Expansion of CD4+CD25+ suppressive regulatory T cells from rhesus macaque peripheral blood by FN18/antihuman CD28-coated Dynal beads.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Human Immunology

• Publication date

  2007-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/J.HUMIMM.2007.02.011PMID 17509447PMCID PMC1976303
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Analysis of FOXP3 protein expression in human CD4(+)CD25(+) regulatory T cells at the single-cell level.

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• Interleukin-2-dependent mechanisms of tolerance and immunity in vivo

  2006influential reference
• Interleukin-2-Dependent Mechanisms of Tolerance and Immunity In Vivo1

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• Only the CD45RA+ subpopulation of CD4+CD25high T cells gives rise to homogeneous regulatory T-cell lines upon in vitro expansion.

  2006cited by this paper
• CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells

  2006cited by this paper
• Analysis of FOXP3 protein expression in human CD4+CD25+ regulatory T cells at the single‐cell level

  2005cited by this paper
• FOCIS abstract supplement

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  2005cited by this paper
• Regulation of CD4+CD25+ regulatory T cell activity: it takes (IL‐)two to tango

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• CD25+ CD4+ T cells compete with naive CD4+ T cells for IL-2 and exploit it for the induction of IL-10 production.

  2005cited by this paper
• Differentiation of Tr1 cells by immature dendritic cells requires IL-10 but not CD25+CD4+ Tr cells.

  2005influential reference
• Human CD25+ regulatory T cells: two subsets defined by the integrins alpha 4 beta 7 or alpha 4 beta 1 confer distinct suppressive properties upon CD4+ T helper cells.

  2004cited by this paper
• TGF-beta 1 plays an important role in the mechanism of CD4+CD25+ regulatory T cell activity in both humans and mice.

  2004cited by this paper
• Cutting Edge: IL-2 Is Critically Required for the In Vitro Activation of CD4+CD25+ T Cell Suppressor Function

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• Large scale in vitro expansion of polyclonal human CD4+CD25high regulatory T cells

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• In vitro-expanded human CD4(+)CD25(+) T-regulatory cells can markedly inhibit allogeneic dendritic cell-stimulated MLR cultures.

  2004influential reference
• Interleukin‐2 is essential for CD4+CD25+ regulatory T cell function

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• Activation requirements for the induction of CD4+CD25+ T cell suppressor function

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• Metastable Tolerance to Rhesus Monkey Renal Transplants Is Correlated with Allograft TGF-β1+CD4+ T Regulatory Cell Infiltrates1

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  2004cited by this paper
• TGF-β1 Plays an Important Role in the Mechanism of CD4+CD25+ Regulatory T Cell Activity in Both Humans and Mice

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• Human CD25+ regulatory T cells: two subsets defined by the integrins α4β7 or α4β1 confer distinct suppressive properties upon CD4+ T helper cells

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• Supporting Online Material

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cord and adult blood

  2002influential reference
• CD4+CD25+ Immunoregulatory T Cells

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  2001cited by this paper
• Human CD4+CD25+ thymocytes and peripheral T cells have immune suppressive activity in vitro

  2001cited by this paper
• CD4+CD25high Regulatory Cells in Human Peripheral Blood1

  2001cited by this paper
• Human anergic/suppressive CD4+CD25+ T cells: a highly differentiated and apoptosis‐prone population

  2001influential reference
• The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

  2001cited by this paper
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• Immunoregulatory role of CD8alpha in the veto effect.

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• Commentary Endothelial Ligands for L-Selectin From Lymphocyte Recirculation to Allograft Rejection

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• CD4+CD25+ T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells.

  1998cited by this paper
• Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state.

  1998cited by this paper
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  1995cited by this paper
• Generalized autoimmune disease in interleukin‐2‐deficient mice is triggered by an uncontrolled activation and proliferation of CD4+ T cells

  1995cited by this paper
• Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

  1995influential reference

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• Non-human primate regulatory T cells: current biology and implications for transplantation.

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