Alpha-V-dependent outside-in signaling is required for the regulation of CD44 surface expression, MMP-2 secretion, and cell migration by osteopontin in human melanoma cells.

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Experimental Cell Research

• Publication date

  2006-07-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/J.YEXCR.2006.03.022PMID 16631740
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The influence of CD44v3-v10 on adhesion, invasion and MMP-14 expression in prostate cancer cells.

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• Osteopontin induces multiple changes in gene expression that reflect the six “hallmarks of cancer” in a model of breast cancer progression

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• [Expressions of osteopontin and CD44v6 in hepatocellular carcinoma and their clinical significance].

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• αvβ3-dependent cross-presentation of matrix metalloproteinase–2 by melanoma cells gives rise to a new tumor antigen

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• Matrix Metalloproteinase-2 and −9 Differentially Regulate Smooth Muscle Cell Migration and Cell-Mediated Collagen Organization

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• Osteopontin deficiency produces osteoclast dysfunction due to reduced CD44 surface expression.

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• Predicting hepatitis B virus–positive metastatic hepatocellular carcinomas using gene expression profiling and supervised machine learning

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• The Integrin {alpha}v{beta}3 and CD44 Regulate the Actions of Osteopontin on Osteoclast Motility

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• Rho-dependent Rho Kinase Activation Increases CD44 Surface Expression and Bone Resorption in Osteoclasts*

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• Correlation of matrix metalloproteinase-2, −9, tissue inhibitor-1 of matrix metalloproteinase and CD44 variant 6 in head and neck cancer metastasis

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• RhoA induces MMP-9 expression at CD44 lamellipodial focal complexes and promotes HMEC-1 cell invasion.

  2003cited by this paper
• Specific αv integrin receptors modulate K1735 murine melanoma cell behavior

  2003cited by this paper
• Osteopontin overproduced by tumor cells acts as a potent angiogenic factor contributing to tumor growth.

  2003cited by this paper
• Specific alpha v integrin receptors modulate K1735 murine melanoma cell behavior.

  2003cited by this paper
• An in vivo model of prostate carcinoma growth and invasion in bone

  2002cited by this paper
• Melanoma development and progression: a conspiracy between tumor and host.

  2002cited by this paper
• Hyaluronan-CD44s signaling regulates matrix metalloproteinase-2 secretion in a human lung carcinoma cell line QG90.

  2002cited by this paper
• Hyaluronan–CD44 interaction hampers migration of osteoclast-like cells by down-regulating MMP-9

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• Osteopontin Deficiency Reduces Experimental Tumor Cell Metastasis to Bone and Soft Tissues

  2001cited by this paper
• The metastasis gene osteopontin: a candidate target for cancer therapy.

  2001cited by this paper
• Role of osteopontin in cellular signaling and toxicant injury.

  2001cited by this paper
• Intracellular osteopontin is an integral component of the CD44‐ERM complex involved in cell migration

  2000cited by this paper
• Coexpression of Integrin αvβ3 and Matrix Metalloproteinase-2 (MMP-2) Coincides with MMP-2 Activation: Correlation with Melanoma Progression

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• Mechanically Strained Cells of the Osteoblast Lineage Organize Their Extracellular Matrix Through Unique Sites of αVβ3‐Integrin Expression

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• Matrix metalloproteinases in human melanoma.

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• Mechanically strained cells of the osteoblast lineage organize their extracellular matrix through unique sites of alphavbeta3-integrin expression.

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• Rho-A Is Critical for Osteoclast Podosome Organization, Motility, and Bone Resorption*

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• Gelsolin Deficiency Blocks Podosome Assembly and Produces Increased Bone Mass and Strength

  2000cited by this paper
• Coexpression of integrin alpha(v)beta3 and matrix metalloproteinase-2 (MMP-2) coincides with MMP-2 activation: correlation with melanoma progression.

  2000cited by this paper
• Rho-kinase (ROK) promotes CD44v(3,8-10)-ankyrin interaction and tumor cell migration in metastatic breast cancer cells.

  1999cited by this paper
• Integrin signaling.

