Roles of NAD (P) H-Quinone Oxidoreductase 1 (NQO1) On Cancer Progression and Chemoresistance

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Journal of Clinical & Experimental Oncology

• Publication date

  2017-07-22

• Fields of study

  Medicine

• Identifiers
  DOI 10.4172/2324-9110.1000192
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• The Nrf 2-ARE signaling pathway : An update on its regulation and possible role in cancer prevention and treatment

  2017cited by this paper
• Contradictory roles of Nrf2/Keap1 signaling pathway in cancer prevention/promotion and chemoresistance.

  2017cited by this paper
• Clinicopathological implications of NQO1 overexpression in the prognosis of pancreatic adenocarcinoma

  2017cited by this paper
• Downregulation of NAD(P)H:quinone oxidoreductase 1 inhibits proliferation, cell cycle and migration of cholangiocarcinoma cells.

  2017cited by this paper
• Overexpression of NAD(P)H:quinone oxidoreductase 1 (NQO1) and genomic gain of the NQO1 locus modulates breast cancer cell sensitivity to quinones.

  2016cited by this paper
• High expression of NQO1 is associated with poor prognosis in serous ovarian carcinoma

  2015cited by this paper
• NAD(P)H:quinone oxidoreductase-1 overexpression predicts poor prognosis in small cell lung cancer.

  2014cited by this paper
• Suppression of NAD(P)H-quinone oxidoreductase 1 enhanced the susceptibility of cholangiocarcinoma cells to chemotherapeutic agents

  2014cited by this paper
• Clinical implications of high NQO1 expression in breast cancers

  2014cited by this paper
• NQO1 overexpression is associated with poor prognosis in squamous cell carcinoma of the uterine cervix

  2014cited by this paper
• Significance of NQO1 overexpression for prognostic evaluation of gastric adenocarcinoma.

  2014cited by this paper
• [Prognostic significance of NADPH quinine oxidoreductase 1 overexpression in head and neck squamous cell carcinoma].

  2014cited by this paper
• Association of NQO1 Pro187Ser polymorphism with the risks for colorectal cancer and colorectal adenoma: a meta-analysis

  2012cited by this paper
• Upsides and Downsides of Reactive Oxygen Species for Cancer: The Roles of Reactive Oxygen Species in Tumorigenesis, Prevention, and Therapy

  2012cited by this paper
• A Functional NQO1 609C>T Polymorphism and Risk of Gastrointestinal Cancers: A Meta-Analysis

  2012cited by this paper
• NQO1 expression correlates with cholangiocarcinoma prognosis.

  2012cited by this paper
• NAD(P)H:Quinone Oxidoreductase 1 and its Potential Protective Role in Cardiovascular Diseases and Related Conditions

  2011cited by this paper
• The NQO1*2/*2 polymorphism is associated with poor overall survival in patients following resection of stages II and IIIa non-small cell lung cancer.

  2011cited by this paper
• Inhibitors of NQO1: identification of compounds more potent than dicoumarol without associated off-target effects.

  2011cited by this paper
• NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1), a multifunctional antioxidant enzyme and exceptionally versatile cytoprotector.

  2010influential reference
• The NAD(P)H:Quinone Oxidoreductase 1 induces cell cycle progression and proliferation of melanoma cells.

  2010cited by this paper
• Dicoumarol enhances doxorubicin‐induced cytotoxicity in p53 wild‐type urothelial cancer cells through p38 activation

  2010cited by this paper
• Dicoumarol enhances gemcitabine-induced cytotoxicity in high NQO1-expressing cholangiocarcinoma cells.

  2010cited by this paper
• NRH:quinone oxidoreductase 2 and NAD(P)H:quinone oxidoreductase 1 protect tumor suppressor p53 against 20s proteasomal degradation leading to stabilization and activation of p53.

  2007cited by this paper
• The p53 network: p53 and its downstream genes.

  2007cited by this paper
• Dicoumarol potentiates cisplatin-induced apoptosis mediated by c-Jun N-terminal kinase in p53 wild-type urogenital cancer cell lines

  2006cited by this paper
• Ubiquitin-independent degradation: lessons from the p53 model.

  2006cited by this paper
• Genetic deletion of NAD(P)H:quinone oxidoreductase 1 abrogates activation of nuclear factor-kappaB, IkappaBalpha kinase, c-Jun N-terminal kinase, Akt, p38, and p44/42 mitogen-activated protein kinases and potentiates apoptosis.

  2006cited by this paper
• Inhibition of NAD(P)H:quinone oxidoreductase 1 activity and induction of p53 degradation by the natural phenolic compound curcumin.

  2005cited by this paper
• NAD(P)H:quinone oxidoreductase 1: role as a superoxide scavenger.

