmation of maternal transmission effect on severity.

  1992cited by this paper
• Molecular characterization of chromosome 22 deletions in schwannomas

  1992cited by this paper
• Neurofibromatosis type 2 appears to be a genetically homogeneous disease.

  1992cited by this paper
• Parental origin of chromosome 22 loss in sporadic and NF2 neuromas.

  1991cited by this paper
• Loss of chromosome 22 alleles in human sporadic spinal schwannomas

  1991cited by this paper
• New markers for the neurofibromatosis-2 region generated by microdissection of chromosome 22.

  1991cited by this paper
• Flanking markers bracket the neurofibromatosis type 2 (NF2) gene on chromosome 22.

  1990cited by this paper
• Assessment of chromosome 22 anomalies in neurinomas by combined karyotype and RFLP analyses.

  1990cited by this paper
• NIH conference. Neurofibromatosis 1 (Recklinghausen disease) and neurofibromatosis 2 (bilateral acoustic neurofibromatosis). An update.

  1990cited by this paper
• Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction.

  1989cited by this paper
• The association of posterior capsular lens opacities with bilateral acoustic neuromas in patients with neurofibromatosis type 2.

  1989cited by this paper
• Neurofibromatosis 2: clinical and DNA linkage studies of a large kindred.

  1988cited by this paper
• Neurofibromatosis 2 (bilateral acoustic neurofibromatosis).

  1988cited by this paper
• Common pathogenetic mechanism for three tumor types in bilateral acoustic neurofibromatosis.

  1987cited by this paper
• Genetic linkage of bilateral acoustic neurofibromatosis to a DNA marker on chromosome 22

  1987cited by this paper
• Molecular genetic approach to human meningioma: loss of genes on chromosome 22.

  1987cited by this paper
• Loss of genes on chromosome 22 in tumorigenesis of human acoustic neuroma

  1986cited by this paper
• DNA sequencing with chain-terminating inhibitors.

  1977cited by this paper

• Nf2-FAK signaling axis is critical for cranial bone ossification and regeneration

  2025cites this paper
• Pathogenic noncoding variants in the neurofibromatosis and schwannomatosis predisposition genes

  2021cites this paper
• Frequency of the Loss of Heterozygosity of the NF2 Gene in Sporadic Spinal Schwannomas.

  2018cites this paper
• The Human Y Chromosome

  2017cites this paper
• Using the Neurofibromatosis Tumor Predisposition Syndromes to Understand Normal Nervous System Development

  2014cites this paper
• Structure and function analysis of the Merlin Sip1 complex

  2011cites this paper
• Merlin; NF2 Tumor Suppressor and Regulator of Receptor Distribution/Signaling

  2011cites this paper
• Merlin/NF2 Tumor Suppressor and Ezrin–Radixin–Moesin (ERM) Proteins in Cancer Development and Progression

  2010cites this paper
• Neurofibromatosis.

  2007cites this paper
• Mutational spectrum of the NF2 gene: a meta‐analysis of 12 years of research and diagnostic laboratory findings

  2007cites this paper
• Tumor suppressor gene regulation of cell growth

  2007cites this paper
• To my Parents List of Publications

  2006cites this paper
• Regulation of the Neurofibromatosis 2 gene promoter expression during embryonic development

  2006cites this paper
• Novel functions of the Neurofibromatosis 2 tumour suppressor protein merlin

  2005cites this paper
• Evolution and origin of merlin, the product of the Neurofibromatosis type 2 (NF2) tumor-suppressor gene

  2005cites this paper
• Development and Application of Microarray-Based Comparative Genomic Hybridization

  2005cites this paper
• The Role of Drosophila Merlin in the Control of Mitosis Exit and Development

  2005cites this paper
• STUDIES ON MESOTHELIAL DIFFERENTIATION PROGNOSTIC AND THERAPEUTIC APPROACHES TO MALIGNANT MESOTHELIOMA

  2005cites this paper
• Characterization of the NF2 protein merlin and the ERM protein ezrin in human, rat, and mouse central nervous system.

  2005cites this paper
• Activation of the tumor suppressor merlin by myosin/moesin phosphatase

  2004cites this paper
• Characterization of chicken Nf2/merlin indicates regulatory roles in cell proliferation and migration

  2004cites this paper
• Activation of the Tumor Suppressor Merlin by Mosin/Moesin Phosphatase

  2004cites this paper
• Mir: A Novel Erm-Like Protein in the Nervous System

  2001cites this paper
• MIR a Novel ERM-like Protein in the Nervous System

  2001cites this paper
• ClC-2 Cl- channels in human lung epithelia: activation by arachidonic acid, amidation, and acid-activated omeprazole.

