Knockdown of thioredoxin-interacting protein ameliorates high glucose-induced epithelial to mesenchymal transition in renal tubular epithelial cells.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Cellular Signalling

• Publication date

  2013-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.cellsig.2013.09.009PMID 24041652
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• AMP-activated protein kinase inhibits TGF-β-, angiotensin II-, aldosterone-, high glucose-, and albumin-induced epithelial-mesenchymal transition.

  2013cited by this paper
• Induction of renal fibrotic genes by TGF-β1 requires EGFR activation, p53 and reactive oxygen species.

  2013cited by this paper
• Thioredoxin-interacting Protein Mediates High Glucose-induced Reactive Oxygen Species Generation by Mitochondria and the NADPH Oxidase, Nox4, in Mesangial Cells*

  2013cited by this paper
• Early-Outgrowth Bone Marrow Cells Attenuate Renal Injury and Dysfunction via an Antioxidant Effect in a Mouse Model of Type 2 Diabetes

  2012cited by this paper
• Transforming growth factor‐β/Smad signalling in diabetic nephropathy

  2012cited by this paper
• Angiotensin II Induces Epithelial-to-Mesenchymal Transition in Renal Epithelial Cells through Reactive Oxygen Species/Src/Caveolin-Mediated Activation of an Epidermal Growth Factor Receptor–Extracellular Signal-Regulated Kinase Signaling Pathway

  2012cited by this paper
• Angiotensin-(1-7) attenuates high glucose-induced proximal tubular epithelial-to-mesenchymal transition via inhibiting ERK1/2 and p38 phosphorylation.

  2012cited by this paper
• Knockdown of thioredoxin interacting protein attenuates high glucose‐induced apoptosis and activation of ASK1 in mouse mesangial cells

  2011cited by this paper
• The Role of the p38 MAPK Signaling Pathway in High Glucose-Induced Epithelial-Mesenchymal Transition of Cultured Human Renal Tubular Epithelial Cells

  2011cited by this paper
• Epac1-mediated, high glucose-induced renal proximal tubular cells hypertrophy via the Akt/p21 pathway.

  2011cited by this paper
• p38 MAPK pathway is involved in high glucose‐induced thioredoxin interacting protein induction in mouse mesangial cells

  2010cited by this paper
• Troglitazone ameliorates high glucose-induced EMT and dysfunction of SGLTs through PI3K/Akt, GSK-3β, Snail1, and β-catenin in renal proximal tubule cells.

  2010cited by this paper
• Cardiovascular , Pulmonary and Renal Pathology Transcription Factors Krüppel-Like Factor 6 and Peroxisome Proliferator-Activated Receptor-Mediate High Glucose-Induced Thioredoxin-Interacting Protein

  2010cited by this paper
• High glucose condition upregulated Txnip expression level in rat mesangial cells through ROS/MEK/MAPK pathway

  2010cited by this paper
• New insights into epithelial-mesenchymal transition in kidney fibrosis.

  2010cited by this paper
• Mechanisms of tubulointerstitial fibrosis.

  2010cited by this paper
• Expression, localization, and function of the thioredoxin system in diabetic nephropathy.

  2009cited by this paper
• Transcription factors Krüppel-like factor 6 and peroxisome proliferator-activated receptor-{gamma} mediate high glucose-induced thioredoxin-interacting protein.

  2009cited by this paper
• Oxidative Stress as a Major Culprit in Kidney Disease in Diabetes

  2008cited by this paper
• Rap1b GTPase ameliorates glucose-induced mitochondrial dysfunction.

  2008cited by this paper
• Histopathology of diabetic nephropathy.

  2007cited by this paper
• High glucose-induced thioredoxin-interacting protein in renal proximal tubule cells is independent of transforming growth factor-beta1.

  2007cited by this paper
• Connective tissue growth factor plays an important role in advanced glycation end product-induced tubular epithelial-to-mesenchymal transition: implications for diabetic renal disease.

