Noradrenergic Agonists and Antagonists Influence Migration of Cortical Spreading Depression in Rat—a Possible Mechanism of Migraine Prophylaxis and Prevention of Postischemic Neuronal Damage

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Journal of Cerebral Blood Flow and Metabolism

• Publication date

  2005-04-13

• Fields of study

  Medicine

• Identifiers
  DOI 10.1038/sj.jcbfm.9600120PMID 15829916
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Compromised metabolic recovery following spontaneous spreading depression in the penumbra.

  2004cited by this paper
• The aura-headache connection in migraine: a historical analysis.

  2004cited by this paper
• Noradrenaline increases the firing rate of a subpopulation of rat subthalamic neurones through the activation of alpha 1-adrenoceptors.

  2003cited by this paper
• Klinische Studien im Bereich der Neurologie in Deutschland

  2003cited by this paper
• Neues bei Migräne und Kopfschmerzen

  2003cited by this paper
• In vivo inhibition of neuronal activity in the rat ventromedial prefrontal cortex by midbrain-raphe nuclei: role of 5-HT1A receptors.

  2003cited by this paper
• Serotonin 5-HT1A receptors might control the output of cortical glutamatergic neurons in rat cingulate cortex.

  2003cited by this paper
• Alpha2 antagonist yohimbine suppresses maintained firing of rat prefrontal neurons in vivo

  2003influential reference
• Alpha 2 adrenoceptor-mediated presynaptic inhibition of primary afferent glutamatergic transmission in rat substantia gelatinosa neurons.

  2003cited by this paper
• Contemporary concepts of migraine pathogenesis

  2003cited by this paper
• [Prophylactic drug management of migraine].

  2003cited by this paper
• Chronic Daily Headache Prophylaxis With Tizanidine: A Double‐Blind, Placebo‐Controlled, Multicenter Outcome Study

  2002cited by this paper
• Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model

  2002cited by this paper
• Spreading and Synchronous Depressions of Cortical Activity in Acutely Injured Human Brain

  2002influential reference
• Presynaptic cross‐talk of β‐adrenoreceptor and 5‐hydroxytryptamine receptor signalling in the modulation of glutamate release from cerebrocortical nerve terminals

  2002cited by this paper
• Inhibition of voltage-gated Ca2+ channels by antazoline

  2002cited by this paper
• [Prophylactic drug management of migraine].

  2002cited by this paper
• Chronic headache: New advances in treatment strategies

  2002cited by this paper
• Blockade of voltage-gated calcium channels in rat inhibits repetitive cortical spreading depression.

  2002cited by this paper
• Mechanisms of spreading depression and hypoxic spreading depression-like depolarization.

  2001influential reference
• α2A-Adrenoceptor Stimulation Reduces Capsaicin-Induced Glutamate Release from Spinal Cord Synaptosomes

  2001cited by this paper
• Is there a correlation between spreading depression, neurogenic inflammation, and nociception that might cause migraine headache?

  2001cited by this paper
• The prevention of migraine: a critical review with special emphasis on beta-adrenoceptor blockers.

  2001cited by this paper
• Facilitation of constitutive alpha(2A)-adrenoceptor activity by both single amino acid mutation (Thr(373)Lys) and g(alphao) protein coexpression: evidence for inverse agonism.

  2000cited by this paper
• Norepinephrine exhibits two distinct profiles of action on sensory cortical neuron responses to excitatory synaptic stimuli

  2000cited by this paper
• Facilitation of Constitutive α2A-Adrenoceptor Activity by Both Single Amino Acid Mutation (Thr373Lys) and Gαo Protein Coexpression: Evidence for Inverse Agonism

  2000cited by this paper
• The vasocontractive action of norepinephrine and serotonin in deep arterioles of rat cerebral gray matter.

  2000cited by this paper
• The effects of propranolol on heterogeneity of rat cerebral small vein oxygen saturation.

  1999cited by this paper
• Neuroprotection by the alpha2-adrenoceptor agonist, dexmedetomidine, in rat focal cerebral ischemia.

  1999cited by this paper
• Effects of ionotropic glutamate receptor blockade and 5-HT1A receptor activation on spreading depression in rat neocortical slices.

  1999cited by this paper
• Neuroprotection by the α2-adrenoceptor agonist, dexmedetomidine, in rat focal cerebral ischemia

  1999cited by this paper
• Presynaptic α2‐adrenoceptors control excitatory, but not inhibitory, transmission at rat hippocampal synapses

  1999cited by this paper
• Two functionally distinct α2-adrenergic receptors regulate sympathetic neurotransmission

  1999cited by this paper
• Analysis of the PKC-γ-Related Immunocrossreactive Region of a Novel Leukocyte Protein γ-rp

  1999cited by this paper
• Analysis of the PKC-gamma-related immunocrossreactive region of a novel leukocyte protein gamma-rp.

