Autophagy Is Required for Sortilin-Mediated Degradation of Apolipoprotein B100

No abstract is available for this paper.

• Publication year

  2018

• Venue

  Circulation Research

• Publication date

  2018-02-16

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1161/CIRCRESAHA.117.311240PMID 29301854PMCID PMC5815905
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Sortilin mediates vascular calcification via its recruitment into extracellular vesicles.

  2016cited by this paper
• The enigmatic role of sortilin in lipoprotein metabolism.

  2015cited by this paper
• Degradation of lipid droplet-associated proteins by chaperone-mediated autophagy facilitates lipolysis

  2015cited by this paper
• Secretory autophagy.

  2015cited by this paper
• Induction of autophagy in rats upon overexpression of wild-type and mutant optineurin gene

  2015cited by this paper
• Fatty acid synthase is preferentially degraded by autophagy upon nitrogen starvation in yeast

  2015cited by this paper
• Sorting receptor sortilin—a culprit in cardiovascular and neurological diseases

  2014cited by this paper
• Deficient chaperone-mediated autophagy in liver leads to metabolic dysregulation.

  2014cited by this paper
• Sortilin and lipoprotein metabolism: making sense out of complexity

  2014cited by this paper
• The autophagic roles of Rab small GTPases and their upstream regulators

  2014cited by this paper
• Insulin-dependent apolipoprotein B degradation is mediated by autophagy and involves class I and class III phosphatidylinositide 3-kinases.

  2013cited by this paper
• Sortilin turnover is mediated by ubiquitination.

  2013cited by this paper
• Insulin suppression of apolipoprotein B in McArdle RH7777 cells involves increased sortilin 1 interaction and lysosomal targeting.

  2013cited by this paper
• The machinery of macroautophagy

  2013cited by this paper
• Insulin-Stimulated Degradation of Apolipoprotein B100: Roles of Class II Phosphatidylinositol-3-Kinase and Autophagy

  2013cited by this paper
• Guidelines for the use and interpretation of assays for monitoring autophagy

  2012cited by this paper
• Activation of ER stress and mTORC1 suppresses hepatic sortilin-1 levels in obese mice.

  2012cited by this paper
• Sortilin is required for toxic action of Aβ oligomers (AβOs): extracellular AβOs trigger apoptosis, and intraneuronal AβOs impair degradation pathways.

  2012cited by this paper
• Hepatic sortilin regulates both apolipoprotein B secretion and LDL catabolism.

  2012cited by this paper
• The hairpin-type tail-anchored SNARE syntaxin 17 targets to autophagosomes for fusion with endosomes/lysosomes.

  2012cited by this paper
• TRIM13 regulates ER stress induced autophagy and clonogenic ability of the cells.

  2012cited by this paper
• The degradation of apolipoprotein B100: multiple opportunities to regulate VLDL triglyceride production by different proteolytic pathways.

  2012cited by this paper
• Neuronal Brain-derived Neurotrophic Factor Is Synthesized in Excess, with Levels Regulated by Sortilin-mediated Trafficking and Lysosomal Degradation

  2011cited by this paper
• Huh-7 or HepG2 cells: which is the better model for studying human apolipoprotein-B100 assembly and secretion?[S]

  2011cited by this paper
• Altered lipid content inhibits autophagic vesicular fusion

  2010cited by this paper
• From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus

  2010cited by this paper
• Biological, Clinical, and Population Relevance of 95 Loci for Blood Lipids

  2010cited by this paper
• Sort1, encoded by the cardiovascular risk locus 1p13.3, is a regulator of hepatic lipoprotein export.

  2010cited by this paper
• The Vps10p-domain receptor family

  2009cited by this paper
• Sorting of lysosomal proteins.

  2009cited by this paper
• Autophagy regulates lipid metabolism

  2009cited by this paper
• AP-1 and retromer play opposite roles in the trafficking of sortilin between the Golgi apparatus and the lysosomes.

  2008cited by this paper
• Autophagy of an oxidized, aggregated protein beyond the ER: A pathway for remarkably late-stage quality control

  2008cited by this paper
• Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

  2008cited by this paper
• Presecretory oxidation, aggregation, and autophagic destruction of apoprotein-B: A pathway for late-stage quality control

  2008cited by this paper
• Palmitoylation Controls Recycling in Lysosomal Sorting and Trafficking

  2008cited by this paper
• The many intersecting pathways underlying apolipoprotein B secretion and degradation.

  2008cited by this paper
• Amyloid-beta aggregation.

  2007cited by this paper
• Sequence variations in PCSK9, low LDL, and protection against coronary heart disease.

