Is the hypotensive effect of clonidine and related drugs due to imidazoline binding sites?

No abstract is available for this paper.

• Publication year

  1997

• Venue

  American Journal of Physiology. Regulatory Integrative and Comparative Physiology

• Publication date

  1997-11-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1152/ajpregu.1997.273.5.R1580PMID 29586575
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Pharmacology of reticulospinal vasomotor neurons in cardiovascular regulation.

  1996cited by this paper
• Imidazoline receptors and their endogenous ligands.

  1996cited by this paper
• Central Hypotensive Effects of the α2a-Adrenergic Receptor Subtype

  1996cited by this paper
• Role of medulla oblongata in generation of sympathetic and vagal outflows.

  1996cited by this paper
• Distribution of α2C‐adrenergic receptor‐like immunoreactivity in the rat central nervous system

  1996cited by this paper
• I2-imidazoline binding sites: relationship with different monoamine oxidase domains and identification of histidine residues mediating ligand binding regulation by H+1.

  1996cited by this paper
• Neurons and Receptors in the Rostroventrolateral Medulla Mediating the Antihypertensive Actions of Drugs Acting at Imidazoline Receptors

  1996cited by this paper
• Synthesis and Pharmacologic Evaluation of 2‐endo‐Amino‐3‐exo‐ isopropylbicyclo(2.2.1)heptane: A Potent Imidazoline1 Receptor Specific Agent.

  1996influential reference
• Synthesis and pharmacologic evaluation of 2-endo-amino-3-exo-isopropylbicyclo[2.2.1]heptane: a potent imidazoline1 receptor specific agent.

  1996cited by this paper
• Coupling of I1-imidazoline receptors to diacylglyceride accumulation in PC12 rat pheochromocytoma cells.

  1996cited by this paper
• Cardiovascular Regulation in Mice Lacking α2-Adrenergic Receptor Subtypes b and c

  1996cited by this paper
• Cardiovascular responses to agmatine, a clonidine-displacing substance, in anesthetized rat.

  1995cited by this paper
• Imidazoline/Guanidinium Binding Domains on Monoamine Oxidases

  1995cited by this paper
• GABA-mediated inhibition of pacemaker neurons of rostral ventrolateral medulla by clonidine in vitro.

  1995cited by this paper
• C1 neurons of neonatal rats: intrinsic beating properties and alpha 2-adrenergic receptors.

  1995cited by this paper
• Central monoamine systems and new antihypertensive agents.

  1995cited by this paper
• I1-imidazoline receptors. Definition, characterization, distribution, and transmembrane signaling.

  1995influential reference
• I1‐Imidazoline Receptors

  1995cited by this paper
• Imidazoline/Guanidinium Binding Domains on Monoamine Oxidases RELATIONSHIP TO SUBTYPES OF IMIDAZOLINE-BINDING PROTEINS AND TISSUE-SPECIFIC INTERACTION OF IMIDAZOLINE LIGANDS WITH MONOAMINE OXIDASE B*

  1995cited by this paper
• Agmatine: an endogenous clonidine-displacing substance in the brain.

  1994influential reference
• Alpha 2A-adrenergic receptors are present in lower brainstem catecholaminergic and serotonergic neurons innervating spinal cord.

  1994cited by this paper
• Selective antihypertensive action of moxonidine is mediated mainly by I1-imidazoline receptors in the rostral ventrolateral medulla.

  1994cited by this paper
• Is the sympathoinhibitory effect of rilmenidine mediated by alpha-2 adrenoceptors or imidazoline receptors?

  1994influential reference
• Mediation of the hypotensive action of systemic clonidine in the rat by α2‐adrenoceptors

  1993cited by this paper
• Mediation of the hypotensive action of systemic clonidine in the rat by alpha 2-adrenoceptors.

  1993cited by this paper
• Cloning of two mouse genes encoding alpha 2-adrenergic receptor subtypes and identification of a single amino acid in the mouse alpha 2-C10 homolog responsible for an interspecies variation in antagonist binding.

  1992cited by this paper
• Pharmacological characterization of rat alpha 2-adrenergic receptors.

  1991cited by this paper
• Rilmenidine lowers arterial pressure via imidazole receptors in brainstem C1 area.

  1991cited by this paper
• An imidazoline-specific mechanism for the hypotensive effect of clonidine: a study with yohimbine and idazoxan.

  1990cited by this paper
• Role of imidazole receptors in the vasodepressor response to clonidine analogs in the rostral ventrolateral medulla.

