Inhibitory effect of Lovastatin on spontaneous metastases derived from a rat lymphoma

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Clinical and Experimental Metastasis

• Publication date

  1999-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1023/A:1026448026716PMID 10390143
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Tumor angiogenesis

  2020cited by this paper
• Low density lipoproteins and Lovastatin modulate the organ-specific transendothelial migration of primary and metastatic human colon adenocarcinoma cell lines in vitro

  1998cited by this paper
• Mevalonic Acid Is Limiting for N-Linked Glycosylation and Translocation of the Insulin-like Growth Factor-1 Receptor to the Cell Surface

  1996cited by this paper
• Proteases as prognostic markers in cancer.

  1996cited by this paper
• Exposure to vinorelbine inhibits in vitro proliferation and invasiveness of transitional cell bladder carcinoma.

  1996cited by this paper
• Carcinogenicity of lipid-lowering drugs.

  1996cited by this paper
• Carcinogenicity of lipid-lowering drugs.

  1996cited by this paper
• Lipid Metabolism as a Target for Brain Cancer Therapy: Synergistic Activity of Lovastatin and Sodium Phenylacetate Against Human Glioma Cells

  1996cited by this paper
• Biology of tumor cell invasion: Interplay of cell adhesion and matrix degradation

  1996influential reference
• Effects of monoterpenes and mevinolin on murine colon tumor CT-26 in vitro and its hepatic "metastases" in vivo.

  1996cited by this paper
• Combined effects of an angiogenesis inhibitor (TNP-470) and hyperthermia.

  1996cited by this paper
• Carcinogenicity of lipid-lowering drugs.

  1996cited by this paper
• Hypoxia arrests ovarian carcinoma cell cycle progression, but invasion is unaffected.

  1996cited by this paper
• Serum cholesterol and apolipoprotein B levels may reflect disease activity in ovarian cancer patients.

  1996cited by this paper
• Phase I study of lovastatin, an inhibitor of the mevalonate pathway, in patients with cancer.

  1996cited by this paper
• Uptake of temozolomide in a rat glioma model in the presence and absence of the angiogenesis inhibitor TNP-470.

  1996cited by this paper
• Low cholesterol and cancer.

  1996cited by this paper
• CARCINOGENICITY OF LIPID-LOWERING DRUGS. AUTHORS' REPLY

  1996cited by this paper
• Correlation of high lactate levels in human cervical cancer with incidence of metastasis.

  1995cited by this paper
• In vivo enhanced antitumor activity of carmustine [N,N'-bis(2-chloroethyl)-N-nitrosourea] by simvastatin.

  1995cited by this paper
• Antiangiogenic treatment (TNP-470/minocycline) increases tissue levels of anticancer drugs in mice bearing Lewis lung carcinoma.

  1995cited by this paper
• Effect of lovastatin alone and as an adjuvant chemotherapeutic agent on hepatoma tissue culture-4 cell growth

  1995cited by this paper
• Disposition and metabolism of the angiogenic moderator O-(chloroacetyl-carbamoyl) fumagillol (TNP-470; AGM-1470) in human hepatocytes and tissue microsomes.

  1995cited by this paper
• Efficacy of the angiogenesis inhibitor O-(chloroacetyl-carbamoyl)fumagillol (AGM-1470) on osteosarcoma growth and lung metastasis in rats.

  1995cited by this paper
• Critical factors in the biology of human cancer metastasis.

  1995cited by this paper
• Suppression of pulmonary metastasis by angiogenesis inhibitor TNP‐470 in murine osteosarcoma

  1995cited by this paper
• Dormancy of micrometastases: Balanced proliferation and apoptosis in the presence of angiogenesis suppression

  1995cited by this paper
• Characterization of the response of growth and differentiation to lipoproteins and agents affecting cholesterol metabolism in murine neuroblastoma cells

  1994cited by this paper
• Selective inhibition of primary acute myeloid leukaemia cell growth by lovastatin.

