The disordered C-terminal domain of human DNA glycosylase NEIL1 contributes to its stability via intramolecular interactions.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Journal of Molecular Biology

• Publication date

  2013-07-10

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.jmb.2013.03.030PMID 23542007PMCID PMC3779128
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Enhancement of NEIL1 Protein-initiated Oxidized DNA Base Excision Repair by Heterogeneous Nuclear Ribonucleoprotein U (hnRNP-U) via Direct Interaction*

  2012cited by this paper
• Structural and energetic basis of allostery.

  2012cited by this paper
• Human DNA Glycosylase NEIL1’s Interactions with Downstream Repair Proteins Is Critical for Efficient Repair of Oxidized DNA Base Damage and Enhanced Cell Survival

  2012cited by this paper
• Thermodynamic Dissection of the Intrinsically Disordered N-terminal Domain of Human Glucocorticoid Receptor*

  2012cited by this paper
• Intrinsic disorder in cell signaling and gene transcription.

  2012cited by this paper
• Protein stability in the presence of cosolutes.

  2011cited by this paper
• X-ray solution scattering (SAXS) combined with crystallography and computation: defining accurate macromolecular structures, conformations and assemblies in solution.

  2011cited by this paper
• Structure of Full-length Drosophila Cryptochrome

  2011cited by this paper
• Characterizing flexible and intrinsically unstructured biological macromolecules by SAS using the Porod-Debye law.

  2011cited by this paper
• Intrinsically disordered proteins from A to Z.

  2011cited by this paper
• Human flap endonuclease structures, DNA double-base flipping, and a unified understanding of the FEN1 superfamily.

  2011cited by this paper
• Bridging the solution divide: comprehensive structural analyses of dynamic RNA, DNA, and protein assemblies by small-angle X-ray scattering.

  2010cited by this paper
• Specific Inhibition of NEIL-initiated Repair of Oxidized Base Damage in Human Genome by Copper and Iron

  2010cited by this paper
• The mouse ortholog of NEIL3 is a functional DNA glycosylase in vitro and in vivo

  2010cited by this paper
• Functions of disordered regions in mammalian early base excision repair proteins

  2010cited by this paper
• RPA physically interacts with the human DNA glycosylase NEIL1 to regulate excision of oxidative DNA base damage in primer-template structures.

  2010cited by this paper
• Structural dynamics in DNA damage signaling and repair.

  2010cited by this paper
• An Ensemble View of Allostery

  2010cited by this paper
• Software for the high-throughput collection of SAXS data using an enhanced Blu-Ice/DCS control system

  2010cited by this paper
• FoXS: a web server for rapid computation and fitting of SAXS profiles

  2010cited by this paper
• Structural basis for recognition of 5′-phosphotyrosine adducts by TDP2

  2009cited by this paper
• Robust, high-throughput solution structural analyses by small angle X-ray scattering (SAXS)

  2009cited by this paper
• Ku and DNA-dependent Protein Kinase Dynamic Conformations and Assembly Regulate DNA Binding and the Initial Non-homologous End Joining Complex*

  2009cited by this paper
• Rational modulation of conformational fluctuations in adenylate kinase reveals a local unfolding mechanism for allostery and functional adaptation in proteins

  2009cited by this paper
• Nbs1 flexibly tethers Ctp1 and Mre11-Rad50 to coordinate DNA double-strand break processing and repair.

  2009cited by this paper
• Structure and flexibility within proteins as identified through small angle X-ray scattering.

  2009cited by this paper
• Interaction of the Human DNA Glycosylase NEIL1 with Proliferating Cell Nuclear Antigen

  2008cited by this paper
• Early steps in the DNA base excision/single-strand interruption repair pathway in mammalian cells

  2008cited by this paper
• Physical and Functional Interaction between Human Oxidized Base-specific DNA Glycosylase NEIL1 and Flap Endonuclease 1*

  2008cited by this paper
• ATSAS 2.1 – towards automated and web-supported small-angle scattering data analysis

  2007cited by this paper
• Intrinsic disorder as a mechanism to optimize allosteric coupling in proteins

  2007cited by this paper
• The intricate structural chemistry of base excision repair machinery: implications for DNA damage recognition, removal, and repair.

  2007cited by this paper
• The Human Werner Syndrome Protein Stimulates Repair of Oxidative DNA Base Damage by the DNA Glycosylase NEIL1*

  2007cited by this paper
• DNA induces folding in alpha-synuclein: understanding the mechanism using chaperone property of osmolytes.

