Chemistry and biology of landomycins, an expanding family of polyketide natural products.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Mini-Reviews in Medical Chemistry

• Publication date

  2009-07-31

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.2174/138955709788922593PMID 19689401
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Function of lanI in regulation of landomycin A biosynthesis in Streptomyces cyanogenus S136 and cross-complementation studies with Streptomyces antibiotic regulatory proteins encoding genes

  2008cited by this paper
• De novo synthesis of the trisaccharide subunit of landomycins A and E.

  2008cited by this paper
• Coordination of export and glycosylation of landomycins in Streptomyces cyanogenus S136.

  2008cited by this paper
• Type II polyketide synthases: gaining a deeper insight into enzymatic teamwork.

  2007cited by this paper
• Mechanisms underlying the anticancer activities of the angucycline landomycin E.

  2007cited by this paper
• Generation of New Landomycins with Altered Saccharide Patterns through Over‐expression of the Glycosyltransferase Gene lanGT3 in the Biosynthetic Gene Cluster of Landomycin A in Streptomyces cyanogenus S‐136

  2007cited by this paper
• Anticancer activity of the lanthanum compound [tris(1,10-phenanthroline)lanthanum(III)]trithiocyanate (KP772; FFC24).

  2006cited by this paper
• On the acceptor substrate of C-glycosyltransferase UrdGT2: three prejadomycin C-Glycosides from an engineered mutant of Streptomyces globisporus 1912 DeltalndE(urdGT2).

  2006cited by this paper
• A putative proteinase gene is involved in regulation of landomycin E biosynthesis in Streptomyces globisporus 1912.

  2006cited by this paper
• Expression of the regulatory protein LndI for landomycin E production in Streptomyces globisporus 1912 is controlled by the availability of tRNA for the rare UUA codon.

  2006cited by this paper
• Targeting multidrug resistance in cancer

  2006cited by this paper
• Identification of the function of gene lndM2 encoding a bifunctional oxygenase-reductase involved in the biosynthesis of the antitumor antibiotic landomycin E by Streptomyces globisporus 1912 supports the originally assigned structure for landomycinone.

  2005cited by this paper
• DNA-binding activity of LndI protein and temporal expression of the gene that upregulates landomycin E production in Streptomyces globisporus 1912.

  2005cited by this paper
• LanGT2 Catalyzes the First Glycosylation Step during Landomycin A Biosynthesis

  2005cited by this paper
• Generation of Novel Landomycins M and O through Targeted Gene Disruption

  2005cited by this paper
• Glycosyltransferases involved in the biosynthesis of biologically active natural products that contain oligosaccharides.

  2005cited by this paper
• Tumour stem cells and drug resistance

  2005cited by this paper
• LanV, a Bifunctional Enzyme: Aromatase and Ketoreductase during Landomycin A Biosynthesis

  2005cited by this paper
• Iteratively acting glycosyltransferases involved in the hexasaccharide biosynthesis of landomycin A.

  2005cited by this paper
• Effect of landomycin E on expression of mRNA coding for transforming growth factor beta ligands and specific receptors in MCF-7 cells.

  2005cited by this paper
• Rational Saccharide Extension by Using the Natural Product Glycosyltransferase LanGT4

  2004cited by this paper
• Generation of new landomycins by combinatorial biosynthetic manipulation of the LndGT4 gene of the landomycin E cluster in S. globisporus.

  2004cited by this paper
• Anthracyclines: Molecular Advances and Pharmacologic Developments in Antitumor Activity and Cardiotoxicity

  2004cited by this paper
• Efficient synthesis of the hexasaccharide fragment of landomycin A: using phenyl 2,3-O-thionocarbonyl-1-thioglycosides as 2-deoxy-beta-glycoside precursors.

  2002cited by this paper
• Studies on the synthesis of landomycin A: synthesis and glycosidation reactions of L-rhodinosyl acetate derivatives.

  2001cited by this paper
• Elucidation of the function of two glycosyltransferase genes (lanGT1 and lanGT4) involved in landomycin biosynthesis and generation of new oligosaccharide antibiotics.

  2001cited by this paper
• Altering the glycosylation pattern of bioactive compounds.

  2001cited by this paper
• Cloning and characterization of a gene cluster from Streptomyces cyanogenus S136 probably involved in landomycin biosynthesis.

  1999cited by this paper
• A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin.

  1999cited by this paper
• Landomycin A inhibits DNA synthesis and G1/S cell cycle progression.

  1999cited by this paper
• Cellular resistance to anthracyclines.

  1996cited by this paper
• Angucycline group antibiotics.

  1992cited by this paper
• Landomycins, new angucycline antibiotics from Streptomyces sp. I. Structural studies on landomycins A-D.

  1990cited by this paper
• Metabolic products of microorganisms. 240. Urdamycins, new angucycline antibiotics from Streptomyces fradiae. II. Structural studies of urdamycins B to F.