  1999cited by this paper
• Actions of alpha2 adrenoceptor ligands at alpha2A and 5-HT1A receptors: the antagonist, atipamezole, and the agonist, dexmedetomidine, are highly selective for alpha2A adrenoceptors.

  1998cited by this paper
• Subtypes of functional alpha1- and alpha2-adrenoceptors.

  1998cited by this paper
• Pathophysiology of the Ischemic Penumbra—Revision of a Concept

  1998cited by this paper
• Investigation of the subtypes of α2-adrenoceptor mediating prejunctional inhibition in rat atrium and cerebral cortex

  1998cited by this paper
• Investigation of the subtypes of alpha2-adrenoceptor mediating prejunctional inhibition in rat atrium and cerebral cortex.

  1998cited by this paper
• Actions of α2 adrenoceptor ligands at α2A and 5-HT1A receptors: the antagonist, atipamezole, and the agonist, dexmedetomidine, are highly selective for α2A adrenoceptors

  1998cited by this paper
• Subtypes of functional a 1- and a 2-adrenoceptors

  1998cited by this paper
• Noradrenaline Modulates GIutamate‐mediated Neurotransmission in the Rat Basolateral Amygdala In Vitro

  1997cited by this paper
• Subtype determination of soma-dendritic α2-autoreceptors in slices of rat locus coeruleus

  1997cited by this paper
• Isoproterenol potentiates synaptic transmission primarily by enhancing presynaptic calcium influx via P- and/or Q-type calcium channels in the rat amygdala

  1996cited by this paper
• Inhibition of N‐type Calcium Channels: The Only Mechanism by which Presynaptic α2‐Autoreceptors Control Sympathetic Transmitter Release

  1996cited by this paper
• Transient and long-lasting effects of iontophoretically administered norepinephrine on somatosensory cortical neurons in halothane-anesthetized cats.

  1996cited by this paper
• Effects of antimigraine drugs on retinal spreading depression

  1996influential reference
• [3H]RX821002 (2-methoxyidazoxan) binds to alpha 2-adrenoceptor subtypes and a non-adrenoceptor imidazoline binding site in rat kidney.

  1996cited by this paper
• Effects of Dexmedetomidine on Hypoxia-evoked Glutamate Release and Glutamate Receptor Activity in Hippocampal Slices

  1996cited by this paper
• Alpha- and beta-adrenoceptors: from the gene to the clinic. 1. Molecular biology and adrenoceptor subclassification.

  1995cited by this paper
• Pathophysiology of the migraine aura: the spreading depression theory.

  1995cited by this paper
• Alpha 1-adrenoceptors: pharmacological classification and newer therapeutic applications.

  1995cited by this paper
• Viability thresholds and the penumbra of focal ischemia

  1994cited by this paper
• Locus coeruleus noradrenaline system and focal penicillin hippocampal epilepsy: neurophysiological study.

  1994influential reference
• Pathophysiology of the migraine aura. The spreading depression theory.

  1994cited by this paper
• Protection of focal ischemic infarction by rilmenidine in the animal: evidence that interactions with central imidazoline receptors may be neuroprotective.

  1994cited by this paper
• Spreading depression can be restricted to distinct depths of the rat cerebral cortex.

  1993cited by this paper
• Cellular localization of messenger RNA for beta-1 and beta-2 adrenergic receptors in rat brain: an in situ hybridization study.

  1993cited by this paper
• Norepinephrine inhibits calcium currents and EPSPs via a G-protein- coupled mechanism in olfactory bulb neurons

  1992cited by this paper
• Resting and reactive astrocytes express adrenergic receptors in the adult rat brain.

  1992cited by this paper
• Topical application of clonidine relieves hyperalgesia in patients with sympathetically maintained pain

  1991cited by this paper
• Decreased Gs alpha mRNA levels accompany the fall in Gs and adenylyl cyclase activities in compensated left ventricular hypertrophy. In heart failure, only the impairment in adenylyl cyclase activation progresses.

  1991cited by this paper
• Spreading depression is not associated with neuronal injury in the normal brain.

  1988cited by this paper
• Role of adrenal catecholamines in cerebrovasodilation evoked from brain stem.

  1987cited by this paper
• Inhibition of neurosympathetic cerebroarterial constriction by clonidine in cats.

