Identification of ZCCHC8 as fusion partner of ROS1 in a case of congenital glioblastoma multiforme with a t(6;12)(q21;q24.3)

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Genes, Chromosomes and Cancer

• Publication date

  2016-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/gcc.22369PMID 27121553
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2013cited by this paper
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  2013cited by this paper
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  2012cited by this paper
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  2012cited by this paper
• Clinical and molecular characteristics of congenital glioblastoma.

  2012cited by this paper
• DELLY: structural variant discovery by integrated paired-end and split-read analysis

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• Congenital Brain Tumors: Diagnostic Pitfalls and Therapeutic Interventions

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  2009cited by this paper
• ISCN 2009 - An International System for Human Cytogenetic Nomenclature

  2009cited by this paper
• Congenital glioblastoma

  2009cited by this paper
• Glioblastoma Multiforme Oncogenomics and Signaling Pathways

  2009influential reference
• Congenital Glioblastoma Multiforme: Case Report and Review of the Literature

  2008cited by this paper
• Congenital Glioblastoma: A Clinicopathologic and Genetic Analysis

  2007cited by this paper
• Paired-End Mapping Reveals Extensive Structural Variation in the Human Genome

  2007cited by this paper
• Congenital glioblastoma multiforme. Case report and review of the literature.

  2006cited by this paper
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  2006cited by this paper
• Epidemiology and etiology of gliomas

  2005cited by this paper
• Genetic Pathways to Glioblastoma

  2004cited by this paper
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  2003cited by this paper
• World Health Organization Classification of Tumours

  2002cited by this paper
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  2001cited by this paper
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  2001cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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  1999cited by this paper
• Genetic alterations in pediatric high-grade astrocytomas.

  1999cited by this paper
• Cytogenetics of pediatric central nervous system tumors.

  1996cited by this paper
• Accumulation of chromosomal changes in human glioma progression. A cytogenetic study of 50 cases.

  1995cited by this paper
• Human gliomas with wild-type p53 express bcl-2.

  1995cited by this paper
• [Chromosomal abnormalities].

  1995cited by this paper
• Chromosomal abnormalities in 47 pediatric brain tumors.

  1995cited by this paper
• Case report.

  1995cited by this paper
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  1994cited by this paper
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  1994cited by this paper
• Minimal residual disease in acute leukemia.

  1991cited by this paper
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  1984cited by this paper
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  1964cited by this paper
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  1964cited by this paper
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  1951cited by this paper
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  2024cites this paper
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  2023cites this paper
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• Pediatric Gliomas: Molecular Landscape and Emerging Targets.

  2021cites this paper
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  2021cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2019influential citation
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  2019cites this paper
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  2019cites this paper
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