  1987cited by this paper

• Bioactive Angucyclines/Angucyclinones Discovered from 1965 to 2023

  2025cites this paper
• Mining the cryptic specialized metabolome of Streptomyces cyanogenus S136

  2024cites this paper
• Divergence of Classical and C-Ring-Cleaved Angucyclines: Elucidation of Early Tailoring Steps in Lugdunomycin and Thioangucycline Biosynthesis

  2024cites this paper
• Insights into the Biological Properties of Ligands and Identity of Operator Site for LanK Protein Involved in Landomycin Production

  2023cites this paper
• Sequences Similar to the lan-Cluster (Streptomyces cyanogenus S136) Were Found in the Genomes of Other Streptomycetes

  2023cites this paper
• The carbohydrate tail of landomycin A is responsible for its interaction with the repressor protein LanK

  2022cites this paper
• Similarity and difference of organizations of streptomycetic landomycins clusters

  2022cites this paper
• Complete genome sequence of Streptomyces cyanogenus S136, producer of anticancer angucycline landomycin A

  2021cites this paper
• Landomycins as glutathione-depleting agents and natural fluorescent probes for cellular Michael adduct-dependent quinone metabolism

  2021cites this paper
• Hauser–Kraus, Sammes, Staunton–Weinreb, and Tamura Annulations

  2021cites this paper
• Total synthesis of landomycins Q and R and related core structures for exploration of the cytotoxicity and antibacterial properties

  2021cites this paper
• Functional and Structural Insights into a Novel Promiscuous Ketoreductase of the Lugdunomycin Biosynthetic Pathway

  2020cites this paper
• Enhancement of angucycline production by combined UV mutagenesis and ribosome engineering and fermentation optimization in Streptomyces dengpaensis XZHG99T

  2020cites this paper
• Bacterial Type II Polyketide Synthases

  2019cites this paper
• Landomycin biosynthesis and its regulation in Streptomyces

  2019cites this paper
• Heterologous AdpA transcription factors enhance landomycin production in Streptomyces cyanogenus S136 under a broad range of growth conditions

  2018cites this paper
• A general strategy for diverse syntheses of anhydrolandomycinone, tetrangulol, and landomycinone.

  2018cites this paper
• Self-Organization of Pristine C 60 Fullerene and its Complexes with Chemotherapy Drugs in Aqueous Solution as Promising Anticancer Agents

  2018cites this paper
• Development of Conditions of Submerged Biosynthesis of Landomycin A

  2017cites this paper
• Study of the complexation between Landomycin A and C60 fullerene in aqueous solution

  2016cites this paper
• Insights into Complex Oxidation during BE-7585A Biosynthesis: Structural Determination and Analysis of the Polyketide Monooxygenase BexE.

  2016cites this paper
• Complete Sequence of Landomycin E Biosynthetic Gene Cluster from Streptomyces globisporus 1912

  2015cites this paper
• THE ROLE OF REACTIVE OXYGEN SPECIES IN TUMOR CELLS APOPTOSIS INDUCED BY LANDOMYCIN A.

  2015cites this paper
• Structure-based engineering of angucyclinone 6-ketoreductases.

  2014cites this paper
• Ruthenium-catalyzed cross-metathesis with electron-rich phenyl vinyl sulfide enables access to 2,3-dideoxy-D-ribopyranose ring system donors

  2014cites this paper
• Structural and functional analysis of angucycline C-6 ketoreductase LanV involved in landomycin biosynthesis.

  2013cites this paper
• Saquayamycins G-K, cytotoxic angucyclines from Streptomyces sp. Including two analogues bearing the aminosugar rednose.

  2012cites this paper
• Organocuprate‐Initiated Domino Michael–Intramolecular Aldol Reaction – Application to the Formation of Ring B of the Aglycon of Landomycins

  2012cites this paper
• Delineation of gilvocarcin, jadomycin, and landomycin pathways through combinatorial biosynthetic enzymology.

  2012cites this paper
• Landomycins P-W, cytotoxic angucyclines from Streptomyces cyanogenus S-136.

  2011cites this paper
• Current state and perspectives of biotechnological production of antibiotics

  2011cites this paper
• Functional analysis of environmental DNA-derived type II polyketide synthases reveals structurally diverse secondary metabolites

  2011cites this paper
• Investigating Mithramycin Deoxysugar Biosynthesis: Enzymatic Total Synthesis of TDP‐D‐Olivose

  2011cites this paper
• Identification and characterization of the Streptomyces globisporus 1912 regulatory gene lndYR that affects sporulation and antibiotic production.

  2011cites this paper
• Chemistry and Biology of Landomycins, an Expanding Family of Polyketide Natural Products

  2010cites this paper
• Synthesis of the landomycinone skeleton.

  2010cites this paper