A common variant alters SCN5A–miR-24 interaction and associates with heart failure mortality

No abstract is available for this paper.

• Publication year

  2018

• Venue

  Journal of Clinical Investigation

• Publication date

  2018-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1172/JCI95710PMID 29457789PMCID PMC5824852
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• KChIP2 is a core transcriptional regulator of cardiac excitability

  2017cited by this paper
• Cancer: fundamentals behind pH targeting and the double-edged approach

  2016cited by this paper
• GMAP and GSNAP for Genomic Sequence Alignment: Enhancements to Speed, Accuracy, and Functionality

  2016cited by this paper
• Elucidation of transcriptome-wide microRNA binding sites in human cardiac tissues by Ago2 HITS-CLIP

  2016cited by this paper
• Aberrant sodium influx causes cardiomyopathy and atrial fibrillation in mice.

  2016cited by this paper
• Effect of angiotensin-converting enzyme inhibitors and receptor blockers on appropriate implantable cardiac defibrillator shock in patients with severe systolic heart failure (from the GRADE Multicenter Study).

  2015cited by this paper
• RNA-Seq identifies novel myocardial gene expression signatures of heart failure.

  2015cited by this paper
• Regulation of SCN5A by microRNAs: miR-219 modulates SCN5A transcript expression and the effects of flecainide intoxication in mice.

  2015cited by this paper
• ASEQ: fast allele-specific studies from next-generation sequencing data

  2015cited by this paper
• Post-transcriptional regulation of cardiac sodium channel gene SCN5A expression and function by miR-192-5p.

  2015cited by this paper
• Novel SCN5A mutation in amiodarone-responsive multifocal ventricular ectopy-associated cardiomyopathy.

  2014cited by this paper
• MicroRNAs as Therapeutic Targets and Biomarkers of Cardiovascular Disease

  2014cited by this paper
• Genome-Wide Identification of Expression Quantitative Trait Loci (eQTLs) in Human Heart

  2014cited by this paper
• mRNA destabilization is the dominant effect of mammalian microRNAs by the time substantial repression ensues.

  2014cited by this paper
• A common genetic variant within SCN10A modulates cardiac SCN5A expression.

  2014cited by this paper
• Sequencing of SCN5A Identifies Rare and Common Variants Associated With Cardiac Conduction: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium

  2014cited by this paper
• Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death

  2013cited by this paper
• MicroRNAs in cardiovascular disease: from pathogenesis to prevention and treatment.

  2013cited by this paper
• Genome- and Phenome-Wide Analyses of Cardiac Conduction Identifies Markers of Arrhythmia Risk

  2013cited by this paper
• In Vivo Suppression of MicroRNA-24 Prevents the Transition Toward Decompensated Hypertrophy in Aortic-Constricted Mice

  2013cited by this paper
• PolymiRTS Database 3.0: linking polymorphisms in microRNAs and their target sites with human diseases and biological pathways

  2013cited by this paper
• SCN5A splicing variants and the possibility of predicting heart failure-associated arrhythmia

  2013cited by this paper
• A New Level of Complexity: The Role of MicroRNAs in Cardiovascular Development

  2012cited by this paper
• miRdSNP: a database of disease-associated SNPs and microRNA target sites on 3'UTRs of human genes

  2012cited by this paper
• Functional screening identifies miRNAs inducing cardiac regeneration

  2012cited by this paper
• Integration of Genetics into a Systems Model of Electrocardiographic Traits Using HumanCVD BeadChip

  2012cited by this paper
• Ribosome Profiling Shows That miR-430 Reduces Translation Before Causing mRNA Decay in Zebrafish

  2012cited by this paper
• miRNA-Mediated Gene Silencing by Translational Repression Followed by mRNA Deadenylation and Decay

  2012cited by this paper
• SCN5A Variation Is Associated With Electrocardiographic Traits in the Jackson Heart Study

  2011cited by this paper
• Informatic and Functional Approaches to Identifying a Regulatory Region for the Cardiac Sodium Channel

  2011cited by this paper
• Production of a reference transcriptome and transcriptomic database (PocilloporaBase) for the cauliflower coral, Pocillopora damicornis

  2011cited by this paper
• A linear complexity phasing method for thousands of genomes

