The structure of the MAP2K MEK6 reveals an autoinhibitory dimer.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Structure

• Publication date

  2009-01-14

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.str.2008.11.007PMID 19141286PMCID PMC3689539
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• X-ray solution scattering (SAXS) combined with crystallography and computation: defining accurate macromolecular structures, conformations and assemblies in solution.

  2011cited by this paper
• Substrate and Docking Interactions in Serine/Threonine Protein Kinases

  2008cited by this paper
• Structure of human synaptotagmin 1 C2AB in the absence of Ca2+ reveals a novel domain association.

  2007cited by this paper
• Substrate and docking interactions in serine/threonine protein kinases.

  2007cited by this paper
• Differential regulation and properties of MAPKs

  2007cited by this paper
• Docking interactions induce exposure of activation loop in the MAP kinase ERK2.

  2006cited by this paper
• Regulation of cellular functions by the ERK5 signalling pathway.

  2006cited by this paper
• An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor.

  2006cited by this paper
• Mechanisms of MAPK signalling specificity.

  2006influential reference
• Structural analysis of flexible proteins in solution by small angle X-ray scattering combined with crystallography.

  2006cited by this paper
• Structural basis of docking interactions between ERK2 and MAP kinase phosphatase 3.

  2006cited by this paper
• Mechanisms of drug inhibition of signalling molecules

  2006cited by this paper
• The extracellular signal-regulated kinase: Multiple substrates regulate diverse cellular functions

  2006cited by this paper
• Conserved docking site is essential for activation of mammalian MAP kinase kinases by specific MAP kinase kinase kinases.

  2005influential reference
• Structural comparison of p38 inhibitor-protein complexes: a review of recent p38 inhibitors having unique binding interactions.

  2005cited by this paper
• Mechanistic link between PKR dimerization, autophosphorylation, and eIF2alpha substrate recognition.

  2005cited by this paper
• Activation and signaling of the p38 MAP kinase pathway

  2005cited by this paper
• Electronic Reprint Biological Crystallography Optimal Description of a Protein Structure in Terms of Multiple Groups Undergoing Tls Motion Biological Crystallography Optimal Description of a Protein Structure in Terms of Multiple Groups Undergoing Tls Motion

  2005cited by this paper
• The role of docking interactions in mediating signaling input, output, and discrimination in the yeast MAPK network.

  2005cited by this paper
• Mechanistic Link between PKR Dimerization, Autophosphorylation, and eIF2α Substrate Recognition

  2005cited by this paper
• High Intensity ras Signaling Induces Premature Senescence by Activating p38 Pathway in Primary Human Fibroblasts*

  2004cited by this paper
• Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125

  2004cited by this paper
• Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF.

  2004influential reference
• Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition

  2004influential reference
• Crystal structure of the TAO2 kinase domain: activation and specificity of a Ste20p MAP3K.

  2004cited by this paper
• Targeting JNK for therapeutic benefit: from junk to gold?

  2003cited by this paper
• Signalling specificity of Ser/Thr protein kinases through docking-site-mediated interactions.

  2003cited by this paper
• Docking sites on mitogen-activated protein kinase (MAPK) kinases, MAPK phosphatases and the Elk-1 transcription factor compete for MAPK binding and are crucial for enzymic activity.

  2003influential reference
• Small-angle scattering: a view on the properties, structures and structural changes of biological macromolecules in solution

  2003cited by this paper
• Molecular recognitions in the MAP kinase cascades.

  2003cited by this paper
• Mitogen-Activated Protein Kinase Pathways Mediated by ERK, JNK, and p38 Protein Kinases

  2002cited by this paper
• Crystal structures of MAP kinase p38 complexed to the docking sites on its nuclear substrate MEF2A and activator MKK3b.

  2002cited by this paper
• The PyMOL Molecular Graphics System

  2002cited by this paper
• Substructure solution with SHELXD.

  2002cited by this paper
• The conformational plasticity of protein kinases.

  2002cited by this paper
• Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions.

  2001cited by this paper
• MAP kinases.

  2001cited by this paper
• Determination of domain structure of proteins from X-ray solution scattering.

  2001influential reference
• Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch.

  2000cited by this paper
• Molecular determinants that mediate selective activation of p38 MAP kinase isoforms

  2000cited by this paper
• A Novel Method for Measurement of Submembrane ATP Concentration*

  2000cited by this paper
• The structure of phosphorylated p38gamma is monomeric and reveals a conserved activation-loop conformation.

  1999cited by this paper
• Automated protein model building combined with iterative structure refinement

  1999cited by this paper
• Overcoming expression and purification problems of RhoGDI using a family of "parallel" expression vectors.

  1999cited by this paper
• Crystal structure of JNK3: a kinase implicated in neuronal apoptosis.

  1998cited by this paper
• Crystallography & NMR system: A new software suite for macromolecular structure determination.

  1998cited by this paper
• Processing of X-ray diffraction data collected in oscillation mode.

  1997cited by this paper
• Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog

  1997cited by this paper
• The structure of mitogen-activated protein kinase p38 at 2.1-A resolution.

  1997cited by this paper
• Refinement of macromolecular structures by the maximum-likelihood method.

  1997influential reference
• Activation mechanism of the MAP kinase ERK2 by dual phosphorylation.

  1997cited by this paper
• [20] Processing of X-ray diffraction data collected in oscillation mode.