  1994cited by this paper
• Cytostatic inhibition of endothelial cell growth by the angiogenesis inhibitor TNP-470 (AGM-1470).

  1994cited by this paper
• Stimulation of angiogenesis as an explanation of matrigel‐enhanced tumorigenicity

  1994cited by this paper
• Inhibition of isoprenoid biosynthesis induces apoptosis in human promyelocytic HL-60 cells.

  1994cited by this paper
• Lovastatin Inhibits Pancreatic Cancer Growth Regardless of RAS Mutation

  1994cited by this paper
• Enhanced suppression of tumor growth by combination of angiogenesis inhibitor O-(chloroacetyl-carbamoyl)fumagillol (TNP-470) and cytotoxic agents in mice.

  1994cited by this paper
• The effect of AGM-1470 in an improved intracranial 9L gliosarcoma rat model.

  1994cited by this paper
• Inhibition of angiogenesis and growth of human nerve-sheath tumors by AGM-1470.

  1993cited by this paper
• Molecular aspects of tumor cell invasion and metastasis

  1993cited by this paper
• Ras-responsive genes and tumor metastasis.

  1993cited by this paper
• Inhibition of tumor growth and metastasis of rodent tumors by the angiogenesis inhibitor O-(chloroacetyl-carbamoyl)fumagillol (TNP-470; AGM-1470).

  1993cited by this paper
• Angiogenesis inhibitor TNP-470 (AGM-1470) potently inhibits the tumor growth of hormone-independent human breast and prostate carcinoma cell lines.

  1993cited by this paper
• Cancer progression and growth: relationship of paracrine and autocrine growth mechanisms to organ preference of metastasis.

  1993cited by this paper
• Increased expression of nucleoside diphosphate kinase/nm23 and c-Ha-ras mRNA is associated with spontaneous lung metastasis in rat-transplantable osteosarcomas.

  1993cited by this paper
• Metastasis of B16F10 mouse melanoma inhibited by lovastatin, an inhibitor of cholesterol biosynthesis.

  1993cited by this paper
• Posttranscriptional control of thymidine kinase messenger RNA accumulation in cells released from G0-G1 phase blocks.

  1993cited by this paper
• Expression of gelatinise/type IV collagenase in tumor necrosis correlates with cell detachment and tumor invasion

  1992cited by this paper
• Requirement for mevalonate in the control of proliferation of human breast cancer cells.

  1992cited by this paper
• Inhibition of pancreatic adenocarcinoma cell growth by lovastatin.

  1992cited by this paper
• Protein prenylation: key to ras function and cancer intervention?

  1992cited by this paper
• Urokinase‐type plasminogen activator mediates basic fibroblast growth factor‐induced bovine endothelial cell migration independent of its proteolytic activity

  1992cited by this paper
• Why do cancer cells metastasize into particular organs?

  1992cited by this paper
• Antiangiogenic agents potentiate cytotoxic cancer therapies against primary and metastatic disease.

  1992cited by this paper
• Synchronization of tumor and normal cells from G1 to multiple cell cycles by lovastatin.

  1991cited by this paper
• Potent anti-angiogenic action of AGM-1470: comparison to the fumagillin parent.

  1991cited by this paper
• Cell cycle-specific effects of lovastatin.

  1991cited by this paper
• In vivo regulation of human leukocyte 3-hydroxy-3-methylglutaryl coenzyme A reductase: increased enzyme protein concentration and catalytic efficiency in human leukemia and lymphoma.

  1991cited by this paper
• Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth

  1990cited by this paper
• Delivery of novel therapeutic agents in tumors: physiological barriers and strategies.

  1990cited by this paper
• Increase in the active form of 3-hydroxy-3-methylglutaryl coenzyme A reductase in human hepatocellular carcinoma: possible mechanism for alteration of cholesterol biosynthesis.

