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Comparative case-control study of homocysteine, vitamin B12, and folic acid levels in patients with epilepsy.

L. Fontes,M. P. Fontes,P. Jimenez,J. Perez,M. Iriarte

Published 2017 in Neurologia

ABSTRACT

Abstract Introduction Increased blood homocysteine levels are a known cardiovascular risk factor. Epileptic patients on long-term treatment with antiepileptic drugs may present higher homocysteine levels and, consequently, a potential increase in cardiovascular risk. Material and methods We conducted an observational case-control study to compare plasma levels of homocysteine, folic acid, and vitamin B 12 . Results Our study included a total of 88 subjects: 52 patients with epilepsy and 36 controls. Epileptic patients showed higher homocysteine levels ( P  = .084) and lower levels of folic acid ( P Conclusion Homocysteine levels should be monitored in epileptic patients on long-term treatment with antiepileptic drugs. We suggest starting specific treatment in patients with high homocysteine levels.

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