  1997cited by this paper
• Development and validation of a genetic algorithm for flexible docking.

  1997cited by this paper
• Characterization of the Structure and Function of a Novel MAP Kinase Kinase (MKK6) (*)

  1996cited by this paper
• The 2.2 Å crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with RaplA and a GTP analogue

  1995cited by this paper
• Biochemical and biological analysis of Mek1 phosphorylation site mutants.

  1995cited by this paper
• The CCP4 suite: programs for protein crystallography.

  1994cited by this paper
• Overcoming non-isomorphism by phase permutation and likelihood scoring: solution of the TrpRS crystal structure.

  1994cited by this paper
• Atomic structure of the MAP kinase ERK2 at 2.3 Å resolution

  1994cited by this paper
• Contribution of unusual Arginine-Arginine short-range interactions to stabilization and recognition in proteins

  1994cited by this paper
• A comparison of effect of temperature on phosphorus metabolites, pH and Mg2+ in human and ground squirrel red cells.

  1993cited by this paper
• Ordered phosphorylation of p42mapk by MAP kinase kinase

  1992cited by this paper
• Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase.

  1991cited by this paper
• Use of synthetic amino acid polymers for assay of protein-tyrosine and protein-serine kinases.

  1991cited by this paper
• Improved methods for building protein models in electron density maps and the location of errors in these models.

  1991cited by this paper
• Loops in globular proteins: a novel category of secondary structure.

  1986cited by this paper
• Synthetic tyrosine polymers as substrates and inhibitors of tyrosine-specific protein kinases.

  1984cited by this paper

• Molecular basis of mitogen-activated protein kinase ERK2 activation by its upstream kinase MEK1

  2026cites this paper
• Structural basis for MEKK2 dimerization and substrate recognition

  2025cites this paper
• Discovery of pyrazolo[3,4-d]pyrimidines as novel mitogen-activated protein kinase kinase 3 (MKK3) inhibitors.

  2023cites this paper
• Architecture of the MKK6-p38α complex defines the basis of MAPK specificity and activation

  2023cites this paper
• Reckoning apigenin and kaempferol as a potential multi-targeted inhibitor of EGFR/HER2-MEK pathway of metastatic colorectal cancer identified using rigorous computational workflow

  2022cites this paper
• Crystal structure of the phosphorylated Arabidopsis MKK5 reveals activation mechanism of MAPK kinases

  2022cites this paper
• Quadruple and Truncated MEK3 Mutants Identified from Acute Lymphoblastic Leukemia Promote Degradation and Enhance Proliferation

  2021cites this paper
• MAP2K6 remodels chromatin and facilitates reprogramming by activating Gatad2b-phosphorylation dependent heterochromatin loosening

  2021cites this paper
• Atypical p38 Signaling, Activation, and Implications for Disease

  2021cites this paper
• Pazopanib and Trametinib as a Synergistic Strategy against Osteosarcoma: Preclinical Activity and Molecular Insights

  2020cites this paper
• Conformational Dynamics Analysis of MEK1 Using Hydrogen/Deuterium Exchange Mass Spectrometry.

  2020cites this paper
• A phosphorylated intermediate in the activation of WNK kinases.

  2020cites this paper
• Preparation of Phosphorylated Proteins for NMR Spectroscopy.

  2019cites this paper
• Machine learning and data mining frameworks for predicting drug response in cancer: An overview and a novel in silico screening process based on association rule mining.

  2019cites this paper
• Structural basis of autoregulatory scaffolding by apoptosis signal-regulating kinase 1

  2017influential citation
• A crucial role of Cys218 in configuring an unprecedented auto-inhibition form of MAP2K7.

  2016cites this paper
• Regulation of ERK by MEK1 Inhibition in the Brain

  2015cites this paper
• The Crystal Structure of Cancer Osaka Thyroid Kinase Reveals an Unexpected Kinase Domain Fold*

  2015cites this paper
• Regulation of ERK Kinase by MEK1 Kinase Inhibition in the Brain*

  2015cites this paper
• MAP kinase modules: the excursion model and the steps that count.

  2014cites this paper
• Chloride Sensing by WNK1 Involves Inhibition of Autophosphorylation

  2014cites this paper
• Precisely Ordered Phosphorylation Reactions in the p38 Mitogen-activated Protein (MAP) Kinase Cascade*

  2013cites this paper
• Implementation and performance of SIBYLS: a dual endstation small-angle X-ray scattering and macromolecular crystallography beamline at the Advanced Light Source

  2013cites this paper
• Profiling the substrate specificity of protein kinases by on-bead screening of peptide libraries.

  2013cites this paper
• Crystal structure of non-phosphorylated MAP2K6 in a putative auto-inhibition state.

  2012cites this paper
• CURRICULUM VITAE PERSONAL: Name:

  2011cites this paper
• Structures of human MST3 kinase in complex with adenine, ADP and Mn2+.

  2010cites this paper
• Mechanisms and functions of p38 MAPK signalling.

  2010cites this paper
• Software for the high-throughput collection of SAXS data using an enhanced Blu-Ice/DCS control system

  2010cites this paper
• Structural studies of MAP Kinase cascade components.

  2010cites this paper
• Small‐angle scattering for structural biology—Expanding the frontier while avoiding the pitfalls

  2010cites this paper
• Structural effects of clinically observed mutations in JAK2 exons 13-15: comparison with V617F and exon 12 mutations

  2009cites this paper