TRPV3 as a therapeutic target for itch.

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Journal of Investigative Dermatology

• Publication date

  2012-08-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1038/jid.2012.97PMID 22475759
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• TRP channel regulates EGFR signaling in hair morphogenesis and skin barrier formation.

  2010influential reference
• Impact of the Gly573Ser substitution in TRPV3 on the development of allergic and pruritic dermatitis in mice.

  2009cited by this paper
• Frontiers in pruritus research: scratching the brain for more effective itch therapy.

  2006cited by this paper
• The neurobiology of itch

  2006cited by this paper
• Potentiation of TRPV3 channel function by unsaturated fatty acids

  2006cited by this paper
• Nitric oxide activates TRP channels by cysteine S-nitrosylation

  2006cited by this paper
• Association of a mutation in TRPV3 with defective hair growth in rodents.

  2006cited by this paper
• Increased capsaicin receptor TRPV1 in skin nerve fibres and related vanilloid receptors TRPV3 and TRPV4 in keratinocytes in human breast pain

  2005cited by this paper
• Impaired Thermosensation in Mice Lacking TRPV3, a Heat and Camphor Sensor in the Skin

  2005cited by this paper
• A cluster randomized controlled trial of a behavioral intervention to facilitate the development and implementation of clinical practice guidelines in Latin American maternity hospitals: the Guidelines Trial: Study protocol [ISRCTN82417627]

  2005cited by this paper
• TRPV3 is a calcium-permeable temperature-sensitive cation channel

  2002cited by this paper
• The temporal reliability of serum estrogens, progesterone, gonadotropins, SHBG and urinary estrogen and progesterone metabolites in premenopausal women

  2002cited by this paper
• A Heat-Sensitive TRP Channel Expressed in Keratinocytes

  2002cited by this paper
• Itch-associated response induced by experimental dry skin in mice.

  2002cited by this paper
• Oxidative Targets in the Stratum corneum

  2001cited by this paper
• Scratching Behavior in Various Strains of Mice

  2001cited by this paper
• Opiate and H1 antagonist effects on histamine induced pruritus and alloknesis

  1997cited by this paper
• The antipruritic effect of a sedative and a non‐sedative antihistamine in atopic dermatitis

  1990cited by this paper

• Activation of transient receptor potential vanilloid 3 is required for keratinocyte differentiation and epidermal barrier formation

  2025cites this paper
• Selective inhibition of TRPV3 channel by natural rosmarinic acid and its analogs for alleviation of skin lesions through downregulation of NF-κB pathway

  2025cites this paper
• Repositioning Fluoxetine as a TRPV3 Channel Inhibitor to Alleviate Skin Inflammation and Pruritus

  2025cites this paper
• Pathogenesis and management of TRPV3-related Olmsted syndrome

  2024cites this paper
• Mouse Models of Itch.

  2024cites this paper
• Inhibition of Cutaneous TRPV3 Channels by Natural Caffeic Acid for the Alleviation of Skin Inflammation

  2024cites this paper
• A Diterpenoid of the Medicinal Plant Andrographis paniculata Targets Cutaneous TRPV3 Channel and Relieves Itch.

  2024cites this paper
• Pain Hypersensitivity in SLURP1 and SLURP2 Knock-out Mouse Models of Hereditary Palmoplantar Keratoderma

  2024cites this paper
• TRPV3 activation by different agonists accompanied by lipid dissociation from the vanilloid site

  2024cites this paper
• An update on mechanisms of pruritus and their potential treatment in primary cutaneous T-cell lymphoma

  2023cites this paper
• Topical borneol relieves nonhistaminergic pruritus via targeting TRPA1 and TRPM8 channels in peripheral nerve terminals of mice.

  2023cites this paper
• TRPV3: Structure, Diseases and Modulators

  2023cites this paper
• TRPV3 Ion Channel: From Gene to Pharmacology

  2023cites this paper
• Borneol exerts its antipruritic effects by inhibiting TRPA1 and activating TRPM8.

  2023cites this paper
• Inhibition of Ca2+-permeable TRPV3 and inflammatory cytokine release by honokiol and magnolol in human epidermal keratinocytes.

