Indoxyl sulfate, a valuable biomarker in chronic kidney disease and dialysis

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Hemodialysis international. International Symposium on Home Hemodialysis

• Publication date

  2016-09-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1111/hdi.12483PMID 27616754
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Indoxyl sulfate suppresses endothelial progenitor cell-mediated neovascularization.

  2016cited by this paper
• Serum Indoxyl Sulfate Associates with Postangioplasty Thrombosis of Dialysis Grafts.

  2016cited by this paper
• A Randomized, Controlled Trial of Oral Intestinal Sorbent AST-120 on Renal Function Deterioration in Patients with Advanced Renal Dysfunction.

  2016cited by this paper
• Klotho Protects Against Indoxyl Sulphate-Induced Myocardial Hypertrophy.

  2015cited by this paper
• Randomized Placebo-Controlled EPPIC Trials of AST-120 in CKD.

  2015cited by this paper
• Indoxyl sulfate exacerbates low bone turnover induced by parathyroidectomy in young adult rats.

  2015cited by this paper
• Effects of oral carbonic adsorbent (AST-120) on kidney of early-stage chronic kidney disease rats

  2015cited by this paper
• Association of indoxyl sulfate with heart failure among patients on hemodialysis.

  2015cited by this paper
• Indoxyl sulfate induces oxidative stress and hypertrophy in cardiomyocytes by inhibiting the AMPK/UCP2 signaling pathway.

  2015cited by this paper
• CB1 cannabinoid receptor antagonist attenuates left ventricular hypertrophy and Akt-mediated cardiac fibrosis in experimental uremia.

  2015cited by this paper
• Role of Indoxyl Sulfate as a Predisposing Factor for Atrial Fibrillation in Renal Dysfunction

  2015cited by this paper
• The uremic toxicity of indoxyl sulfate and p-cresyl sulfate: a systematic review.

  2014cited by this paper
• Effect of increasing dietary fiber on plasma levels of colon-derived solutes in hemodialysis patients.

  2014cited by this paper
• Challenges and opportunities in late-stage chronic kidney disease

  2014cited by this paper
• Differential Effects of Indoxyl Sulfate and Inorganic Phosphate in a Murine Cerebral Endothelial Cell Line (bEnd.3)

  2014cited by this paper
• Vascular calcification: pathophysiology and clinical implications

  2013cited by this paper
• Numerous protein-bound solutes are cleared by the kidney with high efficiency

  2013cited by this paper
• p-Cresol sulfate and indoxyl sulfate induce similar cellular inflammatory gene expressions in cultured proximal renal tubular cells.

  2013cited by this paper
• Very Low Protein Diet Reduces Indoxyl Sulfate Levels in Chronic Kidney Disease

  2013cited by this paper
• Accumulated uremic toxins attenuate bone mechanical properties in rats with chronic kidney disease.

  2013cited by this paper
• HPLC-fluorescence method for measurement of the uremic toxin indoxyl sulfate in plasma.

  2013cited by this paper
• Indoxyl sulfate promotes cardiac fibrosis with enhanced oxidative stress in hypertensive rats.

  2013cited by this paper
• Indoxyl sulfate predicts cardiovascular disease and renal function deterioration in advanced chronic kidney disease.

  2012cited by this paper
• Uremic Toxins Induce Kidney Fibrosis by Activating Intrarenal Renin–Angiotensin–Aldosterone System Associated Epithelial-to-Mesenchymal Transition

  2012cited by this paper
• The role of protein-bound uremic toxins on peripheral artery disease and vascular access failure in patients on hemodialysis.

  2012cited by this paper
• Normal and pathologic concentrations of uremic toxins.

  2012cited by this paper
• Indoxyl sulfate-induced epithelial-to-mesenchymal transition and apoptosis of renal tubular cells as novel mechanisms of progression of renal disease

  2012cited by this paper
• The production of p-cresol sulfate and indoxyl sulfate in vegetarians versus omnivores.

  2012cited by this paper
• Indoxyl Sulfate Induces Epithelial-to-Mesenchymal Transition in Rat Kidneys and Human Proximal Tubular Cells

  2011cited by this paper
• Indoxyl sulfate-induced endothelial dysfunction in patients with chronic kidney disease via an induction of oxidative stress.

  2011cited by this paper
• Oral adsorbent AST-120 ameliorates tubular injury in chronic renal failure patients by reducing proteinuria and oxidative stress generation.

  2011cited by this paper
• Chronic Kidney Disease-Induced Cardiac Fibrosis Is Ameliorated by Reducing Circulating Levels of a Non-Dialysable Uremic Toxin, Indoxyl Sulfate

  2011cited by this paper
• Does indoxyl sulfate, a uraemic toxin, have direct effects on cardiac fibroblasts and myocytes?

