Energy for wild-type acetylcholine receptor channel gating from different choline derivatives.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Biophysical Journal

• Publication date

  2013-02-05

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.bpj.2012.11.3833PMID 23442907PMCID PMC3566445
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Action of nicotine and analogs on acetylcholine receptors having mutations of transmitter-binding site residue αG153

  2013cited by this paper
• The intrinsic energy of the gating isomerization of a neuromuscular acetylcholine receptor channel

  2012cited by this paper
• Thinking in cycles: MWC is a good model for acetylcholine receptor‐channels

  2012cited by this paper
• Structure of the pentameric ligand-gated ion channel ELIC cocrystallized with its competitive antagonist acetylcholine

  2012cited by this paper
• Sources of energy for gating by neurotransmitters in acetylcholine receptor channels

  2012cited by this paper
• Design and control of acetylcholine receptor conformational change

  2011cited by this paper
• Structural basis of open channel block in a prokaryotic pentameric ligand-gated ion channel

  2010cited by this paper
• Linking the acetylcholine receptor-channel agonist-binding sites with the gate.

  2010cited by this paper
• From the Cover: Inaugural Article: Nicotinic pharmacophore: The pyridine N of nicotine and carbonyl of acetylcholine hydrogen bond across a subunit interface to a backbone NH

  2010cited by this paper
• Docking flexible ligands in proteins with a solvent exposure- and distance-dependent dielectric function

  2010cited by this paper
• Energetics of gating at the apo–acetylcholine receptor transmitter binding site

  2010cited by this paper
• Acetylcholine receptor channels activated by a single agonist molecule.

  2010cited by this paper
• Detection and Trapping of Intermediate States Priming Nicotinic Receptor Channel Opening

  2009cited by this paper
• Unliganded gating of acetylcholine receptor channels

  2009cited by this paper
• Agonist and blocking actions of choline and tetramethylammonium on human muscle acetylcholine receptors

  2009cited by this paper
• Energy and structure of the M2 helix in acetylcholine receptor-channel gating.

  2009cited by this paper
• Access and Binding of Local Anesthetics in the Closed Sodium Channel

  2008cited by this paper
• Use of calculated cation-pi binding energies to predict relative strengths of nicotinic acetylcholine receptor agonists.

  2008cited by this paper
• On the nature of partial agonism in the nicotinic receptor superfamily

  2008cited by this paper
• Sodium channels: ionic model of slow inactivation and state-dependent drug binding.

  2007cited by this paper
• Acetylcholine Receptor Gating at Extracellular Transmembrane Domain Interface: the “Pre-M1” Linker

  2007cited by this paper
• Monte Carlo-energy minimization of correolide in the Kv1.3 channel: possible role of potassium ion in ligand-receptor interactions

  2007cited by this paper
• Block of Muscle Nicotinic Receptors by Choline Suggests that the Activation and Desensitization Gates Act as Distinct Molecular Entities

  2006cited by this paper
• Estimating Binding Affinities of the Nicotinic Receptor for Low-efficacy Ligands Using Mixtures of Agonists and Two-dimensional Concentration–Response Relationships

  2006cited by this paper
• Gating of acetylcholine receptor channels: brownian motion across a broad transition state.

  2005cited by this paper
• Refined structure of the nicotinic acetylcholine receptor at 4A resolution.

  2005cited by this paper
• Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations

  2005cited by this paper
• Dynamics of the acetylcholine receptor pore at the gating transition state.

  2005cited by this paper
• Nicotine and carbamylcholine binding to nicotinic acetylcholine receptors as studied in AChBP crystal structures.

  2004cited by this paper
• Structural dynamics of the M4 transmembrane segment during acetylcholine receptor gating.

  2004cited by this paper
• Activation and block of mouse muscle‐type nicotinic receptors by tetraethylammonium

  2003cited by this paper
• The Role of Loop 5 in Acetylcholine Receptor Channel Gating

  2003cited by this paper
• Aromatics at the murine nicotinic receptor agonist binding site: mutational analysis of the αY93 and αW149 residues

  2001cited by this paper
• Aromatics at the murine nicotinic receptor agonist binding site: mutational analysis of the alphaY93 and alphaW149 residues.