  1990cited by this paper
• The imidazoline preferring receptor: binding studies in bovine, rat and human brainstem.

  1989cited by this paper
• Hypotensive action of clonidine analogues correlates with binding affinity at imidazole and not alpha‐2-adrenergic receptors in the rostral ventrolateral medulla

  1988cited by this paper
• Ventrolateral medullary pressor area: site of hypotensive action of clonidine.

  1987cited by this paper
• A1 noradrenergic neurons tonically inhibit sympathoexcitatory neurons of C1 area in rat brainstem.

  1986cited by this paper
• Selective alpha-2 adrenoceptor blockade by SK&F 86466: in vitro characterization of receptor selectivity.

  1986cited by this paper
• Central cardiovascular effects of alpha adrenergic drugs: differences between catecholamines and imidazolines.

  1984cited by this paper
• Distribution of α2 agonist binding sites in the rat and human central nervous system: Analysis of some functional, anatomic correlates of the pharmacologic effects of clonidine and related adrenergic agents

  1984cited by this paper
• Characterization of alpha-adrenoceptors participating in the central hypotensive and sedative effects of clonidine using yohimbine, rauwolscine and corynanthine.

  1981cited by this paper
• Distribution of α2A‐adrenergic receptor‐like immunoreactivity in the rat central nervous system

  year unknowncited by this paper

• Cardiovascular effects of dobutamine, norepinephrine and phenylephrine in isoflurane-anaesthetized dogs administered dexmedetomidine-vatinoxan.

  2022cites this paper
• Sarcolemmal α2-adrenoceptors in feedback control of myocardial response to sympathetic challenge.

  2019cites this paper
• Responsiveness of α2-adrenoceptor/I1-imidazoline receptor in the rostral ventrolateral medulla to cardiovascular regulation is enhanced in conscious spontaneously hypertensive rat

  2019cites this paper
• Randomized clinical trial to compare the efficacy to improve the quality of surgical field of hypotensive anesthesia with clonidine or dexmedetomidine during functional endoscopic sinus surgery

  2019cites this paper
• Use of α2-Adrenergic Agonists to Improve Surgical Field Visibility in Endoscopy Sinus Surgery: A Systematic Review of Randomised Controlled Trials.

  2018cites this paper
• Antidepressant-like activity of venlafaxine and clonidine in mice exposed to single prolonged stress - A model of post-traumatic stress disorder. Pharmacodynamic and molecular docking studies.

  2017cites this paper
• Peripheral versus central effect of intravenous moxonidine on rat carotid sinus baroreflex‐mediated sympathetic arterial pressure regulation

  2017cites this paper
• A Prospective Single Blind Comparative Study of Levobupivacaine with Fentanyl and Levobupivacaine with Clonidine in Thoracic Epidural Block for Laparoscopic Cholecystectomy

  2016cites this paper
• Transfer of SAR information from hypotensive indazole to indole derivatives acting at α-adrenergic receptors: In vitro and in vivo studies.

  2016cites this paper
• A COMPARATIVE STUDY OF LEVOBUPIVACAINE WITH CLONIDINE AND LEVOBUPIVACAINE WITH DEXMEDETOMIDINE IN THORACIC EPIDURAL BLOCK FOR LAPAROSCOPIC CHOLECYSTECTOMY

  2016cites this paper
• GABA mechanisms of the nucleus of the solitary tract regulates the cardiovascular and sympathetic effects of moxonidine.

  2016influential citation
• α- and β-Adrenoreceptor Binding

  2016cites this paper
• FACULTAD DE FARMACIA UNIVERSIDAD COMPLUTENSE

  2015cites this paper
• COMPARATIVE STUDY BETWEEN LEVOBUPIVACAINE WITH CLONIDINE AND ROPIVACAINE WITH CLONIDINE IN THORACIC EPIDURAL BLOCK FOR LAPAROSCOPIC CHOLECYSTECTOMY

  2015cites this paper
• α- and β-Adrenoceptor Binding

  2015cites this paper
• Therapeutic Approaches in the Attenuation of Seizure-Induced Cardiomyopathy

  2015cites this paper
• Hypotensive and vasorelaxant effects of (E) - methyl isoeugenol: a naturally occurring food flavour.

  2014cites this paper
• Brain stem adenosine receptors modulate centrally mediated hypotensive responses in conscious rats: A review

  2014cites this paper
• Clonidine and Dexmedetomidine Increase the Pressor Response to Norepinephrine in Experimental Sepsis: A Pilot Study*

  2013cites this paper
• Commissural nucleus of the solitary tract regulates the antihypertensive effects elicited by moxonidine.

