Parallel supercritical fluid chromatography/mass spectrometry system for high-throughput enantioselective optimization and separation.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Journal of Chromatography A

• Publication date

  2007-10-26

• Fields of study

  Medicine, Chemistry, Engineering

• Identifiers
  DOI 10.1016/J.CHROMA.2007.08.079PMID 17900596
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Solving multicomponent chiral separation challenges using a new SFC tandem column screening tool.

  2007cited by this paper
• Multiparallel microfluidic high-performance liquid chromatography for high-throughput normal-phase chiral analysis.

  2007cited by this paper
• Multiparallel chiral method development screening using an 8-channel microfluidic HPLC system.

  2006cited by this paper
• Chiral separations on polysaccharide stationary phases using polar organic mobile phases.

  2006cited by this paper
• Enantioselective chromatography in drug discovery.

  2005cited by this paper
• Integration of supercritical fluid chromatography into drug discovery as a routine support tool. Part I. fast chiral screening and purification.

  2005cited by this paper
• Trends in the development of chiral drugs.

  2004cited by this paper
• Effect of amine mobile phase additives on chiral subcritical fluid chromatography using polysaccharide stationary phases.

  2004cited by this paper
• Chiral separations.

  2004cited by this paper
• Rapid method development for chiral separation in drug discovery using multi-column parallel screening and circular dichroism signal pooling.

  2004cited by this paper
• Transforming chiral liquid chromatography methodologies into more sensitive liquid chromatography-electrospray ionization mass spectrometry without losing enantioselectivity.

  2004cited by this paper
• Rapid method development for chiral separation in drug discovery using sample pooling and supercritical fluid chromatography-mass spectrometry.

  2003cited by this paper
• Pharmaceutical and biomedical applications of chiral capillary electrophoresis and capillary electrochromatography: An update

  2003cited by this paper
• High-throughput method for the production and analysis of large natural product libraries for drug discovery.

  2002cited by this paper
• An evaluation of a four-channel multiplexed electrospray tandem mass spectrometry for higher throughput quantitative analysis.

  2002cited by this paper
• High-throughput mass-directed parallel purification incorporating a multiplexed single quadrupole mass spectrometer.

  2002cited by this paper
• Super/subcritical fluid chromatography chiral separations with macrocyclic glycopeptide stationary phases.

  2002cited by this paper
• High-throughput analysis of natural product compound libraries by parallel LC-MS evaporative light scattering detection.

  2002cited by this paper
• Enantioseparations in super- and subcritical fluid chromatography.

  2001cited by this paper
• Effect of mobile phase acidic additives on enantioselectivity for phenylalanine analogs.

  2001cited by this paper
• An integrated ten-pump, eight-channel parallel LC/MS system for automated high-throughput analysis of proteins.

  2001cited by this paper
• Evaluation of a four-channel multiplexed electrospray triple quadrupole mass spectrometer for the simultaneous validation of LC/MS/MS methods in four different preclinical matrixes.

  2001cited by this paper
• Effect of mobile phase amine additives on enantioselectivity for phenylalanine analogs.

  2001cited by this paper
• Enantiospecific analysis by capillary electrophoresis: Applications in drug metabolism and pharmacokinetics

  2000cited by this paper
• SFC of drug enantiomers.

  2000cited by this paper
• High-throughput chiral liquid chromatography/tandem mass spectrometry.

  2000cited by this paper
• Liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry enantiomeric separation of dl-threo-methylphenidate, (Ritalin) using a macrocyclic antibiotic as the chiral selector.

  1999cited by this paper
• Determination of the enantiomers of salbutamol and its 4-O-sulphate metabolites in biological matrices by chiral liquid chromatography tandem mass spectrometry.

  1998cited by this paper
• Developments of a fully automated parallel HPLC/mass spectrometry system for the analytical characterization and preparative purification of combinatorial libraries

  1998cited by this paper
• Analytical supercritical fluid chromatography using fully automated column and modifier selection valves for the rapid development of chiral separations

  1998cited by this paper

• Mass spectrometry coupling of chip-based supercritical fluid chromatography enabled by make-up flow-assisted backpressure regulation

  2024cites this paper
• Enantiodiscriminating Lipophilic Liquid Membrane-Based Assay for High-Throughput Nanomolar Enantioenrichment of Chiral Building Blocks

  2023cites this paper
• Parallel chiral sub/supercritical fluid chromatography screening as a framework for accelerated purification of pharmaceutical targets.

