Effect of Extent of Supersaturation on the Evolution of Kinetic Solubility Profiles.

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Molecular Pharmaceutics

• Publication date

  2017-01-03

• Fields of study

  Medicine, Materials Science, Chemistry

• Identifiers
  DOI 10.1021/acs.molpharmaceut.6b00788PMID 28043130
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Characterization of Supersaturated Danazol Solutions – Impact of Polymers on Solution Properties and Phase Transitions

  2016cited by this paper
• Polymer Inhibition of Crystal Growth by Surface Poisoning

  2016cited by this paper
• Impact of polymer type on bioperformance and physical stability of hot melt extruded formulations of a poorly water soluble drug.

  2016cited by this paper
• Indomethacin-Kollidon VA64 Extrudates: A Mechanistic Study of pH-Dependent Controlled Release.

  2016cited by this paper
• Evolution of supersaturation of amorphous pharmaceuticals: nonlinear rate of supersaturation generation regulated by matrix diffusion.

  2015cited by this paper
• Role of the Strength of Drug-Polymer Interactions on the Molecular Mobility and Crystallization Inhibition in Ketoconazole Solid Dispersions.

  2015cited by this paper
• Adsorption of Polyvinylpyrrolidone and its Impact on Maintenance of Aqueous Supersaturation of Indomethacin via Crystal Growth Inhibition.

  2015cited by this paper
• Evolution of supersaturation of amorphous pharmaceuticals: the effect of rate of supersaturation generation.

  2013cited by this paper
• Crystal Nucleation Kinetics from Induction Times and Metastable Zone Widths

  2013cited by this paper
• Maintenance of supersaturation II: indomethacin crystal growth kinetics versus degree of supersaturation.

  2013cited by this paper
• Impact of polymers on crystal growth rate of structurally diverse compounds from aqueous solution.

  2013cited by this paper
• Evaluation of the structural determinants of polymeric precipitation inhibitors using solvent shift methods and principle component analysis.

  2013cited by this paper
• Formulation of a danazol cocrystal with controlled supersaturation plays an essential role in improving bioavailability.

  2013cited by this paper
• Supersaturation in human gastric fluids.

  2012cited by this paper
• A win-win solution in oral delivery of lipophilic drugs: supersaturation via amorphous solid dispersions increases apparent solubility without sacrifice of intestinal membrane permeability.

  2012cited by this paper
• Supersaturation-nucleation behavior of poorly soluble drugs and its impact on the oral absorption of drugs in thermodynamically high-energy forms.

  2012cited by this paper
• Drug precipitation-permeation interplay: supersaturation in an absorptive environment.

  2012cited by this paper
• A new view on the metastable zone width during cooling crystallization

  2012cited by this paper
• Solubility advantage of amorphous pharmaceuticals, part 3: Is maximum solubility advantage experimentally attainable and sustainable?

  2011cited by this paper
• An investigation into the dissolution properties of celecoxib melt extrudates: understanding the role of polymer type and concentration in stabilizing supersaturated drug concentrations.

  2011cited by this paper
• Maintenance of supersaturation I: indomethacin crystal growth kinetic modeling using an online second-derivative ultraviolet spectroscopic method.

  2011cited by this paper
• Naproxen Cocrystals with Pyridinecarboxamide Isomers

  2011cited by this paper
• The developability classification system: application of biopharmaceutics concepts to formulation development.

  2010cited by this paper
• Using polymeric precipitation inhibitors to improve the absorption of poorly water-soluble drugs: A mechanistic basis for utility

  2010cited by this paper
• Understanding the Behavior of Amorphous Pharmaceutical Systems during Dissolution

  2010cited by this paper
• Enhanced absorption of the poorly soluble drug fenofibrate by tuning its release rate from ordered mesoporous silica.

  2010cited by this paper
• Solubility advantage of amorphous pharmaceuticals: I. A thermodynamic analysis.

  2010cited by this paper
• Supersaturating drug delivery systems: the answer to solubility-limited oral bioavailability?

  2009cited by this paper
• Utility of Hydroxypropylmethylcellulose Acetate Succinate (HPMCAS) for Initiation and Maintenance of Drug Supersaturation in the GI Milieu

  2009cited by this paper
• Comparative interaction of 2-hydroxypropyl-beta-cyclodextrin and sulfobutylether-beta-cyclodextrin with itraconazole: phase-solubility behavior and stabilization of supersaturated drug solutions.

  2008cited by this paper
• Stabilization of low glass transition temperature indomethacin formulations: impact of polymer-type and its concentration.

