Phage display as a novel promising antivenom therapy: a review.

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Toxicon

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.toxicon.2014.11.001PMID 25447775
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Serrumab: A novel human single chain-fragment antibody with multiple scorpion toxin-neutralizing capacities

  2014cited by this paper
• A novel human recombinant antibody fragment capable of neutralizing Mexican scorpion toxins.

  2013cited by this paper
• Prospective identification of parasitic sequences in phage display screens

  2013cited by this paper
• Human antibody fragments specific for Bothrops jararacussu venom reduce the toxicity of other Bothrops sp. venoms

  2013cited by this paper
• 2012 Annual Report of the American Association of Poison Control Centers’ National Poison Data System (NPDS): 30th Annual Report

  2013cited by this paper
• Assessing the preclinical efficacy of antivenoms: from the lethality neutralization assay to antivenomics.

  2013cited by this paper
• Pathogenic mechanisms underlying adverse reactions induced by intravenous administration of snake antivenoms.

  2013cited by this paper
• Serrumab: A human monoclonal antibody that counters the biochemical and immunological effects of Tityus serrulatus venom

  2012cited by this paper
• Production of human antibody fragments binding to melittin and phospholipase A2 in Africanised bee venom: minimising venom toxicity.

  2012cited by this paper
• Diversity of Phage-Displayed Libraries of Peptides during Panning and Amplification

  2011cited by this paper
• Protection against the toxic effects of Loxosceles intermedia spider venom elicited by mimotope peptides.

  2011cited by this paper
• Lonomia obliqua venom: In vivo effects and molecular aspects associated with the hemorrhagic syndrome.

  2010cited by this paper
• Strategies and challenges for the next generation of therapeutic antibodies

  2010cited by this paper
• Mining on scorpion venom biodiversity.

  2010cited by this paper
• Exploiting Cross-reactivity to Neutralize Two Different Scorpion Venoms with One Single Chain Antibody Fragment*

  2010cited by this paper
• A bispecific nanobody to provide full protection against lethal scorpion envenoming

  2010cited by this paper
• Toxins and venoms.

  2009cited by this paper
• A compact phage display human scFv library for selection of antibodies to a wide variety of antigens

  2009cited by this paper
• Identification of potent nanobodies to neutralize the most poisonous polypeptide from scorpion venom.

  2009cited by this paper
• Expression of human recombinant antibody fragments capable of partially inhibiting the phospholypase activity of Crotalus durissus terrificus venom.

  2009cited by this paper
• VHH, bivalent domains and chimeric Heavy chain-only antibodies with high neutralizing efficacy for scorpion toxin AahI'.

  2008cited by this paper
• Trends in snakebite envenomation therapy: scientific, technological and public health considerations.

  2007cited by this paper
• A fast and efficient procedure to produce scFvs specific for large macromolecular complexes.

  2007cited by this paper
• Expression of recombinant human antibody fragments capable of inhibiting the phospholipase and myotoxic activities of Bothrops jararacussu venom.

  2006cited by this paper
• Potent antibody therapeutics by design

  2006cited by this paper
• Selecting and screening recombinant antibody libraries

  2005cited by this paper
• Generation of high-affinity human antibodies by combining donor-derived and synthetic complementarity-determining-region diversity

  2005cited by this paper
• The protein composition of honeybee venom reconsidered by a proteomic approach.

  2005cited by this paper
• Engineered antibody fragments and the rise of single domains

  2005cited by this paper
• A strategy for the generation of specific human antibodies by directed evolution and phage display

  2005cited by this paper
• A novel helper phage that improves phage display selection efficiency by preventing the amplification of phages without recombinant protein.

  2003cited by this paper
• Research Article Design and evaluation of a diabody to improve protection against a potent scorpion neurotoxin

  2003cited by this paper
• Molecular localization and crossreactivity of two epitopes of noxiustoxin from scorpion Centruroides noxius, identified by a panel of monoclonal antibodies and peptide mimotopes.

