Buformin exhibits anti-proliferative and anti-invasive effects in endometrial cancer cells.

No abstract is available for this paper.

• Publication year

  2016

• Venue

  American journal of translational research

• Publication date

  2016-06-15

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 27398153PMCID PMC4931164
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Metformin prevents aggressive ovarian cancer growth driven by high-energy diet: similarity with calorie restriction

  2015cited by this paper
• Cancer statistics, 2015

  2015cited by this paper
• Biguanides and targeted anti-cancer treatments

  2015cited by this paper
• The biguanides metformin and phenformin inhibit angiogenesis, local and metastatic growth of breast cancer by targeting both neoplastic and microenvironment cells

  2015cited by this paper
• Effects of Metformin, Buformin, and Phenformin on the Post-Initiation Stage of Chemically Induced Mammary Carcinogenesis in the Rat

  2015cited by this paper
• Metformin and Gynecologic Cancers

  2014cited by this paper
• The complex triad of obesity, diabetes and race in Type I and II endometrial cancers: prevalence and prognostic significance.

  2014cited by this paper
• Synergistic Anti-Cancer Effect of Phenformin and Oxamate

  2014cited by this paper
• Metformin: A Potential Therapeutic Agent for Recurrent Colon Cancer

  2014cited by this paper
• Simvastatin, an HMG-CoA reductase inhibitor, exhibits anti-metastatic and anti-tumorigenic effects in endometrial cancer.

  2014cited by this paper
• Phenformin enhances the therapeutic benefit of BRAFV600E inhibition in melanoma

  2013cited by this paper
• E-cadherin–integrin crosstalk in cancer invasion and metastasis

  2013cited by this paper
• Metformin Blocks Melanoma Invasion and Metastasis Development in AMPK/p53-Dependent Manner

  2013cited by this paper
• Prediagnosis body mass index, physical activity, and mortality in endometrial cancer patients.

  2013cited by this paper
• Metabolic roles of AMPK and metformin in cancer cells

  2013cited by this paper
• Type I and II endometrial cancers: have they different risk factors?

  2013cited by this paper
• Metformin potentiates the effects of paclitaxel in endometrial cancer cells through inhibition of cell proliferation and modulation of the mTOR pathway.

  2012cited by this paper
• Phenformin as prophylaxis and therapy in breast cancer xenografts

  2012cited by this paper
• Hyperactivation of 4E-Binding Protein 1 as a Mediator of Biguanide-Induced Cytotoxicity during Glucose Deprivation

  2012cited by this paper
• Metformin decreases the dose of chemotherapy for prolonging tumor remission in mouse xenografts involving multiple cancer cell types.

  2011cited by this paper
• Metformin treatment exerts antiinvasive and antimetastatic effects in human endometrial carcinoma cells.

  2011cited by this paper
• Recurrent Endometrial Cancer

  2011cited by this paper
• Metformin is a potent inhibitor of endometrial cancer cell proliferation--implications for a novel treatment strategy.

  2010cited by this paper
• Lactic Acidosis Induced by Metformin

  2010cited by this paper
• Chemical genomics identifies the unfolded protein response as a target for selective cancer cell killing during glucose deprivation.

  2009cited by this paper
• Biguanide-induced mitochondrial dysfunction yields increased lactate production and cytotoxicity of aerobically-poised HepG2 cells and human hepatocytes in vitro.

  2008cited by this paper
• Diabetes mellitus is a multivariate independent prognostic factor in endometrial carcinoma: a clinicopathologic study on 313 patients.

  2007cited by this paper
• Buformin suppresses the expression of glyceraldehyde 3-phosphate dehydrogenase.

  2006cited by this paper
• Obesity, diabetes, and other factors in relation to survival after endometrial cancer diagnosis

  2006cited by this paper
• Central and Peripheral Effects of Insulin/IGF‐1 Signaling in Aging and Cancer: Antidiabetic Drugs as Geroprotectors and Anticarcinogens

  2005cited by this paper
• Insulin and longevity: antidiabetic biguanides as geroprotectors

  2004cited by this paper
• Buformin‐Induced Lactic Acidosis—A Symptom of Modern Healthcare Malady

  2004cited by this paper
• Involvement of organic cation transporter 1 in the lactic acidosis caused by metformin.

  2003cited by this paper
• Insulin/IGF-1 signaling pathway driving aging and cancer as a target for pharmacological intervention.

  2003cited by this paper
• An overview of metformin in the treatment of type 2 diabetes mellitus.

  1997cited by this paper
• Biguanide-associated lactic acidosis. Case report and review of the literature.

  1992cited by this paper
• [Inhibition of the blastomogenic effect of 7,12-dimethylbenz(a)anthracene in female rats by buformin, diphenin, a polypeptide pineal extract and L-DOPA].

  1980cited by this paper

• Metformin-Induced Apoptosis Is Mediated Through Mitochondrial VDAC1

  2025cites this paper
• The Effects of Metformin on Weight Loss, Cardiovascular Health, and Longevity.

  2024cites this paper
• Buformin alleviates sepsis-induced acute lung injury via inhibiting NLRP3-mediated pyroptosis through an AMPK-dependent pathway.

  2022cites this paper
• Ascorbate Plus Buformin in AML: A Metabolic Targeted Treatment

  2022cites this paper
• Biguanides drugs: Past success stories and promising future for drug discovery.

  2021cites this paper
• Targeting the metabolism of cancer stem cells by energy disruptor molecules.

  2021cites this paper
• Perspectives of metformin use in endometrial cancer and other gynaecological malignancies

  2021cites this paper
• Synthesis, Anti-Proliferative Evaluation and Mechanism of 4-Trifluoro Methoxy Proguanil Derivatives with Various Carbon Chain Length

  2021cites this paper
• Buformin suppresses osteosarcoma via targeting AMPK signaling pathway

  2020cites this paper
• A dual-functional buformin-mimicking poly(amido amine) for efficient and safe gene delivery

  2020cites this paper
• Nanomicelles Potentiate HDAC Inhibitor Efficacy In Vitro.

  2020cites this paper
• Long noncoding RNA CHL1‐AS1 promotes cell proliferation and migration by sponging miR‐6076 to regulate CHL1 expression in endometrial cancer

  2019cites this paper
• Soluble guanylyl cyclase α1 subunit is a key mediator of proliferation, survival, and migration in ECC-1 and HeLa cell lines

  2019cites this paper
• ONC201 demonstrates anti-tumorigenic and anti-metastatic activity in uterine serous carcinoma in vitro.

  2018cites this paper
• Buformin suppresses proliferation and invasion via AMPK/S6 pathway in cervical cancer and synergizes with paclitaxel

  2018cites this paper
• Buformin increases radiosensitivity in cervical cancer cells via cell-cycle arrest and delayed DNA-damage repair

  2018cites this paper
• Metformin is associated with reduced cell proliferation in human endometrial cancer by inbibiting PI3K/AKT/mTOR signaling

  2018cites this paper
• Buformin inhibits the stemness of erbB-2-overexpressing breast cancer cells and premalignant mammary tissues of MMTV-erbB-2 transgenic mice

  2017influential citation
• Phenformin has anti-tumorigenic effects in human ovarian cancer cells and in an orthotopic mouse model of serous ovarian cancer

  2017cites this paper