Velvet antler peptide prevents pressure overload-induced cardiac fibrosis via transforming growth factor (TGF)-β1 pathway inhibition.

No abstract is available for this paper.

• Publication year

  2016

• Venue

  European Journal of Pharmacology

• Publication date

  2016-07-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.ejphar.2016.04.039PMID 27108788
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Molecular switches under TGFβ signalling during progression from cardiac hypertrophy to heart failure

  2016cited by this paper
• Bioactive components of velvet antlers and their pharmacological properties.

  2014cited by this paper
• The contribution of deer velvet antler research to the modern biological medicine

  2014cited by this paper
• Aqueous Extract of Red Deer Antler Promotes Hair Growth by Regulating the Hair Cycle and Cell Proliferation in Hair Follicles

  2014cited by this paper
• Attenuated development of cardiac fibrosis in left ventricular pressure overload by SM16, an orally active inhibitor of ALK5.

  2014cited by this paper
• Berberine improves pressure overload-induced cardiac hypertrophy and dysfunction through enhanced autophagy.

  2014cited by this paper
• The anti-osteoporotic effect of velvet antler polypeptides from Cervus elaphus Linnaeus in ovariectomized rats.

  2013cited by this paper
• Oxidative stress, fibrosis, and early afterdepolarization-mediated cardiac arrhythmias

  2013cited by this paper
• Natural velvet antler polypeptide conformation prediction and molecular docking study with TGF-β1 complex

  2013cited by this paper
• Cardiac fibroblasts, fibrosis and extracellular matrix remodeling in heart disease

  2012cited by this paper
• Isolation of cardiac myocytes and fibroblasts from neonatal rat pups.

  2012cited by this paper
• The Effects of Velvet Antler of Deer on Cardiac Functions of Rats with Heart Failure following Myocardial Infarction

  2012cited by this paper
• Wound healing by a 3.2 kDa recombinant polypeptide from velvet antler of Cervusnippon Temminck

  2012cited by this paper
• CCN2 Is Required for the TGF-β Induced Activation of Smad1 - Erk1/2 Signaling Network

  2011cited by this paper
• Oxidative stress and glutathione in TGF-beta-mediated fibrogenesis.

  2010cited by this paper
• Connective Tissue Growth Factor-(CTGF, CCN2) – A Marker, Mediator and Therapeutic Target for Renal Fibrosis

  2009cited by this paper
• Angiotensin II Induces Connective Tissue Growth Factor and Collagen I Expression via Transforming Growth Factor–&bgr;–Dependent and –Independent Smad Pathways: The Role of Smad3

  2009cited by this paper
• [Protective effects of peptides from velvet antler of Cervus nippon on acute ischemic myocardial injury in rats].

  2009cited by this paper
• Connective tissue growth factor and cardiac fibrosis

  2009cited by this paper
• Oxidative stress triggers cardiac fibrosis in the heart of diabetic rats.

  2008cited by this paper
• The regulation of extracellular signal-regulated kinase (ERK) in mammalian cells.

  2008cited by this paper
• Preparation of Velvet Antlers Small Peptides and Stimulating Effects on Osteosarcoma Cell Proliferation

  2008cited by this paper
• Oxidative stress mediates cardiac fibrosis by enhancing transforming growth factor-beta1 in hypertensive rats

  2008cited by this paper
• Plasma connective tissue growth factor is a novel potential biomarker of cardiac dysfunction in patients with chronic heart failure

  2008cited by this paper
• Evaluation of the renin-angiotensin system in cardiac tissues of cats with pressure-overload cardiac hypertrophy.

  2008cited by this paper
• TGF‐β activates Erk MAP kinase signalling through direct phosphorylation of ShcA

  2007cited by this paper
• TGF-beta activates Erk MAP kinase signalling through direct phosphorylation of ShcA.

  2007cited by this paper
• Increased Connective Tissue Growth Factor Relative to Brain Natriuretic Peptide as a Determinant of Myocardial Fibrosis

  2007cited by this paper
• TGF-beta signaling in vascular fibrosis.

  2007cited by this paper
• TGF-β signaling in vascular fibrosis

  2007cited by this paper
• Fibrosis in heart disease: understanding the role of transforming growth factor‐β1 in cardiomyopathy, valvular disease and arrhythmia

  2006cited by this paper
• A novel polypeptide from Cervus nippon Temminck proliferation of epidermal cells and NIH3T3 cell line.

  2006cited by this paper
• cAMP Inhibits Transforming Growth Factor-β-Stimulated Collagen Synthesis via Inhibition of Extracellular Signal-Regulated Kinase 1/2 and Smad Signaling in Cardiac Fibroblasts

  2006cited by this paper
• Individual domains of connective tissue growth factor regulate fibroblast proliferation and myofibroblast differentiation

  2005cited by this paper
• Biological effect of velvet antler polypeptides on neural stem cells from embryonic rat brain.

  2005cited by this paper
• Angiotensin II Activates the Smad Pathway in Vascular Smooth Muscle Cells by a Transforming Growth Factor-β–Independent Mechanism

  2005cited by this paper
• Smad3 and extracellular signal-regulated kinase 1/2 coordinately mediate transforming growth factor-beta-induced expression of connective tissue growth factor in human fibroblasts.

  2005cited by this paper
• Protective and anti-arthritic effects of deer antler aqua-acupuncture (DAA), inhibiting dihydroorotate dehydrogenase, on phosphate ions-mediated chondrocyte apoptosis and rat collagen-induced arthritis.

