Vasoinhibins prevent retinal vasopermeability associated with diabetic retinopathy in rats via protein phosphatase 2A-dependent eNOS inactivation.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Journal of Clinical Investigation

• Publication date

  2008-06-02

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1172/JCI34508PMID 18497878PMCID PMC2391065
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2007cited by this paper
• Screening for and managing diabetic retinopathy: current approaches.

  2007influential reference
• Management of diabetic retinopathy: a systematic review.

  2007cited by this paper
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  2007cited by this paper
• Targeting amyloid-β in glaucoma treatment

  2007cited by this paper
• Targeting amyloid-beta in glaucoma treatment.

  2007cited by this paper
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  2006cited by this paper
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  2006cited by this paper
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  2005cited by this paper
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  2005influential reference
• The use of okadaic acid to elucidate the intracellular role(s) of protein phosphatase 2A: lessons from the mast cell model system.

  2005cited by this paper
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  2005cited by this paper
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  2004cited by this paper
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  2004cited by this paper
• Prolactin in eyes of patients with retinopathy of prematurity: implications for vascular regression.

  2004influential reference
• 16K-prolactin inhibits activation of endothelial nitric oxide synthase, intracellular calcium mobilization, and endothelium-dependent vasorelaxation.

  2004influential reference
• Vasodilator effect and mechanism of action of vascular endothelial growth factor in skin vasculature.

  2004cited by this paper
• Nitric oxide in vascular biology

  2003cited by this paper
• Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales.

  2003cited by this paper
• Intracellular signal transduction pathways activated by ceramide and its metabolites.

  2003cited by this paper
• Flow-dependent regulation of endothelial nitric oxide synthase: role of protein kinases.

  2003influential reference
• Vascular endothelial growth factor and diabetic retinopathy: pathophysiological mechanisms and treatment perspectives

  2003cited by this paper
• Expression and purification of the angiogenesis inhibitor 16-kDa prolactin fragment from insect cells.

  2003cited by this paper
• Macular edema reflects generalized vascular hyperpermeability in type 2 diabetic patients with retinopathy.

  2002cited by this paper
• Pericytes and the pathogenesis of diabetic retinopathy.

  2002cited by this paper
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  2002cited by this paper
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  2002cited by this paper
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  2002cited by this paper
• Role of mTOR in the degradation of IRS‐1: Regulation of PP2A activity

  2002cited by this paper
• Nitric oxide and angiogenesis.

  2002cited by this paper
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  2002cited by this paper
• Insulin-stimulated Activation of eNOS Is Independent of Ca2+ but Requires Phosphorylation by Akt at Ser1179 *

  2001cited by this paper
• Predominant role of endothelial nitric oxide synthase in vascular endothelial growth factor-induced angiogenesis and vascular permeability

  2001cited by this paper
• Sensitive blood-retinal barrier breakdown quantitation using Evans blue.

  2001cited by this paper
• Estrogen Induces the Akt-dependent Activation of Endothelial Nitric-oxide Synthase in Vascular Endothelial Cells*

  2001cited by this paper
• VEGF-initiated blood-retinal barrier breakdown in early diabetes.

  2001cited by this paper
• Coordinated Control of Endothelial Nitric-oxide Synthase Phosphorylation by Protein Kinase C and the cAMP-dependent Protein Kinase*

  2001cited by this paper
• Expression of prolactin gene and secretion of prolactin by rat retinal capillary endothelial cells.

  2001cited by this paper
• Investigation

  2000cited by this paper
• The antiangiogenic factor 16K PRL induces programmed cell death in endothelial cells by caspase activation.

  2000cited by this paper
• Vascular endothelial growth factor (VEGF)-induced retinal vascular permeability is mediated by intercellular adhesion molecule-1 (ICAM-1).

  2000cited by this paper
• Nitric Oxide and Angiogenesis

  2000cited by this paper
• VEGF-induced permeability increase is mediated by caveolae.

  1999cited by this paper
• Regulation of protein kinase cascades by protein phosphatase 2A.

  1999cited by this paper
• Role for nitric oxide in the hyperpermeability and hemodynamic changes induced by intravenous VEGF.

  1999cited by this paper
• 16K human prolactin inhibits vascular endothelial growth factor-induced activation of Ras in capillary endothelial cells.

  1999cited by this paper
• Inhibition of urokinase activity by the antiangiogenic factor 16K prolactin: activation of plasminogen activator inhibitor 1 expression.

  1998cited by this paper
• Vascular Permeability Factor/Vascular Endothelial Cell Growth Factor-mediated Permeability Occurs through Disorganization of Endothelial Junctional Proteins*

  1998cited by this paper
• VEGF localisation in diabetic retinopathy

  1998cited by this paper
• Vascular endothelial growth factor and severity of nonproliferative diabetic retinopathy mediate retinal hemodynamics in vivo: a potential role for vascular endothelial growth factor in the progression of nonproliferative diabetic retinopathy.

  1998cited by this paper
• Vascular permeability in experimental diabetes is associated with reduced endothelial occludin content: vascular endothelial growth factor decreases occludin in retinal endothelial cells. Penn State Retina Research Group.

  1998cited by this paper
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  1997cited by this paper
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  1997cited by this paper
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  1997cited by this paper
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  1997cited by this paper
• Intravitreous injections of vascular endothelial growth factor produce retinal ischemia and microangiopathy in an adult primate.

  1996cited by this paper
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  1994cited by this paper
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  1993cited by this paper
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  1992cited by this paper
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  1989cited by this paper
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  1987cited by this paper

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  2010cites this paper
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  2010cites this paper
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  2010cites this paper
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  2010cites this paper
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  2010cites this paper
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  2009influential citation
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  2009cites this paper
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  2009influential citation
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  2009cites this paper
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  2008cites this paper