Effects of t‐butyl‐4‐hydroxyanisole and other phenolic antioxidants on tumoral cells and Trypanosoma parasites

The antioxidant food additives 2(3)‐tert‐butyl‐4‐hydroxyanisole (BHA), 2,6‐di(tert‐butyl)‐p‐cresol (BHT) and the methyl and propyl esters of gallic acid inhibited Trypanosoma cruzi culture growth and oxygen consumption. The I 50 values for growth and oxygen uptake with BHA were 0.284 and 0.400 and for BHT 0.083 and 0.235 mM, respectively. Moreover, BHA inhibited the respiration of several tumor cells, as well as of the procyclic and bloodstream trypomastigote forms of T. brucei brucei, with I 50 in the range 0.29–0.52 mM. Inhibition of the parasites' oxygen uptake by BHA was not of the pure Michaelis‐Menten type, but may be of a mixed form. It is postulated that these compounds are inhibitors because they resemble ubiquinone.

• Publication year

  1988

• Venue

  FEBS Letters

• Publication date

  1988-07-18

• Fields of study

  Biology, Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1016/0014-5793(88)80143-1PMID 3292295
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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