  2004cited by this paper
• Treatment of Pancreatic Cancer Cells with Dicumarol Induces Cytotoxicity and Oxidative Stress

  2004cited by this paper
• Dicumarol inhibition of NADPH:quinone oxidoreductase induces growth inhibition of pancreatic cancer via a superoxide-mediated mechanism.

  2003cited by this paper
• Interaction of Human NAD(P)H:Quinone Oxidoreductase 1 (NQO1) with the Tumor Suppressor Protein p53 in Cells and Cell-free Systems*

  2003cited by this paper
• Genetic susceptibility to benzene-induced toxicity: role of NADPH: quinone oxidoreductase-1.

  2003cited by this paper
• NAD(P)H:quinone oxidoreductase 1 deficiency and increased susceptibility to 7,12-dimethylbenz[a]-anthracene-induced carcinogenesis in mouse skin.

  2001cited by this paper
• Expression of DT-diaphorase and cytochrome P450 reductase correlates with mitomycin C activity in human bladder tumors.

  2001cited by this paper
• Regulation of genes encoding NAD(P)H:quinone oxidoreductases.

  2000cited by this paper
• NAD(P)H:quinone oxidoreductase 1 (NQO1): chemoprotection, bioactivation, gene regulation and genetic polymorphisms.

  2000cited by this paper
• Immunodetection of NAD(P)H:quinone oxidoreductase 1 (NQO1) in human tissues.

  2000cited by this paper
• Quinone Reductase Inhibitors Block SAPK/JNK and NFκB Pathways and Potentiate Apoptosis*

  1999cited by this paper
• Immunological Quantitation of DT‐Diaphorase in Carcinoma Cell Lines and Clinical Colon Cancers: Advanced Tumors Express Greater Levels of DT‐Diaphorase

  1998cited by this paper
• Disruption of the DT Diaphorase (NQO1) Gene in Mice Leads to Increased Menadione Toxicity*

  1998cited by this paper
• p53, the Cellular Gatekeeper Review for Growth and Division

  1997cited by this paper
• Human NAD(P)H:quinone oxidoreductase (NQO1) gene structure and induction by dioxin.

  1991cited by this paper
• Clinical Pharmacology: Advances and Applications Dovepress the Clinical Potential of Influencing Nrf2 Signaling in Degenerative and Immunological Disorders

  year unknowncited by this paper

• AP-2 Transcription Factors as Regulators of Ferroptosis: A Family-Wide Profiling in Diverse Cancer Contexts

  2026cites this paper
• Recent advances in drug repositioning and rediscovery for different therapeutic activities utilizing updated technological approaches

  2025cites this paper
• Identification of rheochrysin as a potential anti-cancer inhibitor of NAD(P) H quinone oxidoreductase 1 through ensemble virtual screening, molecular dynamics, MM-GBSA and DFT.

  2025cites this paper
• Dual-Lock System for High Sensitivity and Selectivity in Redox Enzyme Activation and Imaging.

  2025cites this paper
• The Binding Capacity of the Lead Phytochemical Molecule to Cancer Cell Target Proteins and its Potential Anticancer Properties with Respect to Standard Drugs

  2024cites this paper
• Arene Variation of Highly Cytotoxic Tridentate Naphthoquinone-Based Ruthenium(II) Complexes and In-Depth In Vitro Studies

  2022cites this paper
• A bioactive ligand-conjugated iridium(III) metal-based complex as a Keap1–Nrf2 protein-protein interaction inhibitor against acetaminophen-induced acute liver injury

  2021cites this paper
• Synthesis and structure-activity relationship study of novel 3-diethoxyphosphorylfuroquinoline-4,9-diones with potent antitumor efficacy.

  2021cites this paper
• R. vesicarius L. exerts nephroprotective effect against cisplatin-induced oxidative stress

  2021influential citation
• Virtual Screening for Potential Phytobioactives as Therapeutic Leads to Inhibit NQO1 for Selective Anticancer Therapy

  2021cites this paper
• Toward Ratiometric Detection of NAD(P)H Quinone Oxidoreductase-1: Benzocoumarin-Based Fluorescent Probes

  2020cites this paper
• The Nrf2-mediated defense mechanism associated with HFE genotype limits vulnerability to oxidative stress-induced toxicity.

  2020cites this paper
• Cancer-Specific hNQO1-Responsive Biocompatible Naphthalimides Providing a Rapid Fluorescent Turn-On with an Enhanced Enzyme Affinity

  2019cites this paper
• An Activatable Photosensitizer Targeting Human NAD(P)H: Quinone Oxidoreductase 1.

  2019cites this paper
• Betulin-1,4-quinone hybrids: Synthesis, anticancer activity and molecular docking study with NQO1 enzyme.

  2019cites this paper
• Protective effect of Citrus macroptera fruit pulp juice rendering Nrf2-pathway against cisplatin-induced genotoxicity

  2018cites this paper