Nuclear Accumulation of Globular Actin as a Cellular Senescence Marker

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Cancer Research

• Publication date

  2004-01-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1158/0008-5472.CAN-03-1856PMID 14744771
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Deferoxamine arrests in vitro the proliferation of porcine hepatocyte in G1 phase of the cell cycle.

  2008cited by this paper
• Senescent Phenotype Can Be Reversed by Reduction of Caveolin Status*

  2003cited by this paper
• Reversal of human cellular senescence: roles of the p53 and p16 pathways

  2003cited by this paper
• Constitutive Induction of p-Erk1/2 Accompanied by Reduced Activities of Protein Phosphatases 1 and 2A and MKP3 Due to Reactive Oxygen Species during Cellular Senescence*

  2003cited by this paper
• Initiation and Transduction of Stretch-induced RhoA and Rac1 Activation through Caveolae

  2003cited by this paper
• Iron chelation-induced senescence-like growth arrest in hepatocyte cell lines: association of transforming growth factor beta1 (TGF-beta1)-mediated p27Kip1 expression.

  2002cited by this paper
• p53: good cop/bad cop.

  2002cited by this paper
• Protein Kinase C Induces Actin Reorganization via a Src- and Rho-dependent Pathway*

  2002cited by this paper
• Mitosis-dependent phosphorylation and activation of LIM-kinase 1.

  2002cited by this paper
• LIM kinase and Diaphanous cooperate to regulate serum response factor and actin dynamics

  2002cited by this paper
• Phosphatidylinositol-dependent actin filament binding by the SWI/SNF-like BAF chromatin remodeling complex

  2002cited by this paper
• Down‐regulation of Receptor‐mediated Endocytosis Is Reponsible for Senescence‐associated Hyporesponsiveness

  2002cited by this paper
• Induction of senescence by oncogenic Ras.

  2001cited by this paper
• Down‐regulation of amphiphysin‐1 is responsible for reduced receptor‐mediated endocytosis in the senescent cells

  2001cited by this paper
• TAT-mediated protein transduction into mammalian cells.

  2001cited by this paper
• Human fibroblast replicative senescence can occur in the absence of extensive cell division and short telomeres

  2001cited by this paper
• Cytoplasmic retention of p-Erk1/2 and nuclear accumulation of actin proteins during cellular senescence in human diploid fibroblasts.

  2000cited by this paper
• Ras and Rho GTPases: a family reunion.

  2000cited by this paper
• Searching for a function for nuclear actin.

  2000cited by this paper
• Up-regulation of Caveolin Attenuates Epidermal Growth Factor Signaling in Senescent Cells*

  2000cited by this paper
• Longevity, stress response, and cancer in aging telomerase-deficient mice.

  1999cited by this paper
• Signal-regulated activation of serum response factor is mediated by changes in actin dynamics.

  1999cited by this paper
• Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling.

  1998cited by this paper
• Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization

  1998cited by this paper
• Rho family proteins and Ras transformation: the RHOad less traveled gets congested

  1998cited by this paper
• Increased p16 expression with first senescence arrest in human mammary epithelial cells and extended growth capacity with p16 inactivation

  1998cited by this paper
• Rho GTPases*

  1998cited by this paper
• Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling.

  1998cited by this paper
• Nuclear export of actin: a novel mechanism regulating the subcellular localization of a major cytoskeletal protein

  1998cited by this paper
• Peripheral nuclear matrix actin forms perinuclear shells

  1998cited by this paper
• Evidence for a role of CRM1 in signal-mediated nuclear protein export.

  1997influential reference
• CRM1 is responsible for intracellular transport mediated by the nuclear export signal

  1997cited by this paper
• Telomere shortening and tumor formation by mouse cells lacking telomerase RNA.

  1997cited by this paper
• CRM1 is an export receptor for leucine-rich nuclear export signals.

  1997cited by this paper
• Dephosphorylation of Serine 3 Regulates Nuclear Translocation of Cofilin*

  1996cited by this paper
• A role for gelsolin in actuating epidermal growth factor receptor- mediated cell motility

  1996cited by this paper
• A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

  1995cited by this paper
• Costimulatory signals for human T-cell activation induce nuclear translocation of pp19/cofilin.