  2011cited by this paper
• A synonymous variant in IRGM alters a binding site for miR-196 and causes deregulation of IRGM-dependent xenophagy in Crohn's disease

  2011cited by this paper
• NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart

  2010cited by this paper
• Several common variants modulate heart rate, PR interval and QRS duration

  2010cited by this paper
• Reactive Oxygen Species Originating From Mitochondria Regulate the Cardiac Sodium Channel

  2010cited by this paper
• Common variants at ten loci modulate the QT interval duration in the QTSCD Study

  2009cited by this paper
• Genome-wide association study of electrocardiographic conduction measures in an isolated founder population: Kosrae.

  2009cited by this paper
• Sodium channel β1 subunit mutations associated with Brugada syndrome and cardiac conduction disease in humans.

  2008cited by this paper
• The E1784K mutation in SCN5A is associated with mixed clinical phenotype of type 3 long QT syndrome.

  2008cited by this paper
• The role of site accessibility in microRNA target recognition

  2007cited by this paper
• The role of reactive oxygen species in the hearts of dystrophin-deficient mdx mice.

  2007cited by this paper
• Cardiac sodium channel Nav1.5 and its associated proteins.

  2007cited by this paper
• Arrhythmogenic ion-channel remodeling in the heart: heart failure, myocardial infarction, and atrial fibrillation.

  2007cited by this paper
• Mutation in Glycerol-3-Phosphate Dehydrogenase 1–Like Gene (GPD1-L) Decreases Cardiac Na+ Current and Causes Inherited Arrhythmias

  2007cited by this paper
• Expression of the Voltage-Gated Sodium Channel NaV1.5 in the Macrophage Late Endosome Regulates Endosomal Acidification1

  2007cited by this paper
• A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure

  2006cited by this paper
• Cardiac Sodium Channel Nav1.5 Is Regulated by a Multiprotein Complex Composed of Syntrophins and Dystrophin

  2006cited by this paper
• SCN5A Mutation Associated with Cardiac Conduction Defect and Atrial Arrhythmias

  2006cited by this paper
• Aldosterone synthase promoter polymorphism predicts outcome in African Americans with heart failure: results from the A-HeFT Trial.

  2006cited by this paper
• Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets.

  2005cited by this paper
• Sodium channel mutations and susceptibility to heart failure and atrial fibrillation.

  2005cited by this paper
• Impaired Impulse Propagation in Scn5a-Knockout Mice: Combined Contribution of Excitability, Connexin Expression, and Tissue Architecture in Relation to Aging

  2005cited by this paper
• Nav1.5 E1053K mutation causing Brugada syndrome blocks binding to ankyrin-G and expression of Nav1.5 on the surface of cardiomyocytes.

  2004cited by this paper
• A common SCN5A polymorphism modulates the biophysical effects of an SCN5A mutation.

  2003cited by this paper
• Slowed conduction and ventricular tachycardia after targeted disruption of the cardiac sodium channel gene Scn5a

  2002cited by this paper
• A single Na(+) channel mutation causing both long-QT and Brugada syndromes.

  1999cited by this paper
• Genetic basis and molecular mechanism for idiopathic ventricular fibrillation

  1998cited by this paper
• Molecular mechanism for an inherited cardiac arrhythmia

  1995cited by this paper

• Heritability and causality of QRS duration and chronic heart failure risk

  2025cites this paper
• Voltage-Gated Sodium Channels: A Therapeutic Target in Ischemic Heart Disease

  2025cites this paper
• A Common Variant in NID1 Gene Associated with the Prognosis of Heart Failure

  2025cites this paper
• Oxidative Stress Causes Mitochondrial and Electrophysiologic Dysfunction to Promote Atrial Fibrillation in Pitx2+/− Mice

  2025cites this paper
• Mechanism of Action of NvZhen ErXian HeJi in Ovariectomized Rats with Myocardial Infarction based on Network Pharmacology.

  2024cites this paper
• Long-QT Trafficking Map.