  2022cites this paper
• Chiral chromatography method screening strategies: Past, present and future.

  2021cites this paper
• Chiral Analytical Scale SFC – Method Development, Stationary Phases, and Mobile Phases

  2019cites this paper
• Chapter 16 – Pharmaceutical Applications

  2017cites this paper
• Hyphenated Detectors: Mass Spectrometry

  2017cites this paper
• General screening and optimization strategy for fast chiral separations in modern supercritical fluid chromatography.

  2017cites this paper
• Use and practice of achiral and chiral supercritical fluid chromatography in pharmaceutical analysis and purification.

  2016cites this paper
• Toward structure-based predictive tools for the selection of chiral stationary phases for the chromatographic separation of enantiomers.

  2016cites this paper
• Effects of Hexane in Supercritical Fluid Chromatography for the Separation of Enantiomers.

  2016cites this paper
• The many faces of packed column supercritical fluid chromatography--a critical review.

  2015cites this paper
• Supercritical Fluid Chromatography–Mass Spectrometry

  2014cites this paper
• Effects of organic modifier and temperature on the enantiomeric separation of several azole drugs using supercritical fluid chromatography and the Chiralpak AD column.

  2014cites this paper
• Chromatographie en phase supercritique : nouvelles perspectives dans le domaine de l'analyse pharmaceutique

  2014cites this paper
• SFC in Process Analytical Chemistry

  2014cites this paper
• Supercritical fluid chromatography as a tool for enantioselective separation; a review.

  2014cites this paper
• Supercritical Fluid Chromatography of Natural Products

  2014cites this paper
• Enantioselective Separations with Supercritical Fluids - Review

  2013cites this paper
• MS Applications in Support of Medicinal Chemistry Sciences

  2013cites this paper
• Atropisomerism and Axial Chirality in Heteroaromatic Compounds

  2012cites this paper
• Supercritical fluid chromatography for the enantioseparation of pharmaceuticals.

  2012cites this paper
• Structure-based design of pyridopyrimidinediones as dipeptidyl peptidase IV inhibitors.

  2012cites this paper
• Supercritical Fluid Chromatography

  2012cites this paper
• Orthogonal analytical screening for liquid chromatography-mass spectrometry method development and preparative scale-up.

  2011cites this paper
• Resolution of racemic γ-lactone flavors on Chiralpak AD by packed column supercritical fluid chromatography.

  2011cites this paper
• Two-dimensional supercritical fluid chromatography/mass spectrometry for the enantiomeric analysis and purification of pharmaceutical samples.

  2011cites this paper
• High Throughput Screening Approach to Lead Discovery

  2010cites this paper
• Characterization of stationary phases by a linear solvation energy relationship utilizing supercritical fluid chromatography.

  2010cites this paper
• High‐Throughput Screening and Method Development Strategies to Separate Chiral Drug Compounds in HPLC, SFC, and CE

  2010cites this paper
• Separation of Chiral Compounds on Polysaccharide Columns

  2010cites this paper
• Emerging analytical separation techniques with high-throughput potential for pharmaceutical analysis, part II: Novel chromatographic modes.

  2010cites this paper
• Importance of mobile phase and injection solvent selection during rapid method development and sample analysis in drug discovery bioanalysis illustrated using convenient multiplexed LC-MS/MS

  2010cites this paper
• Capillary electrophoretic enantioseparation of m-nisoldipine using two different beta-cyclodextrins.

  2009cites this paper
• Advances in High Throughput Supercritical Fluid Chromatography

  2009cites this paper
• Appareil de génération de petits débits dans un canal

  2009cites this paper
• Supercritical Fluid Chromatography‚ÄìMass Spectrometry

  2009cites this paper
• Preparative chromatographic resolution of racemates using HPLC and SFC in a pharmaceutical discovery environment.

  2008cites this paper
• Structure-based design and synthesis of benzimidazole derivatives as dipeptidyl peptidase IV inhibitors.

  2008cites this paper
• Parallel SFC/MS-MUX screening to assess enantiomeric purity.

  2008cites this paper
• Expanding SFC Capability Novel centrifugal fraction collector facilitates SFC-MS purification

  2008cites this paper
• Supercritical fluid chromatography.

  2008cites this paper
• Comparison of the factors that contribute to retention on immobilized polysaccharide-based chiral stationary phases and macrocyclic glycopeptide chiral stationary phases with the Abraham model.

  2008cites this paper