Apigenin inhibits the proliferation and invasion of osteosarcoma cells by suppressing the Wnt/β-catenin signaling pathway.

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Oncology Report

• Publication date

  2015-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.3892/or.2015.4022PMID 26035210
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Wnt signaling in osteosarcoma.

  2014cited by this paper
• miR-451: potential role as tumor suppressor of human hepatoma cell growth and invasion.

  2014cited by this paper
• Overexpression of cytoplasmic β-catenin inhibits the metastasis of the murine osteosarcoma cell line LM8

  2014cited by this paper
• MicroRNA-34a Inhibits the Proliferation and Metastasis of Osteosarcoma Cells Both In Vitro and In Vivo

  2012cited by this paper
• Apigenin induces apoptosis through mitochondrial dysfunction in U-2 OS human osteosarcoma cells and inhibits osteosarcoma xenograft tumor growth in vivo.

  2012cited by this paper
• SiRNA-mediated silencing of beta-catenin suppresses invasion and chemosensitivity to doxorubicin in MG-63 osteosarcoma cells.

  2011cited by this paper
• Salinomycin inhibits osteosarcoma by targeting its tumor stem cells.

  2011cited by this paper
• Osteosarcoma: review of the past, impact on the future. The American experience.

  2009cited by this paper
• Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice.

  2009cited by this paper
• Downregulation of Wnt2 and β-catenin by siRNA suppresses malignant glioma cell growth

  2009cited by this paper
• Apigenin inhibited migration and invasion of human ovarian cancer A2780 cells through focal adhesion kinase.

  2008cited by this paper
• Apigenin and cancer chemoprevention: progress, potential and promise (review).

  2007cited by this paper
• Apigenin inhibits pancreatic cancer cell proliferation through G2/M cell cycle arrest

  2006cited by this paper
• Wnt/beta-catenin signaling in development and disease.

  2006cited by this paper
• Prognostic factors for osteosarcoma of the extremity treated with neoadjuvant chemotherapy

  2006cited by this paper
• Beta-catenin up-regulates the expression of cyclinD1, c-myc and MMP-7 in human pancreatic cancer: relationships with carcinogenesis and metastasis.

  2005cited by this paper
• The Wnt signaling pathway in development and disease.

  2004cited by this paper
• Apigenin Induces Apoptosis through Proteasomal Degradation of HER2/neu in HER2/neu-overexpressing Breast Cancer Cells via the Phosphatidylinositol 3-Kinase/Akt-dependent Pathway*

  2004cited by this paper
• Activation of the Wnt pathway in non small cell lung cancer: evidence of dishevelled overexpression

  2003cited by this paper
• Beta-catenin and Tcfs in mammary development and cancer.

  2003cited by this paper
• Current Treatment of Osteosarcoma

  2001cited by this paper
• Cell‐Cycle Arrest at G2/M and Growth Inhibition by Apigenin in Human Colon Carcinoma Cell Lines

  2000cited by this paper
• Wnt signaling and cancer.

  2000cited by this paper
• beta-catenin regulates the expression of the matrix metalloproteinase-7 in human colorectal cancer.

  1999cited by this paper
• β-Catenin Regulates the Expression of the Matrix Metalloproteinase-7 in Human Colorectal Cancer

  1999cited by this paper

• Targeting signaling cascades by bioactive phytocompounds in osteosarcoma: A novel therapeutic approach.

  2026cites this paper
• Integrated in silico and in vitro evaluation of Genistein and Apigenin as dual inhibitors of PARP1 and ESR1 in breast cancer

  2026cites this paper
• Salvia coccinea and Apigenin: A Natural Treasure of Lamiaceae in Pharmacological Innovation

  2026cites this paper
• Regulation of Natural Products on Wnt/β-Catenin Signaling Pathway in Diseases.

  2025cites this paper
• Therapeutic Potential of Flavonoids in Osteosarcoma: Molecular Mechanisms and Clinical Implications

  2025cites this paper
• Bioactive Compounds from Propolis on Bone Homeostasis: A Narrative Review

  2025cites this paper
• The Protective Activity of Apigenin Against Bone and Cartilage Diseases

  2025cites this paper
• The Molecular Mechanisms Underlying the Antineoplastic Profile of Vitexin 2″‐O‐α‐L‐Rhamnopyranoside From Cordyline australis (G.Frost.): Isolation and Constituent Profiling

  2025cites this paper
• Harnessing apigenin for breast cancer treatment: Current insights

  2025cites this paper
• Nano-based apigenin delivery systems for cancer applications

  2024cites this paper
• Targeting the SIRT3/MnSOD and JNK/HMGB1/Beclin 1 Axes: Role of Apigenin in Multifaceted Metabolic Intervention in Colorectal Cancer

  2024cites this paper
• Natural Flavonoid Apigenin, an Effective Agent Against Nervous System Cancers

  2024cites this paper
• Targeting Wnt/β-Catenin Pathway by Flavonoids: Implication for Cancer Therapeutics

  2023cites this paper
• Resources for Human Health from the Plant Kingdom: The Potential Role of the Flavonoid Apigenin in Cancer Counteraction

  2023cites this paper
• Multi-Anticancer Activities of Phytoestrogens in Human Osteosarcoma

  2023cites this paper
• Flavonoids target different molecules of autophagic and metastatic pathways in cancer cells

  2023cites this paper
• Apigenin in cancer therapy: From mechanism of action to nano-therapeutic agent.

