Size-dependent pharmacological activities of differently degraded fucoidan fractions from Fucus vesiculosus.

Fucose-containing sulfated glycans (syn. fucoidans) from brown algae exhibit a wide range of bioactivities and are therefore considered promising candidates for health-supporting and medical applications. In this study, we investigated the pharmacological activities of fucoidan from Fucus vesiculosus and 18 gradually depolymerized fractions, which were obtained by hydrothermal and H2O2 treatment, respectively. All the activities decreased with decreasing molecular mass (Mw) but to a different extent resulting in some modified pharmacological profiles in dependence on the Mw as well as on the degradation method. H2O2 treatment was not only more efficient, simpler and cheaper than hydrothermal degradation, but also led to superior activity profiles and additionally eliminated co-extracted contaminants. Compared to heparin, the prime example of biologically active sulfated glycans, evenly sized H2O2 fractions exhibited considerable effects being relevant for anti-inflammatory activity, however only negligible anticoagulant activity and FXII activating potency. Due to their improved biopharmaceutical characteristics and favorable activities, degraded fucoidan fractions are worth to be further investigated as anti-inflammatory and anticomplementary agents.

• Publication year

  2018

• Venue

  Carbohydrate Polymers

• Publication date

  2018-06-01

• Fields of study

  Biology, Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1016/j.carbpol.2018.02.035PMID 29580394
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Gradual degradation of fucoidan from Fucus vesiculosus and its effect on structure, antioxidant and antiproliferative activities.

  2018cited by this paper
• Regulation of Complement and Contact System Activation via C1 Inhibitor Potentiation and Factor XIIa Activity Modulation by Sulfated Glycans – Structure-Activity Relationships

  2016cited by this paper
• Antioxidant activities of crude extracts of fucoidan extracted from Sargassum glaucescens by a compressional-puffing-hydrothermal extraction process.

  2016cited by this paper
• Antithrombotic activity of oral administered low molecular weight fucoidan from Laminaria Japonica.

  2016cited by this paper
• Sulfated glycans in inflammation.

  2015cited by this paper
• The Structure-Activity Relationship between Marine Algae Polysaccharides and Anti-Complement Activity

  2015cited by this paper
• Interference with the CXCL12/CXCR4 axis as potential antitumor strategy: superiority of a sulfated galactofucan from the brown alga Saccharina latissima and fucoidan over heparins.

  2015cited by this paper
• Factor XII: a novel target for safe prevention of thrombosis and inflammation

  2015cited by this paper
• Fucoidans: pro- or antiangiogenic agents?

  2014cited by this paper
• Heparin/heparan sulphate interactions with complement--a possible target for reduction of renal function loss?

  2014cited by this paper
• Sulfated Galactofucan from the Brown Alga Saccharina latissima—Variability of Yield, Structural Composition and Bioactivity

  2014cited by this paper
• Structure-activity relationship of the pro- and anticoagulant effects of Fucus vesiculosus fucoidan

  2013cited by this paper
• In vitro antioxidant activities of sulfated polysaccharide ascophyllan isolated from Ascophyllum nodosum.

  2013cited by this paper
• Fucoidan from New Zealand Undaria pinnatifida: monthly variations and determination of antioxidant activities.

  2013cited by this paper
• Fucanomics and galactanomics: current status in drug discovery, mechanisms of action and role of the well-defined structures.

  2012cited by this paper
• Adverse effects of heparin.

  2012cited by this paper
• Therapies from Fucoidan; Multifunctional Marine Polymers

  2011cited by this paper
• Algal fucoidan: structural and size-dependent bioactivities and their perspectives

  2011cited by this paper
• Important Determinants for Fucoidan Bioactivity: A Critical Review of Structure-Function Relations and Extraction Methods for Fucose-Containing Sulfated Polysaccharides from Brown Seaweeds

  2011cited by this paper
• Chemical Structures and Bioactivities of Sulfated Polysaccharides from Marine Algae

  2011cited by this paper
• C1 inhibitor, a multi-functional serine protease inhibitor

  2010cited by this paper
• Potential antioxidant and anticoagulant capacity of low molecular weight fucoidan fractions extracted from Laminaria japonica.

  2010cited by this paper
• Fucoidans and fucoidanases—focus on techniques for molecular structure elucidation and modification of marine polysaccharides

  2009cited by this paper
• Evaluation of seasonal variations of the structure and anti-inflammatory activity of sulfated polysaccharides extracted from the red alga Delesseria sanguinea (Hudson) Lamouroux (Ceramiales, Delesseriaceae).