  1994cited by this paper
• Specific association of human telomerase activity with immortal cells and cancer.

  1994cited by this paper
• Identification of a defect in the phospholipase D/diacylglycerol pathway in cellular senescence.

  1994cited by this paper
• Identification of Drosophila cytoskeletal proteins by induction of abnormal cell shape in fission yeast.

  1994cited by this paper
• Telomerase, cell immortality, and cancer.

  1994cited by this paper
• Isolation of a yeast essential gene, COF1, that encodes a homologue of mammalian cofilin, a low-M(r) actin-binding and depolymerizing protein.

  1993cited by this paper
• Cytoplasmic localization and nuclear transport of cofilin in cultured myotubes.

  1993cited by this paper
• Is actin involved in the nuclear division in Amoeba proteus?

  1993cited by this paper
• The biochemistry of mammalian senescence.

  1992cited by this paper
• Cytokinesis.

  1992cited by this paper
• Profilin-actin complexes directly elongate actin filaments at the barbed end.

  1992cited by this paper
• The KKRKK sequence is involved in heat shock-induced nuclear translocation of the 18-kDa actin-binding protein, cofilin.

  1992cited by this paper
• Failure of senescent cells to phosphorylate the RB protein.

  1991cited by this paper
• The relationship between donor age and the growth characteristics of human smooth muscle cultures of aorta and stomach.

  1991cited by this paper
• Senescence as a mode of tumor suppression.

  1991cited by this paper
• Defining the molecular mechanisms of human cell immortalization.

  1991cited by this paper
• A role for both RB and p53 in the regulation of human cellular senescence.

  1991cited by this paper
• Failure of senescent cells to phosphorylate the RB protein.

  1991cited by this paper
• Replicative senescence: the human fibroblast comes of age.

  1990cited by this paper
• Telomere reduction in human colorectal carcinoma and with ageing

  1990cited by this paper
• Reversible cellular senescence: implications for immortalization of normal human diploid fibroblasts

  1989cited by this paper
• Intracellular determinants of cell aging.

  1984cited by this paper
• Cofilin, a protein in porcine brain that binds to actin filaments and inhibits their interactions with myosin and tropomyosin.

  1984cited by this paper
• Actin polymerizability is influenced by profilin, a low molecular weight protein in non-muscle cells.

  1977cited by this paper
• The relationship between in vitro transformation and tumor formation in vivo.

  1976cited by this paper
• Relationship between cell kinetic changes and metabolic events during cell senescence in vitro.

  1975cited by this paper

• Form and function of actin impacts actin health and aging

  2025cites this paper
• Cellular Senescence as a Risk Factor in Head and Neck Cancer—Diagnostic and Therapeutic Perspective

  2025cites this paper
• Biomarkers of Cellular Senescence and Aging: Current State‐of‐the‐Art, Challenges and Future Perspectives

  2024cites this paper
• Subcellular structure, heterogeneity, and plasticity of senescent cells

  2024cites this paper
• Nuclear Actin Puncta in Senescent Cells

  2023cites this paper
• Senescent cells and SASP in cancer microenvironment: New approaches in cancer therapy.

  2023cites this paper
• Cellular senescence: the good, the bad and the unknown

  2022cites this paper
• Fate-resolved gene regulatory signatures of individual B lymphocytes in the early stages of Epstein-Barr Virus infection

  2022cites this paper
• Time-resolved transcriptomes reveal diverse B cell fate trajectories in the early response to Epstein-Barr virus infection.

  2022cites this paper
• Role of stress granules in modulating senescence and promoting cancer progression: Special emphasis on glioma

  2021cites this paper
• Deterioration of Nuclear morphology and architecture: A hallmark of senescence and aging.

