Interference with Clp protease impairs carotenoid accumulation during tomato fruit ripening

The stromal Clp protease complex influences chromoplast differentiation and ensures proper carotenoid metabolism during tomato fruit ripening, probably in co-ordination with plastidial chaperones.

• Publication year

  2018

• Venue

  Journal of Experimental Botany

• Publication date

  2018-01-29

• Fields of study

  Biology, Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1093/jxb/erx491PMID 29385595PMCID 5888976
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Interference with plastome gene expression and Clp protease activity in Arabidopsis triggers a chloroplast unfolded protein response to restore protein homeostasis

  2017influential reference
• A chemical genetic roadmap to improved tomato flavor

  2017cited by this paper
• The Epigenome and Transcriptional Dynamics of Fruit Ripening.

  2017cited by this paper
• ClpB/Hsp100 proteins and heat stress tolerance in plants

  2016influential reference
• Tomato fruit carotenoid biosynthesis is adjusted to actual ripening progression by a light-dependent mechanism.

  2016cited by this paper
• Chloroplast Proteases: Updates on Proteolysis within and across Suborganellar Compartments1[OPEN]

  2016cited by this paper
• Selection of Reference Genes for Quantitative Real-Time RT-PCR Studies in Tomato Fruit of the Genotype MT-Rg1

  2016cited by this paper
• Differential Subplastidial Localization and Turnover of Enzymes Involved in Isoprenoid Biosynthesis in Chloroplasts

  2016cited by this paper
• Orange protein has a role in phytoene synthase stabilization in sweetpotato

  2016cited by this paper
• A Comprehensive Analysis of Carotenoid Cleavage Dioxygenases Genes in Solanum Lycopersicum

  2016cited by this paper
• Specific Hsp100 Chaperones Determine the Fate of the First Enzyme of the Plastidial Isoprenoid Pathway for Either Refolding or Degradation by the Stromal Clp Protease in Arabidopsis

  2016cited by this paper
• Evolutionary Recycling of Light Signaling Components in Fleshy Fruits: New Insights on the Role of Pigments to Monitor Ripening

  2016cited by this paper
• Distinct Mechanisms of the ORANGE Protein in Controlling Carotenoid Flux1[OPEN]

  2016cited by this paper
• A Comprehensive Analysis of Chromoplast Differentiation Reveals Complex Protein Changes Associated with Plastoglobule Biogenesis and Remodeling of Protein Systems in Sweet Orange Flesh1[OPEN]

  2015cited by this paper
• Plastid Proteomic Analysis in Tomato Fruit Development

  2015cited by this paper
• Exploring the diversity in Citrus fruit colouration to decipher the relationship between plastid ultrastructure and carotenoid composition

  2015cited by this paper
• Conditional repression of essential chloroplast genes: Evidence for new plastid signaling pathways.

  2015cited by this paper
• Organization, function and substrates of the essential Clp protease system in plastids.

  2015cited by this paper
• A Single Amino Acid Substitution in an ORANGE Protein Promotes Carotenoid Overaccumulation in Arabidopsis1[OPEN]

  2015cited by this paper
• Arabidopsis OR proteins are the major posttranscriptional regulators of phytoene synthase in controlling carotenoid biosynthesis

  2015cited by this paper
• Fruit development and ripening

  2014cited by this paper
• Faculty Opinions recommendation of Deoxyxylulose 5-Phosphate Synthase Controls Flux through the Methylerythritol 4-Phosphate Pathway in Arabidopsis.

  2014cited by this paper
• Regulation of carotenoid metabolism in tomato.

  2014cited by this paper
• Conditional Depletion of the Chlamydomonas Chloroplast ClpP Protease Activates Nuclear Genes Involved in Autophagy and Plastid Protein Quality Control[W]

  2014cited by this paper
• Genetic regulation and structural changes during tomato fruit development and ripening

  2014cited by this paper
• Deoxyxylulose 5-Phosphate Synthase Controls Flux through the Methylerythritol 4-Phosphate Pathway in Arabidopsis1[C][W][OPEN]

  2014cited by this paper
• Chromoplast biogenesis and carotenoid accumulation.

  2013cited by this paper
• Subchromoplast Sequestration of Carotenoids Affects Regulatory Mechanisms in Tomato Lines Expressing Different Carotenoid Gene Combinations[C][W]

  2013cited by this paper
• Building phylogenetic trees from molecular data with MEGA.