  2001cited by this paper
• Mapping the conformational wave of acetylcholine receptor channel gating

  2000cited by this paper
• Discrimination of the native from misfolded protein models with an energy function including implicit solvation.

  1999cited by this paper
• A re‐examination of adult mouse nicotinic acetylcholine receptor channel activation kinetics

  1999cited by this paper
• Activation of muscle nicotinic acetylcholine receptor channels by nicotinic and muscarinic agonists

  1999cited by this paper
• Commentary: a plausible model.

  1999cited by this paper
• Serum choline activates mutant acetylcholine receptors that cause slow channel congenital myasthenic syndromes.

  1999cited by this paper
• Dose-response relations for unnatural amino acids at the agonist binding site of the nicotinic acetylcholine receptor: tests with novel side chains and with several agonists.

  1996cited by this paper
• Cation-pi interactions in aromatics of biological and medicinal interest: electrostatic potential surfaces as a useful qualitative guide.

  1996cited by this paper
• Cation-π Interactions in Chemistry and Biology: A New View of Benzene, Phe, Tyr, and Trp

  1996cited by this paper
• Nicotinic receptor binding site probed with unnatural amino acid incorporation in intact cells.

  1995cited by this paper
• Conserved tyrosines in the alpha subunit of the nicotinic acetylcholine receptor stabilize quaternary ammonium groups of agonists and curariform antagonists.

  1994cited by this paper
• A statistical analysis of acetylcholine receptor activation in Xenopus myocytes: stepwise versus concerted models of gating.

  1993cited by this paper
• Mutations affecting agonist sensitivity of the nicotinic acetylcholine receptor.

  1991cited by this paper
• Monte Carlo-minimization approach to the multiple-minima problem in protein folding.

  1987cited by this paper
• Kinetics of unliganded acetylcholine receptor channel gating.

  1986cited by this paper
• Development and use of quantum mechanical molecular models. 76. AM1: a new general purpose quantum mechanical molecular model

  1985cited by this paper
• A NEW FORCE FIELD FOR MOLECULAR MECHANICAL SIMULATION OF NUCLEIC ACIDS AND PROTEINS

  1984cited by this paper
• The Henderson‐Hasselbalch equation revisited

  1983cited by this paper
• On the application of "a plausible model" of allosteric proteins to the receptor for acetylcholine.

  1967cited by this paper
• ON THE NATURE OF ALLOSTERIC TRANSITIONS: A PLAUSIBLE MODEL.

  1965cited by this paper

• Efficiency of an allosteric protein: Multiple affinity-efficacy correlations link agonist binding to nicotinic receptor activation

  2023cites this paper
• Agonist efficiency links binding and gating in a nicotinic receptor

  2023cites this paper
• Structural implications of agonist efficiency estimated from concentration-response curves Running title : agonist efficiency

  2021cites this paper
• Different Classes of Antidepressants Inhibit the Rat α7 Nicotinic Acetylcholine Receptor by Interacting within the Ion Channel: A Functional and Structural Study

  2021cites this paper
• Agonist efficiency from concentration-response curves: structural implications and applications.

  2021cites this paper
• Exploring Cocrystallized Aromatic Cage Binders to Target Histone Methylation Reader Proteins

  2020cites this paper
• Agonist efficiency estimated from concentration-response curves

  2020cites this paper
• Molecular recognition at cholinergic synapses: acetylcholine versus choline

  2017cites this paper
• Agonist activation of a nicotinic acetylcholine receptor.

  2015cites this paper
• Modal affinities of endplate acetylcholine receptors caused by loop C mutations

  2015cites this paper
• Catch-and-hold activation of muscle acetylcholine receptors having transmitter binding site mutations.

  2014cites this paper
• The energy and work of a ligand-gated ion channel.

  2013cites this paper