Early Exercise Affects Mitochondrial Transcription Factors Expression after Cerebral Ischemia in Rats

Increasing evidence shows that exercise training is neuroprotective after stroke, but the underlying mechanisms are unknown. To clarify this critical issue, the current study investigated the effects of early treadmill exercise on the expression of mitochondrial biogenesis factors. Adult rats were subjected to ischemia induced by middle cerebral artery occlusion followed by reperfusion. Expression of two genes critical for transcriptional regulation of mitochondrial biogenesis, peroxisome proliferator-activated receptor coactivator-1 (PGC-1) and nuclear respiratory factor-1 (NRF-1), were examined by RT-PCR after five days of exercise starting at 24 h after ischemia. Mitochondrial protein cytochrome C oxidase subunit IV (COX IV) was detected by Western blot. Neurological status and cerebral infarct volume were evaluated as indices of brain damage. Treadmill training increased levels of PGC-1 and NRF-1 mRNA, indicating that exercise promotes rehabilitation after ischemia via regulation of mitochondrial biogenesis.

• Publication year

  2012

• Venue

  International Journal of Molecular Sciences

• Publication date

  2012-02-06

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.3390/ijms13021670PMID 22408416PMCID 3291985
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Long-term treadmill exercise induces neuroprotective molecular changes in rat brain.

  2011cited by this paper
• Exercise training increases mitochondrial biogenesis in the brain.

  2011influential reference
• Glycogen synthase kinase‐3 inhibition reduces ischemic cerebral damage, restores impaired mitochondrial biogenesis and prevents ROS production

  2011cited by this paper
• The effect of exercise on trkA in the contralateral hemisphere of the ischemic rat brain.

  2010cited by this paper
• Regulation of skeletal muscle mitochondrial function: genes to proteins

  2010cited by this paper
• Transcriptional and post-transcriptional regulation of mitochondrial biogenesis in skeletal muscle: effects of exercise and aging.

  2010cited by this paper
• Regulation of neuron mitochondrial biogenesis and relevance to brain health.

  2010influential reference
• Mechanisms of exercise-induced mitochondrial biogenesis in skeletal muscle.

  2009influential reference
• Mitochondrial biogenesis in exercise and in ageing.

  2009cited by this paper
• Pre-ischemic treadmill training affects glutamate and gamma aminobutyric acid levels in the striatal dialysate of a rat model of cerebral ischemia.

  2009cited by this paper
• Rapidly Increased Neuronal Mitochondrial Biogenesis After Hypoxic-Ischemic Brain Injury

  2008cited by this paper
• Exercise-induced mitochondrial biogenesis in skeletal muscle.

  2007cited by this paper
• Exercise-induced Mitochondrial Biogenesis Begins before the Increase in Muscle PGC-1α Expression*

  2007cited by this paper
• The effect of two physiotherapy approaches on physical and cognitive functions and independent coping at home in stroke rehabilitation. A preliminary follow-up study

  2007cited by this paper
• Stroke patients and long-term training: is it worthwhile? A randomized comparison of two different training strategies after rehabilitation

  2007cited by this paper
• Physical Activity Improves Long-Term Stroke Outcome via Endothelial Nitric Oxide Synthase–Dependent Augmentation of Neovascularization and Cerebral Blood Flow

  2006cited by this paper
• Electrical Forepaw Stimulation During Reversible Forebrain Ischemia Decreases Infarct Volume

  2006cited by this paper
• The mitochondrial biogenesis regulatory program in cardiac adaptation to ischemia--a putative target for therapeutic intervention.

  2005cited by this paper
• Treadmill training and body weight support for walking after stroke.

  2005cited by this paper
• Treadmill Training and Body Weight Support for Walking After Stroke

  2003cited by this paper
• Constraint-Induced Movement Therapy and Rehabilitation Exercises Lessen Motor Deficits and Volume of Brain Injury After Striatal Hemorrhagic Stroke in Rats

  2003cited by this paper
• Early and late treadmill training after focal brain ischemia in rats.