  2006cited by this paper
• Sortilin Controls Intracellular Sorting of Brain-Derived Neurotrophic Factor to the Regulated Secretory Pathway

  2005cited by this paper
• Determining hepatic triglyceride production in mice: comparison of poloxamer 407 with Triton WR-1339 Published, JLR Papers in Press, July 1, 2005. DOI 10.1194/jlr.D500019-JLR200

  2005cited by this paper
• The role of autophagy during the early neonatal starvation period

  2004cited by this paper
• Inhibition of apolipoprotein B secretion by taurocholate is controlled by the N-terminal end of the protein in rat hepatoma McArdle-RH7777 cells.

  2003cited by this paper
• The Triple Threat to Nascent Apolipoprotein B

  2001cited by this paper
• Dissection of Autophagosome Formation Using Apg5-Deficient Mouse Embryonic Stem Cells

  2001cited by this paper
• The sortilin cytoplasmic tail conveys Golgi–endosome transport and binds the VHS domain of the GGA2 sorting protein

  2001cited by this paper
• LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

  2000cited by this paper
• Propeptide cleavage conditions sortilin/neurotensin receptor‐3 for ligand binding

  1999cited by this paper
• Fasting insulin and apolipoprotein B levels and low-density lipoprotein particle size as risk factors for ischemic heart disease.

  1998cited by this paper
• A protein conjugation system essential for autophagy

  1998cited by this paper
• Fasting insulin and apolipoprotein B levels and low density lipoprotein particle size as risk factors for ischemic heart disease.

  1998cited by this paper
• Isolation and Characterization of Rat Liver Amphisomes

  1998cited by this paper
• Molecular Identification of a Novel Candidate Sorting Receptor Purified from Human Brain by Receptor-associated Protein Affinity Chromatography*

  1997cited by this paper
• The chicken CCAAT/enhancer binding protein alpha gene. Cloning, characterisation and tissue distribution.

  1997cited by this paper
• Targeted Disruption of the Mouse apobec-1 Gene Abolishes Apolipoprotein B mRNA Editing and Eliminates Apolipoprotein B48 (*)

  1996cited by this paper
• Expression of carboxyl-terminally truncated forms of human apolipoprotein B in rat hepatoma cells. Evidence that the length of apolipoprotein B has a major effect on the buoyant density of the secreted lipoproteins.

  1991cited by this paper
• The unstirred water layer as a site of control of apolipoprotein B secretion.

  1990cited by this paper
• Apolipoprotein B-48 is the product of a messenger RNA with an organ-specific in-frame stop codon.

  1987cited by this paper
• A novel form of tissue-specific RNA processing produces apolipoprotein-B48 in intestine.

  1987cited by this paper
• Isolation of autophagic vacuoles from rat liver: morphological and biochemical characterization

  1982cited by this paper
• 3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes.

  1982cited by this paper
• Immunochemistry on ultrathin frozen sections

  1980cited by this paper

• Expression of IMD-CBM peptide induces the autophagic degradation of CAV1 (caveolin 1) to inhibit LDL transcytosis and retard diabetic atherosclerosis.

  2026cites this paper
• Caveolin-1-mediated LDL transcytosis across endothelial cells in atherosclerosis.

  2025cites this paper
• Sevoflurane Exposure Exacerbates Memory Impairment and Pathological Manifestation by Inhibiting AKT/mTOR‐Mediated Autophagy in P301L Tau Transgenic Mice

  2025cites this paper
• Current and Emerging Issues in Familial Hypobetalipoproteinemia-related Steatotic Liver Diseases

  2025cites this paper
• CLCF1 promotes IL12Rβ2 proteolysis and limits Th1 differentiation.

  2025cites this paper
• Dihydrotanshinone I Induces Autophagic Cell Death in Ovarian Cancer by Disrupting the SORT1-Mediated Autophagy–Lysosome Pathway

  2025cites this paper
• Finasteride delays atherosclerosis progression in mice and is associated with a reduction in plasma cholesterol in men

  2024cites this paper
• Impaired chaperone-mediated autophagy leads to abnormal SORT1 (sortilin 1) turnover and CES1-dependent triglyceride hydrolysis

  2024cites this paper
• FITM2 deficiency results in ER lipid accumulation, ER stress, and reduced apolipoprotein B lipidation and VLDL triglyceride secretion in vitro and in mouse liver

  2024cites this paper
• Molecular Regulation and Therapeutic Targeting of VLDL Production in Cardiometabolic Disease

  2024cites this paper
• Extracellular vesicles loaded with ApoB-100 protein affect the occurrence of coronary heart disease in patients after injury of spinal cord.