  2013influential citation
• Dexmedetomidine and clonidine induce long-lasting activation of the respiratory rhythm generator of neonatal mice: possible implication for critical care.

  2012cites this paper
• Dexmédétomidine et clonidine : revue de leurs propriétés pharmacodynamiques en vue de définir la place des agonistes alpha-2 adrénergiques dans la sédation en réanimation

  2012cites this paper
• Effect of clonidine on cardiac baroreflex delay in humans and rats

  2011cites this paper
• Effect of clonidine on cardiac baroreflex delay in humans and rats.

  2011cites this paper
• Selective Attenuation of Norepinephrine Release and Stress-Induced Heart Rate Increase by Partial Adenosine A1 Agonism

  2011cites this paper
• humans and rats Effect of clonidine on cardiac baroreflex delay in

  2011cites this paper
• Differential regulation of the central neural cardiorespiratory system by metabotropic neurotransmitters

  2009cites this paper
• Involvement of central α1-adrenoceptors on renal responses to central moxonidine and α-methylnoradrenaline

  2009cites this paper
• Sympathoinhibitory mechanism of moxonidine: role of the inducible nitric oxide synthase in the rostral ventrolateral medulla.

  2009cites this paper
• Clonidine and Dexmedetomidine Produce Antinociceptive Synergy in Mouse Spinal Cord

  2009cites this paper
• Comparative study of alpha2-adrenoceptors in Fischer 344 and Lewis rats. Evidence for clonidine-induced place aversion.

  2008cites this paper
• Sympathoexcitation of moxonidine in the caudal ventrolateral medulla is dependent on I1-imidazoline receptors in anesthetized rats.

  2007cites this paper
• Comparative study of NMDA and AMPA/kainate receptors involved in cardiovascular inhibition produced by imidazoline‐like drugs in anaesthetized rats

  2007cites this paper
• Clonidine accumulation in human neuronal cells.

  2007cites this paper
• Adrenal GRK2 upregulation mediates sympathetic overdrive in heart failure

  2007cites this paper
• Involvement of central α1- and α2-adrenoceptors on cardiovascular responses to moxonidine

  2007cites this paper
• TDIQ (5,6,7,8-tetrahydro-1,3-dioxolo [4,5-g]isoquinoline): discovery, pharmacological effects, and therapeutic potential.

  2007cites this paper
• Study of retention parameters obtained in RP-TLC system and their application on QSAR/QSPR of some alpha adrenergic and imidazoline receptor ligands.

  2007cites this paper
• Contribution of AMPA/kainate receptors in the rostral ventrolateral medulla to the hypotensive and sympathoinhibitory effects of clonidine.

  2007cites this paper
• La balance sympatho-vagale et le bruxisme du sommeil

  2006cites this paper
• TDIQ (5,6,7,8-tetrahydro-1,3-dioxolo[4,5-g]isoquinoline) exhibits anxiolytic-like activity in a marble-burying assay in mice.

  2006cites this paper
• Antihypertensive Responses Elicited by Central Moxonidine in Rats: Possible Role of Nitric Oxide

  2006cites this paper
• RX 821002 as a tool for physiological investigation of alpha(2)-adrenoceptors.

  2006cites this paper
• Rat clonidine mydriasis model: imidazoline receptors are not involved.

  2005cites this paper
• Clonidin in der Kinderanästhesie

  2005cites this paper
• Central blockade of nitric oxide synthesis reduces moxonidine‐induced hypotension

  2004cites this paper
• The Presympathetic Cells of the Rostral Ventrolateral Medulla (RVLM): Anatomy, Physiology and Role in the Control of Circulation

  2004cites this paper
• Interaction between clonidine and N-methyl-D-aspartate receptors in the caudal ventrolateral medulla of rats

  2004cites this paper
• Electrophysiological evidences for the contribution of NMDA receptors to the inhibition of clonidine on the RVLM presympathetic neurons.

  2004cites this paper
• Clinical and pharmacological significance of alpha2-adrenoceptor polymorphisms in cardiovascular diseases.

  2004cites this paper
• Regional distribution of α2C-adrenoceptors in brain and spinal cord of control mice and transgenic mice overexpressing the α2C-subtype: an autoradiographic study with [3H]RX821002 and [3H]rauwolscine

  2003cites this paper
• Involvement of I(1)-imidazoline receptors in baroreceptor reflex in the caudal ventrolateral medulla of rats.