  2008cited by this paper
• Ability of Different Polymers to Inhibit the Crystallization of Amorphous Felodipine in the Presence of Moisture

  2008cited by this paper
• Additives and Crystallization Processes

  2007cited by this paper
• Clinical study of solid dispersions of itraconazole prepared by hot-stage extrusion.

  2005cited by this paper
• Effect of Hydrodynamic Environment on Tablets Dissolution Rate

  2004cited by this paper
• Increased physical stability and improved dissolution properties of itraconazole, a class II drug, by solid dispersions that combine fast- and slow-dissolving polymers.

  2004cited by this paper
• The Effect of Low Concentrations of Molecularly Dispersed Poly(Vinylpyrrolidone) on Indomethacin Crystallization from the Amorphous State

  2003cited by this paper
• Review: Nucleation in solutions revisited

  2003cited by this paper
• What is the True Solubility Advantage for Amorphous Pharmaceuticals?

  2000cited by this paper
• Crystal nucleation and growth of indomethacin polymorphs from the amorphous state

  2000cited by this paper
• Physical chemical properties of oral drug candidates in the discovery and exploratory development settings

  1998cited by this paper
• Noise Reduction in Second Derivative UV-Vis Spectroscopy

  1996cited by this paper
• DERIVATIVE UV-VIS SPECTROPHOTOMETRY IN ANALYTICAL CHEMISTRY

  1996cited by this paper
• Crystallization of indomethacin from the amorphous state below and above its glass transition temperature.

  1994cited by this paper
• Estimating the Fraction Dose Absorbed from Suspensions of Poorly Soluble Compounds in Humans: A Mathematical Model

  1993cited by this paper
• Calculation of interfacial tensions

  1990cited by this paper
• Indomethacin delivery from matrix controlled release indomethacin tablets

  1989cited by this paper
• Measurements and a hypothesis on periodic precipitation processes

  1987cited by this paper
• Fourier transform pulsed-gradient spin-echo studies of molecular diffusion

  1987cited by this paper
• Patterns produced by precipitation at a moving reaction front.

  1986cited by this paper
• Physicochemical characterization of indomethacin polymorphs and the transformation kinetics in ethanol.

  1985cited by this paper
• Dissolution kinetics of carboxylic acids II: effect of buffers.

  1981cited by this paper
• Wettability of pharmaceutical solids: estimates of solid surface polarity.

  1976cited by this paper
• On the Thermodynamic Relation between Surface Tension and Curvature

  1950cited by this paper

• Molecular insights into solubility and crystallization of d -ribose in alcohols: combined experimental and electrostatic potential analysis

  2026cites this paper
• Mechanistic Insights into Amorphous Solid Dispersions: Bridging Theory and Practice in Drug Delivery

  2025cites this paper
• Macrocyclization as a Strategy for Kinetic Solubility Improvement: A Comparative Analysis of Matched Molecular Pairs.

  2025cites this paper
• In vivo performance of amorphous solid dispersions based on water-insoluble versus water-soluble carriers: Fenofibrate case study.

  2025cites this paper
• A Quaternary Solid Dispersion System for Improving the Solubility of Olaparib

  2025cites this paper
• Dissolution Amelioration by Small Amounts of HPMC in the Difficult-to-solve Drug Combination Baicalein-imperatorin Co-Amorphous System: Dispersion and Crystallization Inhibition

  2025cites this paper
• Role of Phospholipids on Drug Dissolution in Polymer Solid Dispersions Prepared by Hot-Melt Extrusion

  2025cites this paper
• DSPindex guides dose selection to extend drug supersaturation lifetime during cocrystal dissolution.

  2025cites this paper
• Study on Several Novel Crystalline Complexes of Sorafenib with Dicarboxylic Acid: Nature Identification and Solubilization Mechanism

  2024cites this paper
• An emerging terpolymeric nanoparticle pore former as an internal recrystallization inhibitor of celecoxib in controlled release amorphous solid dispersion beads: Experimental studies and molecular dynamics analysis

  2024cites this paper
• Optimizing Nonsink Dissolution Testing for Amorphous Solid Dispersions: Exploring Sample Handling Variables.

  2024cites this paper
• Amorphous solid dispersions in high-swelling, low-substituted hydroxypropyl cellulose for enhancing the delivery of poorly soluble drugs.

  2023cites this paper
• Development of Robust Tablet Formulations with Enhanced Drug Dissolution Profiles from Centrifugally-Spun Micro-Fibrous Solid Dispersions of Itraconazole, a BCS Class II Drug

  2023cites this paper
• Bentonite as a water-insoluble amorphous solid dispersion matrix for enhancing oral bioavailability of poorly water-soluble drugs.

