The SecY complex: conducting the orchestra of protein translocation.

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Trends in Cell Biology

• Publication date

  2011-09-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.tcb.2011.04.005PMID 21632250
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Mapping of the SecA·SecY and SecA·SecG Interfaces by Site-directed in Vivo Photocross-linking

  2011cited by this paper
• SecA interacts with ribosomes in order to facilitate posttranslational translocation in bacteria.

  2011cited by this paper
• The Sec translocase.

  2011cited by this paper
• Protein translocation across the ER membrane.

  2011cited by this paper
• The Bacterial SRP Receptor, SecA and the Ribosome Use Overlapping Binding Sites on the SecY Translocon

  2011cited by this paper
• Interaction of calmodulin with Sec61α limits Ca2+ leakage from the endoplasmic reticulum

  2011cited by this paper
• Development of a high-throughput screening assay for the discovery of small-molecule SecA inhibitors.

  2011cited by this paper
• Immobilization of the Plug Domain Inside the SecY Channel Allows Unrestricted Protein Translocation*

  2010cited by this paper
• Hydrophobically stabilized open state for the lateral gate of the Sec translocon

  2010cited by this paper
• Dynamics of SecY translocons with translocation-defective mutations.

  2010cited by this paper
• Membrane insertion of marginally hydrophobic transmembrane helices depends on sequence context.

  2010cited by this paper
• The mammalian and yeast translocon complexes comprise a characteristic Sec61 channel.

  2010cited by this paper
• Lateral opening of a translocon upon entry of protein suggests the mechanism of insertion into membranes

  2010cited by this paper
• The Hydrophobic Core of the Sec61 Translocon Defines the Hydrophobicity Threshold for Membrane Integration

  2010cited by this paper
• SecB--a chaperone dedicated to protein translocation.

  2010cited by this paper
• The Oligomeric State and Arrangement of the Active Bacterial Translocon*

  2010cited by this paper
• SecA: a tale of two protomers

  2010cited by this paper
• Mapping of the signal peptide-binding domain of Escherichia coli SecA using Förster resonance energy transfer.

  2010cited by this paper
• Modulation of the SecY channel permeability by pore mutations and trivalent cations

  2010cited by this paper
• Reconstitution of the SecY translocon in nanodiscs.

  2010cited by this paper
• The action of cardiolipin on the bacterial translocon

  2010cited by this paper
• Lipid activation of the signal recognition particle receptor provides spatial coordination of protein targeting

  2010cited by this paper
• Effects of Antibiotics and a Proto-Oncogene Homolog on Destruction of Protein Translocator SecY

  2009cited by this paper
• Two cooperating helices constitute the lipid-binding domain of the bacterial SRP receptor.

  2009cited by this paper
• Signal peptides are allosteric activators of the protein translocase

  2009cited by this paper
• Structure of Monomeric Yeast and Mammalian Sec61 Complexes Interacting with the Translating Ribosome

  2009cited by this paper
• Conformational flexibility and peptide interaction of the translocation ATPase SecA.

  2009cited by this paper
• The SecY complex forms a channel capable of ionic discrimination

  2009cited by this paper
• Structure, Binding, and Activity of Syd, a SecY-interacting Protein*

  2009cited by this paper
• Insertion of short transmembrane helices by the Sec61 translocon

  2009cited by this paper
• Mapping polypeptide interactions of the SecA ATPase during translocation

  2009cited by this paper
• Energy transduction in protein transport and the ATP hydrolytic cycle of SecA

  2009cited by this paper
• The ribosome as a platform for co-translational processing, folding and targeting of newly synthesized proteins

  2009cited by this paper
• Lanthanum ions inhibit the mammalian Sec61 complex in its channel dynamics and protein transport activity

  2009cited by this paper
• Constitutive, translation-independent opening of the protein-conducting channel in the endoplasmic reticulum

  2009cited by this paper
• Structure of a complex of the ATPase SecA and the protein-translocation channel

  2008cited by this paper
• A role for the two-helix finger of the SecA ATPase in protein translocation

  2008cited by this paper
• Conformational transition of Sec machinery inferred from bacterial SecYE structures

  2008cited by this paper
• Structural biology: Clamour for a kiss

  2008cited by this paper
• Direct Observation of Chaperone-Induced Changes in a Protein Folding Pathway

  2007cited by this paper
• Protein translocation across the eukaryotic endoplasmic reticulum and bacterial plasma membranes

  2007cited by this paper
• Protein translocation is mediated by oligomers of the SecY complex with one SecY copy forming the channel.