  2006cited by this paper
• TGF-beta1 induces IL-8 and MCP-1 through a connective tissue growth factor-independent pathway.

  2006cited by this paper
• High glucose-induced oxidative stress inhibits Na+/glucose cotransporter activity in renal proximal tubule cells.

  2005cited by this paper
• Role of reactive oxygen species in TGF-beta1-induced mitogen-activated protein kinase activation and epithelial-mesenchymal transition in renal tubular epithelial cells.

  2005cited by this paper
• Role of upstream stimulatory factors in regulation of renal transforming growth factor-beta1.

  2005cited by this paper
• Role of Reactive Oxygen Species in TGF-β1-Induced Mitogen-Activated Protein Kinase Activation and Epithelial-Mesenchymal Transition in Renal Tubular Epithelial Cells

  2005cited by this paper
• The effect of high glucose and PPAR-gamma agonists on PPAR-gamma expression and function in HK-2 cells.

  2004cited by this paper
• Epithelial to mesenchymal transition in renal fibrogenesis: pathologic significance, molecular mechanism, and therapeutic intervention.

  2004cited by this paper
• The effect of high glucose and PPAR-γ agonists on PPAR-γ expression and function in HK-2 cells

  2004cited by this paper
• Advanced glycation end products inhibit de novo protein synthesis and induce TGF-beta overexpression in proximal tubular cells.

  2003cited by this paper
• Reactive oxygen species and matrix remodeling in diabetic kidney.

  2003cited by this paper
• VDUP1 upregulated by TGF-β1 and 1,25-dihydorxyvitamin D3 inhibits tumor cell growth by blocking cell-cycle progression

  2003cited by this paper
• Vitamin D3 up-regulated protein-1 regulates collagen expression in mesangial cells.

  2003cited by this paper
• Loss of active MEK1-ERK1/2 restores epithelial phenotype and morphogenesis in transdifferentiated MDCK cells.

  2003cited by this paper
• Evidence that fibroblasts derive from epithelium during tissue fibrosis.

  2002cited by this paper
• Activation of tubular epithelial cells in diabetic nephropathy.

  2002cited by this paper
• TGF-beta signaling in renal disease.

  2002cited by this paper
• Role of high glucose-induced nuclear factor-kappaB activation in monocyte chemoattractant protein-1 expression by mesangial cells.

  2002cited by this paper
• TGF-β signaling in renal disease

  2002cited by this paper
• J Am Soc Nephrol 13: 894–902, 2002 Role of High Glucose–Induced Nuclear Factor–�B Activation in Monocyte Chemoattractant Protein-1 Expression by

  2001cited by this paper
• The tubulointerstitium in progressive diabetic kidney disease: more than an aftermath of glomerular injury?

  1999cited by this paper
• Identification of Thioredoxin-binding Protein-2/Vitamin D3 Up-regulated Protein 1 as a Negative Regulator of Thioredoxin Function and Expression*

  1999cited by this paper
• Tubular epithelial cell activation and interstitial fibrosis. The role of glomerular ultrafiltration of growth factors in the nephrotic syndrome and diabetic nephropathy.

  1999cited by this paper
• Angiotensin II induces superoxide anion production by mesangial cells.

  1998cited by this paper

• Beyond Redox Regulation: Novel Roles of TXNIP in the Pathogenesis and Therapeutic Targeting of Kidney Disease.

  2025cites this paper
• The Ubiquitin–Proteasome System in Brain Disorders: Pathogenic Pathways, Post-Translational Tweaks, and Therapeutic Frontiers

  2025cites this paper
• Crocin Inhibited Epithelial-Mesenchymal Transition in Renal Tubular Epithelial Cells to Treat Diabetic Nephropathy Through Improving AMPK/mTOR-Mediated Autophagy

  2024cites this paper
• PS-MPs promotes the progression of inflammation and fibrosis in diabetic nephropathy through NLRP3/Caspase-1 and TGF-β1/Smad2/3 signaling pathways.

