The Drosophila maternal-effect gene fs(1)Ya encodes a cell cycle-dependent nuclear envelope component required for embryonic mitosis.

The maternal-effect gene fs(1)Ya is specifically required for embryonic mitosis in Drosophila. fs(1)Ya is involved in the initiation of the first embryonic mitosis and may also be necessary for subsequent embryonic mitotic divisions. fs(1)Ya encodes a 91.3 kd hydrophilic protein containing two putative MPF phosphorylation target sites and two potential nuclear localization signals. This protein is synthesized during postoogenic maturation from its maternal RNA and persists throughout embryogenesis. In early embryos, the fs(1)Ya protein is localized to the nuclear envelope from interphase to metaphase. During anaphase and telophase, it is dispersed in the nucleoplasm and cytoplasm, a behavior that is different from that of both the nuclear envelope and lamins. These results suggest that the fs(1)Ya protein is a cell cycle-dependent component of the nuclear envelope that specifically functions in embryonic mitosis.

• Publication year

  1991

• Venue

  Cell

• Publication date

  1991-01-11

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/0092-8674(91)90208-GPMID 1986869
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cloning and analysis of fs(1) Ya, a maternal effect gene required for the initiation of Drosophila embryogenesis

  2004cited by this paper
• In vitro disassembly of the nuclear lamina and M phase-specific phosphorylation of lamins by cdc2 kinase.

  1990cited by this paper
• Identification of major nucleolar proteins as candidate mitotic substrates of cdc2 kinase.

  1990cited by this paper
• Identification of cell cycle-regulated phosphorylation sites on nuclear lamin C.

  1990cited by this paper
• Driving the cell cycle: M phase kinase, its partners, and substrates

  1990cited by this paper
• Parasites in Drosophila embryos

  1990cited by this paper
• Microorganisms associated with chromosome destruction and reproductive isolation between two insect species

  1990cited by this paper
• Driving the cell cycle: M phase kinase, its partners, and substrates.

  1990cited by this paper
• Genetic analysis of a Drosophila neural cell adhesion molecule: interaction of fasciclin I and Abelson tyrosine kinase mutations.

  1990cited by this paper
• Mutations of phosphorylation sites in lamin A that prevent nuclear lamina disassembly in mitosis.

  1990cited by this paper
• Structure, cell-specific expression, and mating-induced regulation of a Drosophila melanogaster male accessory gland gene.

  1990cited by this paper
• Universal control mechanism regulating onset of M-phase

  1990cited by this paper
• The roles of Drosophila cyclins A and B in mitotic control.

  1990cited by this paper
• Female sterile mutations on the second chromosome of Drosophila melanogaster. I. Maternal effect mutations.

  1989cited by this paper
• SPKK, a new nucleic acid‐binding unit of protein found in histone.

  1989cited by this paper
• Mitosis comes apart.

  1989cited by this paper
• Heat shock and developmental regulation of the Drosophila melanogaster hsp83 gene

  1989cited by this paper
• Mitosis in Drosophila.

  1989cited by this paper
• The gradient morphogen bicoid is a concentration-dependent transcriptional activator.

  1989cited by this paper
• Poly(A) addition during maturation of frog oocytes: distinct nuclear and cytoplasmic activities and regulation by the sequence UUUUUAU.

  1989cited by this paper
• Checkpoints: controls that ensure the order of cell cycle events.

  1989cited by this paper
• Expression and function of Drosophila cyclin A during embryonic cell cycle progression.

  1989cited by this paper
• Mitotic domains reveal early commitment of cells in Drosophila embryos.

  1989cited by this paper
• Genetic control of cell division patterns in the Drosophila embryo.

  1989cited by this paper
• A common RNA recognition motif identified within a defined U1 RNA binding domain of the 70K U1 snRNP protein.

  1989cited by this paper
• Transcripts of one of two Drosophila cyclin genes become localized in pole cells during embryogenesis

  1989cited by this paper
• Directing cell division during development.

  1989cited by this paper
• Regulated polyadenylation controls mRNA translation during meiotic maturation of mouse oocytes.

  1989cited by this paper
• Cyclin synthesis drives the early embryonic cell cycle

  1989cited by this paper
• Dissection of functional domains of the pituitary-specific transcription factor GHF-1

  1989cited by this paper
• Centrosomes, and not nuclei, initiate pole cell formation in Drosophila embryos.