  2009cited by this paper
• Elastase Inhibition Assay with Peptide Substrates – An Example for the Limited Comparability of in vitro Results

  2008cited by this paper
• Contaminated heparin associated with adverse clinical events and activation of the contact system.

  2008cited by this paper
• Pharmacological strategies for inhibition of thrombin activity.

  2008cited by this paper
• Pharmacological profiles of animal- and nonanimal-derived sulfated polysaccharides – comparison of unfractionated heparin, the semisynthetic glucan sulfate PS3, and the sulfated polysaccharide fraction isolated from Delesseria sanguinea

  2008cited by this paper
• The plasma kallikrein–kinin system: its evolution from contact activation

  2007cited by this paper
• Kinetic studies on the interactions of heparin and complement proteins using surface plasmon resonance.

  2005cited by this paper
• Sulfated fucans, fresh perspectives: structures, functions, and biological properties of sulfated fucans and an overview of enzymes active toward this class of polysaccharide.

  2003cited by this paper
• 硫酸化フカン,最新の展望 硫酸化フカンの構造,機能,及び生物学的性質とこのクラスの多糖類に対して活性を示す酵素の概要

  2003cited by this paper
• Inhibition of PMN-elastase activity by semisynthetic glucan sulfates

  2003cited by this paper
• Relationships between chemical characteristics and anticomplementary activity of fucans.

  1996cited by this paper
• Inhibition of complement activation by natural sulfated polysaccharides (fucans) from brown seaweed.

  1994cited by this paper
• The autoactivation of factor XII (Hageman factor) induced by low-Mr heparin and dextran sulphate. The effect of the Mr of the activating polyanion.

  1987cited by this paper
• A SIMPLE AND RAPID PREPARATION OF ALDITOL ACETATES FOR MONOSACCHARIDE ANALYSIS

  1983cited by this paper
• A method for the analysis of sugars in plant cell-wall polysaccharides by gas-liquid chromatography

  1967cited by this paper

• The stability of structural integrity and biological efficacy of an immunostimulating fucoidan isolated from Cystoseira indica under different hydrolysis conditions

  2026cites this paper
• Preparation and bioactivities of low-molecular weight fucoidans and fuco-oligosaccharides: A review.

  2025cites this paper
• Influence of a Very High-Molecular Weight Fucoidan from Laminaria hyperborea on Age-Related Macular Degeneration-Relevant Pathomechanisms in Ocular Cell Models

  2025cites this paper
• Advances in degradation strategies and bioactivities of low-molecular-weight fucoidan: A review.

  2025cites this paper
• Oligosaccharides and oligosaccharide-based noble metal nanoparticles: From preparation to biomedical applications.

  2025cites this paper
• Fucoidan From Brown Algae as a Functional Food Ingredient: A Promising Anticancer Agent

  2025cites this paper
• Comparative Evaluation of Dynamic Maceration and Ultrasonic Assisted Extraction of Fucoidan from Four Arctic Brown Algae on Its Antioxidant and Anticancer Properties

  2025cites this paper
• Advances in fucoidan and fucoidan oligosaccharides: Current status, future prospects, and biological applications.

  2025cites this paper
• Mechanisms of recalcitrant fucoidan breakdown in marine Planctomycetota

  2024cites this paper
• Cystoseira myrica: from beach-cast seaweed to fucoidan with antioxidant and anticoagulant capacity

  2023cites this paper
• Fucoidan from Fucus vesiculosus: Evaluation of the Impact of the Sulphate Content on Nanoparticle Production and Cell Toxicity

  2023cites this paper
• Structural tailoring of fucoidan backbones for maximizing their benefits: Enzymatic, chemical, and physical strategies

  2023cites this paper
• Fucoidan mitigates gastric ulcer injury through managing inflammation, oxidative stress, and NLRP3-mediated pyroptosis.

  2023cites this paper
• Marine fucoidans: Structural, extraction, biological activities and their applications in the food industry

  2023cites this paper
• Comparison of Fucoidans from Saccharina latissima Regarding Age-Related Macular Degeneration Relevant Pathomechanisms in Retinal Pigment Epithelium

  2023cites this paper
• Study on the preparation and biological activities of low molecular weight squid ink polysaccharide from Sepiella maindroni.

  2023cites this paper
• Green biopolysaccharides and its utilisation as biodegradable material in diverse fields: a review

  2023cites this paper
• Pharmacology of Heparin and Related Drugs: An Update

  2023cites this paper
• Relevance of the Extraction Stage on the Anti-Inflammatory Action of Fucoidans

  2023cites this paper
• Fucoidan from Fucus vesiculosus prevents the loss of dopaminergic neurons by alleviating mitochondrial dysfunction through targeting ATP5F1a.