  2002cited by this paper
• “Superhumanized” Antibodies: Reduction of Immunogenic Potential by Complementarity-Determining Region Grafting with Human Germline Sequences: Application to an Anti-CD281

  2002cited by this paper
• Neutralizing Human Anti Crotoxin scFv Isolated from a Nonimmunized Phage Library

  2000cited by this paper
• Adaptive evolution of animal toxin multigene families.

  2000cited by this paper
• Isolation and structure-functional characterization of phage display library-derived mimotopes of noxiustoxin, a neurotoxin of the scorpion Centruroides noxius Hoffmann.

  2000cited by this paper
• Mass envenomations by honey bees and wasps.

  1999cited by this paper
• Comparative study on the ability of IgG and F(ab')2 antivenoms to neutralize lethal and myotoxic effects induced by Micrurus nigrocinctus (coral snake) venom.

  1999cited by this paper
• Venoms, antivenoms and immunotherapy.

  1998cited by this paper
• Antibody engineering: comparison of bacterial, yeast, insect and mammalian expression systems.

  1998cited by this paper
• Functional architectures of animal toxins: a clue to drug design?

  1998cited by this paper
• Antibody phage display technology and its applications.

  1998cited by this paper
• Specificity and binding affinity of an anti-crotoxin combinatorial antibody selected from a phage-displayed library.

  1995cited by this paper
• Snake venom variability: methods of study, results and interpretation.

  1991cited by this paper
• [The mechanism of diphtheria immunity and tetanus immunity in animals. 1890].

  1991cited by this paper
• Ueber das zustandekommen der diphtherie-immunität und der tetanus-immunität bei thieren☆

  1991cited by this paper
• Phage antibodies: filamentous phage displaying antibody variable domains

  1990cited by this paper
• Proteolytic, hemorrhagic and hemolytic activities of snake venoms.

  1988cited by this paper
• Ability of a polyvalent antivenom to neutralize the venom of Lachesis muta melanocephala, a new Costa Rican subspecies of the bushmaster.

  1987cited by this paper
• Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface.

  1985cited by this paper
• Chimeric human antibody molecules: mouse antigen-binding domains with human constant region domains.

  1984cited by this paper
• Emil Behring and Paul Ehrlich: Their Contributions to Science

  1955cited by this paper
• The Action of Proteolytic Enzymes on the Antitoxins and Proteins in Immune Sera: I. True Digestion of the Proteins

  1939cited by this paper
• The Action of Proteolytic Enzymes on the Antitoxins and Proteins in Immune Sera: II. Heat Denaturation after Partial Enzyme Action.

  1939cited by this paper

• Affinity-maturation engineering via phage display to optimize anti-idiotype antibodies for neutralizing antibody assays.

  2026cites this paper
• Practical progress towards the development of recombinant antivenoms for snakebite envenoming

  2025cites this paper
• Optimization of Culture Conditions for Expression of Anti-lipopolysaccharide Single Domain Antibody Clone in Pichia pastoris

  2025cites this paper
• Taking the sting out of scorpions: Electrophysiological investigation of the relative efficacy of three antivenoms against medically significant Centruroides species.

  2024cites this paper
• Pharmacokinetic evaluation of a single chain antibody fragment against scorpion toxins in sheep.

  2024cites this paper
• Revolutionizing snakebite care with novel antivenoms: Breakthroughs and barriers

  2024cites this paper
• Characterization of Sodium Channel Peptides Obtained from the Venom of the Scorpion Centruroides bonito

  2024cites this paper
• Progress and Challenges in the Field of Snakebite Envenoming Therapeutics.

  2024cites this paper
• A personal view on the history of toxins: from ancient times to artificial intelligence.

  2024cites this paper
• Recombinant human scFv antibody fragments against phospholipase A2 from Naja naja and Echis carinatus snake venoms: In vivo neutralization and mechanistic insights.