  1990cited by this paper
• Regulation of the mevalonate pathway

  1990cited by this paper
• Tumor interactions with the vasculature: angiogenesis and tumor metastasis.

  1990cited by this paper
• Critical factors in the biology of human cancer metastasis: twenty-eighth G.H.A. Clowes memorial award lecture.

  1990cited by this paper
• Long-term clinical tolerance of lovastatin and simvastatin.

  1990cited by this paper
• Invasive and metastatic potential of a v-Ha-ras-transformed human bronchial epithelial cell line.

  1989cited by this paper
• Plasma cholesterol, coronary heart disease, and cancer in the Renfrew and Paisley survey.

  1989cited by this paper
• TRANSPLANTABLE OSTEOSARCOMAS WITH HIGH LUNG METASTATIC POTENTIAL IN FISCHER 344 RATS

  1988cited by this paper
• Evidence for modification of lamin B by a product of mevalonic acid.

  1988cited by this paper
• Microangiographic and histologic analysis of the effects of hyperthermia on murine tumor vasculature.

  1988cited by this paper
• Efficacy and long-term adverse effect pattern of lovastatin.

  1988cited by this paper
• CS-514, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase: tissue-selective inhibition of sterol synthesis and hypolipidemic effect on various animal species.

  1986cited by this paper
• Suppression of murine neuroblastoma growth in vivo by mevinolin, a competitive inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

  1985cited by this paper
• The p21 ras C-terminus is required for transformation and membrane association

  1984cited by this paper
• Altered activation state of hydroxymethylglutaryl-coenzyme A reductase in liver tumors.

  1983cited by this paper
• Essential role for mevalonate synthesis in DNA replication.

  1979cited by this paper
• The role of cholesterol in malignancy.

  1978cited by this paper
• Low-density lipoprotein (LDL) receptor activity in human acute myelogenous leukemia cells.

  1978cited by this paper
• Lymphocyte-induced angiogenesis: a quantitative and sensitive assay of the graft-vs.-host reaction

  1975cited by this paper
• Proceedings: Tumor angiogenesis factor.

  1974cited by this paper
• DELETION OF THE CHOLESTEROL-NEGATIVE FEEDBACK SYSTEM IN LIVER TUMORS.

  1964cited by this paper

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  2015cites this paper
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  2015cites this paper
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  2015cites this paper
• Statin Use Is Associated with Reduced Risk of Haematological Malignancies: Evidence from a Meta-Analysis

  2014cites this paper
• Lovastatin inhibits human B lymphoma cell proliferation by reducing intracellular ROS and TRPC6 expression.

  2014cites this paper
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  2014cites this paper
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  2014cites this paper
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  2013cites this paper
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  2010cites this paper
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  2010cites this paper
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  2010cites this paper
• Bisphosphonate Inhibition of Prostate Cancer Cell Invasion, Migration and Cytoskeletal Organization

  2010cites this paper
• RhoA, B, and C in cancer: Study of statin-induced changes in Rho signaling, and identification of isoform-specific Rho effectors

  2009cites this paper
• Targeting the mevalonate pathway for improved anticancer therapy.

  2009cites this paper
• Statin-induced cellular effects mediated by the P2X7 receptor

  2009cites this paper
• Potent Inhibition of Cicatricial Contraction in Proliferative Vitreoretinal Diseases by Statins

  2008cites this paper
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  2008cites this paper
• Ciglitazone, an agonist of peroxisome proliferator-activated receptor gamma, exerts potentiated cytostatic/cytotoxic effects against tumor cells when combined with lovastatin.

  2008cites this paper
• Cancer chemoprevention: a summary of the current evidence.

  2008cites this paper
• Lovastatin enhances the antitumoral and apoptotic activity of doxorubicin in murine tumor models.

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• Overexpression of RhoA enhances peritoneal dissemination: RhoA suppression with Lovastatin may be useful for ovarian cancer

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