  1989cited by this paper
• Putting it on and taking it off: phosphoprotein phosphatase involvement in cell cycle regulation.

  1989cited by this paper
• ‘SPKK’ motifs prefer to bind to DNA at A/T‐rich sites.

  1989cited by this paper
• Mitotic control by metaphase-promoting factor and cdc proteins.

  1989cited by this paper
• The conserved carboxy-terminal cysteine of nuclear lamins is essential for lamin association with the nuclear envelope

  1989cited by this paper
• The leucine zipper: a hypothetical structure common to a new class of DNA binding proteins.

  1988cited by this paper
• How eukaryotic transcriptional activators work

  1988cited by this paper
• The product of the Drosophila gene vasa is very similar to eukaryotic initiation factor-4A

  1988cited by this paper
• Cloning of a gene encoding an antigen associated with the centrosome in Drosophila.

  1988cited by this paper
• Requirements for X-linked zygotic gene activity during cellularization of early Drosophila embryos.

  1988cited by this paper
• A stable genomic source of P element transposase in Drosophila melanogaster.

  1988cited by this paper
• Developmental and mitotic behaviour of two novel groups of nuclear envelope antigens of Drosophila melanogaster.

  1988cited by this paper
• The role of localization of bicoid RNA in organizing the anterior pattern of the Drosophila embryo.

  1988cited by this paper
• A gradient of bicoid protein in Drosophila embryos.

  1988cited by this paper
• Requirements for autosomal gene activity during precellular stages of Drosophila melanogaster.

  1988cited by this paper
• Structure and expression of a Drosophila male accessory gland gene whose product resembles a peptide pheromone precursor.

  1988cited by this paper
• Functional cDNA libraries from Drosophila embryos.

  1988cited by this paper
• Zinc fingers: gilt by association.

  1988cited by this paper
• Analysis of Sp1 in vivo reveals mutiple transcriptional domains, including a novel glutamine-rich activation motif

  1988cited by this paper
• Unraveling of mitotic control mechanisms.

  1988cited by this paper
• The C. elegans cell lineage and differentiation gene unc-86 encodes a protein with a homeodomain and extended similarity to transcription factors.

  1988cited by this paper
• Cyclin in fission yeast

  1988cited by this paper
• Zinc fingers: gilt by association.

  1988cited by this paper
• Cyclin in fission yeast.

  1988cited by this paper
• Nuclear reconstitution in vitro: stages of assembly around protein-free DNA.

  1987cited by this paper
• Comparison of the consensus sequence flanking translational start sites in Drosophila and vertebrates.

  1987cited by this paper
• The gnu mutation of Drosophila causes inappropriate DNA synthesis in unfertilized and fertilized eggs.

  1987cited by this paper
• Of URFs and ORFs: A primer on how to analyze derived amino acid sequences: Russell F. Doolittle, University Science Books, Mill Valley, CA. Paperback. Under $15

  1987cited by this paper
• The white gene as a marker in a new P-element vector for gene transfer in Drosophila.

  1987cited by this paper
• Cell cycle control of the yeast HO gene: cis- and trans-acting regulators.

  1987cited by this paper
• Genetics of Parthenogenesis in DROSOPHILA MELANOGASTER. I. the Modes of Diploidization in the Gynogenesis Induced by a Male-Sterile Mutant, ms(3)K81.

  1986cited by this paper
• The dissociation of nuclear and centrosomal division in gnu, a mutation causing giant nuclei in Drosophila.

  1986cited by this paper
• The nuclear lamins. A multigene family of proteins in evolution and differentiation.

  1986cited by this paper
• Protein import into the cell nucleus.

  1986cited by this paper
• Nuclear lamina and organization of nuclear architecture

  1986cited by this paper
• Cell cycle control by the nucleo-cytoplasmic ratio in early Drosophila development.

  1986cited by this paper
• X-linked female-sterile loci in Drosophila melanogaster.

  1986cited by this paper
• Parameters controlling transcriptional activation during early Drosophila development.

