B-Type Natriuretic Peptide Deletion Leads to Progressive Hypertension, Associated Organ Damage, and Reduced Survival: Novel Model for Human Hypertension

No abstract is available for this paper.

• Publication year

  2015

• Venue

  HYPERTENSION

• Publication date

  2015-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1161/HYPERTENSIONAHA.115.05610PMID 26063669PMCID PMC4467451
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cardiac BNP gene delivery prolongs survival in aged spontaneously hypertensive rats with overt hypertensive heart disease

  2014influential reference
• In the clinic: hypertension.

  2014cited by this paper
• Blood pressure and incidence of twelve cardiovascular diseases: lifetime risks, healthy life-years lost, and age-specific associations in 1·25 million people

  2014cited by this paper
• Identifying multiple causative genes at a single GWAS locus

  2013cited by this paper
• The natriuretic peptides BNP and CNP increase heart rate and electrical conduction by stimulating ionic currents in the sinoatrial node and atrial myocardium following activation of guanylyl cyclase-linked natriuretic peptide receptors.

  2012cited by this paper
• Human hypertension is characterized by a lack of activation of the antihypertensive cardiac hormones ANP and BNP.

  2012cited by this paper
• Sustained blood pressure-lowering actions of subcutaneous B-type natriuretic peptide (nesiritide) in a patient with uncontrolled hypertension.

  2012cited by this paper
• Ablation of the Cardiac-Specific Gene Leucine-Rich Repeat Containing 10 (Lrrc10) Results in Dilated Cardiomyopathy

  2012cited by this paper
• Pro-B-type natriuretic peptide(1-108) circulates in the general community: plasma determinants and detection of left ventricular dysfunction.

  2011cited by this paper
• Contemporary Reviews in Cardiovascular Medicine The Progression of Hypertensive Heart Disease

  2011cited by this paper
• Biomarkers in chronic kidney disease: a review.

  2011cited by this paper
• Long-Term Cardiac pro-B-Type Natriuretic Peptide Gene Delivery Prevents the Development of Hypertensive Heart Disease in Spontaneously Hypertensive Rats

  2011cited by this paper
• Revealing Off-Target Cleavage Specificities of Zinc Finger Nucleases by In Vitro Selection

  2011cited by this paper
• Blood pressure and human genetic variation in the general population

  2010cited by this paper
• Generation of gene-specific mutated rats using zinc-finger nucleases.

  2010cited by this paper
• Zinc finger protein-dependent and -independent contributions to the in vivo off-target activity of zinc finger nucleases

  2010cited by this paper
• Influence of natriuretic peptide receptor-1 on survival and cardiac hypertrophy during development.

  2009cited by this paper
• Association of common variants in NPPA and NPPB with circulating natriuretic peptides and blood pressure

  2009cited by this paper
• Editors' highlights.

  2009cited by this paper
• Assessment of segmental myocardial viability using regional 2-dimensional strain echocardiography.

  2007cited by this paper
• Differential regulation of membrane guanylyl cyclases in congestive heart failure: natriuretic peptide receptor (NPR)-B, Not NPR-A, is the predominant natriuretic peptide receptor in the failing heart.

  2007cited by this paper
• Evaluation of blood pressure measured by tail-cuff methods (without heating) in spontaneously hypertensive rats.

  2006cited by this paper
• Natriuretic peptides as regulators of myocardial structure and function: pathophysiologic and therapeutic implications.

  2006cited by this paper
• Cardiac and Systemic Hemodynamic Characteristics of Hypertension and Prehypertension in Adolescents and Young Adults: The Strong Heart Study

  2006cited by this paper
• Lack of activation of molecular forms of the BNP system in human grade 1 hypertension and relationship to cardiac hypertrophy.

  2006cited by this paper
• Transgenic overexpression of brain natriuretic peptide prevents the progression of diabetic nephropathy in mice

  2006cited by this paper
• Blood Pressure in Adulthood and Life Expectancy With Cardiovascular Disease in Men and Women: Life Course Analysis

  2005cited by this paper
• Prostacyclin signaling in the kidney: implications for health and disease.

  2005cited by this paper
• QRS Duration and QT Interval Predict Mortality in Hypertensive Patients With Left Ventricular Hypertrophy: The Losartan Intervention for Endpoint Reduction in Hypertension Study

  2004cited by this paper
• Cardiovascular Ultrasound BioMed Central Review

  2004cited by this paper
• Pressure‐independent enhancement of cardiac hypertrophy in atrial natriuretic peptide–deficient mice

  2003influential reference
• Predictive performance of renal function equations for patients with chronic kidney disease and normal serum creatinine levels.

