A rapid procedure for measurement of DNA repair in human fibroblasts and for complementation analysis of xeroderma pigmentosum cells.

No abstract is available for this paper.

• Publication year

  1980

• Venue

  Mutation research

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/0027-5107(80)90187-6PMID 6987495
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A seventh complementation group in excision-deficient xeroderma pigmentosum.

  1979cited by this paper
• Clinical, genetic and DNA repair studies on a consecutive series of patients with xeroderma pigmentosum.

  1979cited by this paper
• Single-strand breaks in DNA during repair of UV-induced damage in normal human and xeroderma pigmentosum cells as determined by alkaline DNA unwinding and hydroxylapatite chromatography: effects of hydroxyurea, 5-fluorodeoxyuridine and 1-beta-D-arabinofuranosylcytosine on the kinetics of repair.

  1979cited by this paper
• Enhancement of repair replication in mammalian cells by hydroxyurea.

  1978cited by this paper
• Evaluation of a short-term test for the detection of genetic damage in human cultured cells

  1978cited by this paper
• ATAXIA TELANGIECTASIA: A MODEL INHERITED DISEASE LINKING DEFICIENT DNA REPAIR WITH RADIOSENSITIVITY AND CANCER PRONENESS

  1978cited by this paper
• Testing of known carcinogens and noncarcinogens for their ability to induce unscheduled DNA synthesis in HeLa cells.

  1978cited by this paper
• The relationship of unscheduled DNA synthesis to mutagenesis and chromosomal aberrations

  1978cited by this paper
• A human subject with a new defect in repair of ultraviolet damage.

  1978cited by this paper
• Induction of mammalian somatic cell hybridization by polyethylene glycol.

  1977cited by this paper
• Repair of ultraviolet light damage in a variety of human fibroblast cell strains.

  1977cited by this paper
• Developmental decline in DNA repair in neural retina cells of chick embryos: persistent deficiency of repair competence in a cell line derived from late

  1977cited by this paper
• DNA repair characteristics and skin cancers of xeroderma pigmentosum patients in Japan.

  1977cited by this paper
• Cross-link repair in human cells and its possible defect in Fanconi's anemia cells.

  1977cited by this paper
• Ultraviolet-induced DNA-repair synthesis in lymphocytes from patients with chronic lymphatic leukemia.

  1977cited by this paper
• Cross-link repair in human cells and its possible defect in Fanconi's anemia cells.

  1977cited by this paper
• Chromosome assignment of a human gene for argininosuccinate synthetase expression in Chinese hamsterxhuman somatic cell hybrids.

  1977cited by this paper
• Chapter 18 Induction of Mammalian Somatic Cell Hybridization by Polyethylene Glycol1

  1977cited by this paper
• Ataxia Telangiectasia: An Inherited Human Disease Involving Radiosensitivity, Malignancy and Defective DNA Repair

  1977cited by this paper
• The inhibition of repair in UV irradiated human cells.

  1977cited by this paper
• Enhancement of UV-induced unscheduled DNA synthesis by hydroxyurea. Demonstration by combined biochemical and autoradiographic techniques.

  1977cited by this paper
• Repair replication in human cells. Simplified determination utilizing hydroxyurea.

  1976cited by this paper
• Repair replication in cultured normal and transformed human fibroblasts.

  1976cited by this paper
• Incorporation of (3H)thymidine stimulated by ultraviolet radiation into human fibroblast cultures.

  1976cited by this paper
• Thymidine kinase, DNA synthesis and cancer

  1976cited by this paper
• DNA repair synthesis in human heterokaryons. III. The rapid and slow complementing varieties of xeroderma pigmentosum.

  1976cited by this paper
• DNA excision-repair deficiency of human peripheral blood lymphocytes treated with chemical carcinogens.

  1976cited by this paper
• Ataxia telangiectasia: a human mutation with abnormal radiation sensitivity

  1975cited by this paper
• Five complementation groups in xeroderma pigmentosum.

  1975cited by this paper
• The measurement of chemically-induced DNA repair synthesis in human cells by BND-cellulose chromatography.

