Prophylactic N-acetylcysteine decreases serum CRP but not PCT levels and microalbuminuria following major abdominal surgery. A prospective, randomised, double-blinded, placebo-controlled clinical trial

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Intensive Care Medicine

• Publication date

  2003-04-08

• Fields of study

  Medicine

• Identifiers
  DOI 10.1007/s00134-003-1723-1PMID 12682719
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1995influential reference
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  1995cited by this paper
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  1994influential reference
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  1993influential reference
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  1992influential reference
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  1991cited by this paper
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  1990influential reference
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  1990cited by this paper
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  1989influential reference
• Urinary albumin excretion in healthy adult subjects: reference values and some factors affecting their interpretation.

  1988cited by this paper
• APACHE II: A severity of disease classification system

  1985cited by this paper

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• References

  1966cites this paper