Neuropeptide Y mediates glucocorticoid-induced osteoporosis and marrow adiposity in mice

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Osteoporosis International

• Publication date

  2016-04-14

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s00198-016-3598-3PMID 27080706
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Hdac3 Deficiency Increases Marrow Adiposity and Induces Lipid Storage and Glucocorticoid Metabolism in Osteochondroprogenitor Cells

  2016cited by this paper
• Neuropeptide Y stimulates osteoblastic differentiation and VEGF expression of bone marrow mesenchymal stem cells related to canonical Wnt signaling activating in vitro.

  2016cited by this paper
• Loss of Bone and Wnt10b Expression in Male Type 1 Diabetic Mice Is Blocked by the Probiotic Lactobacillus reuteri.

  2015cited by this paper
• Adipocyte SIRT1 knockout promotes PPARγ activity, adipogenesis and insulin sensitivity in chronic-HFD and obesity

  2015cited by this paper
• MicroRNA-29a mitigates glucocorticoid induction of bone loss and fatty marrow by rescuing Runx2 acetylation.

  2015cited by this paper
• High neuropeptide Y release associates with Ewing sarcoma bone dissemination - in vivo model of site-specific metastases

  2015cited by this paper
• Glucocorticoid-induced osteoporosis: who to treat with what agent?

  2015cited by this paper
• Histone Deacetylase Inhibition Destabilizes the Multi‐Potent State of Uncommitted Adipose‐Derived Mesenchymal Stromal Cells

  2015cited by this paper
• Pharmacological Repression of PPARγ Promotes Osteogenesis

  2015cited by this paper
• p38α function in osteoblasts influences adipose tissue homeostasis

  2015cited by this paper
• Glucocorticoids and bone: local effects and systemic implications.

  2014cited by this paper
• Role of Plasminogen Activator Inhibitor-1 in Glucocorticoid-Induced Diabetes and Osteopenia in Mice

  2014cited by this paper
• Abnormalities in cortical bone, trabecular plates, and stiffness in postmenopausal women treated with glucocorticoids.

  2014cited by this paper
• An Erk/Cdk5 axis controls the diabetogenic actions of PPARγ

  2014cited by this paper
• NPY antagonism reduces adiposity and attenuates age‐related imbalance of adipose tissue metabolism

  2014cited by this paper
• Influence of early zoledronic acid administration on bone marrow fat in ovariectomized rats.

  2014cited by this paper
• Leptin-receptor-expressing mesenchymal stromal cells represent the main source of bone formed by adult bone marrow.

  2014cited by this paper
• Identification of highly efficacious glucocorticoid receptor agonists with a potential for reduced clinical bone side effects.

  2014cited by this paper
• Neuropeptide Y Attenuates Stress‐Induced Bone Loss Through Suppression of Noradrenaline Circuits

  2014influential reference
• Loss of Gsα Early in the Osteoblast Lineage Favors Adipogenic Differentiation of Mesenchymal Progenitors and Committed Osteoblast Precursors

  2014cited by this paper
• Bone marrow leptin signaling mediates obesity-associated adipose tissue inflammation in male mice.

  2014cited by this paper
• Glucocorticoid-induced osteoporosis: mechanisms, management, and future perspectives.

  2013cited by this paper
• The next five years for the JBMR: Opportunities and challenges

  2013cited by this paper
• Neuropeptide Y modulates fracture healing through Y1 receptor signaling

  2013cited by this paper
• Regulation of neuropeptide Y Y1 receptor expression by bone morphogenetic protein 2 in C2C12 myoblasts.

  2013cited by this paper
• PPARγ forms a bridge between DNA methylation and histone acetylation at the C/EBPα gene promoter to regulate the balance between osteogenesis and adipogenesis of bone marrow stromal cells

  2013cited by this paper
• Dexamethasone shifts bone marrow stromal cells from osteoblasts to adipocytes by C/EBPalpha promoter methylation

  2013cited by this paper
• Standardized nomenclature, symbols, and units for bone histomorphometry: A 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee

  2013cited by this paper
• Dexamethasone-induced lipolysis increases the adverse effect of adipocytes on osteoblasts using cells derived from human mesenchymal stem cells.

  2013cited by this paper
• SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β-catenin

  2013cited by this paper
• Selective glucocorticoid receptor modulation maintains bone mineral density in mice

  2012cited by this paper
• Intracellular mechanisms coupled to NPY Y2 and Y5 receptor activation and lipid accumulation in murine adipocytes.

  2012cited by this paper
• Neuropeptide Y1 Receptor in Immune Cells Regulates Inflammation and Insulin Resistance Associated With Diet-Induced Obesity

  2012cited by this paper
• High-fat diet triggers inflammation-induced cleavage of SIRT1 in adipose tissue to promote metabolic dysfunction.

  2012cited by this paper
• Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of Pparγ.

  2012cited by this paper
• Central and peripheral mechanisms of the NPY system in the regulation of bone and adipose tissue.

