Delphinidin Attenuates Neoplastic Transformation in JB6 Cl41 Mouse Epidermal Cells by Blocking Raf/Mitogen-Activated Protein Kinase Kinase/Extracellular Signal-Regulated Kinase Signaling

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Cancer Prevention Research

• Publication date

  2008-12-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1158/1940-6207.CAPR-08-0071PMID 19139002PMCID PMC2832759
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer

  2007cited by this paper
• Sorafenib (BAY 43-9006, Nexavar), a dual-action inhibitor that targets RAF/MEK/ERK pathway in tumor cells and tyrosine kinases VEGFR/PDGFR in tumor vasculature.

  2006cited by this paper
• Raf kinases: Oncogenesis and drug discovery

  2006cited by this paper
• Recent progress in targeting the Raf/MEK/ERK pathway with inhibitors in cancer drug discovery.

  2005cited by this paper
• Signal transduction pathways in cancer development and as targets for cancer prevention.

  2005cited by this paper
• Inhibition of epidermal growth factor‐induced cell transformation and Akt activation by caffeine

  2005cited by this paper
• Targeting the mitogen-activated protein kinase cascade to treat cancer

  2004cited by this paper
• Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF.

  2004cited by this paper
• Cyclooxygenase-2 inhibitor (SC-236) suppresses activator protein-1 through c-Jun NH2-terminal kinase.

  2004influential reference
• BAY 43-9006 Exhibits Broad Spectrum Oral Antitumor Activity and Targets the RAF/MEK/ERK Pathway and Receptor Tyrosine Kinases Involved in Tumor Progression and Angiogenesis

  2004cited by this paper
• Invasive and angiogenic phenotype of MCF-7 human breast tumor cells expressing human cyclooxygenase-2.

  2004cited by this paper
• Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition

  2004cited by this paper
• Cyclooxygenases in the skin: pharmacological and toxicological implications.

  2003cited by this paper
• Clinical predictive value of the in vitro cell line, human xenograft, and mouse allograft preclinical cancer models.

  2003cited by this paper
• Anthocyanidins inhibit activator protein 1 activity and cell transformation: structure-activity relationship and molecular mechanisms.

  2003cited by this paper
• NS-398 and Piroxicam Suppress UVB-induced Activator Protein 1 Activity by Mechanisms Independent of Cyclooxygenase-2*

  2003cited by this paper
• Inflammation and cancer

  2002cited by this paper
• AP-1, NF-kappa-B, and ERK activation thresholds for promotion of neoplastic transformation in the mouse epidermal JB6 model.

  2002cited by this paper
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  2001cited by this paper
• Two novel glycosides from the fruits of Morinda citrifolia (noni) inhibit AP-1 transactivation and cell transformation in the mouse epidermal JB6 cell line.

  2001cited by this paper
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  2001cited by this paper
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  2001cited by this paper
• Development and use of a gene promoter-based screen to identify novel inhibitors of cyclooxygenase-2 transcription.

  2001cited by this paper
• Suppression of skin tumorigenesis in c-Jun NH(2)-terminal kinase-2-deficient mice.

  2001cited by this paper
• Activator protein 1 (AP-1)– and nuclear factor κB (NF-κB)–dependent transcriptional events in carcinogenesis

  2000cited by this paper
• Activation of the c-fos enhancer by the Erk MAP kinase pathway through two sequence elements: the c-fos AP-1 and p62TCF sites

  2000cited by this paper
• The effect of bilberry nutritional supplementation on night visual acuity and contrast sensitivity.

  2000cited by this paper
• Activator protein 1 (AP-1)- and nuclear factor kappaB (NF-kappaB)-dependent transcriptional events in carcinogenesis.

  2000cited by this paper
• Enhanced expression of cyclooxygenase (COX)‐2 in human skin epidermal cancer cells: Evidence for growth suppression by inhibiting COX‐2 expression

  2000cited by this paper
• Signal transduction pathways: targets for chemoprevention of skin cancer.

  2000cited by this paper
• Activation of mitogen-activated protein kinase associated with prostate cancer progression.

  1999cited by this paper
• Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo

  1999cited by this paper
• Transgenic mice demonstrate AP-1 (activator protein-1) transactivation is required for tumor promotion.

  1999cited by this paper
• Inhibitory Effect of Delphinidin from Solanum melongena on Human Fibrosarcoma HT-1080 Invasiveness in vitro

  1998cited by this paper
• Cyclooxygenase in biology and disease

  1998cited by this paper
• Shortage of mitogen-activated protein kinase is responsible for resistance to AP-1 transactivation and transformation in mouse JB6 cells.

  1998cited by this paper
• Activation of the c-fos serum response element by phosphatidyl inositol 3-kinase and rho pathways in HeLa cells.

  1998cited by this paper
• Flavonoids, dietary-derived inhibitors of cell proliferation and in vitro angiogenesis.

  1997cited by this paper
• Prostaglandin endoperoxide synthase: why two isoforms?

  1996cited by this paper
• Anthocyanins in grapes and grape products.

  1995cited by this paper
• Constitutive activation of mitogen-activated protein (MAP) kinases in human renal cell carcinoma.

  1995cited by this paper
• Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells.

  1994cited by this paper
• Transformation of mammalian cells by constitutively active MAP kinase kinase.

  1994cited by this paper
• Blocking of tumor promoter-induced AP-1 activity inhibits induced transformation in JB6 mouse epidermal cells.

  1994cited by this paper
• Wine, alcohol, platelets, and the French paradox for coronary heart disease

  1992cited by this paper
• Protein kinase activity associated with the avian sarcoma virus src gene product.

  1978cited by this paper
• Identification of a transformation-specific antigen induced by an avian sarcoma virus

  1977cited by this paper
• [Inflammation and cancer].

  1974cited by this paper

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  2024cites this paper
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  2023cites this paper
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  2020cites this paper
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  2020cites this paper
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  2019cites this paper
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  2019cites this paper
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  2018cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2016cites this paper
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  2016cites this paper
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  2015cites this paper
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  2015cites this paper
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  2013cites this paper
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  2012cites this paper
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  2011cites this paper
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  2011cites this paper
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