  2024cites this paper
• VLDL Biogenesis and Secretion: It Takes a Village

  2024cites this paper
• DIAPH1 mediates progression of atherosclerosis and regulates hepatic lipid metabolism in mice

  2023cites this paper
• Generation and Characterization of SORT1-Targeted Antibody–Drug Conjugate for the Treatment of SORT1-Positive Breast Tumor

  2023cites this paper
• FITM2 deficiency results in ER lipid accumulation, ER stress, reduced apolipoprotein B lipidation, and VLDL triglyceride secretion in vitro and in mouse liver

  2023cites this paper
• LncRP11-675F6.3 responds to rapamycin treatment and reduces triglyceride accumulation via interacting with HK1 in hepatocytes by regulating autophagy and VLDL-related proteins

  2023influential citation
• A human iPSC-derived hepatocyte screen identifies compounds that inhibit production of Apolipoprotein B

  2023cites this paper
• Functional characterization of interleukin 4 and retinoic acid signaling crosstalk during alternative macrophage activation.

  2023cites this paper
• Development and validation of a method to deliver vitamin A to macrophages.

  2022cites this paper
• A novel therapeutic strategy for atherosclerosis: autophagy-dependent cholesterol efflux

  2022cites this paper
• Sortilin drives hypertension by modulating sphingolipid/ceramide homeostasis and by triggering oxidative stress

  2022cites this paper
• Sortilin restricts secretion of apolipoprotein B-100 by hepatocytes under stressed but not basal conditions

  2022cites this paper
• Sortilin enhances secretion of apolipoprotein(a) through effects on apolipoprotein B secretion and promotes uptake of lipoprotein(a)

  2022cites this paper
• Role of sortilin 1 (SORT1) on lipid metabolism in bovine liver.

  2022cites this paper
• Spatial region-resolved proteome map reveals mechanism of COVID-19-associated heart injury

  2022cites this paper
• Sorting through the extensive and confusing roles of sortilin in metabolic disease

  2022cites this paper
• CELSR2 deficiency suppresses lipid accumulation in hepatocyte by impairing the UPR and elevating ROS level

  2021cites this paper
• Elevation of CSF Sortilin Following Subarachnoid Hemorrhage in Patients and Experimental Model Rats.

  2021cites this paper
• Circular RNA hsa_circ_0110389 promotes gastric cancer progression through upregulating SORT1 via sponging miR-127-5p and miR-136-5p

  2021influential citation
• Lipid Accumulation and Injury in Primary Calf Hepatocytes Challenged With Different Long-Chain Fatty Acids

  2020cites this paper
• β-Carotene conversion to vitamin A delays atherosclerosis progression by decreasing hepatic lipid secretion in mice

  2020cites this paper
• IKKβ Activation Promotes Amphisome Formation and Extracellular Vesicle Secretion in Tumor Cells.

  2020cites this paper
• Caveolin-1 in autophagy: a potential therapeutic target in atherosclerosis.

  2020cites this paper
• Role of Sortilin and Matrix Vesicles in Nε-Carboxymethyl-Lysine-Induced Diabetic Atherosclerotic Calcification

  2020cites this paper
• Focus on the morphogenesis, fate and the role in tumor progression of multivesicular bodies

  2020cites this paper
• Inflammasome Signaling and Impaired Vascular Health in Psoriasis

  2019cites this paper
• Non-Canonical Binding of a Small Molecule to Sortilin Alters Cellular Trafficking of ApoB and PCSK9 in Liver Derived Cells

  2019cites this paper
• Protein quality control in the secretory pathway

  2019cites this paper
• Apolipoprotein(a) Secretion is Modulated by Sortilin, Proprotein Convertase Subtilisin/Kexin Type 9, and Microsomal Triglyceride Transfer Protein

  2019influential citation
• Hsp104 facilitates the endoplasmic‐reticulum–associated degradation of disease‐associated and aggregation‐prone substrates

  2019cites this paper
• Sortilin levels are associated with peripheral arterial disease in type 2 diabetic subjects

  2019cites this paper
• Role of sortilin in lipid metabolism

  2019cites this paper
• Lipid-driven immunometabolic responses in atherosclerosis

  2018cites this paper
• Classical and alternative roles for autophagy in lipid metabolism

  2018cites this paper
• Cholesterol and bile acid-mediated regulation of autophagy in fatty liver diseases and atherosclerosis.

  2018cites this paper
• Etude des polymorphismes altérant la régulation de l'expression des gènes chez le bovin.

  2018cites this paper
• Can modulators of apolipoproteinB biogenesis serve as an alternate target for cholesterol-lowering drugs?

  2018cites this paper