  2013cited by this paper
• Arabidopsis J-Protein J20 Delivers the First Enzyme of the Plastidial Isoprenoid Pathway to Protein Quality Control[C][W]

  2013influential reference
• Fruit development and ripening.

  2013cited by this paper
• Proteomic Analysis of Chloroplast-to-Chromoplast Transition in Tomato Reveals Metabolic Shifts Coupled with Disrupted Thylakoid Biogenesis Machinery and Elevated Energy-Production Components1[W]

  2012cited by this paper
• Characterization of P450 carotenoid beta- and epsilon-hydroxylases of tomato and transcriptional regulation of xanthophyll biosynthesis in root, leaf, petal and fruit.

  2011cited by this paper
• Resolution and segmentation of hyperspectral biomedical images by multivariate curve resolution-alternating least squares.

  2011cited by this paper
• Flexible Tools for Gene Expression and Silencing in Tomato1[W][OA]

  2009cited by this paper
• Carotenoid Crystal Formation in Arabidopsis and Carrot Roots Caused by Increased Phytoene Synthase Protein Levels

  2009cited by this paper
• Subunits of the Plastid ClpPR Protease Complex Have Differential Contributions to Embryogenesis, Plastid Biogenesis, and Plant Development in Arabidopsis[C][W]

  2009cited by this paper
• Genetic engineering of carotenoid formation in tomato fruit and the potential application of systems and synthetic biology approaches.

  2009cited by this paper
• A multisite gateway-based toolkit for targeted gene expression and hairpin RNA silencing in tomato fruits.

  2009cited by this paper
• Gene silencing in plants using artificial microRNAs and other small RNAs.

  2008cited by this paper
• BMC Plant Biology BioMed Central

  2008cited by this paper
• A Mutant Impaired in the Production of Plastome-Encoded Proteins Uncovers a Mechanism for the Homeostasis of Isoprenoid Biosynthetic Enzymes in Arabidopsis Plastids[W]

  2008cited by this paper
• Highly Specific Gene Silencing by Artificial MicroRNAs in Arabidopsis[W][OA]

  2006cited by this paper
• An Arabidopsis thaliana virescent mutant reveals a role for ClpR1 in plastid development

  2006cited by this paper
• Protein degradation machineries in plastids.

  2006cited by this paper
• A graphical user-friendly interface for MCR-ALS: a new tool for multivariate curve resolution in MATLAB

  2005cited by this paper
• Dual Role for Tomato Heat Shock Protein 21: Protecting Photosystem II from Oxidative Stress and Promoting Color Changes during Fruit Maturation

  2005cited by this paper
• Distinct Light-Mediated Pathways Regulate the Biosynthesis and Exchange of Isoprenoid Precursors during Arabidopsis Seedling Development Article, publication date, and citation information can be found at www.plantcell.org/cgi/doi/10.1105/tpc.016204.

  2004cited by this paper
• Metabolic engineering of the mevalonate and non-mevalonate isopentenyl diphosphate-forming pathways for the production of health-promoting isoprenoids in tomato.

  2004cited by this paper
• The tomato carotenoid cleavage dioxygenase 1 genes contribute to the formation of the flavor volatiles beta-ionone, pseudoionone, and geranylacetone.

  2004cited by this paper
• Clp Protease Complexes from Photosynthetic and Non-photosynthetic Plastids and Mitochondria of Plants, Their Predicted Three-dimensional Structures, and Functional Implications*

  2004cited by this paper
• MUSCLE: multiple sequence alignment with high accuracy and high throughput.

  2004cited by this paper
• Evaluation of transgenic tomato plants expressing an additional phytoene synthase in a fruit-specific manner

  2002cited by this paper
• Carotenoid biosynthesis during tomato fruit development: regulatory role of 1-deoxy-D-xylulose 5-phosphate synthase.

  2000cited by this paper
• Regulation of carotenoid biosynthesis during tomato fruit development: expression of the gene for lycopene epsilon-cyclase is down-regulated during ripening and is elevated in the mutant Delta.

