The Efflux Transporter ABCG2 Maintains Prostate Stem Cells

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Molecular Cancer Research

• Publication date

  2016-11-17

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1158/1541-7786.MCR-16-0270-TPMID 27856956PMCID PMC5290130
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Defining a Population of Stem-like Human Prostate Cancer Cells That Can Generate and Propagate Castration-Resistant Prostate Cancer

  2016influential reference
• Prostate Cancer Stem-like Cells Contribute to the Development of Castration-Resistant Prostate Cancer

  2015influential reference
• Mechanisms of the androgen receptor splicing in prostate cancer cells

  2014influential reference
• Human Prostate Side Population Cells Demonstrate Stem Cell Properties in Recombination with Urogenital Sinus Mesenchyme

  2013cited by this paper
• Steroid hormone synthetic pathways in prostate cancer

  2013cited by this paper
• ABCG2 inhibitor YHO-13351 sensitizes cancer stem/initiating-like side population cells to irinotecan.

  2013cited by this paper
• c-Kit mediates chemoresistance and tumor-initiating capacity of ovarian cancer cells through activation of Wnt/β-catenin–ATP-binding cassette G2 signaling

  2013cited by this paper
• Hedgehog signaling regulates drug sensitivity by targeting ABC transporters ABCB1 and ABCG2 in epithelial ovarian cancer

  2013cited by this paper
• Targeting the Unique Methylation Pattern of Androgen Receptor (AR) Promoter in Prostate Stem/Progenitor Cells with 5-Aza-2′-deoxycytidine (5-AZA) Leads to Suppressed Prostate Tumorigenesis*

  2012influential reference
• Advanced prostate cancer—a case for adjuvant differentiation therapy

  2012cited by this paper
• AR intragenic deletions linked to androgen receptor splice variant expression and activity in models of prostate cancer progression

  2011cited by this paper
• Steroidogenic Enzymes and Stem Cell Markers Are Upregulated during Androgen Deprivation in Prostate Cancer

  2011influential reference
• Computer-aided molecular design of 1H-imidazole-2,4-diamine derivatives as potential inhibitors of Plasmodium falciparum DHFR enzyme

  2011cited by this paper
• Improving cancer chemotherapy with modulators of ABC drug transporters.

  2011cited by this paper
• The challenge of exploiting ABCG2 in the clinic.

  2011cited by this paper
• Abcg2 labels multiple cell types in skeletal muscle and participates in muscle regeneration

  2011cited by this paper
• Hunterian Lecture. Characterisation of human prostate epithelial progenitor differentiation in response to androgens.

  2011cited by this paper
• Genome-wide analysis of androgen receptor binding and gene regulation in two CWR22-derived prostate cancer cell lines.

  2010cited by this paper
• ABCG2-mediated DyeCycle Violet efflux defined side population in benign and malignant prostate

  2009cited by this paper
• High level functional expression of the ABCG2 multidrug transporter in undifferentiated human embryonic stem cells.

  2008cited by this paper
• Role of the ATP-Binding Cassette Transporter Abcg2 in the Phenotype and Function of Cardiac Side Population Cells

  2008cited by this paper
• Bicalutamide failure in prostate cancer treatment: involvement of Multi Drug Resistance proteins.

  2008cited by this paper
• Gefitinib inhibition of drug resistance to doxorubicin by inactivating ABCG2 in thyroid cancer cell lines.

  2007cited by this paper
• Maintenance of retinal stem cells by Abcg2 is regulated by notch signaling

  2007influential reference
• Cell- and gene-specific regulation of primary target genes by the androgen receptor.

  2007cited by this paper
• Molecular and cellular characterization of ABCG2 in the prostate

  2007cited by this paper
• Breast cancer resistance protein-mediated efflux of androgen in putative benign and malignant prostate stem cells.

  2005influential reference
• Human limbal epithelium contains side population cells expressing the ATP‐binding cassette transporter ABCG2

  2004cited by this paper
• Persistent expression of the ATP-binding cassette transporter, Abcg2, identifies cardiac SP cells in the developing and adult heart.

  2004cited by this paper
• Potent and specific inhibition of the breast cancer resistance protein multidrug transporter in vitro and in mouse intestine by a novel analogue of fumitremorgin C.

  2002cited by this paper
• Role Reversal for Anticancer Agents

  2002cited by this paper
• The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype

  2001cited by this paper
• Androgen induces differentiation of a human papillomavirus 16 E6/E7 immortalized prostate epithelial cell line.

  2001influential reference
• Liarozole--a novel treatment approach for advanced prostate cancer: results of a large randomized trial versus cyproterone acetate. Liarozole Study Group.

  1998cited by this paper
• Butyrate analogue, isobutyramide, inhibits tumor growth and time to androgen‐independent progression in the human prostate LNCaP tumor model

  1998cited by this paper
• Ligand for peroxisome proliferator-activated receptor gamma (troglitazone) has potent antitumor effect against human prostate cancer both in vitro and in vivo.

  1998cited by this paper
• Androgen-dependent cell cycle arrest and apoptotic death in PC-3 prostatic cell cultures expressing a full-length human androgen receptor.