  2022cites this paper
• The Potential Role of Apigenin in Cancer Prevention and Treatment

  2022influential citation
• Exploring the recent trends in perturbing the cellular signaling pathways in cancer by natural products

  2022cites this paper
• Crosstalk between xanthine oxidase (XO) inhibiting and cancer chemotherapeutic properties of comestible flavonoids- a comprehensive update.

  2022cites this paper
• Role of Plant-Derived Active Constituents in Cancer Treatment and Their Mechanisms of Action

  2022cites this paper
• Apigenin promotes osteogenic differentiation of mesenchymal stem cells and accelerates bone fracture healing via activating Wnt/β-catenin signaling.

  2021cites this paper
• Dietary polyphenols suppress chronic inflammation by modulation of multiple inflammation-associated cell signaling pathways.

  2021cites this paper
• Apigenin Inhibits the Growth of Hepatocellular Carcinoma Cells by Affecting the Expression of microRNA Transcriptome

  2021cites this paper
• Targeting the crosstalk between canonical Wnt/β-catenin and inflammatory signaling cascades: A novel strategy for cancer prevention and therapy.

  2021cites this paper
• An Insight into the Therapeutic Potential of Phytochemicals for Colorectal Cancer: Latest Perspective

  2021cites this paper
• Plant-derived small molecule inhibitors as modulators of EMT pathway in cancer chemoprevention

  2021cites this paper
• Synergistic anti-colon cancer effects and mechanisms by combined phytochemicals

  2021cites this paper
• H19-Wnt/β-catenin regulatory axis mediates the suppressive effects of Apigenin on tumor growth in hepatocellular carcinoma.

  2020cites this paper
• Apigenin as an anticancer agent.

  2020cites this paper
• Nature-derived compounds modulating Wnt/β-catenin pathway: a preventive and therapeutic opportunity in neoplastic diseases

  2020cites this paper
• Pharmacotherapeutic Botanicals for Cancer Chemoprevention

  2020cites this paper
• miR-429 inhibits osteosarcoma progression by targeting HOXA9 through suppressing Wnt/β-catenin signaling pathway

  2020cites this paper
• Apigenin as Tumor Suppressor in Cancers: Biotherapeutic Activity, Nanodelivery, and Mechanisms With Emphasis on Pancreatic Cancer

  2020cites this paper
• Potential Pharmacotherapeutic Phytochemicals from Zingiberaceae for Cancer Prevention

  2020cites this paper
• Rationalizing the therapeutic potential of apigenin against cancer.

  2020cites this paper
• Nano-engineered flavonoids for cancer protection.

  2019cites this paper
• Wnt-β-catenin signaling pathway, the Achilles' heels of cancer multidrug resistance.

  2019cites this paper
• Apigenin, a flavonoid constituent derived from P. villosa, inhibits hepatocellular carcinoma cell growth by CyclinD1/CDK4 regulation via p38 MAPK-p21 signaling.

  2019cites this paper
• Potential proapoptotic phytochemical agents for the treatment and prevention of colorectal cancer

  2019cites this paper
• Down-regulation of microRNA-31-5p inhibits proliferation and invasion of osteosarcoma cells through Wnt/β-catenin signaling pathway by enhancing AXIN1.

  2019cites this paper
• Apigenin inhibits fibroblast proliferation and reduces epidural fibrosis by regulating Wnt3a/β-catenin signaling pathway

  2019cites this paper
• Apigenin as an effective anticancer natural product: Spotlight on TRAIL, WNT/β‐catenin, JAK‐STAT pathways, and microRNAs

  2018cites this paper
• Cytotoxic Activity of Propolis Extracts from the Stingless Bee Trigona Sirindhornae Against Primary and Metastatic Head and Neck Cancer Cell Lines

  2017cites this paper
• Plant Flavone Apigenin: an Emerging Anticancer Agent

  2017cites this paper
• Effects of flavonoids incorporated biological macromolecules based scaffolds in bone tissue engineering.

  2017cites this paper
• Targeted inhibition of miR-340 on β-catenin to potentiate Adriamycin sensitivity of osteosarcoma Saos-2 cells

  2017cites this paper
• Apigenin: A current review on its beneficial biological activities

  2017cites this paper
• Apigenin in cancer therapy: anti-cancer effects and mechanisms of action

  2017cites this paper
• In Vitro and In Vivo Anti-tumoral Effects of the Flavonoid Apigenin in Malignant Mesothelioma

  2017influential citation
• Transcriptomic analyses reveal the underlying pro-malignant functions of PTHR1 for osteosarcoma via activation of Wnt and angiogenesis pathways

  2017cites this paper
• Natural compounds targeting major cell signaling pathways: a novel paradigm for osteosarcoma therapy

  2017cites this paper
• Naturally occurring compounds acting as potent anti‐metastatic agents and their suppressing effects on Hedgehog and WNT/β‐catenin signalling pathways

  2017cites this paper
• Suppression of adriamycin resistance in osteosarcoma by blocking Wnt/β-catenin signal pathway.

  2017cites this paper
• Apigenin inhibits NF-κB and Snail signaling, EMT and metastasis in human hepatocellular carcinoma

  2016cites this paper
• Original Article Apigenin inhibits TGF-β1-induced proliferation and migration of airway smooth muscle cells

  2015cites this paper
• Apigenin inhibits TGF-β1-induced proliferation and migration of airway smooth muscle cells.

  2015cites this paper
• Induction of G2/M Phase Block and Apoptosis by Kaempferol in Human Sarcoma Cells

  year unknowncites this paper
• Suppression of adriamycin resistance in osteosarcoma by blocking Wnt / β-catenin signal pathway

  year unknowncites this paper