  2010cited by this paper
• Senescence and dysfunction of proximal tubular cells are associated with activated p53 expression by indoxyl sulfate.

  2010cited by this paper
• p-Cresyl sulphate and indoxyl sulphate predict progression of chronic kidney disease

  2010cited by this paper
• Uremic toxins originating from colonic microbial metabolism.

  2009cited by this paper
• Development of a biomarker assay for 3-indoxyl sulfate in mouse plasma and brain by liquid chromatography/tandem mass spectrometry.

  2009cited by this paper
• Serum indoxyl sulfate is associated with vascular disease and mortality in chronic kidney disease patients.

  2009cited by this paper
• Oral charcoal adsorbent (AST-120) prevents progression of cardiac damage in chronic kidney disease through suppression of oxidative stress.

  2009cited by this paper
• Indoxyl sulphate promotes aortic calcification with expression of osteoblast-specific proteins in hypertensive rats.

  2008cited by this paper
• An Oral Adsorbent, AST-120 Protects Against the Progression of Oxidative Stress by Reducing the Accumulation of Indoxyl Sulfate in the Systemic Circulation in Renal Failure

  2007cited by this paper
• Indoxyl sulfate-lowering capacity of oral sorbents affects the prognosis of kidney function and oxidative stress in chronic kidney disease.

  2007cited by this paper
• Indoxyl sulfate induces skeletal resistance to parathyroid hormone in cultured osteoblastic cells.

  2007cited by this paper
• The uremic solute indoxyl sulfate induces oxidative stress in endothelial cells

  2007cited by this paper
• Indoxyl Sulfate Reduces Superoxide Scavenging Activity in the Kidneys of Normal and Uremic Rats

  2007cited by this paper
• Definition, evaluation, and classification of renal osteodystrophy: a position statement from Kidney Disease: Improving Global Outcomes (KDIGO).

  2006cited by this paper
• A multicenter, randomized, double-blind, placebo-controlled, dose-ranging study of AST-120 (Kremezin) in patients with moderate to severe CKD.

  2006cited by this paper
• Prospective Randomized Study Evaluating the Efficacy of the Spherical Adsorptive Carbon AST-120 in Chronic Kidney Disease Patients with Moderate Decrease in Renal Function

  2006cited by this paper
• Indoxyl sulfate stimulates proliferation of rat vascular smooth muscle cells.

  2006cited by this paper
• Assessing kidney function--measured and estimated glomerular filtration rate.

  2006cited by this paper
• Indoxyl sulfate induces complex redox alterations in mesangial cells.

  2006cited by this paper
• The clinical epidemiology of cardiovascular disease in chronic kidney disease

  2005cited by this paper
• Nitric oxide and glomerulonephritis.

  2004cited by this paper
• Relation between renal dysfunction and cardiovascular outcomes after myocardial infarction.

  2004cited by this paper
• The uremic solutes p-cresol and indoxyl sulfate inhibit endothelial proliferation and wound repair.

  2004cited by this paper
• Characterization of uremic toxin transport by organic anion transporters in the kidney.

  2004cited by this paper
• Oral Adsorbent AST-120 Decreases Carotid Intima-Media Thickness and Arterial Stiffness in Patients with Chronic Renal Failure

  2004cited by this paper
• Uremic toxins of organic anions up-regulate PAI-1 expression by induction of NF-kappaB and free radical in proximal tubular cells.

  2003cited by this paper
• Effects of the oral adsorbent AST-120 on tryptophan metabolism in uremic patients.

  2003cited by this paper
• Bifidobacterium in gastro-resistant seamless capsule reduces serum levels of indoxyl sulfate in patients on hemodialysis.

  2003cited by this paper
• THE CLINICAL EPIDEMIOLOGY OF CARDIOVASCULAR DISEASES IN CHRONIC KIDNEY DISEASE: Introduction

  2003cited by this paper
• Impact of renal failure on the risk of myocardial infarction and death.

  2002cited by this paper
• Role of organic anion transporters in the tubular transport of indoxyl sulfate and the induction of its nephrotoxicity.

  2002cited by this paper
• Nitric oxide and glomerulonephritis.

  1999cited by this paper
• Indoxyl sulfate stimulates renal synthesis of transforming growth factor-beta 1 and progression of renal failure.

  1997cited by this paper
• Indoxyl sulfate increases the gene expressions of TGF-beta 1, TIMP-1 and pro-alpha 1(I) collagen in uremic rat kidneys.

  1997cited by this paper
• Inhibition of the accumulation of uremic toxins in the blood and their precursors in the feces after oral administration of Lebenin, a lactic acid bacteria preparation, to uremic patients undergoing hemodialysis.

  1996cited by this paper
• Indoxyl sulfate, a circulating uremic toxin, stimulates the progression of glomerular sclerosis.