  2004cited by this paper
• Induction of Connective Tissue Growth Factor by Angiotensin II: Integration of Signaling Pathways

  2003cited by this paper
• Smad-dependent and Smad-independent pathways in TGF-beta family signalling.

  2003cited by this paper
• Smad-dependent and Smad-independent pathways in TGF-β family signalling

  2003cited by this paper
• A Novel Polypeptide from Cervus elaphus Linnaeus

  2002cited by this paper
• Activation of an H2O2-generating NADH Oxidase in Human Lung Fibroblasts by Transforming Growth Factor β1 (*)

  1995cited by this paper
• Enhanced rate of H2O2 release from bovine pulmonary artery endothelial cells induced by TGF-beta 1.

  1993cited by this paper

• Pharmacokinetics Integrated With Network Pharmacology to Investigate the Potential Mechanism of Lu-Jiao Fang Inhibited Endothelial-to-Mesenchymal Transition in Pressure Overload-Induced Cardiac Fibrosis.

  2025cites this paper
• Animal-derived peptides from Traditional Chinese medicines: medicinal potential, mechanisms, and prospects.

  2025cites this paper
• Current status of research on the role of natural products and their active ingredients in the treatment of cardiovascular aging: a narrative review

  2025cites this paper
• Pharmacological activities and mechanisms of proteins and peptides derived from traditional Chinese medicine

  2024cites this paper
• Effect of Luhong formula on the cardiac rehabilitation of patients with chronic heart failure

  2024cites this paper
• Well-known polypeptides of deer antler velvet with key actives: modern pharmacological advances

  2023cites this paper
• Biochemical Assessment of Deer Velvet Antler Extract and its Cytotoxic Effect including Acute Oral Toxicity using an ICR Mice Model

  2023cites this paper
• Peptide Biomarkers Discovery for Seven Species of Deer Antler Using LC-MS/MS and Label-Free Approach

  2022cites this paper
• Docosahexaenoic acid administration improves diabetes-induced cardiac fibrosis through enhancing fatty acid oxidation in cardiac fibroblast.

  2022cites this paper
• Hypertensive heart disease and myocardial fibrosis: how traditional Chinese medicine can help addressing unmet therapeutical needs.

  2022cites this paper
• Health Effects of Peptides Extracted from Deer Antler

  2022cites this paper
• Velvet antler polypeptide combined with calcium phosphate coating to protect peripheral nerve cells from oxidative stress

  2022cites this paper
• Velvet Antler Peptides Reduce Scarring via Inhibiting the TGF-β Signaling Pathway During Wound Healing

  2022cites this paper
• Pilose Antler Peptide-3.2KD Ameliorates Adriamycin-Induced Myocardial Injury Through TGF-β/SMAD Signaling Pathway

  2021cites this paper
• VAP-PLGA microspheres (VAP-PLGA) promote adipose-derived stem cells (ADSCs)-induced wound healing in chronic skin ulcers in mice via PI3K/Akt/HIF-1α pathway

  2021cites this paper
• Impact of Adaptogens of Animal Origin on Microcirculation in Rats

  2021cites this paper
• Morphological and Functional Characteristics of Animal Models of Myocardial Fibrosis Induced by Pressure Overload

  2020cites this paper
• Characterization of hot water extract from Korean deer velvet antler (Cervus canadensis Erxleben)

  2020influential citation
• How transforming growth factor contributes to atrial fibrillation?

  2020cites this paper
• Chlorogenic Acid Alleviates Hyperglycemia-Induced Cardiac Fibrosis through Activation of the NO/cGMP/PKG Pathway in Cardiac Fibroblasts.

  2020cites this paper
• Heart failure as a cause of hospitalization in IPF: comparison of the HFpEF, HFrEF, and PH

  2020cites this paper
• Optimization and Pretreatment for Hot Water Extraction of Korean Deer (Cervus canadensis Erxleben) Velvet Antlers

  2020cites this paper
• Stevioside improved hyperglycemia-induced cardiac dysfunction by attenuating the development of fibrosis and promoting the degradation of established fibrosis

  2020cites this paper
• Ginsenoside Rb1 improved diabetic cardiomyopathy through regulating calcium signaling by alleviating protein O-GlcNAcylation.

  2019cites this paper
• Role of miR-133a in regulating TGF-β1 signaling pathway in myocardial fibrosis after acute myocardial infarction in rats.

  2019cites this paper
• Velvet Antler compounds targeting major cell signaling pathways in osteosarcoma - a new insight into mediating the process of invasion and metastasis in OS

  2019cites this paper
• miR‐29a attenuates cardiac hypertrophy through inhibition of PPARδ expression

  2019cites this paper
• Increase of anticoagulant and fibrinolytic activity of rat blood plasma when using products of velvet antler industry

  2018cites this paper
• Prevention of microcirculatory disorders in rats on suprathreshold physical exertion using the products of velvet antler industry

  2018cites this paper
• Inhibition of TGF-β1 might be a novel therapeutic target in the treatment of cardiac fibrosis.

  2018cites this paper
• Transforming growth factor (TGF)-β1 signal pathway: A promising therapeutic target for attenuating cardiac fibrosis.

  2017cites this paper
• Stachydrine ameliorates pressure overload-induced diastolic heart failure by suppressing myocardial fibrosis.

  2017cites this paper
• Bioactive peptides derived from traditional Chinese medicine and traditional Chinese food: A review.

  2016cites this paper