  2023cites this paper
• Amorphous Solid Dispersion as Drug Delivery Vehicles in Cancer

  2023cites this paper
• Assessing the performance of thermally crosslinked amorphous solid dispersions with high drug loadings.

  2023cites this paper
• Application of biorelevant in vitro assays for the assessment and optimization of ASD-based formulations for pediatric patients.

  2023cites this paper
• Theoretical evaluation of supersaturation of amorphous solid dispersion formulations with different drug/polymer combinations using mathematical modeling.

  2022cites this paper
• Enteric Polymer–Based Amorphous Solid Dispersions Enhance Oral Absorption of the Weakly Basic Drug Nintedanib via Stabilization of Supersaturation

  2022cites this paper
• Design and molecular insights of drug-active metabolite based co-amorphous formulation: a case study of toltrazuril-ponazuril co-amorphous.

  2022cites this paper
• Kinetic solubility improvement and influence of polymers on controlled supersaturation of itraconazole-succinic acid nano-co-crystals.

  2022cites this paper
• High-Drug-Loading Amorphous Solid Dispersions via In Situ Thermal Cross-Linking: Unraveling the Mechanisms of Stabilization.

  2021cites this paper
• A mechanistic review on the dissolution phase behavior and supersaturation stabilization of amorphous solid dispersions

  2021cites this paper
• Mutual Effects of Hydrogen Bonding and Polymer Hydrophobicity on Ibuprofen Crystal Inhibition in Solid Dispersions with Poly(N-vinyl pyrrolidone) and Poly(2-oxazolines)

  2021cites this paper
• On the usefulness of sink index in characterizing the degree of nonsinkness in dissolution studies.

  2021cites this paper
• Role of Permeability on the Biopredictive Dissolution of Amorphous Solid Dispersions

  2021cites this paper
• Tailoring Release Profiles of BCS Class II Drugs Using Controlled Release Amorphous Solid Dispersion Beads with Membrane-Reservoir Design: Effect of Pore Former and Coating Levels.

  2021cites this paper
• Impact of degree of supersaturation on the dissolution and oral absorption behaviors of griseofulvin amorphous solid dispersions

  2020cites this paper
• Enhanced Dissolution Efficiency of Tamoxifen Combined with Methacrylate Copolymers in Amorphous Solid Dispersions

  2020cites this paper
• An integrated computational methodology with data-driven machine learning, molecular modeling and PBPK modeling to accelerate solid dispersion formulation design.

  2020cites this paper
• Polymer structure and property effects on solid dispersions with haloperidol: poly(N-vinyl pyrrolidone) and poly(2-oxazolines) studies.

  2020cites this paper
• A Mechanistic Model for Predicting the Physical Stability of Amorphous Solid Dispersions.

  2020cites this paper
• Polymeric Precipitation Inhibitor–Based Solid Supersaturable SMEDD Formulation of Canagliflozin: Improved Bioavailability and Anti-diabetic Activity

  2020cites this paper
• Applications of Dynamic Mechanical Analysis in the Engineering of Amorphous Solid Dispersions

  2020cites this paper
• Evolution of Supersaturation from Amorphous Solid Dispersions in Water-Insoluble Polymer Carriers: Effects of Swelling Capacity and Interplay between Partition and Diffusion.

  2020cites this paper
• Polymer/lipid interplay in altering in vitro supersaturation and plasma concentration of a model poorly soluble drug.

  2020cites this paper
• Mechanisms of increased bioavailability through amorphous solid dispersions: a review

  2019cites this paper
• Polymeric precipitation inhibitor as an effective trigger to convert supersaturated into supersaturable state in vivo.

  2019cites this paper
• Combined Effects of Supersaturation Rates and Doses on the Kinetic-Solubility Profiles of Amorphous Solid Dispersions Based on Water-Insoluble Poly(2-hydroxyethyl methacrylate) Hydrogels.

  2018cites this paper
• Enhanced delivery of fixed‐dose combination of synergistic antichagasic agents posaconazole‐benznidazole based on amorphous solid dispersions

  2018cites this paper
• Solid dispersions to enhance the delivery of a potential drug candidate LPSF/FZ4 for the treatment of schistosomiasis

  2018cites this paper
• A case study where pharmaceutical salts were used to address the issue of low in vivo exposure

  2018cites this paper
• Supersaturating drug delivery systems: The potential of co-amorphous drug formulations.

  2017cites this paper
• Enhancement of dissolution rate through eutectic mixture and solid solution of posaconazole and benznidazole.

  2017cites this paper