Zika plasma viral dynamics in nonhuman primates provides insights into early infection and antiviral strategies

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  2017-08-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1073/pnas.1704011114PMID 28765371PMCID PMC5565429
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Zika Virus Persistence in the Central Nervous System and Lymph Nodes of Rhesus Monkeys.

  2017cited by this paper
• Zika Virus Antagonizes Type I Interferon Responses during Infection of Human Dendritic Cells

  2017cited by this paper
• Understanding the within-host dynamics of influenza A virus: from theory to clinical implications

  2016cited by this paper
• Infection dynamics in a traveller with persistent shedding of Zika virus RNA in semen for six months after returning from Haiti to Italy, January 2016

  2016cited by this paper
• Heterologous Protection against Asian Zika Virus Challenge in Rhesus Macaques

  2016cited by this paper
• Fetal brain lesions after subcutaneous inoculation of Zika virus in a pregnant nonhuman primate

  2016cited by this paper
• Modelling Virus and Antibody Dynamics during Dengue Virus Infection Suggests a Role for Antibody in Virus Clearance

  2016cited by this paper
• Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth.

  2016cited by this paper
• Zika viral dynamics and shedding in rhesus and cynomolgus macaques

  2016cited by this paper
• Zika virus cell tropism in the developing human brain and inhibition by azithromycin

  2016cited by this paper
• Vaccine Protection Against Zika Virus from Brazil

  2016cited by this paper
• ZIKA virus reveals broad tissue and cell tropism during the first trimester of pregnancy

  2016cited by this paper
• Favipiravir Pharmacokinetics in Nonhuman Primates and Insights for Future Efficacy Studies of Hemorrhagic Fever Viruses

  2016influential reference
• Working with Zika and Usutu Viruses In Vitro

  2016cited by this paper
• Crystal structure of Zika virus NS2B-NS3 protease in complex with a boronate inhibitor

  2016cited by this paper
• Countering the Zika epidemic in Latin America

  2016cited by this paper
• Zika virus in semen and spermatozoa.

  2016cited by this paper
• Full Genome Sequence and sfRNA Interferon Antagonist Activity of Zika Virus from Recife, Brazil

  2016cited by this paper
• Guillain-Barré Syndrome outbreak associated with Zika virus infection in French Polynesia: a case-control study.

  2016cited by this paper
• Transmission of Zika Virus Through Sexual Contact with Travelers to Areas of Ongoing Transmission - Continental United States, 2016.

  2016cited by this paper
• Zika Virus Infection Among U.S. Pregnant Travelers - August 2015-February 2016.

  2016cited by this paper
• Estimating biologically relevant parameters under uncertainty for experimental within-host murine West Nile virus infection

  2016cited by this paper
• Zika virus inhibits type‐I interferon production and downstream signaling

  2016cited by this paper
• Protective efficacy of multiple vaccine platforms against Zika virus challenge in rhesus monkeys

  2016influential reference
• Complete Genome Sequences of Five Zika Virus Isolates

  2016cited by this paper
• Zika virus in Brazil and macular atrophy in a child with microcephaly.

  2016cited by this paper
• Zika Virus Targets Human STAT2 to Inhibit Type I Interferon Signaling.

  2016cited by this paper
• Zika virus infection in French Polynesia.

  2016cited by this paper
• Infectious Zika viral particles in breastmilk.

  2016cited by this paper
• Suspected Female-to-Male Sexual Transmission of Zika Virus - New York City, 2016.

  2016cited by this paper
• Zika virus infection induces mitosis abnormalities and apoptotic cell death of human neural progenitor cells

  2016cited by this paper
• Viremia and Clinical Presentation in Nicaraguan Patients Infected With Zika Virus, Chikungunya Virus, and Dengue Virus

  2016cited by this paper
• Non-vector-borne transmission of Zika virus: A systematic review.

  2016cited by this paper
• Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen

  2016cited by this paper
• Zika Virus Infects Human Placental Macrophages.