  1975cited by this paper
• A sensitive method to measure physical and chemical carcinogen-induced "unscheduled DNA synthesis" in rapidly dividing eukaryotic cells.

  1974cited by this paper
• Unscheduled DNA synthesis in human leucocytes after exposure to UV light, -rays and chemical mutagens.

  1972cited by this paper
• Genetic heterogeneity of xeroderma pigmentosum demonstrated by somatic cell hybridization.

  1972cited by this paper
• The value of hydroxyurea in assessing repair synthesis of DNA in HeLa cells.

  1972cited by this paper
• Studies on DNA repair in human lymphocytes treated with proximate carcinogens and alkylating agents.

  1971cited by this paper
• Normal and defective repair of damaged DNA in human cells: a sensitive assay utilizing the photolysis of bromodeoxyuridine.

  1971cited by this paper
• DNA REPAIR IN ULTRAVIOLET LIGHT IRRADIATED HeLa CELLS AND ITS REVERSIBLE INHIBITION BY HYDROXYUREA

  1971cited by this paper
• DNA Synthesis in Differentiating Skeletal Muscle Cells: Initiation by Ultraviolet Light

  1971cited by this paper
• Repair replication of mammalian cell DNA: effects of compounds that inhibit DNA synthesis or dark repair.

  1969cited by this paper
• METHODS IN CANCER RESEARCH

  1969cited by this paper
• Evidence for excision of ultraviolet-induced pyrimidine dimers from the DNA of human cells in vitro.

  1968cited by this paper
• Evidence for Repair of Ultra-Violet Damaged Deoxyribonucleic Acid in Cultured Mammalian Cells

  1964cited by this paper
• EVIDENCE FOR REPAIR-REPLICATION OF ULTRAVIOLET DAMAGED DNA IN BACTERIA.

  1964cited by this paper

• Unscheduled DNA Synthesis at Sites of Local UV-induced DNA Damage to Quantify Global Genome Nucleotide Excision Repair Activity in Human Cells.

  2023cites this paper
• Neurological disease in xeroderma pigmentosum: prospective cohort study of its features and progression

  2023cites this paper
• TFIIH central activity in nucleotide excision repair to prevent disease.

  2023cites this paper
• Identifying the psychosocial predictors of ultraviolet exposure to the face in patients with xeroderma pigmentosum: a study of the behavioural factors affecting clinical outcomes in this genetic disease

  2022cites this paper
• Aicardi–Goutières syndrome with SAMHD1 deficiency can be diagnosed by unscheduled DNA synthesis test

  2022cites this paper
• Ultraviolet radiation exposure to the face in patients with xeroderma pigmentosum and healthy controls: applying a novel methodology to define photoprotection behaviour

  2021cites this paper
• Preliminary Evidence for a Hormetic Effect on DNA Nucleotide Excision Repair in Veterans with Gulf War Illness

  2019cites this paper
• Actual state of knowledge in the field of diseases related with defective nucleotide excision repair.

  2018cites this paper
• Pigmentation abnormalities in nucleotide excision repair disorders: Evidence and hypotheses

  2018cites this paper
• Disorders with Deficiency in TC-NER: Molecular Pathogenesis of Cockayne Syndrome and UV-Sensitive Syndrome

  2018cites this paper
• Genetic therapy of Xeroderma Pigmentosum: analysis of strategies and translation

  2017cites this paper
• Facile preparation of a fluorescent probe to detect the cellular ability of nucleotide excision repair.

  2017cites this paper
• Deep phenotyping of 89 xeroderma pigmentosum patients reveals unexpected heterogeneity dependent on the precise molecular defect

  2016cites this paper
• Multifaceted role of TREX2 in the skin defense against UV-induced skin carcinogenesis

  2015cites this paper
• Fluorescence detection of cellular nucleotide excision repair of damaged DNA

  2014cites this paper
• Hypomorphic PCNA mutation underlies a human DNA repair disorder.

