Mathematical Modeling for the Pathogenesis of Alzheimer's Disease

Despite extensive research, the pathogenesis of neurodegenerative Alzheimer's disease (AD) still eludes our comprehension. This is largely due to complex and dynamic cross-talks that occur among multiple cell types throughout the aging process. We present a mathematical model that helps define critical components of AD pathogenesis based on differential rate equations that represent the known cross-talks involving microglia, astroglia, neurons, and amyloid-β (Aβ). We demonstrate that the inflammatory activation of microglia serves as a key node for progressive neurodegeneration. Our analysis reveals that targeting microglia may hold potential promise in the prevention and treatment of AD.

• Publication year

  2010

• Venue

  PLoS ONE

• Publication date

  2010-12-14

• Fields of study

  Biology, Mathematics, Medicine

• Identifiers
  DOI 10.1371/journal.pone.0015176PMID 21179474PMCID 3001872
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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