  2007cited by this paper
• A flexible interface between DNA ligase and PCNA supports conformational switching and efficient ligation of DNA.

  2006cited by this paper
• Structural analysis of flexible proteins in solution by small angle X-ray scattering combined with crystallography.

  2006cited by this paper
• Intrinsic disorder in transcription factors.

  2006cited by this paper
• DNA repair: from molecular mechanism to human disease.

  2006cited by this paper
• Visualization of transient encounter complexes in protein–protein association

  2006cited by this paper
• DNA base damage recognition and removal: new twists and grooves.

  2005cited by this paper
• Intrinsically unstructured proteins and their functions

  2005cited by this paper
• The crystal structure of human endonuclease VIII-like 1 (NEIL1) reveals a zincless finger motif required for glycosylase activity.

  2004cited by this paper
• UCSF Chimera—A visualization system for exploratory research and analysis

  2004cited by this paper
• AP endonuclease-independent DNA base excision repair in human cells.

  2004cited by this paper
• Full‐length archaeal Rad51 structure and mutants: mechanisms for RAD51 assembly and control by BRCA2

  2003cited by this paper
• Repair of Oxidized Bases in DNA Bubble Structures by Human DNA Glycosylases NEIL1 and NEIL2*

  2003cited by this paper
• Coupling of folding and binding for unstructured proteins.

  2002cited by this paper
• A novel human DNA glycosylase that removes oxidative DNA damage and is homologous to Escherichia coli endonuclease VIII.

  2002cited by this paper
• Intrinsically unstructured proteins.

  2002cited by this paper
• Identification and Characterization of a Novel Human DNA Glycosylase for Repair of Cytosine-derived Lesions*

  2002cited by this paper
• Identification and characterization of a human DNA glycosylase for repair of modified bases in oxidatively damaged DNA

  2002cited by this paper
• Protein mimicry of DNA from crystal structures of the uracil-DNA glycosylase inhibitor protein and its complex with Escherichia coli uracil-DNA glycosylase.

  1999cited by this paper
• Structure of the DNA repair and replication endonuclease and exonuclease FEN-1: coupling DNA and PCNA binding to FEN-1 activity.

  1998cited by this paper
• The peptide backbone plays a dominant role in protein stabilization by naturally occurring osmolytes.

  1995cited by this paper
• Electrostatic orientation of the electron-transfer complex between plastocyanin and cytochrome c.

  1991cited by this paper
• The reactivity of anti-peptide antibodies is a function of the atomic mobility of sites in a protein

  1984cited by this paper
• Electrostatic recognition between superoxide and copper, zinc superoxide dismutase

  1983cited by this paper
• Validity of the “two‐state” hypothesis for conformational transitions of proteins

  1966cited by this paper

• Development and characterization of a novel NEIL1 nanobody.

  2025cites this paper
• The Functional Significance of Intrinsic Disorder in Enzymes.

  2025cites this paper
• Research progress on the role of the NEIL family in cancer

  2025cites this paper
• Divergent structures of Mammalian and gammaherpesvirus uracil DNA glycosylases confer distinct DNA binding and substrate activity.

  2023cites this paper
• How the Intrinsically Disordered N-Terminus of Cancer/Testis Antigen MAGEA10 Is Responsible for Its Expression, Nuclear Localisation and Aberrant Migration

  2023cites this paper
• Universally Accessible Structural Data on Macromolecular Conformation, Assembly, and Dynamics by Small Angle X-Ray Scattering for DNA Repair Insights.

  2022cites this paper
• Noncatalytic Domains in DNA Glycosylases

  2022cites this paper
• X‐ray scattering reveals disordered linkers and dynamic interfaces in complexes and mechanisms for DNA double‐strand break repair impacting cell and cancer biology

  2021cites this paper
• Molecular basis and functional consequences of the interaction between the base excision repair DNA glycosylase NEIL1 and RPA

  2021cites this paper
• Heritable pattern of oxidized DNA base repair coincides with pre-targeting of repair complexes to open chromatin

  2020cites this paper
• Unique structural features of mammalian NEIL2 DNA glycosylase prime its activity for diverse DNA substrates and environments

  2020cites this paper
• Macromolecular crowding induces compaction and DNA binding in the disordered N-terminal domain of hUNG2.

  2019cites this paper
• A multi-faceted genotoxic network of alpha-synuclein in the nucleus and mitochondria of dopaminergic neurons in Parkinson's disease: Emerging concepts and challenges.

  2019cites this paper
• The C-terminal tail of the NEIL1 DNA glycosylase interacts with the human mitochondrial single-stranded DNA binding protein.

