Targeting pan-resistant bacteria with antibodies to a broadly conserved surface polysaccharide expressed during infection.

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Journal of Infectious Diseases

• Publication date

  2012-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1093/infdis/jis254PMID 22448004PMCID PMC3415848
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Parallel bacterial evolution within multiple patients identifies candidate pathogenicity genes

  2011cited by this paper
• Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study

  2010cited by this paper
• Burkholderia cenocepacia in cystic fibrosis: epidemiology and molecular mechanisms of virulence.

  2010cited by this paper
• The Bps polysaccharide of Bordetella pertussis promotes colonization and biofilm formation in the nose by functioning as an adhesin

  2010cited by this paper
• Association between respiratory tract methicillin-resistant Staphylococcus aureus and survival in cystic fibrosis.

  2010cited by this paper
• Infection with transmissible strains of Pseudomonas aeruginosa and clinical outcomes in adults with cystic fibrosis.

  2010cited by this paper
• Synthetic β-(1→6)-Linked N-Acetylated and Nonacetylated Oligoglucosamines Used To Produce Conjugate Vaccines for Bacterial Pathogens

  2009influential reference
• The pgaABCD Locus of Acinetobacter baumannii Encodes the Production of Poly-β-1-6-N-Acetylglucosamine, Which Is Critical for Biofilm Formation

  2009cited by this paper
• Synthesis of beta-(1-->6)-linked glucosamine oligosaccharides corresponding to fragments of the bacterial surface polysaccharide poly-N-acetylglucosamine.

  2007cited by this paper
• Protection against Escherichia coli infection by antibody to the Staphylococcus aureus poly-N-acetylglucosamine surface polysaccharide

  2007cited by this paper
• Role of active‐site residues of dispersin B, a biofilm‐releasing β‐hexosaminidase from a periodontal pathogen, in substrate hydrolysis

  2007cited by this paper
• Characterization of the Opsonic and Protective Activity against Staphylococcus aureus of Fully Human Monoclonal Antibodies Specific for the Bacterial Surface Polysaccharide Poly-N-Acetylglucosamine

  2006cited by this paper
• Multidrug–resistant organisms in cystic fibrosis: management and infection–control issues

  2006cited by this paper
• Impact of Burkholderia dolosa on lung function and survival in cystic fibrosis.

  2006influential reference
• The multifarious, multireplicon Burkholderia cepacia complex

  2005cited by this paper
• Comparative Opsonic and Protective Activities of Staphylococcus aureus Conjugate Vaccines Containing Native or Deacetylated Staphylococcal Poly-N-Acetyl-β-(1-6)-Glucosamine

  2005cited by this paper
• Poly-N-Acetylglucosamine Production in Staphylococcus aureus Is Essential for Virulence in Murine Models of Systemic Infection

  2005cited by this paper
• The pgaABCD Locus of Escherichia coli Promotes the Synthesis of a Polysaccharide Adhesin Required for Biofilm Formation

  2004cited by this paper
• Contribution of Burkholderia cenocepacia Flagella to Infectivity and Inflammation

  2004cited by this paper
• Human Monoclonal Antibodies to Pseudomonas aeruginosa Alginate That Protect against Infection by Both Mucoid and Nonmucoid Strains1

  2004cited by this paper
• Evidence of transmission of Burkholderia cepacia, Burkholderia multivorans and Burkholderia dolosa among persons with cystic fibrosis.

  2003cited by this paper
• Phagocyte NADPH Oxidase, but Not Inducible Nitric Oxide Synthase, Is Essential for Early Control of Burkholderia cepacia and Chromobacterium violaceum Infection in Mice

  2003cited by this paper
• Comparative Assessment of Genotyping Methods for Epidemiologic Study of Burkholderia cepacia Genomovar III

  2002cited by this paper
• Broadly protective vaccine for Staphylococcus aureus based on an in vivo-expressed antigen.

