Co‐regulation of Transcellular and Paracellular Leak Across Microvascular Endothelium By Dynamin and Rac

No abstract is available for this paper.

• Publication year

  2012

• Venue

  American Journal of Pathology

• Publication date

  2012-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.ajpath.2011.12.002PMID 22203054
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2007influential reference
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  2006cited by this paper
• Transvascular protein transport in mice lacking endothelial caveolae.

  2006influential reference
• Dynasore, a cell-permeable inhibitor of dynamin.

  2006cited by this paper
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  2004cited by this paper
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  2003cited by this paper
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  2003cited by this paper
• Transcytosis: crossing cellular barriers.

  2003cited by this paper
• Caveolae/raft-dependent endocytosis

  2003cited by this paper
• Dynamin at the actin-membrane interface.

  2003cited by this paper
• Microvascular Hyperpermeability in Caveolin-1 (−/−) Knock-out Mice

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• Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement.

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• Staphylococcus aureus alpha-toxin induces apoptosis in endothelial cells.

  2000cited by this paper
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  2000cited by this paper
• Effect of pressure on hydraulic conductivity of endothelial monolayers: role of endothelial cleft shear stress.

  1999cited by this paper
• Histamine induces tyrosine phosphorylation of endothelial cell-to-cell adherens junctions.

  1999cited by this paper
• Redundant and Distinct Functions for Dynamin-1 and Dynamin-2 Isoforms

  1998cited by this paper
• Vascular Endothelial Growth Factor Induces Endothelial Fenestrations In Vitro

  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1997cited by this paper
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  1997cited by this paper
• Gp60 Activation Mediates Albumin Transcytosis in Endothelial Cells by Tyrosine Kinase-dependent Pathway*

  1997cited by this paper
• Regulation of receptor-mediated endocytosis by Rho and Rac

  1996cited by this paper
• Receptor-mediated transcytosis of transferrin through blood-brain barrier endothelial cells.

  1996cited by this paper
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  1995cited by this paper
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  1994cited by this paper
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  1993cited by this paper
• Bacterial lipopolysaccharide induces actin reorganization, intercellular gap formation, and endothelial barrier dysfunction in pulmonary vascular endothelial cells: Concurrent F‐actin depolymerization and new actin synthesis

  1993cited by this paper
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  1992cited by this paper
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  1992cited by this paper
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  1992cited by this paper
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  1989cited by this paper
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  1989cited by this paper
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  1988cited by this paper
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  1988cited by this paper
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  1988cited by this paper
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  1983cited by this paper
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