  2016cited by this paper
• Zika Virus Outbreak in Rio de Janeiro, Brazil: Clinical Characterization, Epidemiological and Virological Aspects

  2016cited by this paper
• Prolonged Shedding of Zika Virus Associated with Congenital Infection.

  2016cited by this paper
• A rhesus macaque model of Asian-lineage Zika virus infection

  2016cited by this paper
• Prolonged Zika Virus Viremia during Pregnancy.

  2016cited by this paper
• BCX4430, a Broad-Spectrum Adenosine Analog Direct-Acting Antiviral Drug, Abrogates Viremia in Rhesus Macaques Challenged with Zika Virus.

  2016cited by this paper
• Biology of Zika Virus Infection in Human Skin Cells

  2015cited by this paper
• Minimal within-host dengue models highlight the specific roles of the immune response in primary and secondary dengue infections

  2015cited by this paper
• Zika Virus Outbreak, Bahia, Brazil

  2015cited by this paper
• Modelling hepatitis C therapy—predicting effects of treatment

  2015cited by this paper
• Modeling viral kinetics and treatment outcome during alisporivir interferon‐free treatment in hepatitis C virus genotype 2 and 3 patients

  2014cited by this paper
• Viral kinetic modeling: state of the art

  2014cited by this paper
• Complete Coding Sequence of Zika Virus from a French Polynesia Outbreak in 2013

  2014cited by this paper
• Within-host viral dynamics of dengue serotype 1 infection

  2014cited by this paper
• Favipiravir (T-705), a novel viral RNA polymerase inhibitor.

  2013cited by this paper
• Antiretroviral dynamics determines HIV evolution and predicts therapy outcome

  2012cited by this paper
• Modeling Within-Host Dynamics of Influenza Virus Infection Including Immune Responses

  2012cited by this paper
• The Split-Apply-Combine Strategy for Data Analysis

  2011cited by this paper
• Influenza A virus infection kinetics: quantitative data and models

  2011cited by this paper
• Estimation of the Initial Viral Growth Rate and Basic Reproductive Number during Acute HIV-1 Infection

  2010influential reference
• In Vitro Antiviral Activity of Favipiravir (T-705) against Drug-Resistant Influenza and 2009 A(H1N1) Viruses

  2010cited by this paper
• An accurate two-phase approximate solution to an acute viral infection model

  2010cited by this paper
• Zika virus outbreak on Yap Island, Federated States of Micronesia.

  2009influential reference
• DEoptim: An R Package for Global Optimization by Differential Evolution

  2009cited by this paper
• Genetic and Serologic Properties of Zika Virus Associated with an Epidemic, Yap State, Micronesia, 2007

  2008cited by this paper
• Mixed‐Effects Models

  2007cited by this paper
• Extension of the SAEM algorithm to left-censored data in nonlinear mixed-effects model: Application to HIV dynamics model

  2006cited by this paper
• Kinetics of Influenza A Virus Infection in Humans

  2006influential reference
• Determining the relative efficacy of highly active antiretroviral therapy.

  2003cited by this paper
• Modelling viral and immune system dynamics

  2002influential reference
• Mixed-Effects Models in S and S-PLUS

  2001cited by this paper
• Modeling plasma virus concentration during primary HIV infection.

  2000influential reference
• Model selection and multi-model inference

  1998cited by this paper
• Hepatitis C Viral Dynamics in Vivo and the Antiviral Efficacy of Interferon-α Therapy

  1998cited by this paper
• Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon-alpha therapy.

  1998cited by this paper
• Endogenous monocyte chemoattractant protein‐1 recruits monocytes in the zymosan peritonitis model

  1998cited by this paper
• Model selection: An integral part of inference

  1997cited by this paper
• Bayesian Model Selection in Social Research

  1995cited by this paper
• Zika virus. I. Isolations and serological specificity.