  2001cites this paper
• Activation Of Human Clc‐2 Cl– Channels: Implications For Cystic Fibrosis

  2000cites this paper
• Cloning and Characterization of SCHIP-1, a Novel Protein Interacting Specifically with Spliced Isoforms and Naturally Occurring Mutant NF2 Proteins

  2000influential citation
• Neurofibromatosis 2: Genetic Analysis of Mild Disease, and Biology of the Gene Product, Merlin

  2000cites this paper
• Allelic expression of the NF2 gene in neurofibromatosis 2 and schwannomatosis

  1999cites this paper
• Inhibition of NF2-negative and NF2-positive primary human meningioma cell proliferation by overexpression of merlin due to vector-mediated gene transfer.

  1999cites this paper
• Expression of the Neurofibromatosis Type 2 Gene in Human Tissues

  1999cites this paper
• Interdomain Interaction of Merlin Isoforms and Its Influence on Intermolecular Binding to NHE-RF*

  1999cites this paper
• Structural Analysis of Drosophila Merlin Reveals Functional Domains Important for Growth Control and Subcellular Localization

  1998cites this paper
• Merlin, the neurofibromatosis type 2 gene product, and beta1 integrin associate in isolated and differentiating Schwann cells.

  1998cites this paper
• Mice heterozygous for a mutation at the Nf2 tumor suppressor locus develop a range of highly metastatic tumors.

  1998cites this paper
• Analysis of molecular domains of epitope-tagged merlin isoforms in Cos-7 cells and primary rat Schwann cells.

  1998cites this paper
• Characterization of the rat neurofibromatosis 2 gene and its involvement in asbestos‐induced mesothelioma

  1997cites this paper
• Neurofibromatosis 2 gene has novel alternative splicings which controls intracellular protein binding.

  1997cites this paper
• Expression of schwannomin in lens and Schwann cells

  1997cites this paper
• Cloning, chromosomal mapping and expression pattern of the mouse Brca2 gene.

  1997cites this paper
• Molecular insights into neurofibromatosis 2.

  1997cites this paper
• Sequence analysis, identification of evolutionary conserved motifs and expression analysis of murine tcof1 provide further evidence for a potential function for the gene and its human homologue, TCOF1.

  1997cites this paper
• Interdomain binding mediates tumor growth suppression by the NF2 gene product

  1997cites this paper
• Neurofibromatosis 2: loss of merlin's protective spell.

  1996cites this paper
• Neurofibromatosis type 2: a new mechanism of tumor suppression.

  1996cites this paper
• Expression of neurofibromatosis 2 transcript and gene product during mouse fetal development.

  1996cites this paper
• Mutational spectrum in the neurofibromatosis type 2 gene in sporadic and familial schwannomas

  1996cites this paper
• Neurofibromatosis 2 gene in human colorectal cancer.

  1995cites this paper
• CNS Young Investigator Award Lecture: molecular analysis of the neurofibromatosis 2 tumor suppressor.

  1995cites this paper
• Widespread but cell type-specific expression of the mouse neurofibromatosis type 2 gene

  1995cites this paper
• Expression of the neurofibromatosis 2 (NF2) gene isoforms during rat embryonic development.

  1995cites this paper
• Neuropathology and Molecular Genetics of Neurofibromatosis 2 and Related Tumors

  1995cites this paper
• Mouse Brca1: localization sequence analysis and identification of evolutionarily conserved domains.

  1995cites this paper
• Transgenic and gene disruption techniques in the study of neurocarcinogenesis

  1995cites this paper
• Tumor suppressor genes as negative growth regulators in development and differentiation.

  1995cites this paper
• Neurofibromatosis type 2.

  1994cites this paper
• Cloning and chromosome localization of the mouse Ews gene.

  1994cites this paper
• An exon 8-spliced out transcript of neurofibromatosis 2 gene is constitutively expressed in various human tissues.

  1994cites this paper
• Exon scanning for mutation of the NF2 gene in schwannomas.

  1994cites this paper
• An anti-Ras function of neurofibromatosis type 2 gene product (NF2/Merlin).

  1994cites this paper
• Alternative transcripts in the mouse neurofibromatosis type 2 (NF2) gene are conserved and code for schwannomins with distinct C-terminal domains.

  1994cites this paper
• Ezrin has a COOH-terminal actin-binding site that is conserved in the ezrin protein family

  1994cites this paper
• Mutational analysis of patients with neurofibromatosis 2.

  1994cites this paper