INHIBITION OF DOPAMINE UPTAKE IN VITRO BY RESERPINE ADMINISTERED IN VIVO.

The accumulation of dopamine-C 14 and its conversion to norepinephrine was measured in adrenal gland homogenates of 29 control cats and 28 cats injected with 2.5 mg of reserpine intraperitoneally. It was observed that up to 2 days after the injection of reserpine the total catecholamine content of the adrenal gland was 70% depleted and its ability to accumulate dopamine was inhibited by about 90%. By the third day the catecholamine content and the ability to accumulate and convert dopamine to norepinephrine began to recover and at the end of 2 weeks were at normal levels. These observations are interpreted to support the hypothesis that reserpine causes a depletion of the catecholamine stores by inhibiting the transport of dopamine into the granules and there its subsequent conversion to norepinephrine.

• Publication year

  1963

• Venue

  Journal of Pharmacology and Experimental Therapeutics

• Publication date

  1963-09-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/s0022-3565(25)26613-7PMID 14064189
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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