  1952cited by this paper

• Enhancing viral dynamics modeling: reliable initial estimation and validity conditions for quasi-steady state approximation (QSSA)

  2025cites this paper
• From Bird Viremia to Bird Surveillance: Identifiability in a Multiscale Vector-Borne Model of Usutu Virus Infection

  2025cites this paper
• A modeling study to define guidelines for antigen screening in schools and workplaces to mitigate COVID-19 outbreaks

  2025cites this paper
• Modeling SARS-CoV-2 Infection Dynamics: Insights into Viral Clearance and Immune Synergy

  2025cites this paper
• The role of nutrition in virus dynamics in vector-borne viral infections.

  2025cites this paper
• Novel and repurposed antiviral molecules for arbovirus infections with epidemic Potential: A systematic review

  2025cites this paper
• Opportunities in multiscale modeling of mosquito-borne flaviviruses

  2025cites this paper
• Incorporating Intracellular Processes in Virus Dynamics Models

  2024cites this paper
• Identifiability investigation of within-host models of acute virus infection

  2024cites this paper
• Spatial dynamics of peripheral and central nervous system infection by an interferon-inducing neuroinvasive virus

  2024cites this paper
• Development of a SARS‐CoV‐2 viral dynamic model for patients with COVID‐19 based on the amount of viral RNA and viral titer

  2024cites this paper
• DETERMINISTIC MODEL OF ZIKA-VIRUS WITH CARRIER MOTHER AND RESERVOIRS: A MATHEMATICAL ANALYSIS APPROACH

  2024cites this paper
• Identifiability investigation of within-host models of acute virus infection

  2024cites this paper
• How robust are estimates of key parameters in standard viral dynamic models?

  2024cites this paper
• Multiple cohort study of hospitalized SARS-CoV-2 in-host infection dynamics: Parameter estimates, identifiability, sensitivity and the eclipse phase

  2023cites this paper
• How reliable are estimates of key parameters in viral dynamic models?

  2023cites this paper
• Early administration of tecovirimat shortens the time to mpox clearance in a model of human infection

  2023cites this paper
• Multiple cohort study of hospitalized SARS-CoV-2 in-host infection dynamics: Parameter estimates, identifiability, sensitivity and the eclipse phase profile

  2023cites this paper
• A Novel Mathematical Model That Predicts the Protection Time of SARS-CoV-2 Antibodies

  2023cites this paper
• Designing isolation guidelines for COVID-19 patients with rapid antigen tests

  2022cites this paper
• Antiviral efficacy of favipiravir against Zika and SARS-CoV-2 viruses in non-human primates

  2022cites this paper
• The area under the effect curve as an efficacy determinant for anti‐infectives

  2022cites this paper
• Identifiability of parameters in mathematical models of SARS-CoV-2 infections in humans

  2022cites this paper
• Eigenvalue analysis of SARS-CoV-2 viral load data: illustration for eight COVID-19 patients

  2022cites this paper
• Mathematical Analysis of a Zika Model with reservoirs and Human Movement

  2022cites this paper
• SARS-coronavirus-2 infections: biological instabilities characterized by order parameters

  2022influential citation
• Functionalized Nanoparticles in Prevention and Targeted Therapy of Viral Diseases With Neurotropism Properties, Special Insight on COVID-19

  2021cites this paper
• Mechanistic Models of COVID-19: Insights into Disease Progression, Vaccines, and Therapeutics

  2021cites this paper
• Modeling the dynamics of Usutu virus infection in birds.