  2023cites this paper
• Inhibition of cutaneous heat‐sensitive Ca2+‐permeable transient receptor potential vanilloid 3 channels alleviates UVB‐induced skin lesions in mice

  2023cites this paper
• Alpha-Mangostin: A Potent Inhibitor of TRPV3 and Pro-Inflammatory Cytokine Secretion in Keratinocytes

  2023cites this paper
• Histamine Sensitization of the Voltage-Gated Sodium Channel Nav1.7 Contributes to Histaminergic Itch in Mice.

  2022cites this paper
• TRPV3 and Itch: The Role of TRPV3 in Chronic Pruritus according to Clinical and Experimental Evidence

  2022influential citation
• Structural basis of TRPV3 inhibition by an antagonist

  2022cites this paper
• Structural mechanism of TRPV3 channel inhibition by the anesthetic dyclonine

  2022cites this paper
• Transient receptor potential vanilloid 3 expression is increased in non‐lesional skin of atopic dermatitis patients

  2022cites this paper
• Abnormal Somatosensory Behaviors Associated With a Gain-of-Function Mutation in TRPV3 Channels

  2022cites this paper
• Dyclonine inhibition of TRPV3: From functional discovery to structural insight.

  2022cites this paper
• The coumarin osthole is a non-electrophilic agonist of TRPA1.

  2022cites this paper
• TRPV Protein Family—From Mechanosensing to Cancer Invasion

  2021cites this paper
• Role of TRP Ion Channels in Pruritus.

  2021cites this paper
• Inhibition of temperature-sensitive TRPV3 channel by two natural isochlorogenic acid isomers for alleviation of dermatitis and chronic pruritus

  2021cites this paper
• Structural mechanism of TRPV3 channel inhibition by the plant‐derived coumarin osthole

  2021cites this paper
• TRPV3 expression and purification for structure determination by Cryo-EM.

  2021cites this paper
• A plant‐derived TRPV3 inhibitor suppresses pain and itch

  2021cites this paper
• Therapeutic inhibition of keratinocyte TRPV3 sensory channel by local anesthetic dyclonine

  2020cites this paper
• TRPM8 channels: A review of distribution and clinical role.

  2020cites this paper
• Inhibition of M/Kv7 Currents Contributes to Chloroquine-Induced Itch in Mice

  2020cites this paper
• 3’-O-Methylorobol Inhibits the Voltage-Gated Sodium Channel Nav1.7 with Anti-Itch Efficacy in A Histamine-Dependent Itch Mouse Model

  2019cites this paper
• Inhibition of the Warm Temperature–Activated Ca2+-Permeable Transient Receptor Potential Vanilloid TRPV3 Channel Attenuates Atopic Dermatitis

  2019cites this paper
• Transient Receptor Potential Cation Channel Subfamily Vanilloid 4 and 3 in the Inner Ear Protect Hearing in Mice

  2019cites this paper
• Pharmacological Inhibition of the Temperature-Sensitive and Ca2+-Permeable Transient Receptor Potential Vanilloid TRPV3 Channel by Natural Forsythoside B Attenuates Pruritus and Cytotoxicity of Keratinocytes

  2018cites this paper
• Antipruritic Effect of Natural Coumarin Osthole through Selective Inhibition of Thermosensitive TRPV3 Channel in the Skin

  2018influential citation
• Molecular Mediators of Acute and Chronic Itch in Mouse and Human Sensory Neurons

  2018influential citation
• TRPV3-ANO1 interaction positively regulates wound healing in keratinocytes

  2018cites this paper
• MrgprA3 shows sensitization to chloroquine in an acetone–ether–water mice model

  2017cites this paper
• Direct Involvement of Arachidonic Acid in the Development of Ear Edema via TRPV3.

  2017cites this paper
• The Ca2+-permeable cation TRPV3 channel: an emerging pivotal target for itch and skin diseases

  2017influential citation
• The Ca 2+ ‐ permeable cation TRPV3 channel: an emerging pivotal target for itch and skin diseases

  2017influential citation
• A pivotal role for the activation of TRPV3 channel in itch sensations induced by the natural skin sensitizer carvacrol

  2017cites this paper
• Decreases in 15-lipoxygenase metabolites in Olmsted syndrome model rats.