  1986cited by this paper
• Of urfs and orfs : a primer on how to analyze devised amino acid sequences

  1986cited by this paper
• Organization of the cytoskeleton in early Drosophila embryos

  1986cited by this paper
• Poly(A) shortening of coregulated transcripts in Drosophila.

  1986cited by this paper
• The engrailed locus of Drosophila: structural analysis of an embryonic transcript.

  1985cited by this paper
• opa: a novel family of transcribed repeats shared by the Notch locus and other developmentally regulated loci in D. melanogaster.

  1985cited by this paper
• A conserved DNA sequence in homoeotic genes of the Drosophila Antennapedia and bithorax complexes

  1984cited by this paper
• Dynamics of the nuclear envelope and of nuclear pore complexes during mitosis in the Drosophila embryo.

  1984cited by this paper
• Dynamics of the nuclear envelope and of nuclear pore complexes during mitosis in the Drosophila embryo.

  1984cited by this paper
• Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing.

  1984cited by this paper
• Sequence of a Drosophila segmentation gene: protein structure homology with DNA-binding proteins

  1984cited by this paper
• Identification, developmental regulation, and response to heat shock of two antigenically related forms of a major nuclear envelope protein in Drosophila embryos: application of an improved method for affinity purification of antibodies using polypeptides immobilized on nitrocellulose blots

  1984cited by this paper
• Gynogenesis in Drosophila melanogaster

  1984cited by this paper
• Synthesis of human insulin gene. VIII. Construction of expression vectors for fused proinsulin production in Escherichia coli.

  1984cited by this paper
• Studies of nuclear and cytoplasmic behaviour during the five mitotic cycles that precede gastrulation in Drosophila embryogenesis.

  1983cited by this paper
• Nuclear structure: determination of the fate of the nuclear envelope in Drosophila during mitosis using monoclonal antibodies.

  1983cited by this paper
• Monoclonal antibodies against a nuclear membrane protein of Drosophila. Localization by indirect immunofluorescence and detection of antigen using a new protein blotting procedure.

  1981cited by this paper
• Chimaeras of Drosophila melanogaster obtained by injection of haploid nuclei

  1980cited by this paper
• Monoclonal antibodies against chromosomal proteins of Drosophila melanogaster

  1980cited by this paper
• Nonessential Sequences, Genes, and the Polytene Chromosome Bands of DROSOPHILA MELANOGASTER.

  1978cited by this paper
• Mass isolation of pole cells from Drosophila melanogaster.

  1977cited by this paper
• Developmental genetics of the Drosophila egg. I. Identification of 59 sex-linked cistrons with maternal effects on embryonic development.

  1977cited by this paper
• Autoradiographic study of protein and RNA formation during early development of Drosophila eggs.

  1976cited by this paper
• Mung bean nuclease I. Terminally directed hydrolysis of native DNA.

  1976cited by this paper
• Paternal loss (pal): a meiotic mutant in Drosophila melanogaster causing loss of paternal chromosomes.

  1975cited by this paper
• Isolation and characterization of sex-linked female-sterile mutants in Drosophila melanogaster.

  1975cited by this paper
• Developmental defects of female-sterile mutants of Drosophila melanogaster.

  1975cited by this paper
• The units of DNA replication in Drosophila melanogaster chromosomes.

  1974cited by this paper
• An examination of the one cistron: one chromomere concept.

  1974cited by this paper
• The anatomy and function of a segment of the X chromosome of Drosophila melanogaster.

  1972cited by this paper
• The interaction of steroids with Rana pipiens Oocytes in the induction of maturation.

  1971cited by this paper
• Cytoplasmic control of nuclear behavior during meiotic maturation of frog oocytes.

  1971cited by this paper
• A DNA and RNA-containing cytoplasmic body in Drosophila melanogaster and its relation to flies.

  1965cited by this paper

• The Drosophila nucleoporin ELYS is required for parental chromosome arrangement at fertilization

  2025influential citation
• Kr-h1 maintains distinct caste-specific neurotranscriptomes in response to socially regulated hormones.