  2002cited by this paper
• Overexpression of brain natriuretic peptide in mice ameliorates immune-mediated renal injury.

  2001cited by this paper
• Brain natriuretic peptide appears to act locally as an antifibrotic factor in the heart.

  2001cited by this paper
• Comparison Of Telemetric And Tail‐Cuff Blood Pressure Monitoring In Adrenocorticotrophic Hormone‐Treated Rats

  2001cited by this paper
• Relation of QT interval and QT dispersion to echocardiographic left ventricular hypertrophy and geometric pattern in hypertensive patients. The LIFE study.

  2001cited by this paper
• Pressure-independent enhancement of cardiac hypertrophy in natriuretic peptide receptor A-deficient mice.

  2001cited by this paper
• Cardiac fibrosis in mice lacking brain natriuretic peptide.

  2000cited by this paper
• Natriuretic peptide receptor 1 expression influences blood pressures of mice in a dose-dependent manner.

  1998cited by this paper
• BNP: increasing importance in the pathophysiology and diagnosis of congestive heart failure.

  1997cited by this paper
• BNP: increasing importance in the pathophysiology and diagnosis of congestive heart failure.

  1997cited by this paper
• Comparison of atrial natriuretic peptide B-type natriuretic peptide, and N-terminal proatrial natriuretic peptide as indicators of left ventricular systolic dysfunction.

  1996cited by this paper
• New insights into the cardiac natriuretic peptides.

  1996cited by this paper
• Mechanisms of action of atrial natriuretic factor and C-type natriuretic peptide.

  1996cited by this paper
• Rapid ventricular induction of brain natriuretic peptide gene expression in experimental acute myocardial infarction.

  1995cited by this paper
• Natriuretic peptides inhibit angiotensin II-induced proliferation of rat cardiac fibroblasts by blocking endothelin-1 gene expression.

  1995cited by this paper
• Transition from compensatory hypertrophy to dilated, failing left ventricles in Dahl saltsensitive rats:a new model for the study of heart failure

  1995cited by this paper
• Molecular cloning of the complementary DNA and gene that encode mouse brain natriuretic peptide and generation of transgenic mice that overexpress the brain natriuretic peptide gene.

  1994cited by this paper
• Transition from compensatory hypertrophy to dilated, failing left ventricles in Dahl salt-sensitive rats.

  1994cited by this paper
• Selective changes in natriuretic peptide and early response gene expression in isolated rat atria following stimulation by stretch or endothelin-1.

  1994cited by this paper
• Prostaglandins protect kidneys against ischemic and toxic injury by a cellular effect.

  1992cited by this paper
• Brain natriuretic peptide as a novel cardiac hormone in humans. Evidence for an exquisite dual natriuretic peptide system, atrial natriuretic peptide and brain natriuretic peptide.

  1991cited by this paper
• Role of the heart as an endocrine organ.

  1991cited by this paper
• Partial characterization of atrial natriuretic factor in the hearts of Dahl salt-sensitive and salt-resistant rats.

  1987cited by this paper
• Atrial natriuretic factor in inbred Dahl salt-sensitive and salt-resistant rats.

  1986cited by this paper
• Limitations of creatinine as a filtration marker in glomerulopathic patients.

  1985cited by this paper
• Atrial natriuretic factor—a circulating hormone stimulated by volume loading

  1985cited by this paper
• Expression of the beta-nerve growth factor gene correlates with the density of sympathetic innervation in effector organs.

  1984cited by this paper
• Genetic Influence of the Kidneys on Blood Pressure: Evidence from Chronic Renal Homografts in Rats with Opposite Predispositions to Hypertension

  1974cited by this paper

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  2025cites this paper
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• Natriuretic peptide system in hypertension: current understandings of its regulation, targeted therapies and future challenges.

  2024cites this paper
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  2024cites this paper
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• Natriuretic Peptide Normative Levels and Deficiency: The National Health and Nutrition Examination Survey.

  2023cites this paper
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  2023cites this paper
• The role of dietary salt in metabolism and energy balance: Insights beyond cardiovascular disease

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  2022cites this paper
• Acacetin inhibits myocardial mitochondrial dysfunction by activating PI3K/AKT in SHR rats fed with fructose

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  2020cites this paper
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