  2014cites this paper
• Hypomorphic PCNA mutation underlies a novel human DNA repair disorder

  2014cites this paper
• A rapid, comprehensive system for assaying DNA repair activity and cytotoxic effects of DNA-damaging reagents

  2014cites this paper
• Investigation of the molecular basis of three new disorders of brain growth and development identified amongst the Amish

  2014cites this paper
• Xeroderma Pigmentosum: Man Deprived of His Right to Light

  2013cites this paper
• Patients with xeroderma pigmentosum complementation groups C, E and V do not have abnormal sunburn reactions

  2013cites this paper
• Transcript Levels Pigmentosum and Consequences at the Cell, Protein, and Mutations in the XPC Gene in Families with Xeroderma

  2013cites this paper
• Xeroderma Pigmentosum: A Multidisciplinary Approach

  2013cites this paper
• Spotlight on ‘xeroderma pigmentosum’

  2012cites this paper
• Xeroderma pigmentosum

  2011cites this paper
• Differential contributory roles of nucleotide excision and homologous recombination repair for enhancing cisplatin sensitivity in human ovarian cancer cells

  2011cites this paper
• A semi-automated non-radioactive system for measuring recovery of RNA synthesis and unscheduled DNA synthesis using ethynyluracil derivatives.

  2010cites this paper
• A rapid non-radioactive technique for measurement of repair synthesis in primary human fibroblasts by incorporation of ethynyl deoxyuridine (EdU)

  2008influential citation
• Six Genes Associated with the Clinical Phenotypes of Individuals with Deficient and Proficient DNA Repair

  2008cites this paper
• Persistence of repair proteins at unrepaired DNA damage distinguishes diseases with ERCC2 (XPD) mutations: cancer‐prone xeroderma pigmentosum vs. non‐cancer‐prone trichothiodystrophy

  2008cites this paper
• Neurological symptoms and natural course of xeroderma pigmentosum.

  2008cites this paper
• Mutations in the C7orf11 (TTDN1) gene in six nonphotosensitive trichothiodystrophy patients: no obvious genotype–phenotype relationships

  2007cites this paper
• Syndrome and Xeroderma Pigmentosum Early Defect in Cells from Individuals with Cockayne ' s Failure of RNA Synthesis to Recover after UV Irradiation : An Updated

  2006cites this paper
• Test fonctionnel de mesure des activités enzymatiques de réparation de l'ADN par excision resynthèse sur support miniaturisé : mise au point et applications

  2006cites this paper
• A novel mutation in the XPA gene associated with unusually mild clinical features in a patient who developed a spindle cell melanoma

  2006cites this paper
• Syndrome Xeroderma Pigmentosum and Cockayne from Patients with Combined Features of Xeroderma Pigmentosum Group D Cells Transcription-Associated Breaks in

  2005cites this paper
• Two new XPD patients compound heterozygous for the same mutation demonstrate diverse clinical features.

  2005cites this paper
• Flow cytometric characterization of the response of Fanconi's anemia cells to mitomycin C treatment.

  2005cites this paper
• Transcription-Associated Breaks in Xeroderma Pigmentosum Group D Cells from Patients with Combined Features of Xeroderma Pigmentosum and Cockayne Syndrome

  2005cites this paper
• Two individuals with features of both xeroderma pigmentosum and trichothiodystrophy highlight the complexity of the clinical outcomes of mutations in the XPD gene.

  2001cites this paper
• Mutations in the XPC gene in families with xeroderma pigmentosum and consequences at the cell, protein, and transcript levels.

  2000cites this paper
• Xeroderma pigmentosum and trichothiodystrophy are associated with different mutations in the XPD (ERCC2) repair/transcription gene.

  1997cites this paper
• Molecular and cellular analysis of the DNA repair defect in a patient in xeroderma pigmentosum complementation group D who has the clinical features of xeroderma pigmentosum and Cockayne syndrome.

  1995cites this paper
• Genotoxin-Induced Apoptosis: Implications for Carcinogenesis

  1994cites this paper
• Induction of internucleosomal DNA fragmentation by carcinogenic chromate: relationship to DNA damage, genotoxicity, and inhibition of macromolecular synthesis.

  1994cites this paper
• The Cell Cycle

  1994cites this paper
• Apoptosis is the mode of cell death caused by carcinogenic chromium.

  1994cites this paper
• Preferential formation and repair of chromium-induced DNA adducts and DNA--protein crosslinks in nuclear matrix DNA.