  2021cites this paper
• Genetic Analyses of Elys Mutations in Drosophila Show Maternal-Effect Lethality and Interactions with Nucleoporin Genes

  2018cites this paper
• Calcineurin-dependent Protein Phosphorylation Changes During Egg Activation in Drosophila melanogaster

  2018cites this paper
• Maternal Proteins That Are Phosphoregulated upon Egg Activation Include Crucial Factors for Oogenesis, Egg Activation and Embryogenesis in Drosophila melanogaster

  2017cites this paper
• Zygotes segregate entire parental genomes in distinct blastomere lineages causing cleavage-stage chimerism and mixoploidy

  2016cites this paper
• The intimate genetics of Drosophila fertilization

  2015cites this paper
• Quantitative proteomics reveals the dynamics of protein changes during Drosophila oocyte maturation and the oocyte-to-embryo transition

  2014cites this paper
• Nuclear Envelope Dynamics in Drosophila Pronuclear Formation and in Embryos

  2013cites this paper
• Phospho-Regulation Pathways During Egg Activation in Drosophila melanogaster

  2013cites this paper
• Rna Regulation During Gametogenesis And Triggers Of Egg Activation In Drosophila Melanogaster

  2013cites this paper
• Protein phosphorylation changes reveal new candidates in the regulation of egg activation and early embryogenesis in D. melanogaster.

  2012cites this paper
• Nature And Regulation Of Protein Phosphorylation Changes During Egg Activation In Drosophila Melanogaster

  2012cites this paper
• Cytoplasmic Polyadenylation Of Maternal Transcripts By Wispy In Drosophila Melanogaster

  2010cites this paper
• The evolutionary significance of variation in sperm–egg interactions

  2009cites this paper
• YA is needed for proper nuclear organization to transition between meiosis and mitosis in Drosophila

  2009cites this paper
• Evaluation of Mammalian Cell-free Systems of Nuclear Disassembly and Assembly

  2008cites this paper
• PHOSPHORYLATION CHANGES DURING EGG ACTIVATION AND ON REGULATORS OF THE FIRST EMBRYONIC CELL CYCLE IN DROSOPHILA

  2008cites this paper
• Transitioning from egg to embryo: Triggers and mechanisms of egg activation

  2008cites this paper
• 1.6 – Molecular Genetics of Insect Fertilization

  2005cites this paper
• Zygotic transcription and cell proliferation duringDrosophila embryogenesis

  2005cites this paper
• A hydrophilic lamin-binding domain from the Drosophila YA protein can target proteins to the nuclear envelope

  2003cites this paper
• Regulation of maternal transcript destabilization during egg activation in Drosophila.

  2003cites this paper
• Sperm chromatin remodelling and Wolbachia-induced cytoplasmic incompatibility in Drosophila.

  2003cites this paper
• Dynamic interactions of nuclear lamina proteins with chromatin and transcriptional machinery

  2003cites this paper
• The Drosophila nuclear lamina protein YA binds to DNA and histone H2B with four domains.

  2002cites this paper
• Targeting and Retention of Proteins in the Inner and Pore Membranes of the Nuclear Envelope

  2002cites this paper
• Interaction of the essential Drosophila nuclear protein YA with P0/AP3 in the cytoplasm and in vitro: implications for developmental regulation of YA's subcellular location.

  2002cites this paper
• Mutational Analyses of fs( 1 )Ya, an Essential, Developmentally Regulated, Nuclear Envelope Protein in Drosophila

  2002cites this paper
• Dynamics of the nuclear envelope at mitosis and during apoptosis

  2001cites this paper
• The nuclear envelope: emerging roles in development and disease

  2001cites this paper
• Nuclear membrane protein LAP2beta mediates transcriptional repression alone and together with its binding partner GCL (germ-cell-less).

  2001cites this paper
• Toucan protein is essential for the assembly of syncytial mitotic spindles in Drosophila melanogaster

  2001cites this paper
• The maternal effect mutation sésame affects the formation of the male pronucleus in Drosophila melanogaster.

  2000cites this paper
• Nonlamin components of the lamina: a paucity of proteins.

  1999cites this paper
• Nuclear entry of the Drosophila melanogaster nuclear lamina protein YA correlates with developmentally regulated changes in its phosphorylation state.

  1999cites this paper
• Somatic signaling mediated by fs(1)Yb is essential for germline stem cell maintenance during Drosophila oogenesis.

  1999cites this paper
• Functional organization of the nuclear lamina

  1999cites this paper
• Functional Dissection of YA, an Essential, Developmentally Regulated Nuclear Lamina Protein in Drosophila melanogaster

  1998cites this paper
• Paternal effects in Drosophila: implications for mechanisms of early development.