  1994cited by this paper
• Pathophysiology of atherosclerosis.

  1992cited by this paper
• Accumulation of indoxyl sulfate, an inhibitor of drug-binding, in uremic serum as demonstrated by internal-surface reversed-phase liquid chromatography.

  1988cited by this paper
• Determination of indoxyl sulfate in plasma of patients with renal failure by use of ion-pairing liquid chromatography.

  1986cited by this paper
• Accelerated atherosclerosis in prolonged maintenance hemodialysis.

  1974cited by this paper

• The gut-brain axis in diabetic neuropathy, cognitive impairment, and emotional disorders.

  2026cites this paper
• Maternal Toxoplasma gondii Infection Perturbs Foetal and Maternal Foetal Interface Metabolism, Exposing the Foetus to Kynurenine.

  2026cites this paper
• Clinical Quantitative Method Development of serum indoxyl sulfate (IS) assay using LC-MS/MS

  2025cites this paper
• Food Sensitization Is Associated With Atopic Dermatitis Severity, Gut‐Derived Metabolites and Leaky Gut in Adults

  2025cites this paper
• Intersecting Pathways of Inflammation, Oxidative Stress, and Atherogenesis in the Evaluation of CKD: Emerging Biomarkers PCSK9, EPHX2, AOPPs, and TBARSs

  2025cites this paper
• Visual Ratiometric Fluorescent Capsule for Ultralow Detection of Indoxyl Sulfate: A Paradigm Shift in Point-of-Care Chronic Kidney Disease Diagnostics.

  2025cites this paper
• Severity of atopic dermatitis is associated with gut-derived metabolites and leaky gut-related biomarkers

  2025cites this paper
• Indoxyl sulfate as a potential tubular function marker across kidney disease models.

  2025cites this paper
• Effects of Waterpipe Smoke Exposure on Experimentally Induced Chronic Kidney Disease in Mice

  2024influential citation
• Determination of indoxyl sulfate by spectrofluorimetric method in human plasma through extraction with deep eutectic solvent

  2024cites this paper
• Uremic toxin indoxyl sulfate and its possible influence by diet

  2024cites this paper
• Association between serum total indoxyl sulfate, intraperitoneal inflammation, and peritoneal dialysis technique failure: a 3-year prospective cohort study

  2024cites this paper
• Mitochondrial Dysfunction and Ion Imbalance in a Rat Model of Hemodialysis-Induced Myocardial Stunning

  2024cites this paper
• Gut microbiota and kidney diseases. Literature review

  2024cites this paper
• Amino acid metabolism in kidney health and disease

  2024cites this paper
• Integrating untargeted and targeted LC-MS-based metabolomics to identify the serum metabolite biomarkers for tuberculosis.

  2024cites this paper
• Analysis of indoxyl sulfate in biological fluids with emphasis on sample preparation techniques: A comprehensive analytical review

  2024cites this paper
• Systems-level multi-omics characterization provides novel molecular insights into indomethacin toxicity.

  2023cites this paper
• Does Indoxyl Sulfate Have a Role in Uremic Pruritus? A Laboratory and Interventional Study

  2023cites this paper
• Mitochondrial Impairment: A Link for Inflammatory Responses Activation in the Cardiorenal Syndrome Type 4

  2023cites this paper
• Fecal short chain fatty acids and urinary 3-indoxyl sulfate do not discriminate between patients with Crohn´s disease and ulcerative colitis and are not of diagnostic utility for predicting disease severity

  2023cites this paper
• Chronic kidney disease and gut microbiota

  2023cites this paper
• Identifying disease progression in chronic kidney disease using proton magnetic resonance spectroscopy.

  2023cites this paper
• Gut-Derived Uremic Toxins in CKD: An Improved Approach for the Evaluation of Serum Indoxyl Sulfate in Clinical Practice

  2023cites this paper
• Activation of aryl hydrocarbon receptor (AhR) in Alzheimer’s disease: role of tryptophan metabolites generated by gut host-microbiota

  2023cites this paper
• Production of Indole and Indole-Related Compounds by the Intestinal Microbiota and Consequences for the Host: The Good, the Bad, and the Ugly

  2022cites this paper
• p-Cresyl Sulfate Predicts Ischemic Stroke among Patients on Hemodialysis: A Prospective Cohort Study

  2022cites this paper
• Highlight on some immune disorders in chronic kidney disease

  2022cites this paper
• NMR-Based Metabolomics in Differential Diagnosis of Chronic Kidney Disease (CKD) Subtypes

  2022cites this paper
• Examination of the emerging role of transporters in the assessment of nephrotoxicity

  2022cites this paper
• The Relationship of Uremic Toxin Indoxyl Sulfate and Intestinal Elimination Mechanisms in Hemodialysis Patients