  2021cites this paper
• Interphase Chromosomes in Replicative Senescence: Chromosome Positioning as a Senescence Biomarker and the Lack of Nuclear Motor-Driven Chromosome Repositioning in Senescent Cells

  2021cites this paper
• Sulfated syndecan 1 is critical to preventing cellular senescence by modulating fibroblast growth factor receptor endocytosis

  2020cites this paper
• Effect of Cyclosporine A-induced Senescence on Cultured Human Corneal Endothelial Cells

  2020cites this paper
• Cell Biology International

  2020cites this paper
• Nuclear actin regulates cell proliferation and migration via inhibition of SRF and TEAD

  2020cites this paper
• Involvement of 8-O-acetylharpagide for Ajuga taiwanensis mediated suppression of senescent phenotypes in human dermal fibroblasts

  2020cites this paper
• Molecular Mechanisms to Target Cellular Senescence in Hepatocellular Carcinoma

  2020cites this paper
• Up‐regulation of cofilin‐1 in cell senescence associates with morphological change and p27kip1‐mediated growth delay

  2020cites this paper
• Analysis of nuclear actin-interacting proteins and actin-regulated transcription factors

  2019cites this paper
• Phosphatidylinositol-3-phosphate-mediated actin domain formation linked to DNA synthesis upon insulin treatment in rat hepatoma-derived H4IIEC3 cells.

  2019cites this paper
• The Clearance Effect of Tetrahedral DNA Nanostructures on Senescent Human Dermal Fibroblasts.

  2019cites this paper
• Understanding the role of chondrocytes in osteoarthritis: utilizing proteomics

  2019cites this paper
• The homeobox transcription factor HB9 induces senescence and blocks differentiation in hematopoietic stem and progenitor cells

  2018cites this paper
• “Social Life” of Senescent Cells: What Is SASP and Why Study It?

  2018cites this paper
• In vitro comprehensive analysis of VA692 a new chemical entity for the treatment of osteoarthritis

  2018cites this paper
• TIS21/BTG2 inhibits doxorubicin-induced stress fiber-vimentin networks via Nox4-ROS-ABI2-DRF-linked signal cascade.

  2017cites this paper
• "Социальная жизнь" стареющих клеток: что такое SASP и зачем его изучать?

  2017cites this paper
• From Cytoskeleton to Gene Expression: Actin in the Nucleus.

  2016cites this paper
• Characterizing the Functional Importance of Actin Dynamics in the Nucleus

  2016cites this paper
• Regulations of Reversal of Senescence by PKC Isozymes in Response to 12-O-Tetradecanoylphorbol-13-Acetate via Nuclear Translocation of pErk1/2

  2016cites this paper
• Shifting p53-induced senescence to cell death by TIS21(/BTG2/Pc3) gene through posttranslational modification of p53 protein.

  2016cites this paper
• Investigate correlation between mechanical property and aging biomarker in passaged human dermal fibroblasts

  2015cites this paper
• Downregulation of PEA-15 reverses G1 arrest, and nuclear and chromatin changes of senescence phenotype via pErk1/2 translocation to nuclei.

  2015cites this paper
• Silver Nanoparticles: the Immediate Benefits of Low Bacterial Resistance and the Long-Term Risk of Persistent Stress In Mammalian Cells

  2015cites this paper
• Dynamics of nuclear actin

  2014cites this paper
• The primary cilium as a regulator of cellular senescence in human fibroblasts

  2014cites this paper
• The hallmarks of fibroblast ageing.

  2014cites this paper
• American Cancer Society (ACS)

  2014cites this paper
• Rho, nuclear actin, and actin-binding proteins in the regulation of transcription and gene expression

  2014cites this paper
• Low-dose etoposide-treatment induces endoreplication and cell death accompanied by cytoskeletal alterations in A549 cells: Does the response involve senescence? The possible role of vimentin

  2013influential citation
• Using surfaces to modulate the morphology and structure of attached cells-a case of cancer cells on chitosan membranes

  2013cites this paper
• Stimulation of in vivo nuclear transport dynamics of actin and its co-factors IQGAP1 and Rac1 in response to DNA replication stress.

  2013cites this paper
• 17AAG Treatment Accelerates Doxorubicin Induced Cellular Senescence: Hsp90 Interferes with Enforced Senescence of Tumor Cells

  2012cites this paper
• Stiffening of human skin fibroblasts with age.

  2012cites this paper
• Loss of p21(Sdi1) expression in senescent cells after DNA damage accompanied with increase of miR-93 expression and reduced p53 interaction with p21(Sdi1) gene promoter.

  2011cites this paper
• Reduction of exportin 6 activity leads to actin accumulation via failure of RanGTP restoration and NTF2 sequestration in the nuclei of senescent cells.