  1999cited by this paper
• Cloning and characterization of the cDNA for lycopene β-cyclase from tomato reveals decrease in its expression during fruit ripening

  1996cited by this paper
• Reversible Inhibition of Tomato Fruit Gene Expression at High Temperature (Effects on Tomato Fruit Ripening)

  1996cited by this paper

• Family alliances feeding the carotenoid pathway in tomato

  2025cites this paper
• ORANGE family proteins: multifunctional chaperones shaping plant carotenoid level, plastid development, stress tolerance, and more

  2025cites this paper
• Recent advance on the physiological functions of proteases in chloroplast.

  2025cites this paper
• The Deg5 and Deg8 thylakoid lumenal proteases are dispensable for photosynthesis and fruit ripening in Solanum lycopersicum.

  2025cites this paper
• Tomato ripening regulator SlSAD8 disturbs nuclear gene transcription and chloroplast-associated protein degradation

  2025cites this paper
• Comprehensive metabolome and transcriptome analyses shed light on the regulation of SlNF-YA3b in carotenoid biosynthesis in tomato fruit

  2025cites this paper
• Update on carotenoid and apocarotenoid metabolisms and functions in plants.

  2025cites this paper
• Silencing an ATP-Dependent Caseinolytic Protease Proteolytic Subunit Gene Enhances the Resistance of Rice to Nilaparvata lugens

  2024cites this paper
• Carotenoids in berries: Composition, benefits, metabolic processes and influencing factors - A review

  2024cites this paper
• Nudix hydrolase 23 post-translationally regulates carotenoid biosynthesis in plants.

  2024cites this paper
• Effect of Ultraviolet B Radiation on the Biosynthesis of Carotenoids in Foxtail Millet Grains

  2024cites this paper
• The variegated canalized-1 tomato mutant is linked to photosystem assembly

  2024cites this paper
• The role of SlCHRC in carotenoid biosynthesis and plastid development in tomato fruit.

  2024cites this paper
• Diversity in plastids contributes to variation in fruit color

  2024cites this paper
• Research progress on differentiation and regulation of plant chromoplasts

  2024cites this paper
• Intra-chloroplast proteases: A holistic network view of chloroplast proteolysis.

  2024cites this paper
• Histone H3K27 Demethylase SlJMJ3 Modulates Fruit Ripening in Tomato.

  2024cites this paper
• (E)-2-hexenal regulates the chloroplast degradation in tomatoes

  2023cites this paper
• Involvement of Transcription Factors and Regulatory Proteins in the Regulation of Carotenoid Accumulation in Plants and Algae.

  2023cites this paper
• Regulation and Improvement of Carotenoid Metabolism in Tomato

  2023cites this paper
• The tomato chloroplast stromal proteome compendium elucidated by leveraging a plastid protein-localization prediction Atlas

  2023cites this paper
• Co-chaperoning of Chlorophyll and Carotenoid Biosynthesis by ORANGE Family Proteins in Plants.

  2023cites this paper
• Regulation of chloroplast protein degradation.

  2023cites this paper
• MEP pathway products allosterically promote monomerization of deoxy-D-xylulose-5-phosphate synthase to feedback-regulate their supply

  2022cites this paper
• Fruit ripening: dynamics and integrated analysis of carotenoids and anthocyanins

  2022cites this paper
• Plant carotenoids: recent advances and future perspectives

  2022cites this paper
• The Intron Retention Variant CsClpP3m Is Involved in Leaf Chlorosis in Some Tea Cultivars

  2022cites this paper
• Orchestration of Chlorophyll and Carotenoid Biosynthesis by ORANGE Family Proteins in Plant

  2022cites this paper
• Protein-protein interaction techniques to investigate post-translational regulation of carotenogenesis.

  2022cites this paper
• Phytoene Synthase: The Key Rate-Limiting Enzyme of Carotenoid Biosynthesis in Plants

  2022cites this paper
• The regulation of nutrients and flavors metabolism in tomato fruits

  2022cites this paper
• A proteostasis network safeguards the chloroplast proteome

  2022cites this paper
• Allosteric feedback inhibition of deoxy-D-xylulose-5-phosphate synthase involves monomerization of the active dimer

  2022cites this paper
• Prospects of chloroplast metabolic engineering for developing nutrient-dense food crops

  2022cites this paper
• Overexpression of PSY1 increases fruit skin and flesh carotenoid content and reveals associated transcription factors in apple (Malus × domestica)

  2022cites this paper
• “Omics” insights into plastid behavior toward improved carotenoid accumulation

  2022influential citation
• A xanthophyll-derived apocarotenoid regulates carotenogenesis in tomato chromoplasts.