  1980influential reference
• Anion permeability in spreading depression investigated with ion-sensitive microelectrodes.

  1979cited by this paper
• Quantitative changes in regional cerebral blood flow of rats induced by alpha- and beta-adrenergic stimulants.

  1979cited by this paper
• Extracellular ionic variations during spreading depression.

  1978cited by this paper
• The mechanism and applications of Leão's spreading depression of electroencephalographic activity

  1974influential reference
• The prophylactic value of propranolol in angina pectoris.

  1966cited by this paper
• SPREADING DEPRESSION OF ACTIVITY IN THE CEREBRAL CORTEX

  1944cited by this paper

• Is canonical SD a clinically relevant model of migraine? Argument pro

  2025influential citation
• Cortical spreading depolarizations in stroke: Mechanisms, neuroprotective interventions, and monitoring techniques.

  2025cites this paper
• Probiotic modulation of central and peripheral sensitization in a migraine model via the gut–brain–trigeminal axis

  2025cites this paper
• Cortical spreading depression dynamics are altered by topical D2 receptor ligands.

  2025cites this paper
• Spreading depolarization as a therapeutic target in migraine

  2025cites this paper
• Evaluating brain mechanisms of combined vagus nerve stimulation and mindfulness training for migraine: A randomized 2 × 2 factorial clinical trial protocol.

  2025cites this paper
• Research Status on the Pathogenesis of Migraine

  2025cites this paper
• Mild hypothermia reduces spreading depolarizations and infarct size in a swine model

  2023cites this paper
• Cold Case of Thrombolysis: Cold Recombinant Tissue Plasminogen Activator Confers Enhanced Neuroprotection in Experimental Stroke

  2023cites this paper
• Trigeminovascular effects of propranolol in men and women, role for sex steroids

  2022cites this paper
• Central sympathetic nerve activation in subarachnoid hemorrhage

  2021cites this paper
• Noradrenaline modulates neuronal and perceptual visual detectability via β-adrenergic receptor

  2021cites this paper
• Efficacy profile of noninvasive vagus nerve stimulation on cortical spreading depression susceptibility and the tissue response in a rat model

  2021cites this paper
• Propranolol modulation of tetrodotoxin-resistant Na+ channels in dural afferent neurons.

  2021cites this paper
• Adrenergic inhibition facilitates normalization of extracellular potassium after cortical spreading depolarization

  2021cites this paper
• A critical review of the neurovascular nature of migraine and the main mechanisms of action of prophylactic antimigraine medications

  2021cites this paper
• Vagus nerve stimulation reduces spreading depolarization burden and cortical infarct volume in a rat model of stroke

  2020cites this paper
• The Pegasus Review: UCF The Pegasus Review: UCF Undergraduate (URJ) (URJ) Perception of Facial Expressions in Social Anxiety and Gaze Perception of Facial Expressions in Social Anxiety and Gaze Anxiety Anxiety

  2020cites this paper
• Clinical and vascular responses to propranolol and candesartan in migraine patients: A randomized controlled clinical trial

  2020cites this paper
• Therapeutic implications of cortical spreading depression models in migraine.

  2020cites this paper
• [Migraine prophylaxis-all just antibodies? : Medical and nonmedical migraine preventive treatment in times of CGRP antibodies].

  2020cites this paper
• Migräneprophylaxe – alles nur noch Antikörper?

  2020cites this paper
• Vagus nerve stimulation inhibits cortical spreading depression exclusively via central mechanisms.

  2020cites this paper
• Headache and the Heart

  2019cites this paper
• Propranolol prevents cerebral blood flow changes and pain-related behaviors in migraine model mice.

  2019cites this paper
• Recurrent administration of the nitric oxide donor, isosorbide dinitrate, induces a persistent cephalic cutaneous hypersensitivity: A model for migraine progression

  2018cites this paper
• Arguments against the role of cortical spreading depression in migraine

  2018cites this paper
• Current Prophylactic Medications for Migraine and Their Potential Mechanisms of Action

  2018cites this paper
• Systematic review of the pharmacological agents that have been tested against spreading depolarizations

  2018cites this paper
• Propranolol treatment prevents chronic central sensitization induced by repeated dural stimulation

  2017cites this paper
• Novel Therapeutic Targets Against Spreading Depression

  2017influential citation
• Effects of cathodal transcranial direct current stimulation on cortical spreading depression

  2017cites this paper
• Modulation of brainstem activity and connectivity by respiratory-gated auricular vagal afferent nerve stimulation in migraine patients

