CXCR4 Signaling Negatively Modulates the Bipotential State of Hemogenic Endothelial Cells Derived from Embryonic Stem Cells by Attenuating the Endothelial Potential

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Stem Cells

• Publication date

  2016-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/stem.2441PMID 27340788
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Single-cell resolution of morphological changes in hemogenic endothelium

  2015cited by this paper
• Activin A in combination with OP9 cells facilitates development of Flk-1(+) PDGFRα(-) and Flk-1(+) PDGFRα(+) hematopoietic mesodermal cells from murine embryonic stem cells.

  2015cited by this paper
• Tracing the Origin of the HSC Hierarchy Reveals an SCF-Dependent, IL-3-Independent CD43− Embryonic Precursor

  2014cited by this paper
• Arteries are formed by vein-derived endothelial tip cells

  2014cited by this paper
• Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from MSM/Ms mice

  2013cited by this paper
• Peripheral nerve-derived CXCL12 and VEGF-A regulate the patterning of arterial vessel branching in developing limb skin.

  2013cited by this paper
• Sox17 is indispensable for acquisition and maintenance of arterial identity

  2013cited by this paper
• ETV2 expression marks blood and endothelium precursors, including hemogenic endothelium, at the onset of blood development

  2012cited by this paper
• Hierarchical organization and early hematopoietic specification of the developing HSC lineage in the AGM region

  2011cited by this paper
• Microarray analysis of retinal endothelial tip cells identifies CXCR4 as a mediator of tip cell morphology and branching.

  2010cited by this paper
• In vivo imaging of haematopoietic cells emerging from the mouse aortic endothelium

  2010cited by this paper
• Induction of myogenic differentiation by SDF‐1 via CXCR4 and CXCR7 receptors

  2010cited by this paper
• CXCR4 promotes differentiation of oligodendrocyte progenitors and remyelination

  2010cited by this paper
• A Runx1 Intronic Enhancer Marks Hemogenic Endothelial Cells and Hematopoietic Stem Cells

  2010cited by this paper
• The haemangioblast generates haematopoietic cells through a haemogenic endothelium stage

  2009cited by this paper
• Continuous single-cell imaging of blood generation from haemogenic endothelium

  2009cited by this paper
• Runx1 is required for the endothelial to hematopoietic cell transition but not thereafter

  2009cited by this paper
• Foxo1 is essential for in vitro vascular formation from embryonic stem cells.

  2009cited by this paper
• The CXCL12 (SDF-1)/CXCR4 axis is essential for the development of renal vasculature.

  2009cited by this paper
• Fate tracing reveals the endothelial origin of hematopoietic stem cells.

  2008cited by this paper
• ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specification.

  2008cited by this paper
• Distinct hemogenic potential of endothelial cells and CD41+ cells in mouse embryos

  2007cited by this paper
• The forkhead transcription factors, Foxc1 and Foxc2, are required for arterial specification and lymphatic sprouting during vascular development.

  2006cited by this paper
• Progressive divergence of definitive haematopoietic stem cells from the endothelial compartment does not depend on contact with the foetal liver

  2005cited by this paper
• Tracking mesoderm induction and its specification to the hemangioblast during embryonic stem cell differentiation

  2003cited by this paper
• SCL/tal‐1‐dependent process determines a competence to select the definitive hematopoietic lineage prior to endothelial differentiation

  2002cited by this paper
• Hematopoietic stem cells localize to the endothelial cell layer in the midgestation mouse aorta.

  2002cited by this paper
• Chemokine receptor inhibition by AMD3100 is strictly confined to CXCR4

  2002cited by this paper
• Requirement of Runx1/AML1/PEBP2αB for the generation of haematopoietic cells from endothelial cells

  2001cited by this paper
• Expression of alpha4-integrin defines the earliest precursor of hematopoietic cell lineage diverged from endothelial cells.

  1999cited by this paper
• AML1(−/−) embryos do not express certain hematopoiesis-related gene transcripts including those of the PU.1 gene

  1998cited by this paper
• In vitro generation of lymphohematopoietic cells from endothelial cells purified from murine embryos.

  1998cited by this paper
• Progressive lineage analysis by cell sorting and culture identifies FLK1+VE-cadherin+ cells at a diverging point of endothelial and hemopoietic lineages.

  1998cited by this paper
• The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract

  1998cited by this paper
• AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis.

  1996cited by this paper
• Definitive hematopoiesis is autonomously initiated by the AGM region.

  1996cited by this paper
• Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis.

  1996cited by this paper
• Involvement of the c-kit receptor in the adhesion of hematopoietic stem cells to stromal cells.

  1994cited by this paper

• Characterization of the mammalian prodefinitive angio-hematopoietic lineage.

  2025cites this paper
• Cross-species transcriptomics reveals bifurcation point during the arterial-to-hemogenic transition

  2023cites this paper
• Engineering a niche supporting hematopoietic stem cell development using integrated single-cell transcriptomics

  2022cites this paper
• CD34dim cells identified as pluripotent stem cell‐derived definitive hemogenic endothelium purified using bone morphogenetic protein 4

  2022cites this paper
• Enhanced HSC-like cell generation from mouse pluripotent stem cells in a 3D induction system cocultured with stromal cells

  2021cites this paper
• Identification of Novel Hemangioblast Genes in the Early Chick Embryo

  2018cites this paper
• Morphology regulation in vascular endothelial cells

  2018cites this paper
• Instructions for use Title Vascular formation : in vitro differentiation of vascular endothelial cells from pluripotent stem cells

  2018cites this paper
• Vascular formation : in vitro differentiation of vascular endothelial cells from pluripotent stem cells

  2017cites this paper
• Etv2 as an essential regulator of mesodermal lineage development.

  2017cites this paper