  2007cited by this paper
• Mutations in the Sec61p Channel Affecting Signal Sequence Recognition and Membrane Protein Topology*

  2007cited by this paper
• Escherichia coli Signal Recognition Particle Receptor FtsY Contains an Essential and Autonomous Membrane-binding Amphipathic Helix*

  2007cited by this paper
• Nanodiscs unravel the interaction between the SecYEG channel and its cytosolic partner SecA

  2007cited by this paper
• Conformational changes in the GTPase modules of the signal reception particle and its receptor drive initiation of protein translocation

  2007cited by this paper
• Structural determinants of lateral gate opening in the protein translocon.

  2007cited by this paper
• Ribosome binding of a single copy of the SecY complex: implications for protein translocation.

  2007cited by this paper
• Determining the conductance of the SecY protein translocation channel for small molecules.

  2007cited by this paper
• The plug domain of the SecY protein stabilizes the closed state of the translocation channel and maintains a membrane seal.

  2007cited by this paper
• Two translocating hydrophilic segments of a nascent chain span the ER membrane during multispanning protein topogenesis

  2007cited by this paper
• Deregulation of the SecYEG translocation channel upon removal of the plug domain.

  2007cited by this paper
• Structural basis for signal-sequence recognition by the translocase motor SecA as determined by NMR.

  2007cited by this paper
• Size, motion, and function of the SecY translocon revealed by molecular dynamics simulations with virtual probes.

  2006cited by this paper
• The plug domain of yeast Sec61p is important for efficient protein translocation, but is not essential for cell viability.

  2006cited by this paper
• Identification of two interaction sites in SecY that are important for the functional interaction with SecA.

  2006cited by this paper
• Protein transport into the endoplasmic reticulum: mechanisms and pathologies.

  2006cited by this paper
• Investigating the SecY plug movement at the SecYEG translocation channel

  2005cited by this paper
• The oligomeric distribution of SecYEG is altered by SecA and translocation ligands.

  2005cited by this paper
• Disulfide bridge formation between SecY and a translocating polypeptide localizes the translocation pore to the center of SecY

  2005cited by this paper
• A selection for mutants that interfere with folding of Escherichia coli thioredoxin-1 in vivo.

  2005cited by this paper
• Recognition of transmembrane helices by the endoplasmic reticulum translocon

  2005cited by this paper
• Architecture of the ribosome-channel complex derived from native membranes.

  2005cited by this paper
• Structure of the E. coli protein-conducting channel bound to a translating ribosome

  2005cited by this paper
• The signal recognition particle and its interactions during protein targeting.

  2005cited by this paper
• Modeling the Effects of prl Mutations on the Escherichia coli SecY Complex

  2005cited by this paper
• Protein translocation by the Sec61/SecY channel.

  2005cited by this paper
• X-ray structure of a protein-conducting channel

  2004cited by this paper
• The endoplasmic reticulum membrane is permeable to small molecules.

  2003cited by this paper
• Cooperation of transmembrane segments during the integration of a double‐spanning protein into the ER membrane

  2003cited by this paper
• Three-dimensional structure of the bacterial protein-translocation complex SecYEG

  2002cited by this paper
• The SecYEG preprotein translocation channel is a conformationally dynamic and dimeric structure

  2002cited by this paper
• Dissociation of the dimeric SecA ATPase during protein translocation across the bacterial membrane

  2002cited by this paper
• Architecture of the protein-conducting channel associated with the translating 80S ribosome.

  2001cited by this paper
• An essential amino acid residue in the protein translocation channel revealed by targeted random mutagenesis of SecY

  2001cited by this paper
• Projection structure and oligomeric properties of a bacterial core protein translocase

  2001cited by this paper
• Mapping the Sites of Interaction between SecY and SecE by Cysteine Scanning Mutagenesis*

  2001cited by this paper
• SecYEG assembles into a tetramer to form the active protein translocation channel

  2000cited by this paper
• The Sec61p complex mediates the integration of a membrane protein by allowing lipid partitioning of the transmembrane domain.

  2000cited by this paper
• The bacterial SecY/E translocation complex forms channel-like structures similar to those of the eukaryotic Sec61p complex.

  1999cited by this paper
• Mapping an Interface of SecY (PrlA) and SecE (PrlG) by Using Synthetic Phenotypes and In Vivo Cross-Linking

  1999cited by this paper
• Signal sequence recognition in posttranslational protein transport across the yeast ER membrane.

  1998cited by this paper
• BiP maintains the permeability barrier of the ER membrane by sealing the lumenal end of the translocon pore before and early in translocation.