  2017cites this paper
• Roads Less Traveled: Sexual Dimorphism and Mast Cell Contributions to Migraine Pathology

  2016cites this paper
• Vagus nerve stimulation inhibits cortical spreading depression

  2016cites this paper
• Analysis of the Pathomechanism and Treatment of Migraines Related to the Role of the Neuropeptide CGRP

  2016cites this paper
• Aalborg Universitet Treatment of chronic migraine with transcutaneous stimulation of the auricular branch of the vagal nerve ( auricular t-VNS )

  2015cites this paper
• Treatment of chronic migraine with transcutaneous stimulation of the auricular branch of the vagal nerve (auricular t-VNS): a randomized, monocentric clinical trial

  2015cites this paper
• Is There a Persistent Dysfunction of Neurovascular Coupling in Migraine?

  2015cites this paper
• Palinopsia revamped: a systematic review of the literature.

  2015cites this paper
• Analysis of the Pathomechanism of Migraines with a Focus on Current Treatment Plans and the Role of the Neuropeptide CGRP

  2015cites this paper
• Effect of qilongtoutong granule on calcitonin gene-related peptide, beta-endorphin, serotonin, dopamine, and noradrenalin in migraine model rats and mice.

  2014cites this paper
• Anesthetic effects on susceptibility to cortical spreading depression.

  2013cites this paper
• Electro-acupuncture Regulation of Central Monoamine Neurotransmitters in Ischaemia-Reperfusion

  2013cites this paper
• The role of noradrenalin in the pathogenesis of primary headaches

  2013cites this paper
• Social anxiety score is high in adolescents with chronic migraine

  2012cites this paper
• Suppressive effect of chronic peroral topiramate on potassium-induced cortical spreading depression in rats

  2012cites this paper
• Gene expression microarray analysis of the spinal trigeminal nucleus in a rat model of migraine with aura

  2012cites this paper
• Altered interictal saccadic reaction time in migraine: a cross-sectional study

  2012cites this paper
• Cortical spreading depression in alpha‐synuclein knockout mice

  2012cites this paper
• Impaired Auditory Information Processing During Acute Migraine: A Magnetoencephalography Study

  2011cites this paper
• The effect of propranolol on cerebrovascular reactivity to visual stimulation in migraine.

  2011cites this paper
• Anxiety disorders in headache patients in a specialised clinic: prevalence and symptoms in comparison to patients in a general neurological clinic

  2011cites this paper
• Sex‐Related Differences in Animal Models of Migraine Headache

  2011cites this paper
• Migraine preventive drugs differentially affect cortical spreading depression in rat.

  2011cites this paper
• Genetic TPH2 variants and the susceptibility for migraine: association of a TPH2 haplotype with migraine without aura

  2010cites this paper
• Patient outcome in migraine prophylaxis: the role of psychopharmacological agents

  2010cites this paper
• Headache Currents

  2009cites this paper
• Pathophysiological basis of migraine prophylaxis.

  2009cites this paper
• Are Cortical Spreading Depression and Headache in Migraine Causally Linked?

  2009cites this paper
• Patterns of neurotransmitter receptor distributions following cortical spreading depression.

  2009cites this paper
• Spreading Depression: From Serendipity to Targeted Therapy in Migraine Prophylaxis

  2009cites this paper
• CSD, BBB and MMP-9 elevations: animal experiments versus clinical phenomena in migraine

  2009cites this paper
• CSD as a Therapeutic Target for Migraine

  2009cites this paper
• Is migraine a lateralization defect?

  2008cites this paper
• Central mechanism of action of antimigraine prophylactic drugs

  2008cites this paper
• Translational imaging studies of cortical spreading depression in experimental models for migraine aura

  2008cites this paper
• Is migraine a lateralization defect

  2008cites this paper
• Possible Precipitation of Migraine Attacks with Prophylactic Treatment

  2008cites this paper
• Nutrition-dependent influence of peripheral electrical stimulation during brain development on cortical spreading depression in weaned rats

  2007cites this paper
• Animal models of migraine: looking at the component parts of a complex disorder

  2006cites this paper
• Future Preventive Therapy: Are There Promising Drug Targets?

  2006cites this paper
• New insights into migraine pathophysiology

  2006cites this paper
• Suppression of cortical spreading depression in migraine prophylaxis

  2006cites this paper
• Cortical Spreading Depression: A Model for Understanding Migraine Biology and Future Drug Targets

  2005cites this paper
• Patient Related Outcome Measures Dovepress Patient Outcome in Migraine Prophylaxis: the Role of Psychopharmacological Agents

  year unknowncites this paper