  2023cites this paper
• The Need for Next-Generation Antivenom for Snakebite Envenomation in India

  2023cites this paper
• Antibodies against Elapidae and Viperidae snake venoms: in vivo neutralization and mechanistic insights

  2023cites this paper
• Applications of the phage display technology in molecular biology, biotechnology and medicine

  2023influential citation
• Discovery and optimization of a broadly-neutralizing human monoclonal antibody against long-chain α-neurotoxins from snakes

  2023cites this paper
• Preparation and Evaluation of a Horse Antiserum against the Venom of Sea Snake Hydrophis curtus from Hainan, China

  2022cites this paper
• Current situation of snakebites envenomation in the Neotropics: Biotechnology, a versatile tool in the production of antivenoms.

  2022cites this paper
• Discovery of a broadly-neutralizing human antibody that can rescue mice challenged with neurotoxin-rich snake venoms

  2022cites this paper
• Predicting the Future: Phage Therapy

  2022cites this paper
• Developing a computational pharmacokinetic model of systemic snakebite envenomation and antivenom treatment.

  2022cites this paper
• Identification and characterization of a monoclonal antibody blocking the SARS-CoV-2 spike protein–ACE2 interaction

  2021cites this paper
• Chicken egg yolk antibodies (IgY)-based antivenom for neutralization of snake venoms: a review

  2021cites this paper
• Snake Antivenom: challenges and alternate approaches.

  2020cites this paper
• Antivenom Neutralization of Coagulopathic Snake Venom Toxins Assessed by Bioactivity Profiling Using Nanofractionation Analytics

  2020cites this paper
• Genomic characterization of a novel virulent phage infecting Shigella fiexneri and isolated from sewage.

  2020cites this paper
• Toxinology provides multidirectional and multidimensional opportunities: A personal perspective

  2020cites this paper
• Recombinant antibodies against Iranian cobra venom as a new emerging therapy by phage display technology

  2020cites this paper
• Naja naja (Indian Cobra).

  2020cites this paper
• Multifunctional Toxins in Snake Venoms and Therapeutic Implications: From Pain to Hemorrhage and Necrosis

  2019cites this paper
• Linear mimotope analysis of Iranian cobra (Naja oxiana) snake venom using peptide displayed phage library

  2019cites this paper
• Pros and cons of different therapeutic antibody formats for recombinant antivenom development

  2018cites this paper
• Production of a Human Recombinant Polyclonal Fab Antivenom against Iranian Viper Echis carinatus.

  2018cites this paper
• Biosynthetic Oligoclonal Antivenom (BOA) for Snakebite and Next-Generation Treatments for Snakebite Victims †

  2018cites this paper
• In vivo neutralization of dendrotoxin-mediated neurotoxicity of black mamba venom by oligoclonal human IgG antibodies

  2018cites this paper
• Basics of Antibody Phage Display Technology

  2018cites this paper
• Discovery of human scFvs that cross-neutralize the toxic effects of B. jararacussu and C. d. terrificus venoms.

  2018cites this paper
• Recombinant snakebite antivenoms: A cost-competitive solution to a neglected tropical disease?

  2017cites this paper
• Guiding recombinant antivenom development by omics technologies.

  2017cites this paper
• Pitfalls to avoid when using phage display for snake toxins

  2017influential citation
• Genetically modified bacteriophages.

  2016cites this paper
• Algae-Made Antibodies and Immunotoxins

  2016cites this paper
• Phage Therapy in Bacterial Infections Treatment: One Hundred Years After the Discovery of Bacteriophages

  2016cites this paper
• Toxin synergism in snake venoms

  2016cites this paper
• Algae-Based Biopharmaceuticals

  2016cites this paper
• Human scFv antibodies (Afribumabs) against Africanized bee venom: Advances in melittin recognition.

  2016cites this paper
• Soluble Expression and Characterization of a New scFv Directed to Human CD123

  2016cites this paper
• Tityus serrulatus venom--A lethal cocktail.

  2015cites this paper
• Snake venomics of monocled cobra (Naja kaouthia) and investigation of human IgG response against venom toxins.

  2015cites this paper