  2011cites this paper
• Nesprin-1 and actin contribute to nuclear and cytoskeletal defects in lamin A/C-deficient cardiomyopathy.

  2011cites this paper
• Features of senescence and cell death induced by doxorubicin in A549 cells: organization and level of selected cytoskeletal proteins

  2010influential citation
• Improved plasma stability and sustained release profile of gemcitabine via polypeptide conjugation.

  2010cites this paper
• Distinct proteomic features of two fibrogenic liver cell populations: Hepatic stellate cells and portal myofibroblasts

  2010cites this paper
• Stiffening of human skin fibroblasts with age.

  2010cites this paper
• PAPEL DA PROTEÍNA COFILINA-1 NA RESISTÊNCIA À CISPLATINA EM CÂNCER DE PULMÃO DE NÃO-PEQUENAS CÉLULAS

  2010cites this paper
• Molecular analysis of FER/actin complexes in prostate cancer

  2009cites this paper
• Cell and molecular biology of nuclear actin.

  2009cites this paper
• Phosphorylated Extracellular Signal-regulated Protein Kinases 1 and 2 Phosphorylate Sp1 on Serine 59 and Regulate Cellular Senescence via Transcription of p21Sdi1/Cip1/Waf1*

  2009cites this paper
• Znaczenie starzenia na poziomie komórki w walce z chorobą nowotworową

  2009cites this paper
• Cellular senescence in oral cancer and precancer and treatment implications: A review

  2008cites this paper
• ADF/Cofilin, Actin Dynamics, and Disease

  2008cites this paper
• Marcadores de senescencia celular en cáncer y precáncer oral

  2008cites this paper
• Nuclear actin dynamics – From form to function

  2008cites this paper
• ING1a expression increases during replicative senescence and induces a senescent phenotype

  2008cites this paper
• CD52 over-expression affects rituximab-associated complement-mediated cytotoxicity but not antibody-dependent cellular cytotoxicity: Preclinical evidence that targeting CD52 with alemtuzumab may reverse acquired resistance to rituximab in non-Hodgkin lymphoma

  2007cites this paper
• The role of ageing in atherogenesis : two in vivo models

  2006cites this paper
• A selective block of nuclear actin export stabilizes the giant nuclei of Xenopus oocytes

  2006cites this paper
• Proteomics Analyses of Specific Protein Oxidation and Protein Expression in Aged Rat Brain and Its Modulation by L-Acetylcarnitine: Insights Into the Mechanisms of Action of This Proposed Therapeutic Agent for CNS Disorders Associated with Oxidative Stress

  2006cites this paper
• The possible role of EWS-Fli1 in evasion of senescence in Ewing family tumors.

  2006cites this paper
• Profiling of genes in healthy hGF, aging hGF, healthy hPDLF and inflammatory hPDLF by DNA microarray

  2006cites this paper
• Proteomic profiling and identification of cofilin responding to oxidative stress in vascular smooth muscle

  2006cites this paper
• Prohibitin Facilitates Cellular Senescence by Recruiting Specific Corepressors To Inhibit E2F Target Genes

  2006cites this paper
• Thioredoxin overexpression in HT‐1080 cells induced cellular senescence and sensitization to gamma radiation

  2005cites this paper
• Proteomic characterization of human normal articular chondrocytes: A novel tool for the study of osteoarthritis and other rheumatic diseases

  2005cites this paper
• Phenotypic changes of adult porcine mesenchymal stem cells induced by prolonged passaging in culture

  2005cites this paper
• REDOX PROTEOMICS IDENTIFICATION OF OXIDATIVELY MODIFIED PROTEINS AND THEIR PHARMACOLOGICAL MODULATION: INSIGHT INTO OXIDATIVE STRESS IN BRAIN AGING, AGE-RELATED COGNITIVE IMPAIRMENT

  2005cites this paper
• Identification of Mammalian Proteins Cross-linked to DNA by Ionizing Radiation*

  2005cites this paper
• Literature Watch

  2004cites this paper
• Literature Watch

  2004cites this paper
• Subcellular localization of WD40 repeat 1 protein in PC12 rat pheochromocytoma cells.

  2004cites this paper