Peripheral chemoreceptors determine the respiratory sensitivity of central chemoreceptors to CO2: role of carotid body CO2

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Journal of Physiology

• Publication date

  2014-04-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1113/JP270114PMID 26171601PMCID PMC4594294
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Foundations of Clinical Research: Applications to Practice

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  2014influential reference
• Regulation of breathing and autonomic outflows by chemoreceptors.

  2014influential reference
• Role of chemoreception in cardiorespiratory acclimatization to, and deacclimatization from, hypoxia.

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  2013influential reference
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  2012cited by this paper
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  2012influential reference
• Hypercapnia attenuates inspiratory amplitude and expiratory time responsiveness to hypoxia in vagotomized and vagal-intact rats.

  2012cited by this paper
• Central-peripheral respiratory chemoreflex interaction in humans.

  2012cited by this paper
• Breathing without CO2 Chemosensitivity in Conditional Phox2b Mutants

  2011cited by this paper
• Serotonergic neurons in the nucleus raphe obscurus contribute to interaction between central and peripheral ventilatory responses to hypercapnia

  2011cited by this paper
• The role of the central chemoreceptors: a modeling perspective.

  2010cited by this paper
• An interdependent model of central/peripheral chemoreception: evidence and implications for ventilatory control.

  2010influential reference
• Contributions of central and peripheral chemoreceptors to the ventilatory response to CO2/H+.

  2010cited by this paper
• Peripheral chemoreceptors determine the respiratory sensitivity of central chemoreceptors to CO2

  2010influential reference
• Chronic hypoxia increases the gain of the hypoxic ventilatory response by a mechanism in the central nervous system.

  2010influential reference
• Contribution of the carotid body chemoreceptors to eupneic ventilation in the intact, unanesthetized dog.

  2009influential reference
• Central and peripheral chemoreceptors evoke distinct responses in simultaneously recorded neurons of the raphé-pontomedullary respiratory network

  2009cited by this paper
• A negative interaction between brainstem and peripheral respiratory chemoreceptors modulates peripheral chemoreflex magnitude

  2009cited by this paper
• The apneic threshold during non-REM sleep in dogs: sensitivity of carotid body vs. central chemoreceptors.

  2007influential reference
• Brainstem PCO2 modulates phrenic responses to specific carotid body hypoxia in an in situ dual perfused rat preparation

  2007influential reference
• Carotid body function in heart failure.

  2007cited by this paper
• Plasticity of Central Chemoreceptors: Effect of Bilateral Carotid Body Resection on Central CO2 Sensitivity

  2007influential reference
• Peripheral chemoreceptor inputs to retrotrapezoid nucleus (RTN) CO2‐sensitive neurons in rats

  2006cited by this paper
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  2006cited by this paper
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  2005cited by this paper
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  2005cited by this paper
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  2004cited by this paper
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  2003cited by this paper
• Induction of sensory long-term facilitation in the carotid body by intermittent hypoxia: Implications for recurrent apneas

  2003cited by this paper
• Carotid body denervation eliminates apnea in response to transient hypocapnia.

  2003influential reference
• Carotid body denervation in dogs: eupnea and the ventilatory response to hyperoxic hypercapnia.

  2001influential reference
• Exposure to hypoxia produces long-lasting sympathetic activation in humans.

  2001cited by this paper
• Neurocirculatory consequences of intermittent asphyxia in humans.

  2000cited by this paper
• Ventilatory responses to specific CNS hypoxia in sleeping dogs.

  2000cited by this paper
• Identification of fast and slow ventilatory responses to carbon dioxide under hypoxic and hyperoxic conditions in humans

  1999cited by this paper
• Important role of carotid afferents in control of breathing.

  1998influential reference
• Nature of the interaction between central and peripheral chemoreceptor drives in human subjects.

  1996cited by this paper
• Effects of raising carotid sinus pressure on upper airway resistance and EEG frequency in sleeping dogs.

  1995cited by this paper
• Combined hypoxia and hypercapnia evokes long-lasting sympathetic activation in humans.

  1995cited by this paper
• An assessment of central‐peripheral ventilatory chemoreflex interaction using acid and bicarbonate infusions in humans.

  1995cited by this paper
• Ventilatory effects of specific carotid body hypocapnia in dogs during wakefulness and sleep.

  1995cited by this paper
• An assessment of central-peripheral ventilatory chemoreflex interaction in humans.

  1992cited by this paper
• The chemoreflex control of breathing and its measurement

  1990cited by this paper
• The effects of carotid body hypocapnia on ventilation in goats.

  1990cited by this paper
• Central-peripheral chemoreceptor ventilatory interaction in awake goats.

  1989cited by this paper
• Response of the goat carotid body to acute and prolonged hypercapnia.

  1988cited by this paper
• Carotid chemoreceptor activity during acute and sustained hypoxia in goats.

  1988cited by this paper
• Carotid body hypercapnia does not elicit ventilatory acclimatization in goats.

  1986cited by this paper
• Central-peripheral chemoreceptor interaction in awake cerebrospinal fluid-perfused goats.

  1984cited by this paper
• Central respiratory CO2 sensitivity at extreme hypocapnia.

  1984cited by this paper
• The effects of unilateral carotid body excision on ventilatory control in goats.

  1983cited by this paper
• Input‐output relationships of central neural circuits involved in respiration in cats

  1981cited by this paper
• Recovery of peripheral chemoreceptor function after denervation in ponies.

  1980influential reference
• Central neural respiratory drive and afterdischarge.

  1980cited by this paper
• Carotid bodies, stimulus interaction, and ventilatory control in unanesthetized goats.

  1966influential reference

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• Rethinking O2, CO2 and breathing during wakefulness and sleep

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• Hypercapnic signaling influences hypoxic signalingin the control of breathing in C57BL6 mice.

  2023cites this paper
• A test of the interaction between central and peripheral respiratory chemoreflexes in humans

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  2022cites this paper
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• Exertional dyspnoea in patients with mild‐to‐severe chronic obstructive pulmonary disease: neuromechanical mechanisms

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  2021cites this paper
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  2021cites this paper
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  2021cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2015cites this paper
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  2015cites this paper
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