  2003cited by this paper
• Treadmill Training Effects on Neurological Outcome After Middle Cerebral Artery Occlusion in Rats

  2003cited by this paper
• The effect of voluntary exercise exposure on histological and neurobehavioral outcomes after ischemic brain injury in the rat.

  2003cited by this paper
• Early Training May Exacerbate Brain Damage after Focal Brain Ischemia in the Rat

  1999cited by this paper
• Correlation between motor impairment and infarct volume after permanent and transient middle cerebral artery occlusion in the rat.

  1997cited by this paper
• Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons.

  1995cited by this paper
• Environment influences functional outcome of cerebral infarction in rats.

  1995cited by this paper
• Reversible middle cerebral artery occlusion without craniectomy in rats.

  1989cited by this paper

• Effects of exercise intervention on physical mobility in stroke patients: a scoping review and research progress

  2025cites this paper
• The mitochondrial quality control system: a new target for exercise therapeutic intervention in the treatment of brain insulin resistance-induced neurodegeneration in obesity

  2024cites this paper
• The Role of Exercise in Maintaining Mitochondrial Proteostasis in Parkinson’s Disease

  2023cites this paper
• Preconditioning intensive training ameliorates reduction of transcription biofactors of PGC1α-pathway in paretic muscle due to cerebral ischemia

  2022cites this paper
• Transplantation of Exercise-Induced Extracellular Vesicles as a Promising Therapeutic Approach in Ischemic Stroke

  2022cites this paper
• Obesity and Diabetes: Implications for Brain-Immunometabolism

  2020cites this paper
• Treadmill exercise attenuates cerebral ischaemic injury in rats by protecting mitochondrial function via enhancement of caveolin-1.

  2020cites this paper
• Aerobic Exercise Attenuates Neurodegeneration and Promotes Functional Recovery - Why It Matters For Neurorehabilitation & Neural Repair.

  2020cites this paper
• Activation of PGC-1α and mitochondrial biogenesis protects against prenatal hypoxic-ischemic brain injury.

  2020cites this paper
• PGC-1α, Inflammation, and Oxidative Stress: An Integrative View in Metabolism

  2020cites this paper
• An enriched environment promotes synaptic plasticity and cognitive recovery after permanent middle cerebral artery occlusion in mice

  2019cites this paper
• The effect of antecedent-conditioning high-intensity interval training on BDNF regulation through PGC-1α pathway following cerebral ischemia.

  2019cites this paper
• Enhanced mitochondrial biogenesis is associated with the ameliorative action of creatine supplementation in rat soleus and cardiac muscles.

  2019influential citation
• The Role of PGC-1α/UCP2 Signaling in the Beneficial Effects of Physical Exercise on the Brain

  2019cites this paper
• Neuroprotection of histone deacetylase inhibitor TMP 269 in cerebral ischemia / reperfusion rat

  2018cites this paper
• Brain bioenergetics in rats with acute hyperphenylalaninemia

  2018cites this paper
• Enriched Environment Elicits Proangiogenic Mechanisms After Focal Cerebral Ischemia

  2018cites this paper
• Effects of constraint-induced movement therapy on brain glucose metabolism in a rat model of cerebral ischemia: a micro PET/CT study

  2018cites this paper
• Veterinary Neurologic Rehabilitation: The Rationale for a Comprehensive Approach.

  2018cites this paper
• Is the Intensity or Duration of Treadmill Training Important for Stroke Patients? A Meta-Analysis.

  2018cites this paper
• Adaptive responses of neuronal mitochondria to bioenergetic challenges: Roles in neuroplasticity and disease resistance.