  1998cited by this paper
• Sec‐dependent membrane protein biogenesis: SecYEG, preprotein hydrophobicity and translocation kinetics control the stop‐transfer function

  1998cited by this paper
• Syd, a SecY-interacting Protein, Excludes SecA from the SecYE Complex with an Altered SecY24 Subunit*

  1998cited by this paper
• Alignment of conduits for the nascent polypeptide chain in the ribosome-Sec61 complex.

  1997cited by this paper
• Getting greasy: how transmembrane polypeptide segments integrate into the lipid bilayer.

  1997cited by this paper
• Getting greasy: how transmembrane polypeptide segments integrate into the lipid bilayer

  1997cited by this paper
• Molecular mechanism of membrane protein integration into the endoplasmic reticulum.

  1997cited by this paper
• Product of a New Gene, syd, Functionally Interacts with SecY when Overproduced in Escherichia coli(*)

  1995cited by this paper
• FtsH is required for proteolytic elimination of uncomplexed forms of SecY, an essential protein translocase subunit.

  1995cited by this paper
• Protein translocation into proteoliposomes reconstituted from purified components of the endoplasmic reticulum membrane.

  1993cited by this paper
• Preprotein translocation creates a halide anion permeability in the Escherichia coli plasma membrane.

  1992cited by this paper
• Signal peptides open protein-conducting channels in E. coli.

  1992cited by this paper
• The ATPase activity of SecA is regulated by acidic phospholipids, SecY, and the leader and mature domains of precursor proteins.

  1990cited by this paper
• The purified E. coli integral membrane protein SecY/E is sufficient for reconstitution of SecA-dependent precursor protein translocation.

  1990cited by this paper
• Structure of the PBL

  1988cited by this paper
• Phosphatidylglycerol is involved in protein translocation across Escherichia coli inner membranes

  1988cited by this paper
• Topogenic signals in integral membrane proteins.

  1988cited by this paper

• Edwardsiella piscicida requires SecY homeostasis facilitated by FtsH and YccA for stress resistance and virulence

  2024cites this paper
• Specific biomarker mining and rapid detection of Burkholderia cepacia complex by recombinase polymerase amplification

  2023cites this paper
• A Disturbed Siderophore Transport Inhibits Myxobacterial Predation

  2022cites this paper
• The Molecular Biodiversity of Protein Targeting and Protein Transport Related to the Endoplasmic Reticulum

  2021cites this paper
• Dynamics ante portas

  2021cites this paper
• Nanodiscs as a New Tool to Examine Lipid-Protein Interactions.

  2019cites this paper
• Functions and Mechanisms of the Human Ribosome-Translocon Complex.

  2019cites this paper
• Recent advances in nanodisc technology for membrane protein studies (2012–2017)

  2017cites this paper
• Self-assembly of nanoscale particles with biosurfactants and membrane scaffold proteins

  2017cites this paper
• Structural studies of HDL and applications of EM on membrane proteins

  2017cites this paper
• An iTRAQ-Based Proteomics Approach to Clarify the Molecular Physiology of Somatic Embryo Development in Prince Rupprecht's Larch (Larix principis-rupprechtii Mayr)

  2015cites this paper
• Mitochondrial channels: ion fluxes and more.

  2014cites this paper
• Bacterial-based membrane protein production.

  2014cites this paper
• Enhancement of antibody fragment secretion into the Escherichia coli periplasm by co-expression with the peptidyl prolyl isomerase, FkpA, in the cytoplasm.

  2013cites this paper
• From protein production to genome evolution in Escherichia coli

  2013cites this paper
• Single rRNA Helices Bind Independently to the Protein‐Conducting Channel SecYEG

  2013cites this paper
• Nanodiscs as a new tool to examine lipid-protein interactions.

  2013cites this paper
• Nanodiscs and SILAC-based mass spectrometry to identify a membrane protein interactome.

  2012cites this paper
• Two copies of the SecY channel and acidic lipids are necessary to activate the SecA translocation ATPase

  2012cites this paper
• Investigating the physiological roles of YqjA and YghB: members of the conserved DedA membrane protein family in Escherichia coli

  2012cites this paper
• On the quaternary structure and gating of the bacterial protein translocation channel

  2012cites this paper
• Biogenesis of inner membrane proteins in Escherichia coli.

  2012cites this paper
• Biogenese des Rieske-Eisen-Schwefel-Proteins der Mitochondrien

  2012cites this paper
• Resistance to a Novel Antichlamydial Compound Is Mediated through Mutations in Chlamydia trachomatis secY

  2012cites this paper
• Insights Into ER Translocation Channel Gating. Structural Regulation of the Transition Between the Closed and Open Channel Conformations: A Dissertation

  2011cites this paper