  2021cites this paper
• Comparison and Evaluation of Real-Time Taqman PCR for Detection and Quantification of Ebolavirus

  2021cites this paper
• Revisiting the guidelines for ending isolation for COVID-19 patients

  2021cites this paper
• Kinetics of Asian and African Zika virus lineages over single‐cycle and multi‐cycle growth in culture: Gene expression, cell killing, virus production, and mathematical modeling

  2021influential citation
• The risk of drug resistance during long-acting antimicrobial therapy

  2021cites this paper
• Detection of significant antiviral drug effects on COVID-19 with reasonable sample sizes in randomized controlled trials: A modeling study

  2021cites this paper
• The evolutionary dynamics of viruses: virion release strategies, time delays and fitness minima

  2021cites this paper
• Quantifying the relationship between SARS-CoV-2 viral load and infectiousness

  2021cites this paper
• Time variation in the probability of failing to detect a case of polymerase chain reaction testing for SARS-CoV-2 as estimated from a viral dynamics model

  2021cites this paper
• A quantitative model used to compare within-host SARS-CoV-2, MERS-CoV, and SARS-CoV dynamics provides insights into the pathogenesis and treatment of SARS-CoV-2

  2021cites this paper
• SARS-CoV-2 viral dynamics in non-human primates

  2021cites this paper
• COVA1-18 neutralizing antibody protects against SARS-CoV-2 in three preclinical models

  2021cites this paper
• Quantification of the Tradeoff between Test Sensitivity and Test Frequency in a COVID-19 Epidemic—A Multi-Scale Modeling Approach

  2021cites this paper
• Zika virus dynamics: Effects of inoculum dose, the innate immune response and viral interference

  2021influential citation
• Safely return to schools and offices: early and frequent screening with high sensitivity antigen tests effectively identifies COVID-19 patients

  2021cites this paper
• Lassa viral dynamics in non-human primates treated with favipiravir or ribavirin

  2021cites this paper
• Determining reliable parameter estimates for within-host and within-vector models of Zika virus

  2021cites this paper
• Modeling intra-mosquito dynamics of Zika virus and its dose-dependence confirms the low epidemic potential of Aedes albopictus

  2020cites this paper
• Zika virus reservoirs: Implications for transmission, future

  2020cites this paper
• Model Averaging in Viral Dynamic Models

  2020cites this paper
• Varying Inoculum Dose to Assess the Roles of the Immune Response and Target Cell Depletion by the Pathogen in Control of Acute Viral Infections

  2020cites this paper
• Animal Models of Zika Virus Sexual Transmission

  2020cites this paper
• Modeling Favipiravir Antiviral Efficacy Against Emerging Viruses: From Animal Studies to Clinical Trials

  2020cites this paper
• Modelling the impact of antibody-dependent enhancement on disease severity of Zika virus and dengue virus sequential and co-infection

  2020cites this paper
• Timing of antiviral treatment initiation is critical to reduce SARS-Cov-2 viral load

  2020cites this paper
• A theoretical framework for transitioning from patient-level to population-scale epidemiological dynamics: influenza A as a case study

  2020cites this paper
• Pharmacokinetic bases of the hydroxychloroquine response in COVID-19: implications for therapy and prevention

  2020influential citation
• Treatment Considerations for COVID-19

  2020cites this paper
• Rethinking antiviral effects for COVID-19 in clinical studies: early initiation is key to successful treatment

  2020cites this paper
• Timing of Antiviral Treatment Initiation is Critical to Reduce SARS‐CoV‐2 Viral Load

  2020cites this paper
• Modeling mosquito-borne and sexual transmission of Zika virus in an enzootic host, the African green monkey

  2020cites this paper
• Modeling the viral dynamics of SARS-CoV-2 infection

  2020cites this paper
• Pharmacokinetic Basis of the Hydroxychloroquine Response in COVID-19: Implications for Therapy and Prevention

  2020cites this paper
• EVs Containing Host Restriction Factor IFITM3 Inhibited ZIKV Infection of Fetuses in Pregnant Mice through Trans-placenta Delivery

  2020cites this paper
• Quantification of Ebola virus replication kinetics in vitro

  2020cites this paper
• Using in silico viral kinetic models to guide therapeutic strategies during a pandemic: An example in SARS‐CoV‐2

  2020cites this paper
• Low Aedes aegypti Vector Competence for Zika Virus from Viremic Rhesus Macaques

