Microglia Under the Spotlight: Activity and Complement-Dependent Engulfment of Synapses.

In 2012, Schaefer et al. revealed that microglia regulate the emergence of functional connectivity by engulfing and selectively eliminating synapses in the retinogeniculate system. This synaptic pruning mechanism, which is activity dependent and relies on the complement cascade, has helped define microglia as a central contributor to normal wiring and to brain disorders.

• Publication year

  2018

• Venue

  Trends in Neurosciences

• Publication date

  2018-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.tins.2018.03.017PMID 29801526
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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