  2022cites this paper
• The Effects of Indoxyl Sulfate and Oxidative Stress on the Severity of Peripheral Nerve Dysfunction in Patients with Chronic Kidney Diseases

  2022cites this paper
• Medium Cut-Off Dialysis Membrane and Dietary Fiber Effects on Inflammation and Protein-Bound Uremic Toxins: A Systematic Review and Protocol for an Interventional Study

  2021cites this paper
• The Role of Uremic Intoxication in the Development of Cardiovascular Remodeling in Patients with Chronic Kidney Disease Stages 3a-5d

  2021cites this paper
• Indoxyl Sulfate Elevated Lnc-SLC15A1-1 Upregulating CXCL10/CXCL8 Expression in High-Glucose Endothelial Cells by Sponging MicroRNAs

  2021cites this paper
• Роль уремической интоксикации в развитии сердечно-сосудистого ремоделирования у пациентов с хронической болезнью почек 3А-5Д стадий

  2021cites this paper
• Microbiota-Mediated Immune Regulation in Atherosclerosis

  2021cites this paper
• Canagliflozin protects the cardiovascular system through effects on the gut environment in non-diabetic nephrectomized rats

  2021cites this paper
• Identification of Volatile Organic Compounds in the urine of patients with Cervical Cancer. Test concept for timely screening.

  2021cites this paper
• Chronic Kidney disease and stroke: A Bi-directional risk cascade and therapeutic update

  2021cites this paper
• The Effect of Metformin in Diabetic and Non-Diabetic Rats with Experimentally-Induced Chronic Kidney Disease

  2021cites this paper
• Intestinal microbiota and diabetic kidney diseases: the Role of microbiota and derived metabolites inmodulation of renal inflammation and disease progression.

  2021cites this paper
• Rapid detection of free and bound toxins using molecularly imprinted silica/graphene oxide hybrids.

  2021cites this paper
• Female AhR Knockout Mice Develop a Minor Renal Insufficiency in an Adenine-Diet Model of Chronic Kidney Disease

  2020cites this paper
• Acute kidney injury leading to CKD is associated with a persistence of metabolic dysfunction and hypertriglyceridemia

  2020cites this paper
• Transcriptome Profiling Reveals Indoxyl Sulfate Should Be Culpable of Impaired T Cell Function in Chronic Kidney Disease

  2020cites this paper
• Different Correlation between Serum Levels of Indoxyl Sulfate and Estimated GFR in the Elderly with or without Dementia

  2020cites this paper
• Associations Among Plant-Based Diet Quality, Uremic Toxins, and Gut Microbiota Profile in Adults Undergoing Hemodialysis Therapy.

  2020cites this paper
• Renal Contributions in the Pathophysiology and Neuropathological Substrates Shared by Chronic Kidney Disease and Alzheimer’s Disease

  2020cites this paper
• Amino Acids in Intestinal Physiology and Health.

  2020cites this paper
• High-protein diets for weight management: Interactions with the intestinal microbiota and consequences for gut health. A position paper by the my new gut study group.

  2019cites this paper
• Indoxyl Sulfate Stimulates Angiogenesis by Regulating Reactive Oxygen Species Production via CYP1B1

  2019cites this paper
• Endoplasmic reticulum stress associated apoptosis as a novel mechanism in indoxyl sulfate‑induced cardiomyocyte toxicity.

  2018influential citation
• The effect of sildenafil on rats with adenine-Induced chronic kidney disease.

  2018cites this paper
• Indoxyl Sulfate Generates Free Radicals, Decreases Antioxidant Defense, and Leads to Damage to Mononuclear Blood Cells.

  2018cites this paper
• Dietary Leucine Supplement Ameliorates Hepatic Steatosis and Diabetic Nephropathy in db/db Mice

  2018cites this paper
• Activation mechanism of AhR pathway in intestinal epithelial cells by commensal bacteria

  2018cites this paper
• Limited Effect of Intravenously Administered Indoxyl Sulfate, a Uremic Toxin, on the Hepatic Transport of Pravastatin in Normal Rats

  2018cites this paper
• Satiating Effect of High Protein Diets on Resistance-Trained Individuals in Energy Deficit

  2018cites this paper
• Impact of chronic kidney dysfunction on serum Sulfatides and its metabolic pathway in mice

  2018cites this paper
• Indoxyl Sulfate Induces Apoptosis and Hypertrophy in Human Kidney Proximal Tubular Cells

  2018cites this paper
• Therapeutic Effects of Selaginella tamariscina on the Model of Acute Gout with Hyperuricemia in Rats Based on Metabolomics Analysis

  2017cites this paper
• mPGES-1-Derived PGE2 Contributes to Indoxyl Sulfate-Induced Mesangial Cell Proliferation

  2017cites this paper
• Estudio metabolómico de la enfermedad renal crónica: del modelo experimental al humano

  2017cites this paper