  1999cited by this paper
• The intercellular adhesin involved in biofilm accumulation of Staphylococcus epidermidis is a linear beta-1,6-linked glucosaminoglycan: purification and structural analysis

  1996cited by this paper
• Immune complexes from immunized mice and infected cystic fibrosis patients mediate murine and human T cell killing of hybridomas producing protective, opsonic antibody to Pseudomonas aeruginosa.

  1993cited by this paper
• Immune complexes and Pseudomonas aeruginosa antibodies in cystic fibrosis.

  1988cited by this paper
• Opsonophagocytic killing antibody to Pseudomonas aeruginosa mucoid exopolysaccharide in older noncolonized patients with cystic fibrosis.

  1987cited by this paper
• Pseudomonas cepacia infection in cystic fibrosis: an emerging problem.

  1984cited by this paper

• The course of cystic fibrosis in adult patients with Burkholderia cepacia complex infection

  2025cites this paper
• Poly-β-D-(1,6)-N-acetyl-glucosamine (PNAG) glycan vaccines with broad spectrum neutralizing activities

  2025cites this paper
• Bacterial biofilms in the human body: prevalence and impacts on health and disease

  2023cites this paper
• Synthesis and application of bacterial exopolysaccharides.

  2023cites this paper
• Small-molecule activators of a bacterial signaling pathway inhibit virulence

  2023cites this paper
• Antibodies Targeting a Conserved Surface Polysaccharide Are Protective Against a Wide Range of Microbial Pathogens Producing β-1–6-Linked Poly-N-Acetylglucosamine (PNAG)

  2023cites this paper
• The Airway Microbiome and Metabolome in Preterm Infants: Potential Biomarkers of Bronchopulmonary Dysplasia

  2022cites this paper
• Leveraging monoclonal antibodies as therapeutics to address antimicrobial resistance in bacteria

  2022cites this paper
• Microarray-guided evaluation of the frequency, B-cell origins, and selectivity of human glycan-binding antibodies reveals new insights and novel antibodies

  2022cites this paper
• Microbially-derived cocktail of carbohydrases as an anti-biofouling agents: a ‘green approach’

  2022cites this paper
• Recent chemical syntheses of bacteria related oligosaccharides using modern expeditious approaches.

  2021cites this paper
• Evolution towards Virulence in a Burkholderia Two-Component System

  2021cites this paper
• Immunization and Immunotherapy Approaches against Pseudomonas aeruginosa and Burkholderia cepacia Complex Infections

  2021cites this paper
• Biofilm Targeting Strategy in the Eradication of Burkholderia Infections: A Mini-Review

  2021cites this paper
• Host adaptations in the fixLJ pathway of the Burkholderia cepacia complex increase virulence

  2020cites this paper
• Broadly protective semi-synthetic glycoconjugate vaccine against pathogens capable of producing poly-β-(1→6)-N-acetyl-d-glucosamine exopolysaccharide.

  2020cites this paper
• The lower-airway microbiome and metabolome in preterm infants: Identifying potential predictive biomarkers of bronchopulmonary dysplasia

  2020cites this paper
• Rational Antigen Selection and Delivery Technology for Development of Next Generation Pneumococcal Vaccines

  2019cites this paper
• Structural investigation of human S. aureus-targeting antibodies that bind wall teichoic acid

  2018cites this paper
• Phenotypic Variation during Biofilm Formation: Implications for Anti-Biofilm Therapeutic Design

  2018cites this paper
• Antibody to Poly-N-acetyl glucosamine provides protection against intracellular pathogens: Mechanism of action and validation in horse foals challenged with Rhodococcus equi

  2018cites this paper
• Polysaccharides from Burkholderia species as targets for vaccine development, immunomodulation and chemical synthesis.