  1994cites this paper
• Xeroderma pigmentosum-Cockayne syndrome complex in two patients: absence of skin tumors despite severe deficiency of DNA excision repair.

  1993cites this paper
• The XPD complementation group. Insights into xeroderma pigmentosum, Cockayne's syndrome and trichothiodystrophy.

  1992cites this paper
• Long‐term survival and preservation of natural killer cell activity in a xeroderma pigmentosum patient with spontaneous regression and multiple deposits of malignant melanoma

  1991cites this paper
• Relationship between pyrimidine dimers, 6-4 photoproducts, repair synthesis and cell survival: studies using cells from patients with trichothiodystrophy.

  1990cites this paper
• The repair of identified large DNA adducts induced by 4-nitroquinoline-1-oxide in normal or xeroderma pigmentosum group A human fibroblasts, and the role of DNA polymerases alpha or delta.

  1989cites this paper
• Trichothiodystrophy, a human DNA repair disorder with heterogeneity in the cellular response to ultraviolet light.

  1988cites this paper
• Kinetic analysis of UV-induced incision discriminates between fibroblasts from different xeroderma pigmentosum complementation groups, XPA heterozygotes and normal individuals.

  1988cites this paper
• Alzheimer's disease cells exhibit defective repair of alkylating agent—induced DNA damage

  1987cites this paper
• Molecular Studies on the Nature of the Repair Defect in Ataxia-Telangiectasia and their Implications for Cellular Radiobiology

  1987cites this paper
• The effect of in vivo hydrocortisone administration on the labelling index and size of chromaffin tissue in the postnatal and adult mouse.

  1986cites this paper
• Coordinate regulation of histone mRNAs during growth and differentiation of rat myoblasts.

  1985cites this paper
• The Inhibition of DNA Repair

  1984cites this paper
• DNA damage and chronic neuronal degenerations.

  1984cites this paper
• The scintillometric evaluation of DNA repair synthesis can be distorted by changes of thymidine pool radioactivity.

  1983cites this paper
• A biochemical defect in the repair of alkylated DNA in cells from an immunodeficient patient (46BR).

  1983cites this paper
• A modified method of UDS detection in vitro suitable for screening the DNA-damaging effects of chemicals.

  1983cites this paper
• Isolation and preliminary characterization of u.v.-sensitive mutants from the human cell line EUE.

  1983cites this paper
• Variation in response to mutagens amongst normal and repair-defective human cells.

  1983cites this paper
• Chemical, Physical, and Genetic Factors Interfering with DNA Repair-a Review

  1983cites this paper
• Scintillometric determination of DNA repair in human cell lines: A critical appraisal

  1982cites this paper
• Inhibitors of repair DNA synthesis.

  1982cites this paper
• Rapid complementation method for classifying excision repair-defective xeroderma pigmentosum cell strains

  1982cites this paper
• The response of ataxia-telangiectasia homozygous and heterozygous skin fibroblasts to neocarzinostatin.

  1982cites this paper
• Role of poly(adenosine diphosphate ribose) in deoxyribonucleic acid repair in human fibroblasts.

  1982cites this paper
• Failure of RNA synthesis to recover after UV irradiation: an early defect in cells from individuals with Cockayne's syndrome and xeroderma pigmentosum.

  1982cites this paper
• [Semiconservative and unscheduled DNA-synthesis of rat thymocytes under the influence of some radioprotecting and radiosensitizing agents (author's transl)].

  1982cites this paper
• Genetic diversity of UV-sensitive DNA repair mutants of Chinese hamster ovary cells.

  1981cites this paper
• Genetic and biochemical studies with ataxia telangiectasia. A review.

  1981cites this paper
• Human diseases characterized by heritable DNA instability.

  1981cites this paper
• Growth, DNA repair, sister chromatid exchange and chromosome studies in fibroblasts fromHuntington's disease patients

  1981cites this paper
• Genetic and biochemical studies with ataxia telangiectasia

  1981cites this paper
• Studies on a new case of xeroderma pigmentosum (XP3BR) from complementation group G with cellular sensitivity to ionizing radiation.

  1980cites this paper