  2012cited by this paper
• Osteoporosis: now and the future

  2011cited by this paper
• Osteoblast specific Y1 receptor deletion enhances bone mass.

  2011cited by this paper
• Neuropeptide Y impairs insulin-stimulated translocation of glucose transporter 4 in 3T3-L1 adipocytes through the Y1 receptor.

  2011cited by this paper
• SIRT1 is required for long-term growth of human mesenchymal stem cells

  2011cited by this paper
• Glucocorticoids suppress bone formation by attenuating osteoblast differentiation via the monomeric glucocorticoid receptor.

  2010cited by this paper
• Critical role for Y1 receptors in mesenchymal progenitor cell differentiation and osteoblast activity

  2010cited by this paper
• Neuropeptide Y Knockout Mice Reveal a Central Role of NPY in the Coordination of Bone Mass to Body Weight

  2009cited by this paper
• Greater Bone Formation of Y2 Knockout Mice Is Associated with Increased Osteoprogenitor Numbers and Altered Y1 Receptor Expression*

  2007cited by this paper
• Neuropeptide Y acts directly in the periphery on fat tissue and mediates stress-induced obesity and metabolic syndrome

  2007cited by this paper
• Monosodium glutamate-sensitive hypothalamic neurons contribute to the control of bone mass.

  2003cited by this paper
• Now And The Future

  1999cited by this paper

• Metabolic Rewiring and Post-Translational Modifications: Unlocking the Mechanisms of Bone Turnover in Osteoporosis

  2025cites this paper
• Role of sirtuins in obesity and osteoporosis: molecular mechanisms and therapeutic targets

  2025cites this paper
• Gut microbiome and bone health: update on mechanisms, clinical correlations, and possible treatment strategies

  2024cites this paper
• The multiple actions of dipeptidyl peptidase 4 (DPP-4) and its pharmacological inhibition on bone metabolism: a review

  2024cites this paper
• Crosstalk between bone and brain in Alzheimer's disease: Mechanisms, applications, and perspectives

  2024cites this paper
• The role of sensory and sympathetic nerves in craniofacial bone regeneration.

  2023cites this paper
• Modified Qing’ e Pills exerts anti-osteoporosis effects and prevents bone loss by enhancing type H blood vessel formation

  2022cites this paper
• The Role of NPY in the Regulation of Bone Metabolism

  2022cites this paper
• Neural regulation of bone marrow adipose tissue.

  2021cites this paper
• Animal Model for Glucocorticoid Induced Osteoporosis: A Systematic Review from 2011 to 2021

  2021cites this paper
• Therapeutic potential of phosphodiesterase inhibitors in the treatment of osteoporosis: scopes for therapeutic repurposing and discovery of new oral osteoanabolic drugs.

  2021cites this paper
• Glucocorticoids Influencing Wnt/β-Catenin Pathway; Multiple Sites, Heterogeneous Effects

  2020cites this paper
• Reporting Guidelines, Review of Methodological Standards, and Challenges Toward Harmonization in Bone Marrow Adiposity Research. Report of the Methodologies Working Group of the International Bone Marrow Adiposity Society

  2020cites this paper
• Diabetes Mellitus and Osteoporosis Correlation: Challenges and Hopes.

  2020cites this paper
• Sex differences in behavioral and metabolic effects of gene inactivation: The neuropeptide Y and Y receptors in the brain.

  2020cites this paper
• Divergent effects of peripheral and global neuropeptide Y deletion

  2020cites this paper
• Aging and lineage allocation changes of bone marrow skeletal (stromal) stem cells.

  2019cites this paper
• Inhibition of PPARγ by bisphenol A diglycidyl ether ameliorates dexamethasone-induced osteoporosis in a mouse model

  2019cites this paper
• Heat Shock Protein 60 Regulation of Skeletal Tissue Integrity

  2019cites this paper
• Skeletal phenotype of the neuropeptide Y knockout mouse.

  2019cites this paper
• Overexpression of WNT16 Does Not Prevent Cortical Bone Loss Due to Glucocorticoid Treatment in Mice

  2018cites this paper
• Sclerostin vaccination mitigates estrogen deficiency induction of bone mass loss and microstructure deterioration.

  2018cites this paper
• Bone Marrow Adipose Tissue and Skeletal Health

  2018cites this paper
• Cell–cell communication in bone development and whole‐body homeostasis and pharmacological avenues for bone disorders

  2017cites this paper
• Prenatal stress changes courtship vocalizations and bone mineral density in mice.

  2017cites this paper
• Current views on neuropeptide Y and diabetes-related atherosclerosis

  2017cites this paper
• Histone demethylase UTX counteracts glucocorticoid deregulation of osteogenesis by modulating histone-dependent and -independent pathways

  2017influential citation
• Neuropeptide Y1 Receptor Regulates Glucocorticoid-Induced Inhibition of Osteoblast Differentiation in Murine MC3T3-E1 Cells via ERK Signaling

  2016cites this paper