  1998cites this paper
• Interactions among Drosophila Nuclear Envelope Proteins Lamin, Otefin, and YA

  1998cites this paper
• Control of Cell Proliferation During Development and Animal Evolution

  1998cites this paper
• Formation of the male pronuclear lamina in Drosophila melanogaster.

  1997cites this paper
• Developmental modulation of the nuclear envelope.

  1997cites this paper
• The developmentally regulated Drosophila embryonic nuclear lamina protein 'Young Arrest' (fs(1)Ya) is capable of associating with chromatin.

  1997cites this paper
• Time-resolved, in vivo studies of mitotic spindle formation and nuclear lamina breakdown in Drosophila early embryos.

  1996cites this paper
• Fertilization in Drosophila melanogaster: centrosome inheritance and organization of the first mitotic spindle.

  1996cites this paper
• Paternal investment and intracellular sperm-egg interactions during and following fertilization in Drosophila.

  1996cites this paper
• The dynamic properties and possible functions of nuclear lamins.

  1995cites this paper
• Horka, a dominant mutation of Drosophila, induces nondisjunction and, through paternal effect, chromosome loss and genetic mosaics.

  1995cites this paper
• Mutational analyses of fs(1)Ya, an essential, developmentally regulated, nuclear envelope protein in Drosophila.

  1995cites this paper
• Genetic characterization of ms (3) K81, a paternal effect gene of Drosophila melanogaster.

  1995cites this paper
• Isolation of cDNAs from maternal mRNAs specifically present during early development

  1995cites this paper
• The Drosophila trithorax proteins contain a novel variant of the nuclear receptor type DNA binding domain and an ancient conserved motif found in other chromosomal proteins.

  1995cites this paper
• Intermediate filament proteins.

  1995cites this paper
• Intermediate filament proteins.

  1994cites this paper
• Determinants of Drosophila zw10 protein localization and function.

  1994cites this paper
• Chromosome damage and early developmental arrest caused by the Rex element of Drosophila melanogaster.

  1994cites this paper
• Developmental modification of the Drosophila cell cycle.

  1994cites this paper
• Cell cycle genes of Drosophila.

  1994cites this paper
• The Drosophila fs(1)Ya protein, which is needed for the first mitotic division, is in the nuclear lamina and in the envelopes of cleavage nuclei, pronuclei, and nonmitotic nuclei.

  1994cites this paper
• The Drosophila maternal effect locus deadhead encodes a thioredoxin homolog required for female meiosis and early embryonic development.

  1994cites this paper
• The daughterless gene product in Drosophila is a nuclear protein that is broadly expressed throughout the organism during development.

  1993cites this paper
• Abnormal anaphase resolution (aar): a locus required for progression through mitosis in Drosophila.

  1993cites this paper
• Functional elements of the cytoskeleton in the early Drosophila embryo.

  1993cites this paper
• Developmental regulation of the cell cycle.

  1992cites this paper
• Cyclin B is associated with centrosomes in Drosophila mitotic cells

  1992cites this paper
• Supernova (spno), a new maternal mutant producing variable-sized cleavage nuclei in Drosophila.

  1992cites this paper
• Maternal effect mutations of the sponge locus affect actin cytoskeletal rearrangements in Drosophila melanogaster embryos

  1992cites this paper
• Parallel pathways of gene regulation: homologous regulators SWI5 and ACE2 differentially control transcription of HO and chitinase.

  1992cites this paper
• polo encodes a protein kinase homolog required for mitosis in Drosophila.

  1991cites this paper
• Cell proliferation

  1991cites this paper
• The maternal gene product D7 is not required for early Xenopus development.

  1991cites this paper
• The Drosophila plutonium and pan gu genes regulate entry into S phase at fertilization.

  1991cites this paper
• Chromosome tangling and breakage at anaphase result from mutations in lodestar, a Drosophila gene encoding a putative nucleoside triphosphate-binding protein.

  1991cites this paper
• Distribution of PCNA in Drosophila embryo during nuclear division cycles.

  1991cites this paper
• Determinants of Drosophila zw 10 protein localization and function

  year unknowncites this paper