  2017cites this paper
• Omega-3 Fatty Acids and Mood Stabilizers Alter Behavioural and Energy Metabolism Parameters in Animals Subjected to an Animal Model of Mania Induced by Fenproporex

  2017cites this paper
• Biochemical Mechanisms Associated With Exercise-Induced Neuroprotection in Aging Brains and Related Neurological Diseases

  2017cites this paper
• Exercise in the Early Stage after Stroke Enhances Hippocampal Brain-Derived Neurotrophic Factor Expression and Memory Function Recovery.

  2016cites this paper
• Enriched Environment Enhances Poststroke Neurological Function Recovery on Rat: Involvement of p-ERK1/2.

  2016cites this paper
• The effect of glycyrrhizic acid on traumatic spinal cord injury in rats.

  2016cites this paper
• Acute Carnosine Administration Increases Respiratory Chain Complexes and Citric Acid Cycle Enzyme Activities in Cerebral Cortex of Young Rats

  2015cites this paper
• Exercício físico promove neuroproteção estrutural e funcional em ratos com isquemia cerebral

  2015cites this paper
• Neuroprotection of Early Locomotor Exercise Poststroke: Evidence From Animal Studies

  2015cites this paper
• Physical exercise promotes neuroprotection structural and functional in rats with cerebral ischemia

  2015cites this paper
• Effects of Tannic Acid on the Ischemic Brain Tissue of Rats

  2015cites this paper
• The Impact of Exercise on the Regulation of Mitochondrial Content and Function in the Brain

  2015cites this paper
• Current Understanding of Concussion: Treatment Perspectives

  2014cites this paper
• Impairment of Electron Transfer Chain Induced by Acute Carnosine Administration in Skeletal Muscle of Young Rats

  2014influential citation
• Exercise Pretreatment Promotes Mitochondrial Dynamic Protein OPA1 Expression after Cerebral Ischemia in Rats

  2014influential citation
• Curcumin Prevents Cerebral Ischemia Reperfusion Injury Via Increase of Mitochondrial Biogenesis

  2014cites this paper
• Aerobic exercise effects on neuroprotection and brain repair following stroke: a systematic review and perspective.

  2014cites this paper
• Enriched environment induces angiogenesis and improves neural function outcomes in rat stroke model.

  2014cites this paper
• The effects of exercise preconditioning on cerebral blood flow change and endothelin-1 expression after cerebral ischemia in rats.

  2014cites this paper
• The Effects of Exercise Preco nditioning on Cerebral Blood Flow Change and Endothelin-1 Expression after Cerebral Ischemia in Rats

  2014cites this paper
• The redox-associated adaptive response of brain to physical exercise

  2014cites this paper
• Neuroprotective effects of prior exposure to enriched environment on cerebral ischemia/reperfusion injury in rats: the possible molecular mechanism.

  2013cites this paper
• Avaliação da morfologia cerebral e do desempenho motor de ratos sedentários e exercitados submetidos à isquemia cerebral transitória

  2013influential citation
• EFFECTS OF EXERCISE TRAINING ON BRAIN BIOENERGETICS: LACTATE AS A KEY MEDIATOR

  2013cites this paper
• Early Exercise Protects against Cerebral Ischemic Injury through Inhibiting Neuron Apoptosis in Cortex in Rats

  2013cites this paper
• Combination treatment with progesterone and rehabilitation training further promotes behavioral recovery after acute ischemic stroke in mice

  2013cites this paper
• Lactate administration reproduces specific brain and liver exercise‐related changes

  2013cites this paper
• Effects of medullary administration of a nitric oxide precursor on cardiovascular responses and neurotransmission during static exercise following ischemic stroke.

  2013cites this paper
• Early Exercise Protects the Blood-Brain Barrier from Ischemic Brain Injury via the Regulation of MMP-9 and Occludin in Rats

  2013cites this paper
• Pre-Ischemic Treadmill Training for Prevention of Ischemic Brain Injury via Regulation of Glutamate and Its Transporter GLT-1

  2012cites this paper