  2003cites this paper
• Blockade of N-methyl-D-aspartate receptors within the rostral ventrolateral medulla antagonizes clonidine-induced cardiovascular effects.

  2003cites this paper
• Rostral Ventrolateral Medulla C1 Neurons and Cardiovascular Regulation

  2003cites this paper
• Role of I1‐Imidazoline Receptors Within the Caudal Ventrolateral Medulla in Cardiovascular Responses to Clonidine in Rats

  2003cites this paper
• Baroreceptor reflex pathways and neurotransmitters: 10 years on

  2002cites this paper
• Effects of medullary α2-adrenoceptor blockade in the rat

  2002cites this paper
• Imidazoline antihypertensive drugs: a critical review on their mechanism of action.

  2002cites this paper
• Clonidine in paediatric anaesthesia: : Pharmacokinetic and pharmacodynamic aspects

  2002cites this paper
• Serotonin(3) receptor stimulation in the nucleus tractus solitarii activates non-catecholaminergic neurons in the rat ventrolateral medulla.

  2002cites this paper
• Physiological significance of alpha(2)-adrenergic receptor subtype diversity: one receptor is not enough.

  2002cites this paper
• Evidence for functional presynaptic alpha-2 adrenoceptors and their down-regulation in human heart failure.

  2001cites this paper
• Hypotensive and sedative effects of clonidine injected into the rostral ventrolateral medulla of conscious rats.

  2001cites this paper
• The Antinociceptive and Antiallodynic Effects by Brimonidine, a Selective alpha2 Adrenergic Agonist

  2001cites this paper
• Renal actions of the α2-adrenoceptor agonist, xylazine, in the anaesthetised rat

  2001cites this paper
• Effects of imidazoline antihypertensive drugs on sympathetic tone and noradrenaline release in the prefrontal cortex

  2001cites this paper
• Distribution of α2-Adrenergic Receptor Binding in the Developing Human Brain Stem

  2001cites this paper
• I1 imidazoline agonists. General clinical pharmacology of imidazoline receptors: implications for the treatment of the elderly.

  2000cites this paper
• Clonidine blocks stress‐induced reinstatement of heroin seeking in rats: an effect independent of locus coeruleus noradrenergic neurons

  2000cites this paper
• Single-cell RT-PCR as a tool to study gene expression in central and peripheral autonomic neurones.

  2000cites this paper
• Central nervous system norepinephrine metabolism in hypertension

  2000cites this paper
• In vivo gene modification elucidates subtype-specific functions of alpha(2)-adrenergic receptors.

  2000cites this paper
• Imidazoline receptor proteins are decreased in the hippocampus of individuals with major depression.

  2000cites this paper
• Prototypical imidazoline-1 receptor ligand moxonidine activates alpha2-adrenoceptors in bulbospinal neurons of the RVL.

  2000cites this paper
• Electroconvulsive Therapy and the Alpha-2 Noradrenergic Receptor: Implications of Treatment Schedule Effects

  2000cites this paper
• In Vivo Gene Modification Elucidates Subtype-Specific Functions of α2-Adrenergic Receptors

  2000cites this paper
• Alpha-2 Adrenergic Receptor Agonists Block Stress-Induced Reinstatement of Cocaine Seeking

  2000cites this paper
• The role of the central nervous system in hypertension

  1999cites this paper
• Neural Modulation of Cephalexin Intestinal Absorption Through the Di-and Tripeptide Brush Border Transporter of Rat Jejunum In Vivo 1

  1999cites this paper
• Metabolic effects of moxonidine and other centrally acting antihypertensives

  1999cites this paper
• α2-Adrenoceptor-mediated presynaptic inhibition in bulbospinal neurons of rostral ventrolateral medulla.

  1999cites this paper
• Neural modulation of cephalexin intestinal absorption through the di- and tripeptide brush border transporter of rat jejunum in vivo.

  1999cites this paper
• Relationship between imidazoline and alpha2-adrenoceptors involved in the sympatho-inhibitory actions of centrally acting antihypertensive agents.

  1998cites this paper
• Recent advances in imidazoline receptor research: ligands--localization and isolation--signaling--functional and clinical studies.

  1998cites this paper
• CENTRALLY ACTING ANTIHYPERTENSIVES: NOT OBSOLETE AFTER ALL

  1998cites this paper