Pharmacogenetics of the Alcohol Dehydrogenase System

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Pharmacology

• Publication date

  2000-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1159/000028399PMID 10971204
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1984cited by this paper
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