  2017cites this paper
• A Critical Role for TRP Channels in the Skin

  2017cites this paper
• The Ca2+-Permeable Cation Transient Receptor Potential TRPV3 Channel: An Emerging Pivotal Target for Itch and Skin Diseases

  2017influential citation
• Actions and Regulation of Ionotropic Cannabinoid Receptors.

  2017cites this paper
• The Ca 2 1 -Permeable Cation Transient Receptor Potential TRPV3 Channel: An Emerging Pivotal Target for Itch and Skin Diseases

  2017influential citation
• TRPV3 Channel in Keratinocytes in Scars with Post-Burn Pruritus

  2017cites this paper
• Advances in therapeutic strategies for the treatment of pruritus

  2016cites this paper
• Trp channels and itch

  2016cites this paper
• Are itch and scratching the nausea and vomiting of skin?

  2016cites this paper
• TRP Channels in Skin Biology and Pathophysiology

  2016cites this paper
• Increased activity of TRPV3 in keratinocytes in hypertrophic burn scars with postburn pruritus

  2016cites this paper
• Physically crosslinked-sacran hydrogel films for wound dressing application.

  2016cites this paper
• The G Protein–Coupled Receptor–Transient Receptor Potential Channel Axis: Molecular Insights for Targeting Disorders of Sensation and Inflammation

  2015cites this paper
• Molecular and cellular mechanisms that initiate pain and itch

  2015cites this paper
• Transient receptor potential channels and itch: how deep should we scratch?

  2015cites this paper
• Enhanced nonpeptidergic intraepidermal fiber density and an expanded subset of chloroquine-responsive trigeminal neurons in a mouse model of dry skin itch.

  2015cites this paper
• Role of TRP Channels in Skin Diseases

  2015cites this paper
• Neurobiology of Itch (Pruritus)

  2015cites this paper
• The role of the ion channel, TRPA1, in itch transduction in the mammalian peripheral nervous system. - eScholarship

  2015cites this paper
• Chapter 27 – Conclusions

  2015cites this paper
• Aalborg Universitet A human surrogate model of itch utilizing the TRPA 1 agonist trans-cinnamaldehyde

  2015cites this paper
• Is TRPV3 a Drug Target?—A Decade of Learning

  2015cites this paper
• A human surrogate model of itch utilizing the TRPA1 agonist trans-cinnamaldehyde.

  2015cites this paper
• Increased expression of three types of transient receptor potential channels (TRPA1, TRPV4 and TRPV3) in burn scars with post-burn pruritus.

  2015cites this paper
• TRPV3: time to decipher a poorly understood family member!

  2014cites this paper
• TRP Channel Cannabinoid Receptors in Skin Sensation, Homeostasis, and Inflammation

  2014cites this paper
• Targeting TRP ion channels for itch relief

  2014influential citation
• Antipruritic effect of cold stimulation at the Quchi Acupoint (LI11) in Mice

  2014cites this paper
• Studies on the Pathophysiological Role of TRPV3 in Itchy Dermatitis

  2014influential citation
• Olmsted Syndrome Caused by a Homozygous Recessive Mutation in TRPV3

  2014cites this paper
• Olmsted syndrome caused by a homozygous recessive mutation in TRPV3.

  2014cites this paper
• Calcium — a central regulator of keratinocyte differentiation in health and disease

  2014cites this paper
• Thermally activated TRPV3 channels.

  2014influential citation
• Role of Transient Receptor Potential Channels in Acute and Chronic Itch

  2014cites this paper
• TRPV3: a ‘more than skinny’ channel

  2013cites this paper
• A Counterpart to Pain

  2013cites this paper
• Transient receptor potential channels and dermatological disorders.

  2013cites this paper
• Potential new therapeutic targets for pathological pruritus.

  2013cites this paper
• Targeting TRPV3 for the Development of Novel Analgesics.

  2013cites this paper
• A counterpart to pain : itch

  2013cites this paper
• TRP Channels and Pruritus

  2013cites this paper
• Neural processing of itch.

  2013cites this paper
• Report of the tenth annual International Pachyonychia Congenita Consortium meeting

  2013cites this paper
• Impact of TRPV3 on the development of allergic dermatitis as a dendritic cell modulator

  2013cites this paper
• The challenge of cholestatic pruritus.

  2012cites this paper