  2020cites this paper
• COVID-19 Calls for Mathematics, Part 1: Neuraminidase Inhibitors, Chloroquine and Hydroxychloroquine

  2020cites this paper
• Mechanistic Modeling of SARS‐CoV‐2 and Other Infectious Diseases and the Effects of Therapeutics

  2020cites this paper
• The total number and mass of SARS-CoV-2 virions

  2020cites this paper
• Viral dynamic modeling of SARS-CoV-2 in non-human primates

  2020cites this paper
• Mathematical modelling identifies the role of adaptive immunity as a key controller of respiratory syncytial virus in cotton rats

  2019influential citation
• Zika virus diagnosis: challenges and solutions.

  2019cites this paper
• High susceptibility, viral dynamics and persistence of South American Zika virus in New World monkey species

  2019cites this paper
• European and tropical Aedes albopictus mosquito populations have similar systemic Zika virus infection dynamics

  2019cites this paper
• Towards multiscale modeling of the CD8+ T cell response to viral infections

  2019cites this paper
• Toward Antiviral Therapies for the Treatment of Zika Virus Infection: Lessons Learned from Dengue Virus

  2019cites this paper
• Using Macaques to Address Critical Questions in Zika Virus Research.

  2019cites this paper
• Late Neurological Consequences of Zika Virus Infection: Risk Factors and Pharmaceutical Approaches

  2019cites this paper
• Developing animal models of Zika virus infection for novel drug discovery

  2019cites this paper
• Adverse outcomes of pregnancy-associated Zika virus infection.

  2018cites this paper
• CD8+ lymphocytes modulate acute ZIKV viremia, innate antiviral immunity and tissue dissemination in nonhuman primates

  2018cites this paper
• Early HIV Infection Predictions: Role of Viral Replication Errors

  2018influential citation
• Mathematical Modeling Identifies the Role of Adaptive Immunity as a Key Controller of Respiratory Syncytial Virus (RSV) Titer in Cotton Rats

  2018cites this paper
• Validated Models of Immune Response to Virus Infection.

  2018cites this paper
• Interpretation of pathogen load in relationship to infectivity and pathogen reduction efficacy

  2018cites this paper
• Influenza Virus Infection Model With Density Dependence Supports Biphasic Viral Decay

  2018cites this paper
• Enhancing the antiviral potency of ER &agr;‐glucosidase inhibitor IHVR‐19029 against hemorrhagic fever viruses in vitro and in vivo

  2018cites this paper
• A PDE multiscale model of hepatitis C virus infection can be transformed to a system of ODEs.

  2018cites this paper
• Antiviral efficacy of favipiravir against Ebola virus: A translational study in cynomolgus macaques

  2018cites this paper
• What Controls the Acute Viral Infection Following Yellow Fever Vaccination?

  2018cites this paper
• Multimodal assessments of Zika virus immune pathophysiological responses in marmosets

  2018cites this paper
• Research Models and Tools for the Identification of Antivirals and Therapeutics against Zika Virus Infection

  2018cites this paper
• Ebola viral dynamics in nonhuman primates provides insights into virus immuno-pathogenesis and antiviral strategies

  2018cites this paper
• Mathematical modeling of within‐host Zika virus dynamics

  2018cites this paper
• Mathematical Analysis of Viral Replication Dynamics and Antiviral Treatment Strategies: From Basic Models to Age-Based Multi-Scale Modeling

  2018cites this paper
• What Controls the Acute Viral Infection Following Yellow Fever Vaccination?

  2017cites this paper
• Assessing Zika virus replication and the development of Zika-specific antibodies after a mid-gestation viral challenge in guinea pigs

  2017cites this paper
• Modelling the effects of phylogeny and body size on within-host pathogen replication and immune response

  2017cites this paper
• Zika virus reservoirs: Implications for transmission, future outbreaks, drug and vaccine development

  2017cites this paper
• Understanding the Pathogenesis of Zika Virus Infection Using Animal Models

  2017cites this paper