Knock‐down of POSH expression is neuroprotective through down‐regulating activation of the MLK3–MKK4–JNK pathway following cerebral ischaemia in the rat hippocampal CA1 subfield

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Journal of Neurochemistry

• Publication date

  2005-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/j.1471-4159.2005.03435.xPMID 16248889
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Activation of extracellular signal‐regulated kinase 5 may play a neuroprotective role in hippocampal CA3/DG region after cerebral ischemia

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• Ischemia Leads to Apoptosis—and Necrosis‐like Neuron Death in the Ischemic Rat Hippocampus

  2004cited by this paper
• Cellular and molecular events underlying ischemia-induced neuronal apoptosis.

  2003cited by this paper
• Opposite reaction of ERK and JNK in ischemia vulnerable and resistant regions of hippocampus: involvement of mitochondria.

  2003cited by this paper
• POSH acts as a scaffold for a multiprotein complex that mediates JNK activation in apoptosis

  2003influential reference
• Repression of phospho‐JNK and infarct volume in ischemic brain of JIP1‐deficient mice

  2003cited by this paper
• Akt2 Negatively Regulates Assembly of the POSH-MLK-JNK Signaling Complex*

  2003cited by this paper
• Role of Mitogen- and Stress-Activated Kinases in Ischemic Injury

  2002cited by this paper
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  2002cited by this paper
• N-methyl-D-aspartate receptor and L-type voltage-gated Ca(2+) channel antagonists suppress the release of cytochrome c and the expression of procaspase-3 in rat hippocampus after global brain ischemia.

  2002influential reference
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• The Kinase Activation Loop Is the Key to Mixed Lineage Kinase-3 Activation via Both Autophosphorylation and Hematopoetic Progenitor Kinase 1 Phosphorylation*

  2001cited by this paper
• c-Jun N-terminal kinase activation in hippocampal CA1 region was involved in ischemic injury

  2001cited by this paper
• Mitogen-activated protein kinases and cerebral ischemia

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• Requirement of the JIP1 scaffold protein for stress-induced JNK activation.

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• Extracellular signal-regulated kinase 1/2 activation in hippocampus after cerebral ischemia may not interfere with postischemic cell death.

  2001influential reference
• The AMPAR subunit GluR2: still front and center-stage.

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• Phosphorylation of c-Jun and Its Localization with Heme Oxygenase-1 and Cyclooxygenase-2 in CA1 Pyramidal Neurons after Transient Forebrain Ischemia

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• The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development.

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• Reperfusion Changes After Stroke and Practical Approaches for Neuroprotection.

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  2018cites this paper
• Homeostatic versus pathological functions of Dual Leucine Zipper Kinase in the adult mouse brain

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• POSH participates in epileptogenesis by increasing the surface expression of the NMDA receptor: a promising therapeutic target for epilepsy

  2017influential citation
• Inflammatory responses in brain ischemia.

  2015cites this paper
• JCB_201404066 1..17

  2015cites this paper
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• Adjunctive and long-acting nanoformulated antiretroviral therapies for HIV-associated neurocognitive disorders

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• Innate inflammatory responses in stroke: mechanisms and potential therapeutic targets.

  2014cites this paper
• Sh3rf2/POSHER Protein Promotes Cell Survival by Ring-mediated Proteasomal Degradation of the c-Jun

  2012cites this paper
• Effect of c-Jun NH₂-terminal kinase-mediated p53 expression on neuron autophagy following traumatic brain injury in rats.

  2012cites this paper
• The Neuroprotective Effect of Losartan through Inhibiting AT1/ASK1/MKK4/JNK3 Pathway Following Cerebral I/R in Rat Hippocampal CA1 Region

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• Sh3rf2/POSHER Protein Promotes Cell Survival by Ring-mediated Proteasomal Degradation of the c-Jun N-terminal Kinase Scaffold POSH (Plenty of SH3s) Protein*

  2011cites this paper
• Hit proteins, mitochondria and cancer.

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• c-Jun N-terminal kinase (JNK) signaling: recent advances and challenges.

  2010cites this paper
• Exploring the functional interaction between POSH and ALIX and the relevance to HIV-1 release

  2009cites this paper
• Preconditioning neuroprotection in global cerebral ischemia involves NMDA receptor-mediated ERK-JNK3 crosstalk.

  2009cites this paper
• Neuroprotection Against Transient Focal Cerebral Ischemia and Oxygen–Glucose Deprivation by Interference with GluR6-PSD95 Protein Interaction

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  2007cites this paper
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  2007cites this paper
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  2006cites this paper
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  2006cites this paper
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