  2024cites this paper
• TXNIP deficiency attenuates renal fibrosis by modulating mTORC1/TFEB-mediated autophagy in diabetic kidney disease

  2024cites this paper
• Epigallocatechin‐3‐Gallate Ameliorates Diabetic Kidney Disease by Inhibiting the TXNIP/NLRP3/IL‐1β Signaling Pathway

  2024cites this paper
• Molecular Regulation of Transforming Growth Factor-β1-induced Thioredoxin-interacting Protein Ubiquitination and Proteasomal Degradation in Lung Fibroblasts: Implication in Pulmonary Fibrosis

  2024cites this paper
• HIF-1 inhibition reverses opacity in a rat model of galactose-induced cataract

  2024cites this paper
• Protective effect of Cordyceps sinensis against diabetic kidney disease through promoting proliferation and inhibiting apoptosis of renal proximal tubular cells

  2023cites this paper
• Irisin Ameliorates Renal Tubulointerstitial Fibrosis by Regulating the Smad4/β-Catenin Pathway in Diabetic Mice

  2023cites this paper
• Blocking REDD1/TXNIP Complex Ameliorates HG-Induced Renal Tubular Epithelial Cell Apoptosis and EMT through Repressing Oxidative Stress

  2022cites this paper
• Involvement of Inflammasome Components in Kidney Disease

  2022cites this paper
• Ras guanine nucleotide-releasing protein-4 promotes renal inflammatory injury in type 2 diabetes mellitus.

  2022cites this paper
• A Cyclopentanone Compound Attenuates the Over-Accumulation of Extracellular Matrix and Fibrosis in Diabetic Nephropathy via Downregulating the TGF-β/p38MAPK Axis

  2022cites this paper
• NLRP3-mediated pyroptosis in diabetic nephropathy

  2022cites this paper
• Klotho prevents epithelial–mesenchymal transition through Egr-1 downregulation in diabetic kidney disease

  2021cites this paper
• Protective Effect of Yi Shen Pai Du Formula against Diabetic Kidney Injury via Inhibition of Oxidative Stress, Inflammation, and Epithelial-to-Mesenchymal Transition in db/db Mice

  2021cites this paper
• Overexpression and Activation of αvβ3 Integrin Differentially Affects TGFβ2 Signaling in Human Trabecular Meshwork Cells

  2021cites this paper
• Etoposide-induced protein 2.4 ameliorates high glucose-induced epithelial-mesenchymal transition by activating adenosine monophosphate-activated protein kinase pathway in renal tubular cells.

  2021cites this paper
• ChREBP deficiency alleviates apoptosis by inhibiting TXNIP/oxidative stress in diabetic nephropathy.

  2021cites this paper
• PP2 Ameliorates Renal Fibrosis by Regulating the NF-κB/COX-2 and PPARγ/UCP2 Pathway in Diabetic Mice

  2021cites this paper
• Urinary Thioredoxin as a Biomarker of Renal Redox Dysregulation and a Companion Diagnostic to Identify Responders to Redox-Modulating Therapeutics

  2021cites this paper
• The effect of lncRNA‐ARAP1‐AS2/ARAP1 on high glucose‐induced cytoskeleton rearrangement and epithelial–mesenchymal transition in human renal tubular epithelial cells

  2020cites this paper
• TXNIP deficiency mitigates podocyte apoptosis via restraining the activation of mTOR or p38 MAPK signaling in diabetic nephropathy.

  2020cites this paper
• Nicorandil ameliorates bleomycin-induced pulmonary fibrosis in rats through modulating eNOS, iNOS, TXNIP and HIF-1α levels.

