HBV-Derived Synthetic Long Peptide Can Boost CD4+ and CD8+ T-Cell Responses in Chronic HBV Patients Ex Vivo

Prototype hepatitis B virus (HBV)-derived synthetic long peptide (SLP) cross-presented by autologous dendritic cells boosted HBV-specific (CD4,CD8) T-cell responses in chronic HBV (CHB) patients ex vivo. Often, PD-L1 blockade improved SLP-responses. This supports therapeutic SLPbased vaccine development for CHB treatment.

• Publication year

  2017

• Venue

  Journal of Infectious Diseases

• Publication date

  2017-12-06

• Fields of study

  Medicine

• Identifiers
  DOI 10.1093/infdis/jix614PMID 29220492PMCID 5853453
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Restoration of T cell function in chronic hepatitis B patients upon treatment with interferon based combination therapy.

  2016cited by this paper
• TLR2 ligand-synthetic long peptide conjugates effectively stimulate tumor-draining lymph node T cells of cervical cancer patients

  2016influential reference
• Efficacy and safety of ombitasvir/paritaprevir/ritonavir and dasabuvir, with or without ribavirin, in adults treated with the regimen approved in Australia, Canada, New Zealand, and Switzerland

  2016cited by this paper
• Adaptive immunity in HBV infection.

  2016cited by this paper
• Hepatitis B Virus--Specific and Global T-Cell Dysfunction in Chronic Hepatitis B.

  2016cited by this paper
• The Effect of Chronic Hepatitis B Virus Infection on BDCA3+ Dendritic Cell Frequency and Function

  2016cited by this paper
• Understanding MHC Class I Presentation of Viral Antigens by Human Dendritic Cells as a Basis for Rational Design of Therapeutic Vaccines

  2014cited by this paper
• Efficient Induction of Antitumor Immunity by Synthetic Toll-like Receptor Ligand–Peptide Conjugates

  2014cited by this paper
• Enhancing Virus-Specific Immunity In Vivo by Combining Therapeutic Vaccination and PD-L1 Blockade in Chronic Hepadnaviral Infection

  2014cited by this paper
• Hepatitis B virus infection.

  2014cited by this paper
• Restoration of HBV-specific CD8+ T cell function by PD-1 blockade in inactive carrier patients is linked to T cell differentiation.

  2014cited by this paper
• Mobilizing monocytes to cross-present circulating viral antigen in chronic infection.

  2013cited by this paper
• Phase I Trial of Overlapping Long Peptides from a Tumor Self-Antigen and Poly-ICLC Shows Rapid Induction of Integrated Immune Response in Ovarian Cancer Patients

  2012cited by this paper
• Global epidemiology of hepatitis B virus infection: new estimates of age-specific HBsAg seroprevalence and endemicity.

  2012cited by this paper
• Restored function of HBV-specific T cells after long-term effective therapy with nucleos(t)ide analogues.

  2012cited by this paper
• Restoration of TLR3-Activated Myeloid Dendritic Cell Activity Leads to Improved Natural Killer Cell Function in Chronic Hepatitis B Virus Infection

  2012cited by this paper
• Combined blockade of programmed death-1 and activation of CD137 increase responses of human liver T cells against HBV, but not HCV.

  2012cited by this paper
• Engineering virus-specific T cells that target HBV infected hepatocytes and hepatocellular carcinoma cell lines.

  2011cited by this paper
• Hepatitis B Virus Lacks Immune Activating Capacity, but Actively Inhibits Plasmacytoid Dendritic Cell Function

  2011cited by this paper
• Viral load reduction improves activation and function of natural killer cells in patients with chronic hepatitis B.

  2011cited by this paper
• Therapeutic vaccines and immune-based therapies for the treatment of chronic hepatitis B: perspectives and challenges.

  2011cited by this paper
• Bystander killing of cancer requires the cooperation of CD4+ and CD8+ T cells during the effector phase

  2010cited by this paper
• CD4+ T-cell help in the tumor milieu is required for recruitment and cytolytic function of CD8+ T lymphocytes.

  2010cited by this paper
• PD‐1/PD‐L1 pathway and T‐cell exhaustion in chronic hepatitis virus infection

  2010cited by this paper
• Antiviral intrahepatic T-cell responses can be restored by blocking programmed death-1 pathway in chronic hepatitis B.

  2010cited by this paper
• Dendritic cells in chronic viral hepatitis B and C: victims or guardian angels?

  2009cited by this paper
• CD8+ T Cell Control of Hepatitis B Virus Replication: Direct Comparison between Cytolytic and Noncytolytic Functions

  2009cited by this paper
• Induction of p53-Specific Immunity by a p53 Synthetic Long Peptide Vaccine in Patients Treated for Metastatic Colorectal Cancer

  2009cited by this paper
• Vaccination against HPV-16 oncoproteins for vulvar intraepithelial neoplasia.