  2018influential citation
• The C-terminal part of the human cytomegalovirus terminase subunit pUL51 is central for terminase complex assembly.

  2018cites this paper
• Acetylation of oxidized base repair-initiating NEIL1 DNA glycosylase required for chromatin-bound repair complex formation in the human genome increases cellular resistance to oxidative stress.

  2018cites this paper
• Regulation of Oxidized Base Repair in Human Chromatin by Posttranslational Modification

  2018cites this paper
• Pre-Replicative Repair of Oxidized Bases Maintains Fidelity in Mammalian Genomes: The Cowcatcher Role of NEIL1 DNA Glycosylase

  2017cites this paper
• Not an exception to the rule: the functional significance of intrinsically disordered protein regions in enzymes.

  2017cites this paper
• What Combined Measurements From Structures and Imaging Tell Us About DNA Damage Responses.

  2017cites this paper
• Crystal structure of mimivirus uracil-DNA glycosylase

  2017cites this paper
• Mechanisms and Dynamics of Oxidative DNA Damage Repair in Nucleosomes

  2016cites this paper
• Destabilization of the PCNA trimer mediated by its interaction with the NEIL1 DNA glycosylase

  2016influential citation
• Characterization of substrate binding and enzymatic removal of a 3-methyladenine lesion from genomic DNA with TAG of MDR A. baumannii.

  2016cites this paper
• Human Apurinic/Apyrimidinic Endonuclease (APE1) Is Acetylated at DNA Damage Sites in Chromatin, and Acetylation Modulates Its DNA Repair Activity

  2016cites this paper
• Regulation of limited N-terminal proteolysis of APE1 in tumor via acetylation and its role in cell proliferation

  2016cites this paper
• Tautomerization-dependent recognition and excision of oxidation damage in base-excision DNA repair

  2016cites this paper
• Conformational characterization of the intrinsically disordered protein Chibby: Interplay between structural elements in target recognition

  2016cites this paper
• Phosphorylation Sites Identified in the NEIL1 DNA Glycosylase Are Potential Targets for the JNK1 Kinase

  2016cites this paper
• Intrinsic Disorder Where You Least Expect It: The Incidence and Functional Relevance of Intrinsic Disorder in Enzymes and the Protein Data Bank

  2016cites this paper
• Envisioning the dynamics and flexibility of Mre11-Rad50-Nbs1 complex to decipher its roles in DNA replication and repair.

  2015cites this paper
• Intrinsically disordered proteins: emerging interaction specialists.

  2015cites this paper
• Dynamic structures in DNA damage responses & cancer.

  2015cites this paper
• Distinct functional consequences of MUTYH variants associated with colorectal cancer: Damaged DNA affinity, glycosylase activity and interaction with PCNA and Hus1.

  2015cites this paper
• The C-terminal Domain (CTD) of Human DNA Glycosylase NEIL1 Is Required for Forming BERosome Repair Complex with DNA Replication Proteins at the Replicating Genome

  2015cites this paper
• Regulation of NEIL1 protein abundance by RAD9 is important for efficient base excision repair

  2015cites this paper
• New paradigms in the repair of oxidative damage in human genome: mechanisms ensuring repair of mutagenic base lesions during replication and involvement of accessory proteins

  2015cites this paper
• Intrinsically disordered proteins and multicellular organisms.

  2015cites this paper
• Intrinsically disordered proteins and intrinsically disordered protein regions.

  2014cites this paper
• OPTIMIZING HYDROPATHY SCALE TO IMPROVE IDP PREDICTION AND CHARACTERIZING IDPS' FUNCTIONS

  2014cites this paper
• A role of disordered domains in regulating protein oligomerization and stability.

  2014cites this paper
• The Role of AF9 and AF9-Mediated Protein Interactions in Hematopoiesis and Leukemogenesis

  2014cites this paper
• The illusive search for the lowest free energy state of globular proteins and RNAs.

  2014cites this paper
• Base excision repair: a critical player in many games.

  2014cites this paper
• Intrinsic Disorder and Allostery in Glucocorticoid Receptor

  2014cites this paper
• Digested disorder

  2014cites this paper
• The most important thing is the tail: Multitudinous functionalities of intrinsically disordered protein termini

  2013cites this paper
• Regulation of biological function by allosteric interactions.

  2013cites this paper
• Prereplicative repair of oxidized bases in the human genome is mediated by NEIL1 DNA glycosylase together with replication proteins

  2013cites this paper