Advanced glycation end products as a biomarker for incisional hernia

BackgroundIncisional hernia is one of the most frequent complications after abdominal surgery, with incidences up to 30%. A reliable biomarker for the prediction of this complication is lacking. Advanced glycosylation end products (AGEs), also known as non-enzymatic collagen crosslinks, are correlated with aging, smoking, hyperglycemia, hyperlipidemia and oxidative stress. In this study the accumulation of AGEs and the relation between AGEs and incisional hernia were investigated.Materials and methodsIn an exploratory case–control study, 23 patients with incisional hernia after midline incision were compared with 17 patients without clinical or radiological signs of incisional hernia after midline incision, AGEs were measured using a Skin Auto Fluorescence (SAF)-reader.ResultsTwenty-three patients with a clinically significant incisional hernia and 17 control patients were included. The study groups had significant differences in mean BMI. There was a significant difference between mean AGEs in patients with and without incisional hernia after midline incision (3.00 ± 0.15 vs. 2.56 ± 0.11, T test p = 0.03).ConclusionAGE accumulation measured in the skin indirectly with autofluorescence might be associated with incisional hernia. Prospective larger trials should confirm this finding.

• Publication year

  2017

• Venue

  Hernia

• Publication date

  2017-04-12

• Fields of study

  Medicine

• Identifiers
  DOI 10.1007/s10029-017-1610-2PMID 28405811PMCID 5517588
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2010cited by this paper
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  2009cited by this paper
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  2008influential reference
• Signs of herniosis in women with vaginal prolapse and/or stress incontinence

  2008cited by this paper
• Collagen, cross-linking, and advanced glycation end products in aging human skeletal muscle.

  2007cited by this paper
• Role of Biomarkers in Incisional Hernias

  2007cited by this paper
• Skin autofluorescence, a measure of cumulative metabolic stress and advanced glycation end products, predicts mortality in hemodialysis patients.

  2005cited by this paper
• Simple Noninvasive Measurement of Skin Autofluorescence

  2005cited by this paper
• Analysis of collagen-interacting proteins in patients with incisional hernias

  2003cited by this paper
• Incision and abdominal wall hernias in patients with aneurysm or occlusive aortic disease.

  2003cited by this paper
• Cross-linking of glycated collagen in the pathogenesis of arterial and myocardial stiffening of aging and diabetes

  2003cited by this paper
• Meta‐analysis of techniques for closure of midline abdominal incisions

  2002cited by this paper
• Influence of laparotomy closure technique on collagen synthesis in the incisional region

  2002cited by this paper
• The search for an ideal method of abdominal fascial closure: a meta-analysis.

  2000cited by this paper
• Abnormal Collagen I to III Distribution in the Skin of Patients with Incisional Hernia

  2000cited by this paper
• Expression of the Extracellular Matrix Proteins Collagen I, Collagen III and Fibronectin and Matrix Metalloproteinase-1 and -13 in the Skin of Patients with Inguinal Hernia

  1999cited by this paper
• Synthesis of type I and III collagen, expression of fibronectin and matrix metalloproteinases-1 and -13 in hernial sac of patients with inguinal hernia.

  1999cited by this paper
• Greater risk of incisional hernia with morbidly obese than steroid-dependent patients and low recurrence with prefascial polypropylene mesh.

  1996cited by this paper
• Changes in metabolism of collagen in genitourinary prolapse.

  1996cited by this paper
• An evaluation of risk factors in incisional hernia recurrence.

  1993cited by this paper

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  2023cites this paper
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  2022cites this paper
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  2020cites this paper
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  2020cites this paper
• Hernia and Cancer: The Points Where the Roads Intersect

  2019cites this paper
• Prevention of Incisional Hernia: What is new?

  2018cites this paper
• Preventive endoprosthetic replacement of the abdominal wall after midline laparotomy

  2018cites this paper