  1997cited by this paper
• Control of LNCaP proliferation and differentiation: Actions and interactions of androgens, Iα,25‐dihydroxycholecalciferol, all‐trans retinoic acid, 9‐cis retinoic acid, and phenylacetate

  1996cited by this paper
• Androgen receptor phosphorylation, turnover, nuclear transport, and transcriptional activation. Specificity for steroids and antihormones.

  1992cited by this paper

• Identification of prognostic biomarkers and development of a prediction model for prostate cancer

  2026cites this paper
• The FOXP1-ABCG2 axis promotes the proliferation of cancer stem cells and induces chemoresistance in pancreatic cancer

  2025cites this paper
• In‐vitro Assessment of BCRP‐Mediated Efflux of Antiseizure Medications in Human Blood‐Brain Barrier Cell Model

  2025cites this paper
• Association of ATP‐binding cassette transporter genomic alterations and expressions with patient survival in breast and prostate cancer

  2025cites this paper
• A review of the efficacy of prostate cancer therapies against castration-resistant prostate cancer.

  2025cites this paper
• A Marine Collagen-Based 3D Scaffold for In Vitro Modeling of Human Prostate Cancer Niche and Anti-Cancer Therapeutic Discovery

  2024cites this paper
• Prostate cancer stem cells and their targeted therapies

  2024cites this paper
• Insights into the Biological Properties of Prostate Cancer Stem Cells: Implications for Cancer Progression and Therapy.

  2024cites this paper
• Cancer stem cell in prostate cancer progression, metastasis and therapy resistance.

  2023cites this paper
• Tumor microenvironment-induced tumor cell plasticity: relationship with hypoxic stress and impact on tumor resistance

  2023cites this paper
• BMP signaling inhibition overcomes chemoresistance of prostate cancer.

  2023cites this paper
• Prostate Cancer Stem Cells: Biology and Treatment Implications

  2023cites this paper
• Doxorubicin-induced senescence promotes resistance to cell death by modulating genes associated with apoptotic and necrotic pathways in prostate cancer DU145 CD133+/CD44+ cells.

  2023cites this paper
• Cancer Stem Cells and Prostate Cancer: A Narrative Review

  2023cites this paper
• Phytochemicals in the Synthetic Era: A Potential Oncosuppressor Against Cancer Stem Cells.

  2023cites this paper
• Prostate Cancer Stem Cells: Clinical Aspects and Targeted Therapies

  2022cites this paper
• Lazertinib improves the efficacy of chemotherapeutic drugs in ABCB1 or ABCG2 overexpression cancer cells in vitro, in vivo, and ex vivo

  2022cites this paper
• Cancer Stem Cell Markers for Urinary Carcinoma

  2022cites this paper
• Role of prostate stem cells and treatment strategies in benign prostate hyperplasia.

  2022cites this paper
• Identification and Validation of Three Hub Genes Involved in Cell Proliferation and Prognosis of Castration-Resistant Prostate Cancer

  2022cites this paper
• Comprehensive Evaluation of Multiple Approaches Targeting ABCB1 to Resensitize Docetaxel-Resistant Prostate Cancer Cell Lines

  2022influential citation
• Eggmanone Effectively Overcomes Prostate Cancer Cell Chemoresistance

  2021cites this paper
• Predictors of therapeutic efficacy of 5-aminolevulinic acid-based photodynamic therapy in human prostate cancer.

  2021cites this paper
• Markers and Reporters to Reveal the Hierarchy in Heterogeneous Cancer Stem Cells

  2021influential citation
• Reporters of Cancer Stem Cells as a Tool for Drug Discovery

  2021cites this paper
• Steroid receptor RNA activator inhibits the migration, invasion and stemness characteristics of renal cell carcinoma cells

  2020cites this paper
• A novel Oct4/Pou5f1-like non-coding RNA controls neural maturation and mediates developmental effects of ethanol.

  2020cites this paper
• Targeted Delivery of Therapeutics to Urological Cancer Stem Cells.

  2020cites this paper
• Pharmacological targeting of mitochondria in cancer stem cells: An ancient organelle at the crossroad of novel anti‐cancer therapies

  2019cites this paper
• Bioactive lipids in cancer stem cells

  2019cites this paper
• Strategy of differentiation therapy: effect of dual-frequency ultrasound on the induction of liver cancer stem-like cells on a HA-based multilayer film system.

  2019cites this paper
• Characterization of Dermal Stem Cells of Diabetic Patients

  2019cites this paper
• Major glucuronide metabolites of testosterone are primarily transported by MRP2 and MRP3 in human liver, intestine and kidney.

  2019cites this paper
• The PI3K/AKT signaling pathway regulates ABCG2 expression and confers resistance to chemotherapy in human multiple myeloma

  2019cites this paper
• Bcl-2 Antiapoptotic Family Proteins and Chemoresistance in Cancer.

  2018cites this paper
• Molecular Targeted Therapies of Prostate Cancer

  2018cites this paper
• ABC Transporters in Cancer Stem Cells: Beyond Chemoresistance

  2017cites this paper