  2022cites this paper
• Inhibitory effects of a low-molecular-weight sulfated fucose-containing saccharide on α-amylase and α-glucosidase prepared from ascophyllan.

  2022cites this paper
• The effect of extraction solution pH level on the physicochemical properties and α-glucosidase inhibitory potential of Fucus vesiculosus polysaccharide

  2022cites this paper
• Structural characterization and in vitro antioxidant and hypoglycemic activities of degraded polysaccharides from sweet corncob

  2022cites this paper
• Marine Biological Macromolecules and Chemically Modified Macromolecules; Potential Anticoagulants

  2022cites this paper
• Anti-angiogenic properties of sulfated polysaccharides fucoidans and their analogs

  2022cites this paper
• Anti-Inflammatory Activity of Fucoidan Extracts In Vitro

  2021cites this paper
• Current developments in the oral drug delivery of fucoidan.

  2021cites this paper
• Structural characterization and pro-angiogenic property of a polysaccharide isolated from red seaweed Bangia fusco-purpurea.

  2021cites this paper
• Influence of Fucoidan Extracts from Different Fucus Species on Adult Stem Cells and Molecular Mediators in In Vitro Models for Bone Formation and Vascularization

  2021cites this paper
• Opportunities and challenges of algal fucoidan for diabetes management

  2021cites this paper
• The Potency of Seaweed Sulfated Polysaccharides for the Correction of Hemostasis Disorders in COVID-19

  2021cites this paper
• Low molecular weight fucoidan prepared by fucoidanase degradation – A promising browning inhibitor

  2021cites this paper
• Evaluation of the Effects of Fucoidans from Fucus Species and Laminaria hyperborea against Oxidative Stress and Iron-Dependent Cell Death

  2021cites this paper
• Brown Algae Carbohydrates: Structures, Pharmaceutical Properties, and Research Challenges

  2021cites this paper
• Mechanisms of Bioactivities of Fucoidan from the Brown Seaweed Fucus vesiculosus L. of the Barents Sea

  2020cites this paper
• Preparation method of standard molecules for the precise estimation of molecular weight cut-off of membranes by gel permeation chromatography

  2020cites this paper
• Initial evaluation of six different brown algae species as source for crude bioactive fucoidans

  2020cites this paper
• Macrophage-stimulating activities of a novel low molecular weight saccharide fragment prepared from ascophyllan with alginate lyase

  2020cites this paper
• A low-molecular-weight ascophyllan prepared from Ascophyllum nodosum: Optimization, analysis and biological activities.

  2020cites this paper
• Immune-modulating and anti-inflammatory marine compounds against cancer.

  2020cites this paper
• A comparative study of sulphated polysaccharide effects on advanced glycation end-product uptake and scavenger receptor class A level in macrophages

  2020cites this paper
• Molar mass effect in food and health

  2020cites this paper
• Comparison of the Effects of Fucoidans on the Cell Viability of Tumor and Non-Tumor Cell Lines

  2019cites this paper
• Fucoidan A2 from the Brown Seaweed Ascophyllum nodosum Lowers Lipid by Improving Reverse Cholesterol Transport in C57BL/6J Mice Fed a High-Fat Diet.

  2019cites this paper
• Degradation of Eight Sulfated Polysaccharides Extracted from Red and Brown Algae and Its Impact on Structure and Pharmacological Activities.

  2019cites this paper
• Fucoidan Suppresses Mitochondrial Dysfunction and Cell Death against 1-Methyl-4-Phenylpyridinum-Induced Neuronal Cytotoxicity via Regulation of PGC-1α Expression

  2019cites this paper
• Degraded Fucoidan Fractions and β-1,3-Glucan Sulfates Inhibit CXCL12-induced Erk1/2 Activation and Chemotaxis in Burkitt Lymphoma Cells.

  2019cites this paper
• Size distribution and chain conformation of six different fucoidans using size-exclusion chromatography with multiple detection.

  2019cites this paper
• Therapies from Fucoidan: New Developments

  2019cites this paper
• Production of Active Poly- and Oligosaccharidic Fractions from Ulva sp. by Combining Enzyme-Assisted Extraction (EAE) and Depolymerization

  2019cites this paper
• Low-molecular-weight fucoidan: Chemical modification, synthesis of its oligomeric fragments and mimetics.

  2019cites this paper
• Size-dependent whitening activity of enzyme-degraded fucoidan from Laminaria japonica.

  2019cites this paper
• Electrochemical Biosensor Based on Nano TiO2 Loaded with Highly Dispersed Photoreduced Nano Platinum

  2018cites this paper
• Phycochemical Constituents and Biological Activities of Fucus spp.

  2018cites this paper