  2009cited by this paper
• Understanding the immunopathogenesis of chronic hepatitis B virus: An Asian prospective

  2008cited by this paper
• Toll-like receptor ligands synergize through distinct dendritic cell pathways to induce T cell responses: Implications for vaccines

  2008cited by this paper
• Host Ethnicity and Virus Genotype Shape the Hepatitis B Virus-Specific T-Cell Repertoire

  2008cited by this paper
• Cancer immunotherapy by dendritic cells.

  2008cited by this paper
• Immunotherapy of established (pre)malignant disease by synthetic long peptide vaccines

  2008influential reference
• Bim-mediated deletion of antigen-specific CD8 T cells in patients unable to control HBV infection.

  2008cited by this paper
• Functional skewing of the global CD8 T cell population in chronic hepatitis B virus infection

  2008cited by this paper
• Regulation of Toll‐like receptor‐2 expression in chronic hepatitis B by the precore protein

  2007cited by this paper
• Characterization of Hepatitis B Virus (HBV)-Specific T-Cell Dysfunction in Chronic HBV Infection

  2007cited by this paper
• Distinct Uptake Mechanisms but Similar Intracellular Processing of Two Different Toll-like Receptor Ligand-Peptide Conjugates in Dendritic Cells*

  2007cited by this paper
• PD-1:PD-L1 Interactions Contribute to the Functional Suppression of Virus-Specific CD8+ T Lymphocytes in the Liver1

  2007cited by this paper
• Triggering TLR signaling in vaccination.

  2006cited by this paper
• Tumor necrosis factor alpha inhibition of hepatitis B virus replication involves disruption of capsid Integrity through activation of NF-kappaB.

  2003cited by this paper
• Tumor Necrosis Factor Alpha Inhibition of Hepatitis B Virus Replication Involves Disruption of Capsid Integrity through Activation of NF-κB

  2003cited by this paper
• The Role of Virus-Specific Cd8+ Cells in Liver Damage and Viral Control during Persistent Hepatitis B Virus Infection

  2000cited by this paper
• In Vivo Regulation of Hepatitis B Virus Replication by Peroxisome Proliferators

  1999cited by this paper
• Viral clearance without destruction of infected cells during acute HBV infection.

  1999cited by this paper
• Hepatitis B virus infection.

  1998cited by this paper

• HLA I immunopeptidome of synthetic long peptide pulsed human dendritic cells for therapeutic vaccine design

  2025cites this paper
• Bioorthogonal click chemistry to visualize an immunogenic HLA-A2-restricted hepatitis B virus epitope in human monocyte-derived dendritic cells.

  2025cites this paper
• PV-10 enhances immune responses in hepatitis B vaccination through STING pathway

  2025cites this paper
• Preclinical evaluation of therapeutic vaccines for chronic hepatitis B that stimulate antiviral activities of T cells and NKT cells

  2024cites this paper
• Targeting the main SARS-Cov-2 pathways with peptide inhibitors by molecular docking and molecular simulation approaches

  2024cites this paper
• Sec22b and Stx4 Depletion Has No Major Effect on Cross-Presentation of PLGA Microsphere-Encapsulated Antigen and a Synthetic Long Peptide In Vitro.

  2023cites this paper
• Induction of broad multifunctional CD8+ and CD4+ T cells by hepatitis B virus antigen-based synthetic long peptides ex vivo

  2023cites this paper
• Influencе of peptides from the bursa of Fabricius in broiler chickens on the functional activity of subpopulations of lymphocytes in immunosuppressed mice

  2022cites this paper
• Research Progress on the Mechanism of Persistent Low-Level HBsAg Expression in the Serum of Patients with Chronic HBV Infection

  2022cites this paper
• Toll-like receptor-mediated innate immunity orchestrates adaptive immune responses in HBV infection

  2022cites this paper
• Immunopeptidome of hepatocytes isolated from patients with HBV infection and hepatocellular carcinoma

  2022cites this paper
• Designing the next‐generation therapeutic vaccines to cure chronic hepatitis B: focus on antigen presentation, vaccine properties and effect measures

  2021cites this paper
• Humoral Immune Responses and Hepatitis B Infection

  2021cites this paper
• Opportunities for Conventional and In Situ Cancer Vaccine Strategies and Combination with Immunotherapy for Gastrointestinal Cancers, A Review

  2020cites this paper
• Design of TLR2-ligand-synthetic long peptide conjugates for therapeutic vaccination of chronic HBV patients.

  2020influential citation
• Peptides to combat viral infectious diseases

  2020cites this paper
• Vaccination against Hepatitis B Virus through Various Strategies

  2019cites this paper
• A review for the neuroprotective effects of andrographolide in the central nervous system.

  2019cites this paper
• Peptide Vaccines: New Trends for Avoiding the Autoimmune Response

  2018cites this paper