  2022cites this paper
• Structure, function, and substrates of Clp AAA+ protease systems in cyanobacteria, plastids, and apicoplasts: A comparative analysis

  2021cites this paper
• The chloroplast-associated protein degradation pathway controls chromoplast development and fruit ripening in tomato

  2021cites this paper
• Making extra room for carotenoids in plant cells: New opportunities for biofortification.

  2021cites this paper
• The Genetic Basis of Tomato Aroma

  2021cites this paper
• Several geranylgeranyl diphosphate synthase isoforms supply metabolic substrates for carotenoid biosynthesis in tomato

  2020cites this paper
• Identification and characterization of carotenoid biosynthesis related genes in a novel dark skinned citrus mutant cultivar ‘Suneat’

  2020influential citation
• Recent Developments in Synthetic Biology Toolbox

  2020cites this paper
• Arabidopsis ORANGE protein regulates plastid preprotein import through interacting with Tic proteins.

  2020cites this paper
• The new kid on the block: A dominant-negative mutation of phototropin1 enhances carotenoid content in tomato fruits

  2020cites this paper
• Synthetic conversion of leaf chloroplasts into carotenoid-rich plastids reveals mechanistic basis of natural chromoplast development

  2020cites this paper
• A transcriptomic, metabolomic and cellular approach to the physiological adaptation of tomato fruit to high temperature.

  2020cites this paper
• Engineering of Microbial Biosynthetic Pathways

  2020cites this paper
• Protein Aggregation in the Pathogenesis of Ischemic Stroke

  2020cites this paper
• Prospects for Carotenoid Biofortification Targeting Retention and Catabolism.

  2020cites this paper
• Plant and Food Carotenoids: Methods and Protocols

  2020cites this paper
• Toward the 'golden' era: The status in uncovering the regulatory control of carotenoid accumulation in plants.

  2020cites this paper
• Identification and characterization of carotenoid biosynthesis related genes in a novel dark skinned citrus mutant cultivar ‘Suneat’

  2020cites this paper
• cis/trans Carotenoid Extraction, Purification, Detection, Quantification, and Profiling in Plant Tissues.

  2020cites this paper
• Carotenoid Pigment Accumulation in Horticultural Plants

  2020cites this paper
• An engineered extraplastidial pathway for carotenoid biofortification of leaves

  2020cites this paper
• Transcriptional Regulation of Carotenoid Biosynthesis in Plants: So Many Regulators, So Little Consensus

  2019cites this paper
• Exogenous phenylalanine application promotes chilling tolerance in tomato fruits during cold storage by ensuring supply of NADPH for activation of ROS scavenging systems

  2019cites this paper
• A basic Helix-Loop-Helix (SlARANCIO), identified from a Solanum pennellii introgression line, affects carotenoid accumulation in tomato fruits

  2019cites this paper
• Synthetic biogenesis of chromoplasts from leaf chloroplasts

  2019cites this paper
• The Role of Carotenogenic Metabolic Flux in Carotenoid Accumulation and Chromoplast Differentiation: Lessons From the Melon Fruit

  2019cites this paper
• The Mars1 kinase confers photoprotection through signaling in the chloroplast unfolded protein response

  2019cites this paper
• Manipulation of Plastidial Protein Quality Control Components as a New Strategy to Improve Carotenoid Contents in Tomato Fruit

  2019cites this paper
• Ectopic expression of ORANGE promotes carotenoid accumulation and fruit development in tomato

  2018cites this paper
• The Multiplanetary Future of Plant Synthetic Biology

  2018cites this paper
• Control of plastidial metabolism by the Clp protease complex.

  2018cites this paper
• A global perspective on carotenoids: Metabolism, biotechnology, and benefits for nutrition and health.

  2018cites this paper
• Emerging Opportunities for Synthetic Biology in Agriculture

  2018cites this paper
• High MT-sHSP23.6 expression increases antioxidant system in ‘Micro-Tom’ tomato fruits during post-harvest hypoxia

  2018cites this paper
• Main Manuscript for Synthetic conversion of leaf chloroplasts into carotenoid-rich plastids reveals mechanistic basis of natural chromoplast development.

  year unknowncites this paper
• The regulation of nutrient and flavor metabolism in tomato fruit

  year unknowncites this paper