  1999cited by this paper
• CD44 variants but not CD44s cooperate with beta1-containing integrins to permit cells to bind to osteopontin independently of arginine-glycine-aspartic acid, thereby stimulating cell motility and chemotaxis.

  1999cited by this paper
• Involvement of CD44 in matrix metalloproteinase‐2 regulation in human melanoma cells

  1999cited by this paper
• Localization of matrix metalloproteinase 9 to the cell surface provides a mechanism for CD44-mediated tumor invasion.

  1999cited by this paper
• Intact Vitronectin Induces Matrix Metalloproteinase-2 and Tissue Inhibitor of Metalloproteinases-2 Expression and Enhanced Cellular Invasion by Melanoma Cells*

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• CD44v3,8–10 is involved in cytoskeleton‐mediated tumor cell migration and matrix metalloproteinase (MMP‐9) association in metastatic breast cancer cells

  1998cited by this paper
• Activation of MMP‐2 by human GCT23 giant cell tumour cells induced by osteopontin, bone sialoprotein and GRGDSP peptides is RGD and cell shape change dependent

  1998cited by this paper
• c-Src Is Required for Stimulation of Gelsolin-associated Phosphatidylinositol 3-Kinase*

  1998cited by this paper
• CD44v(3,8-10) is involved in cytoskeleton-mediated tumor cell migration and matrix metalloproteinase (MMP-9) association in metastatic breast cancer cells.

  1998cited by this paper
• Interaction between CD44 and osteopontin as a potential basis for metastasis formation.

  1997cited by this paper
• CD44 in inflammation and metastasis

  1997cited by this paper
• CD44: structure, function, and association with the malignant process.

  1997cited by this paper
• The role of osteopontin in tumorigenesis and metastasis.

  1997cited by this paper
• Introduction of p130cas signaling complex formation upon integrin-mediated cell adhesion: a role for Src family kinases

  1996cited by this paper
• Receptor-Ligand Interaction Between CD44 and Osteopontin (Eta-1)

  1996cited by this paper
• Osteopontin stimulates gelsolin-associated phosphoinositide levels and phosphatidylinositol triphosphate-hydroxyl kinase.

  1996cited by this paper
• Localization of Matrix Metalloproteinase MMP-2 to the Surface of Invasive Cells by Interaction with Integrin αvβ3

  1996cited by this paper
• Osteopontin activation of c-src in human melanoma cells requires the cytoplasmic domain of the integrin alpha v-subunit.

  1996cited by this paper
• Regulation of vinculin binding to talin and actin by phosphatidyl-inositol-4-5-bisphosphate

  1996cited by this paper
• Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin alpha v beta 3.

  1996cited by this paper
• Requirement of the NPXY motif in the integrin beta 3 subunit cytoplasmic tail for melanoma cell migration in vitro and in vivo

  1995cited by this paper
• Focal adhesion kinase and paxillin bind to peptides mimicking beta integrin cytoplasmic domains

  1995cited by this paper
• Cell motility assay and inhibition by Rho-GDP dissociation inhibitor.

  1995cited by this paper
• A beta turn in the cytoplasmic tail of the integrin alpha v subunit influences conformation and ligand binding of alpha v beta 3.

  1994cited by this paper
• Osteopontin: a protein with diverse functions

  1993cited by this paper
• Functional role of the cytoplasmic domain of the integrin alpha 5 subunit

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• Requirement of the integrin beta 3 subunit for carcinoma cell spreading or migration on vitronectin and fibrinogen

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  1992cited by this paper
• Significance of CD44 gene products for cancer diagnosis and disease evaluation.

  1992cited by this paper
• Integrin expression in human melanoma cells with differing invasive and metastatic properties

  1992cited by this paper
• Role of the alpha v beta 3 integrin in human melanoma cell invasion.

  1992cited by this paper
• Distinct cellular functions mediated by different VLA integrin alpha subunit cytoplasmic domains.

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• Involvement of integrin alpha V gene expression in human melanoma tumorigenicity.

  1992cited by this paper
• Distinct cellular functions mediated by different VLA integrin α subunit cytoplasmic domains

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