  2018cites this paper
• Antibody-based vaccine for tuberculosis: validation in horse foals challenged with the TB-related pathogen Rhodococcus equi

  2018cites this paper
• A Microfluidic‐Based Model for Spatially Constrained Culture of Intestinal Microbiota

  2018cites this paper
• 60 ВЕСТНИК РАМН / 2018 / 73 ( 1 )

  2018cites this paper
• Structure of the 4462 Antibody Fab fragment bound to a Staphylococcus aureus wall techoic acid analog

  2018cites this paper
• Burkholderia cepacia Complex Infections Among Cystic Fibrosis Patients: Perspectives and Challenges

  2017cites this paper
• An Oxygen-Sensing Two-Component System in the Burkholderia cepacia Complex Regulates Biofilm, Intracellular Invasion, and Pathogenicity

  2017cites this paper
• Gram Negative Bacterial Biofilm Formation and Characterisation of Extracellular Polymeric Substances

  2016cites this paper
• Antibiotic resistance and virulence: Understanding the link and its consequences for prophylaxis and therapy

  2016cites this paper
• Extended-spectrum antibodies protective against carbapenemase-producing Enterobacteriaceae.

  2016cites this paper
• The exceptionally broad-based potential of active and passive vaccination targeting the conserved microbial surface polysaccharide PNAG

  2016influential citation
• The synthesis and ring-opening metathesis polymerization of glycomonomers

  2016cites this paper
• Fitness cost of antibiotic susceptibility during bacterial infection

  2015cites this paper
• Escherichia coli ja Klebsiella pneumoniae β-laktaamiresistentsus XXI sajandi teisel kümnendil

  2015cites this paper
• Identification of Poly-N-acetylglucosamine as a Major Polysaccharide Component of the Bacillus subtilis Biofilm Matrix*

  2015cites this paper
• Bacterial Extracellular Polysaccharides in Biofilm Formation and Function

  2015cites this paper
• Microbial biofilm formation: a need to act

  2014cites this paper
• In vitro Studies and Clinical Trials about Monoclonal Antibodies Used in Infectiology

  2014cites this paper
• Infections Caused by Stenotrophomonas maltophilia in Recipients of Hematopoietic Stem Cell Transplantation

  2014cites this paper
• Combating multidrug-resistant Gram-negative bacterial infections

  2014cites this paper
• Emerging approaches to the treatment of ventilator-associated pneumonia

  2014cites this paper
• Linear and cyclic oligo-β-(1→6)-D-glucosamines: Synthesis, conformations, and applications for design of a vaccine and oligodentate glycoconjugates

  2013cites this paper
• Methods for preventing biofilm formation

  2013cites this paper
• Potential Therapeutic Target Via Passive Immunization 2

  2013cites this paper
• Will there ever be a universal Staphylococcus aureus vaccine?

  2013cites this paper
• The K1 Capsular Polysaccharide from Acinetobacter baumannii Is a Potential Therapeutic Target via Passive Immunization

  2013cites this paper
• Antibody to a conserved antigenic target is protective against diverse prokaryotic and eukaryotic pathogens

  2013cites this paper
• Therapeutic antibodies and infectious diseases, Tours, France, November 20−22, 2012

  2013cites this paper
• A Comprehensive Analysis of In Vitro and In Vivo Genetic Fitness of Pseudomonas aeruginosa Using High-Throughput Sequencing of Transposon Libraries

  2013cites this paper
• Identification of New Drug Targets in Multi-Drug Resistant Bacterial Infections

  2013cites this paper
• PNAG: broadening infection protection

  2013cites this paper
• Staphylococcal biofilms: quest for the magic bullet.

  2012cites this paper
• Allosteric activation of exopolysaccharide synthesis through cyclic di‐GMP‐stimulated protein–protein interaction

  2012cites this paper
• Magic bullets for the 21st century: the reemergence of immunotherapy for multi- and pan-resistant microbes.

  2012cites this paper
• Opsonic and Protective Properties of Antibodies Raised to Conjugate Vaccines Targeting Six Staphylococcus aureus Antigens

  2012cites this paper