  2020cites this paper
• Resveratrol protects human renal proximal tubular cells from high glucose and hypoxia / reoxygenation induced injury via inhibiting p 38-MAPK and thioredoxin-interacting protein ( TXNIP ) pathways

  2019influential citation
• Neuroendocrinology Letters-Neuro Endocrinol Lett

  2019cites this paper
• A Nucleoside/Nucleobase-Rich Extract from Cordyceps Sinensis Inhibits the Epithelial–Mesenchymal Transition and Protects against Renal Fibrosis in Diabetic Nephropathy

  2019cites this paper
• High Glucose-Induced Apoptosis in Human Kidney Cells Was Alleviated by miR-15 b-5 p Mimics

  2019cites this paper
• The Cell Culture Medium Affects Growth, Phenotype Expression and the Response to Selenium Cytotoxicity in A549 and HepG2 Cells

  2019cites this paper
• The mechanism of mulberry leaves against renal tubular interstitial fibrosis through ERK1/2 signaling pathway was predicted by network pharmacology and validated in human tubular epithelial cells

  2019cites this paper
• [Detection of carcinoembryonic antigen levels in pleural effusion and serum and their ratio for differential diagnosis of pleural effusion resulting from tuberculosis and lung cancer].

  2019cites this paper
• Thioredoxin‐interacting protein deficiency alleviates phenotypic alterations of podocytes via inhibition of mTOR activation in diabetic nephropathy

  2019cites this paper
• High Glucose-Induced Apoptosis in Human Kidney Cells Was Alleviated by miR-15b-5p Mimics.

  2019cites this paper
• FOXO1 Overexpression Attenuates Tubulointerstitial Fibrosis and Apoptosis in Diabetic Kidneys by Ameliorating Oxidative Injury via TXNIP-TRX

  2019cites this paper
• Novel elucidation and treatment of pancreatic chronic graft-versus-host disease in mice

  2018cites this paper
• The Function of Thioredoxin-Binding Protein-2 (TBP-2) in Different Diseases

  2018cites this paper
• Up-regulation of microRNA-93 inhibits TGF-β1-induced EMT and renal fibrogenesis by down-regulation of Orai1.

  2018cites this paper
• The role of the thioredoxin/thioredoxin reductase system in the metabolic syndrome: towards a possible prognostic marker?

  2018cites this paper
• Thioredoxin-interacting protein deficiency ameliorates kidney inflammation and fibrosis in mice with unilateral ureteral obstruction

  2018influential citation
• NLRP3 deficiency ameliorates renal inflammation and fibrosis in diabetic mice.

  2018cites this paper
• TXNIP mediated the oxidative stress response in glomerular mesangial cells partially through AMPK pathway.

  2018cites this paper
• Exosomes Derived From Mesenchymal Stromal Cells Pretreated With Advanced Glycation End Product-Bovine Serum Albumin Inhibit Calcification of Vascular Smooth Muscle Cells

  2018cites this paper
• Knockdown of NLRP3 alleviates high glucose or TGFB1-induced EMT in human renal tubular cells

  2018cites this paper
• Anthocyanins inhibit high glucose-induced renal tubular cell apoptosis caused by oxidative stress in db/db mice

  2018cites this paper
• Dexmedetomidine protects against renal ischemia and reperfusion injury by inhibiting the P38-MAPK/TXNIP signaling activation in streptozotocin induced diabetic rats.

  2017cites this paper
• Protective effects of probucol on Ox-LDL-induced epithelial-mesenchymal transition in human renal proximal tubular epithelial cells via LOX‑1/ROS/MAPK signaling.

  2017cites this paper
• Allicin inhibits tubular epithelial-myofibroblast transdifferentiation under high glucose conditions in vitro.

  2017cites this paper
• Novel Treatment of Chronic Graft-Versus-Host Disease in Mice Using the ER Stress Reducer 4-Phenylbutyric Acid

  2017cites this paper
• Down-regulation of miR-23a inhibits high glucose-induced EMT and renal fibrogenesis by up-regulation of SnoN

  2017cites this paper
• Thioredoxin is implicated in the anti‑apoptotic effects of grape seed proanthocyanidin extract during hyperglycemia.