  2024cites this paper
• A common variant in PIK3CG gene associated with the prognosis of heart failure

  2024cites this paper
• MicroRNA-452-5p regulates fibrogenesis via targeting TGF-β/SMAD4 axis in SCN5A-knockdown human cardiac fibroblasts

  2024cites this paper
• Genomic approaches to identify and investigate genes associated with atrial fibrillation and heart failure susceptibility

  2023influential citation
• SUMOylation of the Cardiac Sodium Channel NaV1.5 Modifies Inward Current and Cardiac Excitability.

  2023cites this paper
• Modulation of miR-29 influences myocardial compliance likely through coordinated regulation of calcium handling and extracellular matrix

  2023cites this paper
• miR‑124 inhibits cardiomyocyte apoptosis in myocardial ischaemia‑reperfusion injury by activating mitochondrial calcium uniporter regulator 1.

  2023cites this paper
• Inhibition of Wnt/β‐catenin signaling upregulates Nav1.5 channels in Brugada syndrome iPSC‐derived cardiomyocytes

  2023cites this paper
• Genomic and Non-Genomic Regulatory Mechanisms of the Cardiac Sodium Channel in Cardiac Arrhythmias

  2022cites this paper
• MiR-24-3p Attenuates Doxorubicin-induced Cardiotoxicity via the Nrf2 Pathway in Mice

  2022cites this paper
• SUMOylation of the Cardiac Sodium Channel NaV1.5 Modifies Inward Current and Cardiac Excitability

  2022cites this paper
• Sudden cardiac death and cardiac sodium channel diseases

  2022cites this paper
• Multilayer control of cardiac electrophysiology by microRNAs.

  2022cites this paper
• Searching for genetic modulators of the phenotypic heterogeneity in Brugada syndrome

  2022cites this paper
• Versatile role of miR-24/24-1*/24-2* expression in cancer and other human diseases.

  2022cites this paper
• Inhibition of β-catenin Increases Voltage-gated Na + Current in Brugada Syndrome Cardiomyocytes

  2021cites this paper
• Non-Coding RNAs in the Cardiac Action Potential and Their Impact on Arrhythmogenic Cardiac Diseases

  2021cites this paper
• Modulation of the Cardiac Sodium Channel NaV1.5 Peak and Late Currents by NAD+ Precursors

  2020cites this paper
• Structural and Functional Characterization of A Nav1.5-Mitochondrial Couplon.

  2020cites this paper
• Role of Non-Coding Variants in Brugada Syndrome

  2020cites this paper
• MIR448 antagomir reduces arrhythmic risk after myocardial infarction by upregulating the cardiac sodium channel

  2020cites this paper
• Association of rs2070600 in advanced glycosylation end‐product specific receptor with prognosis of heart failure

  2020cites this paper
• Regulation of SCN5A by Non-coding RNAs in the Brugada Syndrome Context

  2020cites this paper
• miR-134-5p inhibition reduces infarct-induced cardiomyocyte apoptosis via Creb1 upregulation.

  2020cites this paper
• Genome-wide association studies of cardiac electrical phenotypes

  2020influential citation
• Exploring Molecular Mechanism of Huangqi in Treating Heart Failure Using Network Pharmacology

  2020cites this paper
• Ischemic Heart Disease and Heart Failure: Role of Coronary Ion Channels

  2020cites this paper
• Non-coding RNAs and Cardiac Arrhythmias.

  2020cites this paper
• Non-coding RNAs in Cardiovascular Diseases

  2020cites this paper
• Real-Time In Vivo Imaging of Mouse Left Ventricle Reveals Fluctuating Movements of the Intercalated Discs

  2020influential citation
• MicroRNA-124 regulates cardiomyocyte apoptosis and myocardial infarction through targeting Dhcr24.

  2019cites this paper
• Mortality risks associated with sibling heart failure.

  2019cites this paper
• Tai Chi Ameliorates Coronary Heart Disease by Affecting Serum Levels of miR-24 and miR-155

  2019cites this paper
• Multiple SCN5A variant enhancers modulate its cardiac gene expression and the QT interval

  2019cites this paper
• When Knowing "Enough" May Still Not Be Enough.

  2018cites this paper
• MicroRNA-Target Interactions Reloaded: Identification of Potentially Functional Sequence Variants Within Validated MicroRNA-Target Interactions

  2018influential citation
• SCN5A: the greatest HITS collection.

  2018cites this paper