  2017cites this paper
• Hepatitis B virus X protein promotes hepatocellular carcinoma invasion and metastasis via upregulating thioredoxin interacting protein.

  2017cites this paper
• High glucose induced endothelial to mesenchymal transition in human umbilical vein endothelial cell.

  2017cites this paper
• Renal protective effect and action mechanism of Huangkui capsule and its main five flavonoids.

  2017cites this paper
• Thioredoxin plays a key role in retinal neuropathy prior to endothelial damage in diabetic mice

  2017cites this paper
• MicroRNA-23b Targets Ras GTPase-Activating Protein SH3 Domain-Binding Protein 2 to Alleviate Fibrosis and Albuminuria in Diabetic Nephropathy.

  2016cites this paper
• Thioredoxin-interacting protein regulates lipid metabolism via Akt/mTOR pathway in diabetic kidney disease.

  2016cites this paper
• Let-7d miRNA prevents TGF-β1-induced EMT and renal fibrogenesis through regulation of HMGA2 expression.

  2016cites this paper
• High glucose promotes TGF-β1 production by inducing FOS expression in human peritoneal mesothelial cells

  2016cites this paper
• Thioredoxin interacting protein expression in the urinary sediment associates with renal function decline in type 1 diabetes

  2016cites this paper
• Thioredoxin-Interacting Protein Mediates NLRP3 Inflammasome Activation Involved in the Susceptibility to Ischemic Acute Kidney Injury in Diabetes

  2016cites this paper
• CD 36 is involved in high glucose-induced epithelial to mesenchymal transition in renal tubular epithelial cells

  2015cites this paper
• REDOX PROCESSES AND OXIDATIVE STRESS IN CELL AND TISSUE DAMAGE

  2015cites this paper
• Inhibition of c-Src/p38 MAPK pathway ameliorates renal tubular epithelial cells apoptosis in db/db mice.

  2015cites this paper
• Resveratrol prevents high glucose-induced epithelial-mesenchymal transition in renal tubular epithelial cells by inhibiting NADPH oxidase/ROS/ERK pathway.

  2015influential citation
• Sirtuin 1: A Target for Kidney Diseases

  2015cites this paper
• CD36 is involved in high glucose-induced epithelial to mesenchymal transition in renal tubular epithelial cells.

  2015cites this paper
• Effect of bone morphogenic protein-7 on the expression of epithelial-mesenchymal transition markers in silicosis model.

  2015cites this paper
• The downregulation of thioredoxin accelerated Neuro2a cell apoptosis induced by advanced glycation end product via activating several pathways.

  2015cites this paper
• Fisiopatología de la hiperfiltración glomerular en la diabetes. Parte 1

  2014cites this paper
• Trps1 is associated with the multidrug resistance of osteosarcoma by regulating MDR1 gene expression

  2014cites this paper
• Antioxidants Maintain E-Cadherin Levels to Limit Drosophila Prohemocyte Differentiation

  2014cites this paper
• Effect of benazepril on the transdifferentiation of renal tubular epithelial cells from diabetic rats.

  2014cites this paper
• E2F1 induces miR‐224/452 expression to drive EMT through TXNIP downregulation

  2014cites this paper
• Hyperglycemia regulates TXNIP/TRX/ROS axis via p38 MAPK and ERK pathways in pancreatic cancer.

  2014cites this paper
• Lipid accumulation is ahead of epithelial-to-mesenchymal transition and therapeutic intervention by acetyl-CoA carboxylase 2 silence in diabetic nephropathy.

  2014cites this paper
• Patofisiología de la hiperfiltración glomerular en la diabetes. Parte II

  2014cites this paper
• Dedifferentiation and reprogramming: origins of cancer stem cells

  2014cites this paper
• IMARS HIGHLIGHTS Research Commentaries for the Members of The International Maillard Reaction Society

  2013cites this paper
• The Role of Thioredoxin Interacting Protein (TxNIP) in the Development of Diabetic Nephropathy

  2013cites this paper